Clinical trials: sponsored by University Hospital, Antwerp
Lung Transplant Failure and Rejection, Primary Graft Dysfunction
CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation
Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD).
- Trial name
- NCT04558333
- Testing
- blood and exhaled breath specimens
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- University Hospital, Antwerp
Colon Cancer
ASPIRIN Trial Belgium
The purpose of this study is to determine whether acetylsalicylic acid is effective on the recurrence and survival of colon cancer patients.
- Trial name
- ASPIRIN (NCT03464305)
- Testing
- acetylsalicylic acid
- Where
- 29 sites in Belgium
- Volunteers
- 148 people
- Sponsor
- University Hospital, Antwerp
Lung Cancer, Nonsmall Cell, Lung Cancer
Implementation of Lung Cancer Screening in the First Line Zone of ZORA (Flanders), Using a Low Dose CT-scan
The goal of this clinical trial is to implement lung cancer screening in a targeted high-risk population of heavy (ex-)smokers in Flanders (Belgium).
- Conditions
- Lung Cancer, Nonsmall Cell, Lung Cancer, Smoking Cessation, Lung Cancer, Small Cell
- Trial name
- ZORALCS (NCT06293833)
- Testing
- Low-dose CT scan, Smoking Cessation
- Where
- Belgium
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
Exercise Capacity Improvement by Conduction System Pacing in heArt Failure patieNts Without Compelling CRT inDication
This randomized controlled trial aims to investigate the impact of conduction system pacing in comparison to right ventricular apical pacing on exercise capacity, as measured by peak oxygen uptake (VO2peak), in heart failure…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction, Heart Conduction Disorder
- Trial name
- ESCPAND (NCT06278844)
- Testing
- Conduction system pacing, Right ventricular apical pacing
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- University Hospital, Antwerp
Marfan Syndrome, FBN1 Mutation
Genome-wide Epistasis for Cardiovascular Severity in Marfan Study
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder with pleiotropic manifestations in the ocular, skeletal and cardiovascular systems.
- Trial name
- GEMS (NCT06257004)
- Testing
- Saliva collection (screening of all participants), Bloodsampling
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Antwerp
Covid19, Athletes Heart
Effect of CoVid-19 (CoronaVirusDisease-19) and Exercise on Myocardial Fibrosis and Ventricular Arrhythmias
COVID-19 can cause myocarditis, which can cause myocardial fibrosis. This has been shown to increase mortality and morbidity among athletes.
- Conditions
- Covid19, Athletes Heart, Myocarditis Viral, Ventricular Arrythmia
- Trial name
- CoViDEx (NCT04726150)
- Testing
- ILR implantation
- Where
- Belgium
- Volunteers
- 85 people
- Sponsor
- University Hospital, Antwerp
Pelvic Organ Prolapse, Rectocele
Multicenter Ventral Mesh Rectopexy Registry Collaborative
The goal of this multicenter observational study is to collect data prospectively of patients with pelvic organ prolapse undergoing ventral mesh rectopexy (as well as rectoceles, entero-/sigmoidoceles/ intussusception/ rectal…
- Conditions
- Pelvic Organ Prolapse, Rectocele, Enterocele, Rectal Prolapse
- Trial name
- M2R2 (NCT05918367)
- Where
- 5 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Antwerp
Coronary Microvascular Dysfunction, Coronary Artery Vasospasm
Belgian Registry on Coronary Function Testing
The goal of this prospective, multicenter registy is to describe the 'real-world' use of coronary function tests, which may consist of bolus thermodilution measurements of coronary microvascular function and/or invasive…
- Trial name
- BELmicro (NCT06089031)
- Testing
- Coronary Function Test
- Where
- 13 sites in Belgium
- Volunteers
- 650 people
- Sponsor
- University Hospital, Antwerp
Cancer
The Immune Reaction Upon COVID-19 Vaccination in the Belgian Cancer Population.
This study investigates the immune response in the cancer population in Belgium being vaccinated with an approved vaccine types being authorized for use in Belgium.
- Trial name
- REAL-V (NCT05033158)
- Testing
- Blood sampling
- Where
- 8 sites in Belgium
- Volunteers
- 402 people
- Sponsor
- University Hospital, Antwerp
Pain, Acute, Anesthesia
Pupillary Dilation Reflex Assessment for Intraoperative Analgesic Titration.
In this double blinded randomized controlled study, the pupillary dilation reflex is used for as a nociceptive indicator for opioid administration during elective surgery under general anesthesia.
- Trial name
- PUP-AIT (NCT03248908)
- Testing
- Pupillary dilation reflex, Standard of care
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- University Hospital, Antwerp
Critical Illness
The Use of Nociception Flexion Reflex and Pupillary Dilatation Reflex in ICU Patients.
The aim of the study was to describe the feasibility of the nociception flexion reflex and the pupillary dilatation reflex as objective pain assessment tools in the Intensive Care Unit (ICU).
- Trial name
- NCT02916004
- Testing
- Measurement of NFR and PDR
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Antwerp
Obesity, Atherosclerosis
Endothelial Dysfunction in Obese Children
The purpose of this study is to objectify the effect of diet and exercise on early markers of atherosclerosis in obese children.
- Trial name
- EDOC (NCT01461226)
- Testing
- Exercise training, Usual care
- Where
- 3 sites in Belgium
- Volunteers
- 61 people
- Sponsor
- University Hospital, Antwerp
Analgesia, Scoliosis Idiopathic
Multidisciplinary Perioperative Care Pathway in Adolescents Undergoing Posterior Spinal Fusion Surgery
Posterior Spinal fusion (PSF) is one of the most invasive orthopedic surgical procedures in children and adolescents, often characterized by extensive tissue trauma, and severe postoperative pain.
- Conditions
- Analgesia, Scoliosis Idiopathic, Surgery, Postoperative Pain
- Trial name
- NCT04038229
- Testing
- Enhanced recovery pathway
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- University Hospital, Antwerp
Angina Pectoris, Variant, Angina Pectoris; Spasm-Induced
ReACHallenge Trial: Acetylcholine Rechallenge After Pretreatment With Vasoactive Drugs
The goal of this clinical trial is to assess the feasibility and clinical value of acetylcholine (ACH) rechallenge after intracoronary verapamil +- nitroglycerine in a patient cohort with angina and non-obstructive coronary…
- Conditions
- Angina Pectoris, Variant, Angina Pectoris; Spasm-Induced, Angina Pectoris With Normal Coronary Arteriogram
- Trial name
- ReACHallenge (NCT05618132)
- Testing
- Acetylcholine rechallenge
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Antwerp
Cardiovascular Diseases
Survey on the Future of Telemedicine in the Daily Care of Cardiology Patients.
The Cardiology research group at the Jessa Hospital Hasselt and the University Hospital Antwerp (in collaboration with the University of Hasselt and the University of Antwerp) is conducting research into remote patient monitoring…
- Trial name
- MEDICAR (NCT05337020)
- Testing
- Survey
- Where
- 2 sites in Belgium
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Traumatic Brain Injury
CENTER-TBI: Collaborative European NeuroTrauma Effectiveness Research in TBI
The research aims of the CENTER-TBI study are to: 1. better characterize Traumatic Brain Injury (TBI) as a disease and describe it in a European context, and 2. identify the most effective clinical interventions for managing TBI.
- Trial name
- CENTER-TBI (NCT02210221)
- Where
- 65 sites in Austria, Belgium and 17 more
- Volunteers
- 4,559 people
- Sponsor
- University Hospital, Antwerp
Atherosclerosis, Restenosis
Blood Endothelium Progenitor Cells and Dendritic Cells as Predictive Biomarkers of In-stent Restenosis
clinically relevant in stent restenosis occurs in 5-10% of the non-diabetic patients treated with a coronary bare metal stent. Recent research has identified endothelial progenitor cells as well as dendritic cells as components…
- Trial name
- NCT00493597
- Where
- Belgium
- Volunteers
- 124 people
- Sponsor
- University Hospital, Antwerp
Atrial Fibrillation and Flutter
Effect of Targeted Education for Atrial Fibrillation Patients (Application Substudy)
The aim of this study is to evaluate a new and innovative educational application based on targeted education on the adherence level for NOACs (non-vitamin K antagonist oral anticoagulants) in AF patients, compared with standard…
- Trial name
- AF-EduApp (NCT03788044)
- Testing
- Education
- Where
- 2 sites in Belgium
- Volunteers
- 194 people
- Sponsor
- University Hospital, Antwerp
Diabetes Mellitus, Type 1
The Link Between "Time In Range" Versus HbA1c and the Presence of Chronic COmplications in Type 1 Diabetes: a Longitudinal Study
HbA1c is currently the only metric of glucose control showing an association with chronic complications of type 1 diabetes mellitus (T1D).
- Trial name
- TIRCO (NCT05530369)
- Volunteers
- 479 people
- Sponsor
- University Hospital, Antwerp
Diabetes Mellitus, Type 1
cArdiopulmonary exerCise Test Assessing Multiple biOmarkers and Hormones iN Type 1 diabetEs Under Different Circumstances
Collection of venous blood samples in 50 persons with type 1 diabetes to evaluate the behavior of different biomarkers (glucose, lactate, beta-hydroxybutyrate), and hormones (cortisol, growth hormone) during and after one morning…
- Trial name
- ACT-ONE (NCT05429359)
- Testing
- CPET: CardioPulmonary Exercise Test for CSII users, AEX1: Aerobic Exercise Test 1 for CSII users, AEX2: Aerobic Exercise Test 2 for CSII users
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp