Clinical trials: sponsored by University Hospital, Brest
Small Cell Lung Carcinoma
Searching for Predictive Biomarkers of Efficacy in Small Cell Lung Cancer Patients Treated With Chemotherapy-immunotherapy Combination Using Imaging Mass Cytometry (HYPE)
The goal of this retrospective study is to identify predictive biomarkers of efficacy in tumor samples of small cell lung cancer patients treated with chemotherapy-immunotherapy combination using imaging mass cytometry.
- Trial name
- HYPE (NCT06558903)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Knee Arthritis
Internal Unicompartmental Arthroplasty After Tibial Valgization Osteotomy
This retrospective, monocentric study is about outcomes concerning patients who benefit from medial unicompartmental knee arthroplasty after previous high tibial osteotomy.
- Trial name
- ArOs (NCT06559592)
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Immune Thrombocytopenia
Observatory of Immunological Thrombopenic Purpura in the Brest Region
Database of patients with ITP, diagnosed, treated and followed in the Brest University Hospital.
- Trial name
- OPTIMIST (NCT06556888)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Brest
Electromagnetic Field
Management of Patients Who Claim to be Electrosensitive
Know qualitatively the ways to deal with these patients, in general medicine in Brittany, and the difficulties encountered, through thematic and lexicometric analysis of responses
- Trial name
- IEI CEM EN MED (NCT06556901)
- Testing
- retrospective study about reasons for consultations
- Where
- France
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Alcohol Withdrawal Syndrome
Evaluation of a Predictive Score for the Onset of Moderate to Severe Alcohol Withdrawal Syndrome, the PAWSS, in a Population of Intensive Care Patients at Brest University Hospital
alcohol use disorder (AUD) is a very common condition in patients admitting in ICU's. Brutal stop of alcohol consumption may lead to a withdrawal syndrome, wich is associated with a worse outcome for ICU patients (longuer ICU and…
- Trial name
- PAWSS-ICU (NCT06555679)
- Where
- France
- Volunteers
- 403 people
- Sponsor
- University Hospital, Brest
Lumbar Canal Stenosis
Anterior Discectomy Surgery With Arthrodesis in Degenerative Spinal Canal sténoses. (ICASC)
Single-center retrospective study to characterize changes in the functional capacity of patients (change in Oswestry Desability Index (ODI)) undergoing anterior approach surgery for the management of symptomatic lumbar spinal…
- Trial name
- ICASC (NCT06555887)
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Brest
Creation of a Warehouse of Clinical Data and Physiological Signals at the Patient's Bedside
Predicting Episodes of Intracranial Hypertension in Neuro-injured Patients: Development of a Decision Algorithm Using Artificial Intelligence (PREDICT-CE)
The investigators wish to build up a database of clinical data and physiological signals with a view to developing a predictive algorithm based on continuous analysis of the intracranial pressure waveform and other parameters…
- Trial name
- PREDICT-CE (NCT06555900)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Brest
the Safety / Feasibility /MORENO Score/Regulation / Secondary Transfers / SAMU 29 / Current Practices
Evaluation of the MORENO Score for the Regulation
The main objective of this work is therefore to evaluate the safety and feasibility of the MORENO score for the regulation of secondary transfers to the SAMU 29 compared to current practices.
- Trial name
- ESMORTSAB19 (NCT06555874)
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Brest
Identify FDG PET/CT Parameters Predictive of Local Control
Local Recurrence Prediction of by Texture Analysis Derived From Positron Emission Tomography (PET / CT) Imaging of Non-small Cell Lung Cancer (NSCLC) Treated With Stereotactic Radiotherapy (SBRT) (Retros MUMOFRAT)
The aim of this retrospective multicentric study was to develop and evaluate a prognostic FDG PET/CT radiomics signature in early-stage non-small cell lung cancer (NSCLC) patients treated with stereotactic radiotherapy (SBRT).
- Trial name
- MUMOFRAT retro (NCT06555861)
- Where
- 4 sites in France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Brest
Rhizarthrosis, Prosthesis Failure
Interest of Bone Scintigraphy in the Search for Scaphotrapezoidal Osteoarthritis
Rhizarthosis can be treated by prothesis of the carpo-metacarpal (CM) joint of the thumb. But, if the scaphotrapeziotrapezoid (STT) joint is also affected by arthrosis, treating the CM joint exclusively may result in partial pain…
- Trial name
- PSR (NCT06555250)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Diving Barotrauma
Practice of Scuba Diving by as Many People as Possible: Effect of Medical Assessment to Provide a Suitable and Individualised Framework for Practice (Plongée Santé)
The study focuses on the practice of recreational scuba diving by people who have obtained medical advice for their practice in the hyperbaric and underwater medicine department of the Brest University Hospital.
- Trial name
- Healthy-diving (NCT06555666)
- Where
- France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Brest
Aging, Premature, HIV Infections
Epidemiological Study of the Markers of Aging in the Cohort of Patient HIV in Brest
RATIONALE: HIV pathology has been associated with accelerated aging of the infected organism, with no known knowledge of virus, immunosuppression, immune response stimulation, antiretroviral toxicity, and "classic" risks.
- Trial name
- VIHVA (NCT06554210)
- Where
- France
- Volunteers
- 213 people
- Sponsor
- University Hospital, Brest
Diabetes Mellitus
Anesthetic Management of Diabetes in Perioperative Urology and Visceral Surgery
It is recognized that a poor glycemic, pre- and intraoperative balance is the source of increase in morbimortality. There was no local protocol at the CHRU Brest regarding the perioperative management of the diabetic patient.
- Trial name
- DIAPRO-BREST (NCT06553170)
- Where
- France
- Volunteers
- 196 people
- Sponsor
- University Hospital, Brest
Myeloproliferative Neoplasm
Evaluation of the Prognostic Impact of Decreased Serum beta2 Microglobulin in the First Year of Follow-up of Myeloproliferative Neoplasia (PRODIGE)
50 patients with a diagnosis of MPN will have an assessment of b2microglobuline at diagnosis and after 1 year. b2mic value decrease will be compared to treatment response.
- Trial name
- PRODIGE (NCT06553638)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Human Papilloma Virus, Infertility, Female
Impact of Human Papillomavirus Carriage on IVF/ICSI Results (HPV AMP)
The prevalence of the papilloma virus in the general population is 12%. This virus is known to impair male fertility but its impact on female infertility remains uncertain.
- Trial name
- HPV-AMP (NCT06550531)
- Where
- France
- Volunteers
- 618 people
- Sponsor
- University Hospital, Brest
Atopic Dermatitis
Atopic Dermatitis Cutaneous Discomfort of the Infant Under the Age of One Year : Analysis of Filmed Sequences (PRE-PRURINEO)
Analysis of filmed sequences for the assessment of discomfort in atopic dermatitis in infants under 1year of age
- Trial name
- PRE-PRURINEO (NCT06551363)
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Brest
Advanced Small Cell Lung Carcinoma
Real-life Second-line Epirubicin-Paclitaxel Regimen as Treatment of Relapsed Small-Cell Lung Cancer : EpiTax Study.
Initial chemosensitivity is known concerning SCLC but relapse is almost systematic, especially at a metastatic stage. Brain metastasis are identified around 40 to 50% during the evolution of the disease.
- Trial name
- EPITAX (NCT06550518)
- Where
- 3 sites in France
- Volunteers
- 29 people
- Sponsor
- University Hospital, Brest
Cardiac Surgery
Management of the Patient at High Risk Hemorrhagic in Cardiac Surgery by Monitoring Viscoelastic Hemostasis.
Evaluation and following of a protocol using viscoelastic test for the management of high risk patients in cardiac surgery
- Trial name
- ELASTICC (NCT06550505)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Noonan Syndrome
Joint and Hematologic Disorders of Noonan Syndrome: French Descriptive Cross-sectional Study
Noonan's syndrome is a rare genetic disease, estimated to be between 1: 1000 to 1: 2500 and characterized by cardiothoracic malformations, sometimes mental retardation, but also by hematologic abnormalities and joint involvement.
- Trial name
- NOORHA (NCT06550635)
- Where
- 4 sites in France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Brest
Multiple Myeloma
Finistere Myeloma Observatory (OMYFIN)
Current molecular risk stratification of multiple myeloma (MM), based on the presence of t(4 ;14) and 17p deletion, cannot fully explain treatment outcome heterogeneity, as other features also predict prognosis.
- Trial name
- OMYFIN (NCT06552221)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest