Clinical trials: sponsored by University Hospital, Brest
Human Papilloma Virus, Infertility, Female
Impact of Human Papillomavirus Carriage on IVF/ICSI Results (HPV AMP)
The prevalence of the papilloma virus in the general population is 12%. This virus is known to impair male fertility but its impact on female infertility remains uncertain.
- Trial name
- HPV-AMP (NCT06550531)
- Where
- France
- Volunteers
- 618 people
- Sponsor
- University Hospital, Brest
Bone Scintigraphy and Knee Arthroplasty
Bone Scintigraphy and Unicompartimental Knee Arthroplasty
Study the potential interest of bone scintigraphy for patients undergoing unicompartmental knee arthroplasty
- Trial name
- PUC-INTEVO (NCT03145090)
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Endodontic Disease
Patients' Experiences During Endodontic Treatments Performed by Hospital Externs at the CHRU of Brest
Root canal treatment (RCT) consists in eliminating infected and / or inflammatory tissues inside the root canal system of the tooth by a chemo-mechanical preparation and then filling the latter in a three-dimensional…
- Trial name
- ENDOVECU (NCT05285176)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Brest
Carbon Monoxide Poisoning
Cardiotoxicity of Carbon Monoxide in Patients Treated With Hyperbaric Oxygen Therapy
Carbon monoxide poisoning is a frequent domestic accident and the leading cause of death from unintentionnal poisoning. Its toxicity is based on the CO binding to hemoglobin and myoglobin, inhibition of mitochondrial cytochrome…
- Trial name
- COCARDIOTOX (NCT06549621)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Brest
Chronic Obstructive Pulmonary Disease
Educational Follow-up in COPD Patients After Pulmonary Rehabilitation.
After pulmonary rehabilitation, the challenge is to maintain the benefits reached during the program and increase physical activity. As exercise training, education is the corner stone of pulmonary rehabilitation.
- Trial name
- EDURESPI (NCT04473313)
- Where
- 2 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Brest
Polycythemia Vera, Essential Thrombocythemia
Myeloproliferative Neoplastic Diseases Observatory From Brest
All patients diagnosed or followed in Brest University Hospital for Philadelphia negative myeloproliferative neoplasms will be included in this observational study.
- Conditions
- Polycythemia Vera, Essential Thrombocythemia, Primary Myelofibrosis
- Trial name
- OBENE (NCT02897297)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Brest
Critical Illness
Setting up a Warehouse of Physiological Data and Biomedical Signals in Adult Intensive Care
The aim of this study is the establishment of a warehouse physiological data and biomedical signal in intensive care adult patients in acute situations from particular records from the Philips Intellivue MP70 monitor.
- Trial name
- REASTOC (NCT02893462)
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Brest
Smoking Cessation
Systematic Screening for COPD in Tabacology Consultation
COPD is a very common disease, an estimated 3 million people are affected in France. Unfortunately, this pathology is under-diagnosed. Several reasons can be mentioned: the banality of the symptoms or the several comorbidities.
- Trial name
- DEBOTA (NCT04843605)
- Where
- France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Brest
Neutropenia, Febrile
Antibiotics Management of Septic Neutropenic Patients in the Intensive Care Unit
Neutropenia, defined by an absolute count of polymorphonuclear neutrophils less than <1500/mm3, exposes patients to infectious complications that can lead to sepsis or septic shock. The mortality risk is higher risk.
- Trial name
- REANEUF (NCT03217721)
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Brest
COPD, Pulmonary Rehabilitation
Effects of Respiratory Rehabilitation by Gender in COPD Patients
Without calling into question the effectiveness of pulmonary rehabilitation in women, the difference in outcome by gender was not established due to insufficient evidence .
- Trial name
- REHABGENRE (NCT04297514)
- Where
- France
- Volunteers
- 504 people
- Sponsor
- University Hospital, Brest
Pneumocystis Pneumonia
Droplet Digital PCR and PCR-free BIOSensors for the Detection of Resistance-associated SNPs in Pneumocystis Jirovecii
The main objective of the proposed research is to identify Pneumocystis jirovecii mutant strains on 4 genes encoding therapeutic targets such as dihydropteroate synthase (DHPS), dihydrofolate reductase (DHFR), cytochrome b (CYB)…
- Trial name
- DDBIOS (NCT06431958)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Colorectal Cancer, Colorectal Adenocarcinoma
Analysis of Histopathological Factors Predictive of Lymph Node Involvement and Management Practices in pT1 Colorectal Cancers Treated by Primary Endoscopic Resection
Colorectal cancers (CRC) extending beyond the muscularis mucosae and invading the submucosa without extending beyond it are classified as pT1.
- Trial name
- PROMOT1 (NCT06339346)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Brest
Esophagus Cancer
Impact of Dose to Cardiac Substructures on Survival in Patients With Esophageal Cancer Treated With Radiotherapy or Chemoradiotherapy (SATIATION)
Treatment of non-operable esophageal cancers is based on radiochemotherapy, or exclusive radiotherapy. The cardiac toxicity of radiotherapy in the treatment of thoracic tumor localizations is well documented, however, more and…
- Trial name
- SATIATION (NCT05996276)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Brest
Pulmonary Embolism, COVID-19
Lung Scintigraphy for Pulmonary Embolism Diagnosis in COVID-19 Patients.
A frequent complication of COVID-19 disease is pulmonary embolism (PE). Lung ventilation/perfusion (V/P) scintigraphy is a well-established test for PE diagnosis.
- Trial name
- SCINTI-COVID (NCT05353608)
- Where
- 2 sites in France
- Volunteers
- 183 people
- Sponsor
- University Hospital, Brest
Polycystic Kidney Diseases
Study and Management of Cystic Complications in Autosomal Dominant Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease is characterised by the development of renal and hepatic cysts. While the main complication is chronic end-stage renal failure, specific cyst-related complications are common…
- Trial name
- COMPLIK (NCT06036992)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Brest
Rheumatoid Arthritis, COVID
Drug Management of Rheumatoid Arthritis in Covid-19 Context : Impact on Therapeutic De-escalation
The current situation of Sars-Cov-2 pandemic generates fears in the general population. Among patients receiving long-term immunomodulatory drugs, especially in the context of auto-immune diseases, there may be legitimates…
- Trial name
- RHUMACOVID (NCT04393233)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Lung Cancer Stage III, Lung Cancer Stage IV
Prognostic Value of Combined Approach Based on KEAP1/NFE2L2 Mutations and Pre-therapeutic FDG-PET/CT Radiomic Analysis in Advanced Non-small-cell Lung Cancer PDL1 ≥ 50% Treated With Pembrolizumab (PEMBROMIC)
Pembrolizumab has been approved for first-line locally advanced or metastatic NSCLC with a tumor proportion score (TPS) ≥50% for PDL1, based on the results of KEYNOTE-024.
- Trial name
- PEMBROMIC (NCT05996263)
- Where
- France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Brest
Atrial Fibrillation, Cardioembolic Stroke
Long-term Results of Percutaneous Left Atrial Closure at Brest University Hospital (CLAPOT)
Atrial Fibrillation represents an important risk of cardioembolic stroke. In more than 90% of cases, thrombus originate in the left atrial appendage.
- Conditions
- Atrial Fibrillation, Cardioembolic Stroke, Left Atrial Appendage Thrombosis, Anticoagulant-induced Bleeding
- Trial name
- CLAPOT (NCT06232278)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Brest
Prosthesis User, Orthopedic Disorder
Study of Patient Preferences in Relation to the Fitting of a Personalized and Connected Joint Prosthesis.
The goal of this observational study is to learn about patients' preference toward the use of customized and connected prosthesis.
- Trial name
- FKprefPat (NCT06100354)
- Testing
- Answering preference
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Brain Metastases, Adult
Stereotactic Radiotherapy Management of Brain Metastases: the Value of a Longitudinal Multimodal Approach (POSTPONE)
The management of brain metastases has evolved́ rapidly in recent years. It is estimated that 20% to 40% of cancer patients will develop brain metastases (BM) during the course of their disease.
- Trial name
- POSTPONE (NCT06029140)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Brest