Clinical trials: sponsored by University Hospital, Brest
Platelet Transfusion, Critical Illness
Platelet Transfusions in Critically Ill Patient
Between 10 and 15% of critically ill patients require platelet transfusion within their intensive care unit (ICU). Platelets (PLT) are given to prevent bleeding in thrombocytopenic patients or to treat bleeding as part of massive…
- Trial name
- RE-CCIP (NCT03325140)
- Where
- 7 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
sjögren Disease
Ultrasound Elastography of Salivary Glands
Ultrasonography in salivary gland has demonstrated its usefulness to diagnose and follow patients with Sjögren syndrome (pSS). More recently, a new imaging technique allows to study the parenchymal elasticity in salivary glands…
- Trial name
- ELSA (NCT02994797)
- Where
- France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Brest
Myeloproliferative Disorder
Clinical Characteristics of Aquagenic Pruritus in Patients With Myeloproliferative Neoplasms
Description of the characteristics of aquagenic pruritus expressed by patients suffering from myeloproliferative neoplasms. Prospective work based on the distribution of a dedicated questionnaire.
- Trial name
- PASYMPLE (NCT03688490)
- Volunteers
- 70 people
- Sponsor
- University Hospital, Brest
Breast Neoplasms, HER-2 Gene Amplification
Evaluation of Pertuzumab-Trastuzumab and Taxane in the Standard Treatment of Metastatic Breast Cancer
This retrospective study evaluated the efficacy and the safety of use of this treatment combined with a taxane for the treatment of HER2-positive metastatic breast cancer and compared the clinical and demographic characteristics…
- Trial name
- EPTTCSM (NCT03979911)
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Brest
Suicide, Attempted
Acceptability Study by Patients Admitted for Suicide and by Medical Staff for Clinical Data Collection Through an E-health Platform
The study goal is to determine the feasbility and interest of monitoring mental health and non mental health related simptoms in Outpatients in order to prevent suicide.
- Trial name
- MeMind (NCT03686670)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Fathers, Premature Birth
Study on the Treatment of Children and Their Families in Services Related to Early Childhood
Breastfeeding is recommended for preterm infants. Development of breastfeeding is an important issue, requiring the involvement of medical and paramedical staff in neonatal units.
- Trial name
- PERAM-QUAL (NCT02201433)
- Where
- 2 sites in France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Keloids Scars
Observational Study of Keloids Scars Treated by Shaving and Cryosurgery
Treatment of keloids scars is difficult and controversial. These keloids have a functional and aesthetic impact. A lot of treatment are described with a lot of relapses and aggravation.
- Trial name
- KELOIDS SCARS (NCT02886091)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Brest
Ventilation, Exercise
Wetsuit and Life Jacket Induced Effects on Spirometry and VO2 in Windsurfers
The purpose of this study is to investigate the effect of wearing both neoprene suit and life jacket on respiratory capacities at rest and cardiopulmonary capacities during exercise in windsurfers.
- Trial name
- WINDSURF (NCT03440294)
- Testing
- resting standard spirometry, maximum exercise testing
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Melanoma, NSCLC
18FDG-PET in Patients With Melanoma or NSCLC Treated With Immunotherapy
Study the EFS and OS according to 18FDG PET in patients with melanoma or non small cell lung cancer treated by immunotherapy.
- Conditions
- Melanoma, NSCLC, Positron-Emission Tomography, Immunotherapy
- Trial name
- IMMUNOPET (NCT03741231)
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Brest
Autoimmune Diseases, Advanced Cancer
Immune Checkpoint Inhibitors and Pre-existing Autoimmune Diseases
The tolerance of immune checkpoint inhibitors is unknown in patients with pre-existing autoimmune conditions. This retrospective nation-wide study will assess their tolerance in patients with pre-existing autoimmune conditions…
- Trial name
- NCT03140137
- Testing
- Checkpoint inhibitor therapy
- Where
- 5 sites in France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Brest
Rheumatoid Arthritis
Does Abatacept Induce Regulatory B Cells in Patients With Rheumatoid Arthritis
Abatacept disrupts T-cell coactivation signals in rheumatoid arthritis (RA). Its potential effects on B cells are not well described.
- Trial name
- ABATACEPT_B (NCT02885818)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Airway Obstruction
Airway Resistance Measurement in Children 3 to 6 Years of Age
In preschool aged children, the most suitable techniques to assess airway obstruction is debit interruption technic (Rint) and plethysmographic measure of specific airway resistance (sRaw).
- Trial name
- ARC36 (NCT02563210)
- Testing
- airway resistance measurement
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Brest
Cardiovascular Disease
Scaling-up Packages of Interventions for Cardiovascular Disease Prevention in Selected Sites in Europe and Sub-Saharan Africa: An Implementation Research
Cardiovascular disease is the leading cause of death in the world. 17.5 million people died in 2012 due to a cerebrovascular disease (31% of all causes of death).
- Trial name
- SPICES_PHASE_1 (NCT03154736)
- Testing
- Interview
- Where
- 21 sites in France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Cerebral Palsy
Independent Walking Onset of Children With Cerebral Palsy
This study will focus the gait analysis, using an optoelectronic system, of children with unilateral cerebral palsy compared to typically developed children in the first 6 months of independent walking.
- Trial name
- BB-AQM (NCT03902886)
- Testing
- gait analysis
- Where
- 2 sites in France, Romania
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Autoimmune Diseases
Lymphocyte Sub-populations and Auto Immune Diseases
To determine if artificial intelligence allow to detect lymphocyte subpopulations specific of diseases (such as primary Sjogren' syndrome and systemic lupus erythematosus) among patients with suspicion of autoimmune diseases.
- Trial name
- SPLIT (NCT03901664)
- Where
- France
- Volunteers
- 3,500 people
- Sponsor
- University Hospital, Brest
Infection, Dental Calculus
Infectious Agents Exposure : Archiving in Dental Plaque
We are studying the possibility of using dental calculus as a reservoir for the genes of an infectious agent that has infected the patient in previous months; as it is done to highlight climate change in ice samples.
- Trial name
- DIAS (NCT03864952)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Brest
Cancer of Head and Neck
Forecasts Impact of the Pre-therapeutic TEP-TDM in the 18-FDG Restaging of Upper Aero-digestive Tract Cancers
Head and neck (HN) cancer is the sixth most common malignancy worldwide, with around 800 000 new cases and 320 000 deaths in 2015.
- Trial name
- RENOVATE (NCT03841175)
- Where
- France
- Volunteers
- 477 people
- Sponsor
- University Hospital, Brest
Major Thoracic and Abdominal Surgery
Automatic Oxygen Administration After Major Abdominal and Thoracic Surgery
The aim of the study is to assess the use feasibility of the FreeO2 system so as to deliver automatically oxygen in the post anesthesia care unit in a patient population admitted for major abdominal and thoracic surgery.
- Trial name
- FreeO2PostOp (NCT02546830)
- Testing
- FreeO2 v2.2 active, FreeO2 v2.2 with manual oxygenation
- Where
- 5 sites in Canada, France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Bullous Pemphigoid
Clinical Characteristics of Pruritus and Evaluation of Quality of Life in Patients With Bullous Pemphigoid
Whereas pruritus is a major symptom in bullous pemphigoid, its characteristics and its impact on quality of life have been little studied.
- Trial name
- PRURIPB (NCT03272958)
- Where
- 16 sites in France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Brest
Chronic Periodontitis, Intensive Care Unit
Chronic Periodontitis in Critically Ill Patients: Diagnosis and Epidemiology
This study evaluates the diagnostic performances of Point of Care P. gingivalis test in saliva with serum IgG P. gingivalis, in reference to dental examination as a gold standard in patients hospitalised in intensive care unit…
- Trial name
- CP-ICU (NCT02672384)
- Testing
- Dental examination and a point of care P. gingivalis test (Denka Seiken Co (Japan) )
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest