Clinical trials: sponsored by University Hospital, Brest
Haemodialysis
Epidemiologic Study and Impact Study of a Dialysis Solution Change on the Electrocardiographic Profile of Patient
Epidemiologic Study and Impact Study of a Dialysis Solution Change on the Electrocardiographic Profile of Patient
- Trial name
- QT_DIAL (NCT02887742)
- Where
- 2 sites in France
- Volunteers
- 57 people
- Sponsor
- University Hospital, Brest
Chronic Obstructive Pulmonary Disease
Inspiratory Muscle Training During Pulmonary Rehabilitation in COPD
Demonstrate that IMT associated with a conventional pulmonary rehabilitation program allows a significant improvement of dyspnea in subjects with severe or very severe COPD than a conventional pulmonary rehabilitation program…
- Trial name
- EMI II (NCT02074813)
- Testing
- Inspiratory muscle training
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Brest
Febrile Neutropenia, Hematological Malignancy
Early Antibiotic Discontinuation in FUO
Febrile neutropenia requires prompt initiation of broad-spectrum antibiotics, which can be responsible for side-effects and selection of resistance.
- Trial name
- ANTIBIOSTOP (NCT02906254)
- Testing
- ECIL-4 guidelines group, Short-course antibiotic therapy
- Where
- France
- Volunteers
- 123 people
- Sponsor
- University Hospital, Brest
Haemodialysis
Evaluation of the Validity of the Prothrombin Time Internation Normalised Ratio (PT/INR) Measured at the point-of Care on the Arterial Bloodline of Haemodialysis Extracorporeal Blood Flow
The purpose of this study is to evaluate the INR value of hemodialyzed patient coagulation state (prothrombin time) measured inside the therapeutical zone and thanks to a portable monitor.
- Trial name
- COAGHEMO (NCT02902848)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Ultrasound in Patients With Atypical Shape of Psoriasis
Ultrasound Study of Entheses and Small Joints of Hands and Feet in Patients With Atypical Form of Psoriasis
Systematic study of the ultrasound infringements of tendons chest expanders of entheses the most involved in spondylarthropathies and small joints of hands and feet in expanding patients of psoriasis to estimate if there is an…
- Trial name
- ECHOPSO (NCT02899429)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Acute Myeloid Leukemia, Invasive Aspergillosis
Invasives Aspergillosis in Acute Myeloid Leukemia
Patients with acute myeloid leukemia (AML) are at risk to develop severe infections whose invasive aspergillosis (IA). These infections are leading to an important morbidity and mortality.
- Trial name
- IA-AML (NCT02900430)
- Testing
- Patients without antifungal prophylaxis, Patients with antifungal prophylaxis
- Where
- France
- Volunteers
- 246 people
- Sponsor
- University Hospital, Brest
Critical Illness, Acute Kidney Injury
Outcomes of Critically Ill Patients With Severe Acute Kidney Injury Requiring Renal Replacement Therapy
This study assess the vital status, renal function and renal recovery of patients admitted to intensive care unit and requiring renal replacement therapy for acute kidney failure.
- Trial name
- PROVEER (NCT02897310)
- Where
- France
- Volunteers
- 245 people
- Sponsor
- University Hospital, Brest
Description of Brown Fat
Description of the Appearance of Brown Fat in Scanner
The aim of this study is to investigate aspects of brown fat in scanner with injection via the PET-CT study.
- Trial name
- BAT (NCT02891889)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Post-burn Innervation
Study of the Cutaneous Reinnervation After Burn
The aim of this study is to understand why the regeneration of the cutaneous sensory nerve fibers is poor in post-burn scar. The presence or the lack of several molecular factors known to regulate neuronal cell development will…
- Trial name
- NERVAL (NCT02356354)
- Testing
- Skin biopsy
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Brest
Next Generation Sequencing for HLA Typing
NGS for HLA Typing of Donors and récipients oh Hematopoietic Stem Cells
The objective of this study is to realize the typing of all HLA loci and validate this technique with continued optimization of next-generation sequencing technology (NGS).
- Trial name
- NGS HLA (NCT02892292)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Purpura, Thrombocytopenic, Idiopathic, Regulatory B Cells
Regulatory B Cells and Chronic Immune Thrombocytopenia
The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells.
- Trial name
- PTIREG (NCT02891109)
- Testing
- Biological tests
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Preoperative Fasting and Hypotension
Effect of the Duration of Preoperative Fasting on Hypotension Induced by General Anesthesia in the Elderly Person
This study aims to determine if prolonged fasting represents an independent risk factor for hypotension during induction of general anesthesia in the elderly.
- Trial name
- JEÛNE PREOP (NCT02891122)
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Brest
Polymyalgia Rheumatica
Lymphocyte and Cytokine Disturbances in Polymyalgia Rheumatica
Pathophysiology of polymyalgia rheumatica (PMR) is ill defined. This study aims at characterizing immunological abnormalities in PMR patients, and to assess the effects of tocilizumab therapy on this abnormalities.
- Trial name
- TENOR-IMMUNO (NCT02888496)
- Testing
- tocilizumab
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Marrow Adiposity Lumbar Spine
Mapping the Lumbar Spine Marrow Adiposity
The objective of this study is to describe the change in the percentage of fat in the lumbar spine.
- Trial name
- FATFRAC (NCT02887716)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Autosomal Dominant Polycystic Kidney Disease
Analysis of Clinical and Molecular Genetic Data Influencing the Evolution and Response to Therapy of ADPKD Patients (Autosomal Dominant Polycystic Kidney Disease)
Genkyst is a regional cohort involving up to nephrologists working in private and public nephrology centers in the West of France.
- Trial name
- GENKYST (NCT02887729)
- Where
- 26 sites in France
- Volunteers
- 4,000 people
- Sponsor
- University Hospital, Brest
Preoperative Assessment of Hemostasis
Auto-administered Questionnaire by Screening of Disorder of the Haemostasis in Preoperative
The main objective of this study is to determine the capacity of a questionnaire to predict a normal balance sheet of haemostasis.
- Trial name
- HEMOSTASE (NCT02886117)
- Where
- France
- Volunteers
- 2,511 people
- Sponsor
- University Hospital, Brest
Campylobacter Infections, Bone Diseases, Infectious
Retrospective Study of Bone Infection Due to Campylobacter Spp
Only 24 cases of Campylobacter bone and joint infection (BJI) have been reported worldwide between 1955 and 2008. Between 2010 and 2012, 7 cases were observed in two University hospitals in France.
- Trial name
- CAMPYLO (NCT02884752)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Brest
Postpartum Hemorrhage
Study of Biological Determinants of Bleeding Postpartum
At the entry of the delivery room, a standard blood analysis will be performed (Blood count, PT, aPTT, Fibrinogen, and D-Dimer) for each women (if they are agree), according to the center's practices.
- Trial name
- HPP-IPF (NCT02884804)
- Where
- France
- Volunteers
- 3,599 people
- Sponsor
- University Hospital, Brest
Wounds and Injury, Bleeding
Management of Bleeding and Coagulopathy in Trauma and Compliance to European Trauma Guidelines
This cohort study describes the epidemiology of trauma patients and their management in a French academic trauma center. It also aims to determine what recommendations from the European trauma guidelines is applied in routine.
- Trial name
- APP (NCT02884999)
- Where
- France
- Volunteers
- 145 people
- Sponsor
- University Hospital, Brest
Motor Disorders, Pain
Care-related Pain and Discomfort in People With Motor Disorder
The combination of motor disabilities, chronic pain, cognitive disabilities limiting the possibilities of communications and repeated potentially painful rehabilitation, exposes patients with motor disabilities to a high risk of…
- Trial name
- DIS-HANDI (NCT02720731)
- Where
- 10 sites in France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Brest