Clinical trials: sponsored by University Hospital, Brest
Respiratory Ilness, Children
Microbiote's Evolution After Use of Nitrous Oxide on Pediatric Patient Needing Airway Samples
The objective of this study is to determine whether the use of MEOPA alters the composition of respiratory microbiota collected by induced sputum in children requiring respiratory sampling for suspected lower respiratory tract…
- Trial name
- MicroNO (NCT07118644)
- Testing
- MEOPA, Standard induced sputum
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Brest
Pruritus
Efficacy and Tolerance of THC 25: CBD 25 in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study
Chronic pruritus affects 10-20% of the population and causes a major reduction in quality of life, comparable to pain, with significant psychological, social, and functional consequences.
- Trial name
- CANNA-ITCH (NCT06435299)
- Testing
- Cannabis oil
- Where
- 6 sites in France
- Volunteers
- 218 people
- Sponsor
- University Hospital, Brest
Virtual Reality, Depression
Use of Virtual Reality as a Tool for Cognitive Remediation in Elderly Depressed Patients
Depression, the most common mental disorder affecting the elderly, represents a major public health issue. This pathology leads to a loss of activity and autonomy in the elderly.
- Trial name
- REVIVED (NCT07119008)
- Testing
- Virtual reality
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Habituation, Psychophysiological, Preterm, Infant
Habituation's Mechanisms in Preterm and Term Infants
Each year in France, 7 % of newborns are born preterm (before 37 weeks of gestational age (GA)). The investigators called very preterm infants those who were born before 33 weeks of GA.
- Trial name
- HABIPREMA (NCT02496104)
- Testing
- Package n°1 of the APIB
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Dental Pain and Sensation Disorder
Study of the Use of Methoxyflurane vs Placebo in the Management of Pain in Oral and Dental Emergencies in Adults: METODO (METhoxyflurane in ODOntology)
With a chronic shortage of dentists in some regions, and an increase in life expectancy and living conditions, the number of patients admitted to oral health emergencies is on the rise.
- Trial name
- METODO (NCT06495372)
- Testing
- Experimenta group (standard of care + Methoxyflurane).
- Where
- France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Brest
Sport Injuries
Accidentology and Traumatology Associated With Foiling in Brittany
In the 2010s, the practice of water sports was turned upside down by the arrival of a new discipline: foiling. The number of sailors, particularly amateurs, is increasing every every year.
- Trial name
- TRAUMAF (NCT06680453)
- Where
- 7 sites in France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Brest
Inflammatory Rheumatism, Polymyalgia Rheumatica
PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS
To date, there is no available tool that allows, at individual level, determination of the probability to develop clinically relevant complications of prolonged glucocorticoid therapy.
- Conditions
- Inflammatory Rheumatism, Polymyalgia Rheumatica, Giant Cell Arteritis, Idiopathic Inflammatory Myopathies
- Trial name
- PRODIGIOUS (NCT04664465)
- Where
- 12 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Chronic Low-back Pain
Does the Therapist's Assessment of Movement Control in Low Back Pain Patients Correspond to an Objective Kinematic Modification
Exercise-based treatment is part of the recommendations for good practice in the treatment of low back pain (acute, sub-acute and chronic). The low back pain population is heterogeneous.
- Trial name
- LOBACOM (NCT05511012)
- Testing
- motion control fault tests
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
First-episode Psychosis
Biomarkers Predictive of Thymic Evolution and Therapeutic Response at 2 Years in Patients With a First Psychotic Episode
Psychosis is a severe, common, and disabling psychological disorder. An epidemiological study conducted in England reported an incidence of 34 new cases per 100,000 person-years, with a peak between 16 and 19 years of age.
- Trial name
- PEPAMARKER (NCT05384392)
- Testing
- Recorded interview, Clinical scales, Blood sample
- Where
- 5 sites in France
- Volunteers
- 217 people
- Sponsor
- University Hospital, Brest
Bladder
FILLing Protocols for the Right Bladder Volume at the RIGHT Time (FILLRIGHT)
The goal of this clinical trial is to compare evaluation of oral hydration protocols for the right optimal bladder filling prior to pelvic ultrasound.
- Trial name
- FILLRIGHT (NCT07642570)
- Testing
- Quantity A, Quantity B, Quantity C
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Prostate Cancer
Diagnostic Performance of PSMA PET/CT for Pre-operative Lymph Node Assessment in Intermediate and High-risk Non-metastasic Prostate Cancer (PREOP-PSMA ).
In France, prostate cancer is the most common cancer in men over 50 years of age (nearly 50,000 new cases per year) and is the second most common cause of cancer death in men (approximately 9,000 deaths per year).
- Trial name
- PREOP-PSMA (NCT04745871)
- Testing
- PSMA PET/CT
- Where
- France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Brest
Stroke
Efficacy and Acceptability of the Luna EMG Rehabilitation Robot on Motor Recovery of the Upper Limb in the Chronic Phase of Stroke
Recent work on large cohorts of chronic stroke (>6 months post-stroke) have shown that intensive training of the upper limb in the chronic stroke patients can lead to substantial motor and functional gains that are maintained at…
- Trial name
- LUNASTROKE (NCT05902910)
- Testing
- LUNA-EMG Robot
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Brest
Shoulder Pain
Influence of Anthropometric Data, Shoulder Complex Muscle Strength, and Abdominal-lumbar Endurance in Closed Kinetic Chain Upper Extremity Stability Test
A previous study of the Closed Kinetic Chain Upper Extremity Stability Test (EPOLTEST) in a population aged 18 to 25 years isolated 3 main factors influencing the CKCUEST score: upper extremity span, weight, and sex of the…
- Trial name
- EPOLTEST 2 (NCT05291273)
- Testing
- Closed Kinetic Chain Upper Extremity Stability Test, Prone Bridge Test, Measurement of the muscle strength of the shoulder complex
- Where
- France
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Stroke, Transient Ischemic Attack
Smartwatch-Guided Secondary Prevention After Stroke
After a first stroke or transient ischemic attack (TIA), the risk of recurrence is high in the weeks and months following the initial event.
- Trial name
- WATCH-STEP (NCT07640360)
- Testing
- Smartwatch-Guided Secondary Prevention after Stroke
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Addiction, Alcohol, Addiction, Substance
Efficiency of Prevention Program Dedicated to Addictive Behaviors (PREVENTURE) of Vulnerable Teenagers
At the age of 17, in Brittany, 94.9% of adolescents have experimented alcohol consumption 78.1% within a month and 25.5% report repeated episodes of Intensive Punctual Alcohol.
- Trial name
- PREVADO (NCT04599270)
- Testing
- PREVENTURE Program, Routine care
- Where
- 5 sites in France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Brest
Skin Disease, Skin Disorder
Coping Strategies, Loneliness, and Resilience in Patients With Dermatosis
The European Society for Dermatology \& Psychiatry (ESDaP) studies the connection between the skin and the mind. Two previous studies of this type were conducted in 13 and 15 European countries, respectively.
- Conditions
- Skin Disease, Skin Disorder, Skin Condition, Inflammatory Skin Conditions
- Trial name
- ESDaP3 (NCT07640373)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Prosthetic Joint Infection
Assessing the Performance of Shotgun Metagenomics in the Diagnosis of Complex Prosthetic Joint Infections
The objectiveof this of a prospective, multicentre study is to evaluate the performance of shotgun metagenomics in the diagnosis of chronic Prosthetic joint infection (PJI) in comparison with the adapted MSIS diagnostic score..
- Trial name
- METAGENOS (NCT06062251)
- Where
- 6 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Brest
Venous Thromboembolism (VTE), Post Partum Women
Prevention of Postpartum Venous Thromboembolism in Women at Intermediate Risk
Venous thromboembolism (VTE) is currently the second cause of death in women of reproductive age worldwide. The incidence of VTE during pregnancy is 1.2 to 1.4/1000 women, half of VTE occurring during postpartum and as PE in…
- Trial name
- MUM-VTE (NCT06845423)
- Testing
- Low molecular weight heparin
- Where
- 18 sites in France
- Volunteers
- 2,400 people
- Sponsor
- University Hospital, Brest
Aneurysm Cerebral
Interest of a Simulated Procedure Performed on a Printed Model in the Endovascular Treatment of Carotid-sylvian Aneurysms
It is now considered that 1% to 2% of the French population has an intracranial aneurysm. The major risk of this malformation is essentially the rupture which will lead in 10% of cases to death immediately, in 30% to 50% death…
- Trial name
- Anev3D (NCT05419661)
- Testing
- Operational Pre-Planning
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Aortic Valve Stenosis
Impact of Local Tissue Inflammation on Intramyocardial Conduction Pathways Post Percutaneous Valve : Evaluation by Positron Emission Tomography on Exploratory Cohort
Aortic valve stenosis is the most common valve disease leading to surgical or percutaneous intervention in Europe and North America.
- Trial name
- IMPACT (NCT05308888)
- Testing
- 18F-FDG PET-CT
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest