Clinical trials: sponsored by University Hospital, Brest
Cervical Cancer
Interest of PET/CT at 18F-FDG in the Post-therapeutic Management of Cervical Cancer
A lot of studies have demonstrated the prognostic value of post therapy 18F-FDG PET/CT in the management of uterine cervical cancer. Post therapy 18F-FDG PET/CT is usually requested by a lot of clinicians.
- Trial name
- COLTEP (NCT04008095)
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Surgery
Virtual Reality in Awake Surgery : Pilot Study VIRAS
The VIRAS (Virtual Reality in Awake Surgery) project is a two-stage, adaptive study. Its goal is to demonstrate the tolerance of the virtual reality (VR) headset for performing cognitive neuro-monitoring during awake brain…
- Trial name
- VIRAS (NCT05151822)
- Testing
- Training session with the virtual reality mask, Monitoring of the device, Acceptability of the device
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Cerebral Palsy
Functional Effects and Impact on Motor Neuronal Activity of Early and Intensive Motrice (Hand and Arm Bimanual Intensive Therapy Including Lower Extremities: HABIT-ILE) Reeducation in Children With Pre-school Bilateral Cerebral Palsy
One of the urgent priorities in the field of pediatric neuro-rehabilitation is the development of efficient early motor interventions for children with cerebral palsy (CP).
- Trial name
- MOOV (NCT04362800)
- Testing
- MRI, Electro-Encephalography-High Density, 3D and EMG analysis
- Where
- 2 sites in France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Brest
Endovascular Treatments, Endovascular Surgery
A Prospective Randomized Study Comparing the Safety of Percutaneous and Open Brachial Access in the Endovascular Treatment of Peripheral Arterial Lesion
Endovascular treatment tends to replace open surgery in the management of peripheral arterial disease. Access via the common femoral artery remains the primary approach for peripheral arterial interventions.
- Conditions
- Endovascular Treatments, Endovascular Surgery, Peripheral Arterial
- Trial name
- BRAVO (NCT07573644)
- Testing
- Experimental arm, Procedure/Standard care
- Where
- 11 sites in France
- Volunteers
- 246 people
- Sponsor
- University Hospital, Brest
Endophthalmitis
First-line Surgical Versus Medical Treatment: A Retrospective Study From 2014 to 2024 in Brest (BRESTE)
The goal of this observational cohort study is to evaluate the impact of early pars plana vitrectomy (PPV) on visual outcomes in adults diagnosed with acute endophthalmitis.
- Trial name
- BRESTE (NCT07514845)
- Testing
- Early pars plana vitrectomy (PPV) with intravitreal antibiotics
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Brest
Inflammatory Arthritis, Rare Auto-immune Diseases
Understanding of Rare Inflammatory Arthritis in Comparison to Classical Inflammatory Arthritis : Tissular Observations and Immune Infiltrate Characterization : the UTOPIC Project
The pathophysiology of certain inflammatory arthritides remains poorly understood, particularly when associated with rare systemic autoimmune diseases such as systemic sclerosis (SSc), or when emerging in the context of…
- Conditions
- Inflammatory Arthritis, Rare Auto-immune Diseases, Immune Checkpoint Inhibitor Related Inflamamtory Arthritis
- Trial name
- UTOPIC (NCT07302074)
- Testing
- Biopsy
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Cervical Cancers, Papillomavirus Infections
Negative HPV Test Results on Infinity/GeneXpert® With the Presence of a Late Amplification Signal: What Does This Mean ? (PaPCR)
The aim of this retrospective, single-center, observational study is to improve the diagnosis and interpretation of cervical cancer by better detection of epithelial lesions in the case of a late HPV PCR amplification signal…
- Conditions
- Cervical Cancers, Papillomavirus Infections, Papillomavirus Type 16/18 Infection
- Trial name
- PaPCR (NCT06919627)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Brest
Obstetrical Brachial Plexus Palsy
Effectiveness and Safety of Early Intramuscular Botulinum Toxin Injections to Prevent Shoulder Deformity in Babies With Obstetrical Brachial Plexus Palsy
In children population with obstetrical brachial plexus palsy (OBPP), shoulder musculoskeletal deformity is the main cause of morbidity, with a loss of range of shoulder motion, pain and a reduction in social participation.
- Trial name
- POPB-TOX (NCT03198702)
- Testing
- Botulinum toxin type A injection
- Where
- 7 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Brest
Giant Cell Arteritis
Association of Ultrasonographic Temporal Artery Lesions and Relapse in Patients With Giant Cell Arteritis
Ultrasound evaluation of the temporal and axillary arteries is currently well recognized in the field of giant cell arteritis (GCA), a disease primarily affecting medium- and large-caliber vessels.
- Trial name
- ALERT (NCT06894602)
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Long Term Corticosteroid Therapy
Evaluation of a Nurse-led Program for the Prevention of Complications of Long-term Corticosteroid Therapy
Long term corticosteroid therapy concerns 0.5 to 1% of the population and about 2.5% of elderly subjects. It is currently used as a cornerstone therapy in a wide variety of clinical contexts.
- Trial name
- COCORTICO (NCT04909606)
- Testing
- nurse-led prevention program, Current care
- Where
- 5 sites in France
- Volunteers
- 191 people
- Sponsor
- University Hospital, Brest
Polycythemia Vera, Essential Thrombocythemia
AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic Complications in JAK2V617F-positive Myeloproliferative Neoplasms
Philadelphia-negative myeloproliferative neoplasms (MPN) are frequent and chronic myeloid malignancies including Polycythemia Vera (PV), essential thrombocythemia (ET), Primary Myelofibrosis (PMF) and Prefibrotic myelofibrosis…
- Conditions
- Polycythemia Vera, Essential Thrombocythemia, Prefibrotic/Early Primary Myelofibrosis, JAK2 V617F
- Trial name
- AVAJAK (NCT05198960)
- Testing
- Direct Oral Anticoagulants, Low-dose aspirin
- Where
- 42 sites in France
- Volunteers
- 1,308 people
- Sponsor
- University Hospital, Brest
Cystic Fibrosis
Epidemiology and Clinical Characteristics of Non-Tuberculous Mycobacteria Infections in Cystic Fibrosis Patients.
An increase in the prevalence of infections due to non-tuberculous mycobacteria (NTM) is observed in many countries and recent data suggest the circulation of dominant clones with a possibility of human-to-human contamination.
- Trial name
- CIMENT (NCT03312075)
- Testing
- Sputum and blood samples
- Where
- 14 sites in France
- Volunteers
- 848 people
- Sponsor
- University Hospital, Brest
Repeated Spontaneous Miscarriages, Fetal Deaths in Utero
Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths
The DEFI-1 study recruited 625 women witnesses and 299 of their spouses. With regard to case couples, 271 cases were recruited from the spontaneous repeated miscarriages (SRM) subgroup (≥3 spontaneous miscarriage (SM) from…
- Trial name
- DEFI-2 (NCT04207814)
- Testing
- biological sample
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Cystic Fibrosis, Congenital Bilateral Absence of Vas Deferens
Establishment of a Primary Epididymal Cell Model From Epididymal Samples to Study CFTR Gene Regulation
The aim of this observational study is to better understand the role and involvement of the regulatory elements of the CFTR gene, with the aim of better describing the 3D organisation of chromatin at the CFTR locus in epididymal…
- Conditions
- Cystic Fibrosis, Congenital Bilateral Absence of Vas Deferens, Sterility, Male
- Trial name
- CFTR-EP (NCT06045702)
- Testing
- Epididymal sample
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Thyroid Diseases
Contribution of ICG Angiography in the Detection of Parathyroids and the Prevention of Hypoparathyroidism Post Total Thyroidectomy
Hypoparathyroidism is the most common complication after a total thyroidectomy surgery. It becomes permanent after 6 months. Untreated permanent hypoparathyroidism is a source of numerous complications in general and therefore…
- Trial name
- HYPOCAAVI (NCT04785443)
- Testing
- ICG, Control group
- Where
- France
- Volunteers
- 242 people
- Sponsor
- University Hospital, Brest
Psychosis of Childhood Borderline, Psychotic Disorder
Study of Self-Recognition and Self/Other Distinction Disorders in Patients With Psychological Vulnerability
The main objective of this study is to establish whether there are differences in self-recognition and self/other distinction in subjects with psychological vulnerability compared to healthy volunteer controls.
- Trial name
- ALTER-EGO (NCT04945278)
- Testing
- Double mirror device ALTER-EGO, EASE test
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Vestibular Neuritis
Boarding Ring Glasses Versus Placebo Glasses or Not Glasses in the Treatment of Vestibular Neuritis
Vestibular neuritis is a brutal and continuous dizzying syndrome of peripheral (vestibular) origin without cochlear or other associated involvement.
- Trial name
- NEVRING (NCT04678167)
- Testing
- Caloric test, Measurement of the speed of Nystagmus, Angle of deviation at Fukuda
- Where
- 2 sites in France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Brest
Intensive Care Unit Syndrome
Study on the Priorities of Patients Admitted to Intensive Care
The goal of this observational study is to learn about the priorities of patients admitted to intensive care units (ICUs) who have a life-threatening condition, as well as the priorities assumed by their designated relatives and…
- Trial name
- PRIOREA (NCT07417592)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Stroke Ischemic
BREMISS : Brain Resilience Minor Stroke Study
The objective of this clinical trial is to develop, based on patients' initial characteristics (in the first few weeks following the stroke), a predictive model of quality of life more than 4 years after the stroke in patients…
- Trial name
- BREMISS (NCT06995040)
- Testing
- Cerebral MRI without contrast agent injection, saliva sample, Questionnaires
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Brest
Pseudarthrosis, Clavicle Fracture
Descriptive Single-center Retrospective Study of a Series of Cases of Clavicle Pseudarthrosis: Epidemiology, Surgical Management, and Functional Outcomes
1. Study identification Study title: PSEUDO-CLAV - Single-center retrospective descriptive study of clavicle nonunion (pseudarthrosis): epidemiology, surgical management, and functional outcomes PSEUDO-clav_Notice non oppositi……
- Conditions
- Pseudarthrosis, Clavicle Fracture, Clavicle Fracture, Non Union/Malunion
- Trial name
- PSEUDO-CLAV (NCT07414654)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest