Clinical trials: sponsored by University Hospital, Caen
Palliative Care
Paracetamol Route in Palliative Care Patients (PARASCIVPALLIA)
Background: Among palliative-care patients, subcutaneous route is often an alternative to intravenous route yet pharmacological and clinical data are lacking.
- Trial name
- PARASCIVPALL (NCT03944044)
- Testing
- Paracetamol route in palliative-care patients: intravenous versus subcutaneous route Pharmacokinetics study protocol
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Antidepressive Agents, Aged
Association Between Prescription of Antidepressants and Delirium in the Elderly : Analysis From the World Health Organization Global Database
Delirium is a frequent reason for hospitalisation of the elderly. Associations between the prescription of some medicines and the risk of delirium have already been demonstrated.
- Conditions
- Antidepressive Agents, Aged, Delirium
- Trial name
- NCT05356078
- Testing
- Antidepressant
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Caen
Exercise Addiction
Personality Traits and Exercise Addiction in Ultra Endurance Athletes
Ultra endurance sports (events exceeding 6 hours) is becoming increasingly popular and Exercise Addiction (EA) is frequent in this type of sports, which are characterized by very high training volume.
- Trial name
- NCT05348798
- Testing
- Web based survey
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Schizophrenia, Physical Activity
A Controlled Study With Remote Web-based Adapted Physical Activity (e-APA) in Psychotic Disorders
In this study, an APA program by web (e-APA) will be offered to two groups of participants (21 patients and 21 healthy volunteers (HV)) in remote video (use of the SAPATIC (Santé Activités Physiques Adaptées utilisant les…
- Conditions
- Schizophrenia, Physical Activity, Schizo Affective Disorder
- Trial name
- PEPSYV@SI (NCT03261817)
- Testing
- Physical activity (APA), Health Education program (HE)
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Premature Birth
Neonatal Precursors of Neurodevelopment
The NEOPRENE project proposes to examine processes that are among the earliest precursors of cognitive functions and assess 1) the relationship between neonatal cognitive precursors and cortical structure, structural connectivity…
- Trial name
- NEOPRENE (NCT04703010)
- Testing
- Electroencephalography-Near infrared spectroscopy, Magnetic resonance imaging, Psychometric testing
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Myocardial Infarction
Assessment of Coronary Endothelial Function in Diabetic Patients With Acute Coronary Syndrome Using 15O-water Positron Emission Tomography
Type 2 diabetes is associated with early and diffuse abnormalities of endothelial function, especially in the coronary arteries, which are a factor of poor prognosis.
- Trial name
- D-TEP (NCT02510703)
- Testing
- Coronary endothelial function measurements by quantitative method (TEP at 15O-H2O)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen
Attention Deficit
Markers of Executive Attention Development in Preschoolers - Behavioral Measures in Various Populations
Executive attention is essential for emotional and behavioral self-regulation. There is inter-individual variability in the level of efficiency of executive attention from kindergarten entry, and this variability predicts…
- Trial name
- MEDiATE-PRV (NCT04831762)
- Testing
- Attention Network task (computerized), Head-toes-knees-schoulders, Laby 5-12
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Social Cognition in Patients With Schizophrenia
Treating Social Cognition With Theta Burst Stimulation: a Multicentric Study
The purpose of the study is to test a new treatment of social cognition deficits in patients with schizophrenia or schizoaffective disorder by transcranial magnetic stimulation (theta-burst).
- Trial name
- TBS-COG (NCT02479919)
- Testing
- Magstim® Active TBS
- Where
- 3 sites in France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Caen
Multiple Sclerosis, Relapsing-Remitting
Real World Effectiveness of Natalizumab Extended Interval Dosing in a French Cohort
Natalizumab (NTZ) use in Multiple Sclerosis (MS) in highly active patients has been largely established during the last Rationale 10 years in both clinical trials and real-world practice.
- Trial name
- RELEVANT (NCT04580381)
- Testing
- Natalizumab Injection [Tysabri]
- Where
- 5 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Caen
Giant Cell Arteritis, Acute Phase
Study of Circulating Microparticles in Giant Cell Arteritis
To demonstrate that microparticles (MPs), having a powerful procoagulant potential, are in larger amounts in the blood of patients with histologically proven giant cell arteritis (GCA), compared with patients matched for age, sex…
- Trial name
- MicroGiant (NCT02333708)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Nutrition Disorders, Dialysis
Estimate for Dietary Intakes and Hemodialysis Patients
The aim of this clinical research is to evaluate the relevance of using the EPA slide to estimate dietary intakes in dialysis patients.
- Conditions
- Nutrition Disorders, Dialysis, Chronic Renal Failure, Dietetician
- Trial name
- EDDEN (NCT03772171)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Hematologic Diseases, Diagnoses Disease
Impact of Sophrology on the Pain Felt During a Bone Marrow Aspiration and Biopsy
The bone marrow aspiration and biopsy (BMAB) is an essential and indispensable examination for the diagnosis and the follow-up of the hematological diseases but which remains painful and dread by the patients.
- Conditions
- Hematologic Diseases, Diagnoses Disease, Pain
- Trial name
- BOM-ZEN (NCT04168983)
- Testing
- sophrology
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Apnea, Postanesthetic, Desaturation of Blood
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Could Decrease the Incidence of Oxygen Desaturation During Suspension Laryngoscopy: a Randomized Controlled Trial (Optilaryngo)
Suspension laryngoscopy is realised during apnea. In effect, surgeons are in the mouth of the patient and we can't have access at the aiways.
- Conditions
- Apnea, Postanesthetic, Desaturation of Blood, Apnea, Anesthesia
- Trial name
- optilaryngo (NCT03843580)
- Testing
- optiflow
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Caen
Sea Sickness
Motion Sickness on Astrolabe's Vessel
Sea sickness syndrome is present for 80% of persons on board when the boat rotation missions Astrolabe, sometimes there is a risk of very significant dehydration.
- Trial name
- SICKVEST (NCT02911402)
- Testing
- sea sickness questionnaires
- Where
- France
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Handicaps Physical
Development, Optimization, Efficiency of the Interface System of Communication and Control of the Environment
The objective of this project is the realization of tests at home and in Hospitals or Functional Rehabilitation for the improvement of the communication with the family and medical entourage, the facility of the emotional…
- Trial name
- DOME-6 (NCT03361696)
- Testing
- Help to use the Interface System of Communication and Control of the Environment
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen
Vaccine Adverse Reaction
Transverse Myelitis Related to SARS-CoV-2 Vaccines
Few patients receiving SARS-CoV-2 vaccines may experience rare but serious adverse events such as transverse myelitis (TM). Today, data about TM are scarce.
- Trial name
- NCT05178264
- Testing
- SARS-CoV-2 vaccines
- Where
- France
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Myeloid Leukemia, Acute
Impact of Allo-HSCT on Bone Remodeling: Evolution of Bone Mineral Density and Architecture Measured by Bone Densitometry
Evaluation of variation of mineral density and bone microarchitecture after allogeneic HSCTs transplant in hematologic malignancies. Comparison with the general population.
- Trial name
- REMODALLO (NCT05161026)
- Testing
- Bone osteodensitometry
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Caen
Age-Related Sarcopenia
Gripwise® Versus JAMAR®
It is recommended to screen ageing patients for sarcopenia, due to the increased risk of morbimortality if detected positive. According to the consensus of the European Working Group on Sarcopenia in Older People, the diagnosis…
- Trial name
- HANDGAGES (NCT05060874)
- Where
- France
- Volunteers
- 348 people
- Sponsor
- University Hospital, Caen
Cancer
Rechallenge of BRAF +/- MEK Inhibitors Following an Adverse Event in Patients With Cancer
Very little data are published on the safety of a rechallenge with a BRAF inhibitor or combination of BRAF and MEK inhibitor (BRAFi and MEKi) after an adverse event (AE).
- Trial name
- BRAFREC (NCT05080361)
- Testing
- BRAF inhibitor
- Volunteers
- 16,000 people
- Sponsor
- University Hospital, Caen
Lymphoma
Endobronchial Diagnosis of Lymphoma
The present study aimed to assess the diagnostic performance of ultrasound-guided endobronchial intra-nodal miniforceps biopsy (EBUS-MFB) in the diagnosis of "de novo" mediastinal lymphoma.
- Trial name
- EnDol (NCT05075655)
- Testing
- Endobronchial ultrasound guided miniforceps biopsy and transbronchial needle aspiration
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Caen