Clinical trials: sponsored by University Hospital, Caen
Alveolar Recruitment Manoeuver, Anesthesia
Effect Alveolar Recruitment Manoeuver on Stroke Volume a Randomized Study
Objective: to compare the effect of alveolar recruitment manouver through stepwise increase and decrease in airway pressure or sustained 30 secondes 30 cmH2O continuous positive airway pressure on cardiac stroke volume estimated…
- Trial name
- hemorecrut-2 (NCT04802421)
- Testing
- alveolar recruitment manoeuver
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Caen
Cancer
Myelodysplastic Syndrome and Acute Myeloid Leukemia Related to PARP Inhibitors (MyeloRIB)
Although PARP inhibitors (PARPi) have proved effective in treating many cancers, few patients receiving PARPi may experience rare but life-threatening adverse events such as myelodysplastic syndrome (MDS) and/or acute myeloid…
- Trial name
- NCT04326023
- Testing
- PARP Inhibitors
- Where
- France
- Volunteers
- 178 people
- Sponsor
- University Hospital, Caen
Atrial Fibrillation, Lone Atrial Fibrillation
Atrial Fibrillation in Young Patients: a Prospective Multicentre Registry
Atrial fibrillation is a rare cardiac arrhythmia in young (i.e. <= 35-year-old) patients. Etiological factors, current management and mid- to long-term outcomes remain unknown.
- Trial name
- YOUNG-AF (NCT04776759)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Hemolysis, Cannulation
Home Hemodialysis Assisted by a Nurse for Arterio-venous Fistula Cannulation
Home HD (HHD) is associated with better outcome in end-stage renal disease patients compared to in-center HD, in particular in terms of quality of life.
- Conditions
- Hemolysis, Cannulation, Arteriovenous Fistula, Nurse's Role
- Trial name
- DIADIDEAL (NCT03633435)
- Testing
- assisted home hemodialysis patients
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Caen
Cancer
Evaluation of Reporting of AdVerse Events Associated With AnTicAncer theRapy (AVATAR)
Anticancer drugs can lead to various adverse events. This study analyses reports of adverse events for treatment including Anatomical Therapeutic Chemical (ATC) classification L (antineoplastic agents, endocrine therapy…
- Trial name
- AVATAR (NCT04696250)
- Testing
- Antineoplastic and Immunomodulating Agents
- Where
- France
- Volunteers
- 5,000,000 people
- Sponsor
- University Hospital, Caen
Ultrasonography, Education
Feasability of Lung Ultrasonography in General Practice
A major barrier to ultrasonography in general practice (GP) is the time restriction of their medical consultation. We aimed to evaluate the feasibility of lung ultrasonography (LUS) realized by general practitioners (GP's) into…
- Conditions
- Ultrasonography, Education, General Practice
- Trial name
- AmBulUs (NCT04644510)
- Testing
- Lung ultrasonography
- Where
- France
- Volunteers
- 111 people
- Sponsor
- University Hospital, Caen
Muscular Dystrophy, Oculopharyngeal, Ptosis
Treatment of Ptosis to Muscular Dystrophy Oculopharyngeal by Myoblast Autologous Graft
Interventional , multicenter , comparative study. One eye receiving the cells and the contralateral eye as a negative control . If effectiveness following review of the primary endpoint and the advice of an independent expert…
- Trial name
- TTT-PT-DOP (NCT02878694)
- Testing
- Myoblast autologous graft
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Caen
Sport Injury, Shoulder Injuries
Shoulder Profile Among Swimmers and Badminton Players
Background: To compare the pre-season clinical measures with shoulder rotator strength and range of motion between bilateral (swimmers) and unilateral (badminton players) overhead athletes.
- Trial name
- SPASB (NCT04641520)
- Testing
- Shoulder clinical testing with isokinetic strength assessment
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Caen
Inflammatory Bowel Diseases, Functional Gastrointestinal Disorders
Functional Gastrointestinal Disorders in Pediatric IBD
Background: Persistent gastrointestinal symptoms have been described in patients who are considered in remission of their inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Functional Gastrointestinal Disorders, Pediatric Disorder, Anxiety Depression
- Trial name
- TFI-MICI (NCT03565263)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Caen
Lower Resp Tract Infection, Ultrasound Therapy; Complications
Diagnostic of Lower Respiratory Tract Infection by Lung Ultrasonography in General Practice
Lower Respiratory Tract Infection (LRTI) is a frequent motive of consultation in General Practice. Cost, irradiation and availability of traditional imagery make it difficult to perform in every patient with suspected LRTI.
- Trial name
- AmbuLUS (NCT04602234)
- Testing
- Lung ultrasonography
- Where
- France
- Volunteers
- 151 people
- Sponsor
- University Hospital, Caen
C10.114.375.500
Impact of the Arrival on the French Market of New First Line Oral Treatments on the Delay Between MS Onset and First Disease Modifying Treatment (DMTs) Administration
The study design matches with a multicenter observational ambispective study. A first pilot study will be undertaken in Caen center and is expected to be extended to Rouen and Lille center.
- Trial name
- PREMISEP (NCT03308994)
- Testing
- Delay between MS onset and introduction of first line DMT, EDI
- Where
- 4 sites in France
- Volunteers
- 650 people
- Sponsor
- University Hospital, Caen
Intubation;Difficult, Awake Intubation
Airtraq Versus Fiberoptic for Awake Tracheal Intubation
The airway management is a vital act in anesthesia. The gold standard technique for planned very difficult intubation is nasotracheal fiberoptic intubation. The success rate with this procedure is 98.8%.
- Conditions
- Intubation;Difficult, Awake Intubation, Airway Complication of Anesthesia
- Trial name
- NCT03539185
- Testing
- Videolaryngoscope Airtraq, Fiberoptic bronchoscope
- Where
- France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Caen
Myocarditis, Cardiomyopathy
Recurrent Acute Myocarditis Registry
The association between myocardial inflammation (clinically represented by acute myocarditis episodes) and the later development of an arrhythmogenic cardiomyopathy is widely elusive.
- Trial name
- RAM (NCT04589156)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Thyroid Surgery
Effect of Cervical Block on Recurrent Laryngeal Nerve Monitoring During Thyroid Surgery
Non-inferiority study aimed to assess the impact of cervical block on recurrent laryngeal nerve monitoring during thyroid surgery Secondary outcomes will assess post-operative recovery, post-operative pain and post-operative…
- Trial name
- THYRODOUL2 (NCT04585126)
- Testing
- Intermediate cervical block
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Caen
Morals
Moral Judgements and Choices of Caregivers in the Time of COVID-19 Pandemic
The XPHI-COVID19 randomized study aims to investigate the mechanisms of moral judgements in a population of caregivers, using a survey, with the results to the Oxford Utilitarianism Scale as primary outcome.
- Trial name
- XPHI-COVID19 (NCT04542122)
- Testing
- Choices and judgements
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Multiple Sclerosis
Excitotoxicity Markers and the Clinical-radiological Progression After a Demyelinating Event: a Prospective Pilot Study
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, beginning most often in subjects aged 20-40 years.
- Trial name
- EXCEED (NCT02523703)
- Testing
- glutamate and aspartate
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Neuropsychiatric Disorders
Study of the Hemispheric Specialization for Language in Subjects With Neuropsychiatric Disorders Compared to Control Subjects
Recently, we have shown functional resonance imaging (fMRI) that variations in signal induced by a language task were significantly lower in a semantic region of the left hemisphere (comprised of that part pars triangularis of…
- Trial name
- BIP (NCT02523742)
- Testing
- IMRf, language task and a reference task (rest and Tamil)
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Postoperative Pain
Transversus Abdominis Plane Block vs Continuous Infiltration Wound Catheter for Analgesia After Caesarean Section
Analgesia following surgery associates different intra-venous or oral analgesic drugs and sometimes opioids. To reduce opioid consumption, loco-regional anaesthesia might be administered as a complement.
- Trial name
- TAP-CAT (NCT03102515)
- Testing
- USG-TAP block, CIC
- Volunteers
- 109 people
- Sponsor
- University Hospital, Caen
Transient Global Amnesia (TGA)
Neuropsycholgy and Neuroimaging in Transient Global Amnesia
The purpose of this study is to establish a diagnosis in transient global amnesia (TGA) in assessing three episodic memory's abilities (mental simulation throught the future, and the past, the learning of personnal actions i-e…
- Trial name
- 2NIA (NCT02562560)
- Testing
- Neuropsychological tests, Cerebral imaging (MRI, PET-FDG)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Total Hip Replacement
Incidence of Dual Mobility Polyethylene Wear in Total Hip Prosthesis. Randomised Study Versus Fixed Insert by Radiostereometric Analysis.
The total hip replacement, with over 120,000 cases per year in France, provides short term, excellent functional results and a significant improvement in quality of life, in almost all cases.
- Trial name
- DOUMOB (NCT02525809)
- Testing
- Novae E®, Sunfit®, Quartz®
- Volunteers
- 82 people
- Sponsor
- University Hospital, Caen