Clinical trials: sponsored by University Hospital, Caen
Respiration, Artificial, Lung Diseases
Impact of Lung Recruitment Maneuvers on Driving Pressure in Cardiac Surgery
In anesthesia the incidence of postoperative pulmonary complications is frequent, especially in cardiac surgery where the incidence can reach 10%.
- Conditions
- Respiration, Artificial, Lung Diseases, Atelectasis, Cardiac Surgical Procedures
- Trial name
- IMPREMO (NCT03976947)
- Where
- France
- Volunteers
- 217 people
- Sponsor
- University Hospital, Caen
Carotid Artery Stenosis
Imaging of Unstable Carotid Plaque in Patient Referred to Endarterectomy
This study will assess unstable plaque imaging features by using high resolution MR imaging and Sodium Fluoride F-18 PET. This is a comparative study between symptomatic and asymptomatic patient referred to carotid…
- Trial name
- CAROTEP (NCT03353103)
- Testing
- Sodium fluoride F-18 PET imaging
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Neurogenic Urinary Bladder, Spastic
Bilateral vs. Unilateral Stimulation in Neurological Bladder Disroders
This study evaluates the effectiveness of bilateral stimulation of the tibial nerve compared to unilateral stimulation in neurological bladder disorders.
- Trial name
- UROSTIM (NCT04225143)
- Testing
- urostim bilateral, urostim unilateral
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Atrial Fibrillation, Cardiac Surgery
Comparison of Two Strategies for the Management of Atrial Fibrillation After Cardiac Surgery
Postoperative atrial fibrillation is a common complication after cardiac surgery with a rate of 30%. However, management of postoperative atrial fibrillation is controversial.
- Trial name
- FAAC (NCT04223739)
- Testing
- Landiolol, Amiodarone
- Where
- France
- Volunteers
- 380 people
- Sponsor
- University Hospital, Caen
Chronic Kidney Disease Requiring Chronic Dialysis, Hemodialysis, Home
Body Composition Monitor Among Daily Home Dialysis With Low Flow Dialysate
The fluid overload measured by the Body Composition Monitor (BCM Fresenius Medical Care) is a new independent risk factor of mortality.
- Conditions
- Chronic Kidney Disease Requiring Chronic Dialysis, Hemodialysis, Home, Electric Impedance
- Trial name
- VOLODIA (NCT03994133)
- Testing
- Measurement of the hydration state by bio-impedance spectroscopy
- Where
- France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Caen
Cancer
Immune Checkpoint Inhibitors Rechallenge After Immune-related Adverse Events
Although immune checkpoint inhibitors (ICIs) have proved effective in treating many cancers, patients receiving ICIs may experience immune-related adverse events (irAEs).
- Trial name
- 19-916 (NCT04169503)
- Testing
- Immune Checkpoint Modulator
- Where
- France
- Volunteers
- 17,562 people
- Sponsor
- University Hospital, Caen
Lymphoma, Leukemia
Clozapine and Haematologic Malignancies: Observational and Retrospective Study Using the WHO Pharmacovigilance Database
Clozapine may lead to various adverse reactions, including neutropenia and agranulocytosis. This study investigates reports of lymphoma and leukaemias for clozapine in the World Health Organization's (WHO) global database of…
- Trial name
- CLOZARIX (NCT04074213)
- Testing
- Clozapine
- Where
- France
- Volunteers
- 1,000,000 people
- Sponsor
- University Hospital, Caen
Coronary Artery Disease, Motivation
Short Physical Activity Program in Coronary Artery Disease.
Coronary artery diseases (CAD) are multifactorial diseases which prognosis and risk factors are improved with increased physical activity (PA).
- Trial name
- NCT04062929
- Testing
- 4-day physical activity program with behavioral intervention
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Caen
Multiple Sclerosis
E-reporting of Adverse Drug Reactions by Patients in Relapsing-remitting Multiple Sclerosis
Adverse drug reactions are collected exhaustively during the experimental development phase of the drug, but the trial population is not representative.
- Trial name
- VigiP-SEP (NCT03029897)
- Testing
- My eReport France
- Where
- France
- Volunteers
- 161 people
- Sponsor
- University Hospital, Caen
Schizophrenia
Research of Anatomo-functional Biomarkers in Schizophrenia
To objectify UR biomarkers, we propose a longitudinal follow-up of resistant patients with schizophrenia, starting before the onset of clozapine and including a multimodal brain imaging assessment (T1 and T2 weighted sequences…
- Trial name
- CLOZAREST (NCT03996122)
- Testing
- fMRI
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Nurse's Role, Simulation
Training Procedural Simulation of Nurses in Reducing Complications Related to Arteriovenous Fistula Puncture
Interest of training in procedural simulation of nurses in the reduction of complications related to arteriovenous fistula puncture in hemodialysis patients
- Conditions
- Nurse's Role, Simulation, Arteriovenous Fistula
- Trial name
- SIMFAV (NCT03680209)
- Testing
- Simulation
- Where
- France
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy
Rendering of a Local 1g Environment for Enhanced Motor Learning in Altered Gravity
Human motor adaptation is crucial to adapt to new environments, such as altered gravity. Dexterous manipulation and fine movements in space require learning new coordinated motor actions.
- Trial name
- Sim1g (NCT03978910)
- Testing
- measurements of the accuracy of the reaching movements
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Hip Arthroplasty, Knee Arthroplasty
Operative Hemodynamic Optimization Using the Plethysmographic Variability Index During Orthopedic Surgery
The purpose of this study is to determine whether an operative hemodynamic optimization using the plethysmographic variability index during orthopedic surgery could decrease the length of hospital stay and the postoperative…
- Conditions
- Hip Arthroplasty, Knee Arthroplasty, General Anesthesia
- Trial name
- OPVI (NCT02207296)
- Testing
- Plethysmographic variability index
- Where
- France
- Volunteers
- 440 people
- Sponsor
- University Hospital, Caen
Head and Neck Cancer
Nutrition and Quality of Life of Patients With Head and Neck Carcinoma After Radiotherapy
Undernutrition in cancerology is frequent because it's present for thirty to fifty percent of the patients at the time of the diagnosis.
- Trial name
- NUQUE3 (NCT02789267)
- Testing
- Regular dietary support
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Caen
Psychotic Disorders
Impact of Case-management on Therapeutic Alliance With First Episode Psychosis Patients (CAMAT)
The first aim of this study is to test the effect of the case management on the evolution of therapeutic alliance in patients with first episode psychosis in comparison with traditional nursing.
- Trial name
- CAMAT (NCT02873884)
- Testing
- Case-management
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Myocardial Infarction, Thrombosis, Coronary
OFDI-Quantified Intracoronary Thrombus, Antiplatelet Pretreatment Effect and Myocardial Reperfusion
The management of ST-elevation myocardial infarction in the acute phase requires an optimal antiaggregation combining aspirin and a P2Y12 inhibitor (clopidogrel, prasugrel or ticagrelor).
- Trial name
- ODIPP (NCT03342521)
- Testing
- optical coherence tomography and VerifyNow
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Caen
Teenager, Sex Behavior
Quantitative Study of Prevalence and Vulnerability Factors of Active Cyber Sexuality Among Teenagers in West Normandy
This study evaluates prevalence of active cybersexuality among teenagers (15-17 old) in West Normandy and find different factors of vulnerability that could induce this behaviour.
- Trial name
- NCT03662321
- Where
- 14 sites in France
- Volunteers
- 1,208 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Transfusion Related Complication
Transfusion Strategy in Hematological Intensive Care Unit
Patients with acute hematological disease (acute leukemia, aplastic anemia, hematopoietic stem cells autologous or allogeneic ...) and hospitalized in an intensive care unit hematology require compensation of anemia and…
- Trial name
- 1VERSUS2CGR (NCT02461264)
- Testing
- Single red blood packed cells Transfusion, Two packed red blood cells Transfusion
- Where
- France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Caen
Mechanical Ventilation
Cough Determinants in Mechanically Ventilated Patients
In our knowledge there is only few data about the cough determinants in mechanically ventilated patients. However some failure of extubation is due to inefficiency cough.
- Trial name
- Extu-Cough (NCT01564745)
- Testing
- Functional respiratory evaluation
- Where
- 2 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Caen
Colorectal Cancer Metastatic
Anticancer Vigilance Of Cardiac Events (AVOCETTE) in Metastatic Colorectal Cancer
This study is a retrospective observational study that evaluates the rate of cardiovascular adverse events leading to hospitalization in metastatic colorectal cancer in the French county Calvados by drug exposure.
- Trial name
- AVOCETTE (NCT03923036)
- Testing
- Antineoplastic Agents
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Caen