Clinical trials: sponsored by University Hospital, Caen
Hodgkin Lymphoma
BV After Allogeneic Hematopoietic Stem Cell Transplantation
Despite a high recovery rate with chemotherapy and radiation therapy treatment, 15 to 30% of patients suffering from Hodgkin lymphoma are refractory or relapsed.
- Trial name
- BV-ALLO (NCT03540849)
- Testing
- Brentuximab Vedotin (Bv)
- Where
- France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Caen
Rectal Cancer, Surgery
Assessment of Functional Digestive and Genitourinary Outcomes in Patients With Rectal Cancer.
Total mesorectal excision and neoadjuvant radio-chemotherapy have revolutionized the management of rectal cancer allowing an increase in survival (between 55 and 68% at 5 years) and allowing a decrease of local recurrence (under…
- Trial name
- Rectqol (NCT03459235)
- Testing
- quality of life
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Caen
Suxamethonium Sensitivity, Aspiration of Gastric Contents Into Respiratory Tract, Part Unspecified
Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia
Succinylcholine is a myorelaxant agent often used during rapid sequence induction for patients who need to undergo general anesthesia but who are at risk of pulmonary aspiration of gastric content.
- Trial name
- CELOTOF (NCT03415607)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Caen
HIV Infections
Older HIV-infected Adults and Drug Interactions: French Cross-sectional Study
Drug interactions between antiretroviral drugs and concomitants drugs and between antiretroviral need to be studied HIV-population is ageing. The referential of interactions is the Liverpool base.
- Trial name
- POPVIH65 (NCT03416881)
- Volunteers
- 13,225 people
- Sponsor
- University Hospital, Caen
Coronary Artery Disease, Coronary Stenosis
Comparison of Devices Evaluating Fractional Flow Reserve in Coronary Arteries
The aim of the study is to compare different devices available to measure fractional flow reserve (FFR) in coronary arteries.
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Myocardial Ischemia
- Trial name
- FFR-DS (NCT03052803)
- Testing
- Fractional flow reserve measure
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Peritoneal Infection
Pharmacokinetics Study of Intraperitoneal Administration of Daptomycin in Peritoneal Infection
Peritoneal infection is still a frequent complication in peritoneal dialysis patients . In France, It contributes to the technique failure, responsible for about 20% of cases of transfer in hemodialysis.
- Trial name
- DAPTODP (NCT02000414)
- Testing
- intraperitoneal daptomycin
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Caen
Delivery
Compared Efficacy of Patient-controlled Epidural Analgesia With or Without Automatic Boluses
Epidural analgesia is a significant feature of the everyday experience of the delivery room. Its benefits on the maternal experience and in terms of security has been widely demonstrated.
- Trial name
- FREE BOLI (NCT03407209)
- Testing
- consumption of local anesthetic measurement
- Where
- France
- Volunteers
- 462 people
- Sponsor
- University Hospital, Caen
Urinary Infection
Incidence of Post Cystography Urinary Tract Infections in the Pediatric Population
Cystography is a frequent pediatric examination, although indications have been recently restricted . Current indications in our center are: The occurrence of 2 episodes of acute pyelonephritis or 1 episode of pyelonephritis if…
- Trial name
- IUCPED (NCT03399682)
- Testing
- cystography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Anesthesia, Airway Morbidity
Preoxygenation Using High Flow Oxygen : Efficacy and Tolerance in Healthy Volunteers
High flow nasal cannula oxygen has been proposed to perform preoxygenation in patients with acute respiratory failure requiring orotracheal intubation in intensive care units.
- Conditions
- Anesthesia, Airway Morbidity, Safety Issues
- Trial name
- PreOx-OHD (NCT03399695)
- Testing
- preoxygenation
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Fabry
Diagnostic Value of the Electrocardiogram in Fabry Disease
Cardiac complications occur in 78% of patients with Fabry disease and are mainly characterized by a high frequency of left ventricular hypertrophy resulting from an accumulation of GL3 in cardiomyocytes.
- Trial name
- DEFY (NCT03362645)
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
C.Surgical Procedure; Cardiac
Hemodynamic Monitoring, Positive Inotropic and Vasoactive Drugs During Cardiac Surgery (EMOA)
Describe the proportion of patients who underwent cardiac surgery in France and benefiting from a monitoring cardiac output, describe the use of positive inotropic and vasoactive agents for cardiac surgery patients operated (type…
- Trial name
- EMOA (NCT02571920)
- Where
- France
- Volunteers
- 3,099 people
- Sponsor
- University Hospital, Caen
Congenital Heart Disease
Northwest Adult Congenital Heart Disease Observatory
The incidence of congenital heart disease is about 8 per thousand live births. Thanks to advances in cardiac surgery, 90% of children born with heart defects reach adolescence and adulthood.
- Trial name
- CARL (NCT02897323)
- Testing
- description
- Where
- France
- Volunteers
- 4,000 people
- Sponsor
- University Hospital, Caen
Pain
Tramadol Clinical Efficiency and Tolerance Correlated to O-desmethyltramadol/Tramadol Ratio (CLINCYTRAM)
Tramadol is a grade II analgesics as World Health Organization definition. It can both be an agonist on mu receptors, which provides it a low opioid action, and also be a Serotonin-norepinephrine reuptake inhibitor, which act on…
- Trial name
- CLINCYTRAM (NCT03357003)
- Testing
- Observational study
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Caen
Light Head Injury
Serum S100B Protein Assay in Mild Head Injury
Head injuries are a major public health issue, with an estimated annual incidence in Europe of 262 per 100,000 population. Light head injury (SCI), defined by a Glasgow score between 13 and 15, constitutes the majority (71% to…
- Trial name
- TCLAS-100B (NCT03345602)
- Testing
- serum S100B protein assay measurement
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Caen
Advanced or Metastatic Hepatocellular Carcinoma
Residual Plasma Concentration of Sorafenib and Adverse Events in CHC
To date, Sorafenib is the only drug therapy to have demonstrated a benefit in overall survival in patients with advanced or metastatic hepatocellular carcinoma.
- Trial name
- PharmacoCHC (NCT03340636)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Alcohol Disorders
Cognitive Remediation in Alcohol Disorders
The individual and societal cost of alcohol use disorders (TUAL), present in 10% of the population in France, is considerable. Despite psychotherapeutic and drug addiction treatment, the relapse rate remains very high, partly…
- Trial name
- ALCOSTIM (NCT03335215)
- Testing
- cognitive remediation
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Neonatal Abstinence Syndrome
Interest of Concentrations in Meconium of Buprenorphine and Methadone as a Prognostic Factor of NAS Outcome
The aim of this study is to characterize the interest of concentrations in meconium of drugs used for treatment of pregnant opioid-dependent woman as a prognostic factor of time, severity and duration of neonatal abstinence…
- Trial name
- SUBOPGEST (NCT03334981)
- Testing
- Concentrations in Meconium of Buprenorphine and Methadone
- Where
- France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Caen
Surgery; Maternal, Uterus or Pelvic Organs, Affecting Fetus
Feasibility of Ambulatory Hysterectomy
Hysterectomy is one of the most performed surgery in women. Public authorities wish that one-day surgery become a majority and hysterectomy could be part of it in the future.
- Trial name
- AMETHYST (NCT03290339)
- Testing
- hysterectomy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Healthy Volunteers
THE INFLUENCE OF GRAVITY
Although most ground studies showed that an egocentric reference frame better supports spatial orientation, it is not proven it will be the same during weightlessness.
- Trial name
- ARGuide (NCT03298139)
- Testing
- 3 levels of gravity (1G, 1.8G, 0G).
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Respiratory Complication, Respiration, Artificial
Ventilation in Cardiac Surgery
The purpose of this study is to evaluate prospectively ventilatory practices in the perioperative cardiac surgery period.
- Conditions
- Respiratory Complication, Respiration, Artificial, Anesthesia, General, Bypass, Cardiopulmonary
- Trial name
- VENICE (NCT03255356)
- Testing
- Survey
- Where
- 10 sites in Belgium, Brazil and 8 more
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Caen