Clinical trials: sponsored by University Hospital, Caen
Pulsed-field Ablation, Deep Sedation
Safety And FEasibility of a Simplified Deep Sedation Protocol for Pulsed-Field Ablation
The aim of the SAFE-PFA study is to demonstrate the feasibility and safety of a simplified deep-sedation protocol for pulsed-field ablation of atrial fibrillation, with a specific focus on patient-reported outcomes.
- Conditions
- Pulsed-field Ablation, Deep Sedation, Atrial Fibrillation (AF)
- Trial name
- SAFE-PFA (NCT07633548)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen
Athlete, Eating Disorder Prevention
Cross-cultural Adaptation and Validation of the French Version of the Athletic Disordered Eating Scale (ADE)
Assessing disordered eating is crucial in athlete health monitoring. However, existing tools are not tailored to athletes' specific needs. In 2024, Buckley et al.
- Conditions
- Athlete, Eating Disorder Prevention, Eating Disorders Symptoms
- Trial name
- ADE-Fr (NCT07617701)
- Testing
- The French version of the Athletic Disordered Eating (ADE-Fr) Scale
- Where
- France
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Lung Neoplasms
Sputum Cytometry Analysis in Lung Cancer Screening After Professional Asbestos Exposure
Workers exposed to asbestos are at high risk of lung cancer. Medical follow-up of this population relies on repeated CT-scans which are more accurate for detection of peripheral lesions, and expose to X-rays and to risk of…
- Trial name
- AMORCE-CBP (NCT01687647)
- Testing
- low-dose CT-scan AND induced sputum sample AND blood test
- Where
- 3 sites in France
- Volunteers
- 463 people
- Sponsor
- University Hospital, Caen
Autistic Disorder
Associative Memory in Autism Spectrum Disorder
The aim of this study is to investigate the neural substrates of associative memory in Autism Spectrum Disorder using both behavioural and EEG assessments.
- Trial name
- MEM-TA (NCT02265094)
- Testing
- Electroencephalography, Neuropsychological assessment
- Where
- France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Multiple Myeloma
Ixazomib -Daratumumab Without Dexamethasone (IDara) in Elderly Relapse Refractory Multiple Myeloma
Multiple myeloma is an incurable hematological malignancy that affects older patients. Currently, despite recent progress, the disease relapses more or less quickly after initial treatment and requires the resumption of treatment…
- Trial name
- IDARA (NCT03757221)
- Testing
- Ixazomib and Daratumumab
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Caen
Nursing Caries, Arteriovenous Fistula
Simulation-based Training for Nurses and Arteriovenous Fistula Puncture in Chronic Hemodialysis Patients
Currently, the technique of arteriovenous fistula puncture is transmitted by companionship within hemodialysis units. Although the main principles of the technique are well known and common to all hemodialysis units, strong…
- Conditions
- Nursing Caries, Arteriovenous Fistula, Simulation-based Training
- Trial name
- SIMFAV2 (NCT05302505)
- Testing
- simulation-based training
- Where
- 9 sites in France
- Volunteers
- 9,600 people
- Sponsor
- University Hospital, Caen
End Stage Chronic Renal Failure
Study of Patient Preferences in Dialysis Treatment Choice: a Discrete Choice Experiment
Background Compared to in-center dialysis, home dialysis is associated with better quality of life and lower healthcare system costs. However, barriers remain to its wider adoption.
- Trial name
- PREFDOM (NCT07535320)
- Testing
- Questionnaire
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Caen
Antibiotics, Subcutaneous Injection
Subcutaneous Daptomycin in Healthy Volunteers (DAPTOSC)
Background: Multidrug-resistant bacteria are a major public health problem worldwide, notably due to excess mortality and an increase in the length of hospital stay.
- Conditions
- Antibiotics, Subcutaneous Injection, Daptomycin
- Trial name
- DAPTOSC (NCT04434300)
- Testing
- Daptomycin
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cerebrovascular Disorders, Brain Lesion
Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2
Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative/developmental disorders and selective…
- Conditions
- Cerebrovascular Disorders, Brain Lesion, Degenerative Disease, Developmental Disability
- Trial name
- CORAC2 (NCT03586258)
- Testing
- Neuropsychological testing, Brain Imaging, Galvanic Vestibular Stimulation (GVS)
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Surgery
Impact of the "Standing Patient" Pathway on Preoperative Anxiety.
For 25 years, the concept of Rapid Rehabilitation After Surgery or RRAC has developed to bring about a global care of the patient by establishing a safe and quality climate.
- Trial name
- ANXIPADE (NCT03355404)
- Testing
- standing patient
- Where
- France
- Volunteers
- 1,217 people
- Sponsor
- University Hospital, Caen
Carpal Tunnel Syndrome
Percutaneous Treatment of Carpal Tunnel Syndrome With Scan
The objective of the study is to evaluate in patients suffering from carpal tunnel syndrome resistant to medical treatment, clinical course after percutaneous treatment under ultrasound guidance.
- Trial name
- ECHOCARPE (NCT02514317)
- Testing
- percutaneous treatment, Ultrasound
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen
Untreated B-Chronic Lymphocytic Leukemia or Diffuse Large B Cells Lymphoma Patients
Dosimetry and Biodistribution of [18F]-Fludarabine in Lymphoid Malignancies
The application of positron emission tomography with lymphoproliferative diseases today provides diagnostic and therapeutic information of major importance , especially in terms of speed and quality of response to treatment.
- Trial name
- FLUDATEP (NCT02128945)
- Testing
- [18F] - Fludarabine PET/CT
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Caen
Childbirth
Evaluation of the Benefits of Glucose Drinks During Childbirth
Fear of full stomach when emergency general anaesthesia is required is the origin of fastening when giving birth. This behaviour does not warranty perfect security for the general anaesthesia.
- Trial name
- SOLISO (NCT01022697)
- Testing
- Glucose drink
- Where
- 9 sites in France
- Volunteers
- 4,142 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Chronic Lymphocytic Leukemia
Autologous Stem Cell Transplantation in Chronic Lymphocytic Leukemia
Phase III trial evaluating the role of autologous stem cell transplantation in previously untreated patients under 65 years with stage B and C B-cell chronic lymphocytic leukemia.
- Trial name
- Auto-LLC 2001 (NCT00931645)
- Testing
- Autologous stem cell transplantation, DHAP rescue and Autologous stem cell transplantation, DHAP rescue and F+C
- Where
- France
- Volunteers
- 241 people
- Sponsor
- University Hospital, Caen
Coronary Surgery With Cardiopulmonary Bypass
Effects of a Goal-directed Hemodynamic Therapy Driven by ECOM on Morbidity and Mortality After Cardiac Surgery?
Goal-directed hemodynamic and fluid optimizations are shown to be a key factor of the medical care during anesthesia.According to medical literature, goal-directed fluid and hemodynamic optimizations are more efficient when based…
- Trial name
- ECOMIII (NCT01535716)
- Testing
- hemodynamic optimization strategy driven by the ECOM, standard management strategy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Physiological Stress, Cognitive Dysfunction
DEEPTIME: Human Adaptation in Time Underground Isolation
The objectives of this scientific expedition are: a/ Evaluation of temporal cognitive perception and collective synchronization in a temporally anomalous universe (underground environment), b/ Influence of group living on the…
- Conditions
- Physiological Stress, Cognitive Dysfunction, Sleep
- Trial name
- DEEPTIME (NCT05603780)
- Testing
- exploratory protocol
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
ST-elevation Myocardial Infarction
Evaluation of Myocardial Reperfusion After Primary PCI in Patients With High Platelet Reactivity Treated by Cangrelor or Not
This study aims to evaluate the impact on myocardial reperfusion and residual thrombotic burden of adding Cangrelor -a potent and immediate P2Y12 inhibitor- to ticagrelor in primary PCI patients with high on ticagrelor platelet…
- Trial name
- ERMIT (NCT04927949)
- Testing
- cangrelor perfusion during PCI, standard PCI
- Where
- France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Caen
Giant Cell Arteritis
Giant Cell Arteritis and Anakinra Trial
SYNOPSIS The giant cell arteritis (GCA) is the most frequent vasculitis in people over 50 years. Despite recent progress and physiopathogenic, corticosteroids remains the standard treatment for decades with a very good initial…
- Trial name
- GiAnT (NCT02902731)
- Testing
- ANAKINRA
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Alzheimer's Disease
Multi-modal Neuroimaging in Alzheimer's Disease IMAP+
Alzheimer's disease (AD) is a major public health problem due to its socio-economic weight. An early diagnosis of AD is urgently needed as it would constitute a determinant breakthrough from a social, financial and research…
- Trial name
- IMAP+ (NCT01638949)
- Testing
- Memory assessment, Circulating biomarkers measure, ApoE4
- Where
- 7 sites in France
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Hyponatremia
Hyponatremia in the Elderly: Benefit From a Change in Drug Therapy?
Mild hyponatremia is the commonest electrolyte imbalance in the older population. Recently, association between hyponatremia and bone fractures in the ambulatory elderly has been shown.
- Trial name
- NATRIPHAR (NCT01212211)
- Testing
- change in drug therapy
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Caen