Clinical trials: sponsored by University Hospital, Caen
Chronic Obstructive Pulmonary Disease
Clinical Trial Assessing the Value of an Antibiotic Protocol Guided by Serum Procalcitonin in Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Intensive Care
Investigators propose to conduct a prospective, randomized, controlled, multicenter assessing the interests of an antibiotic protocol guided by serum procalcitonin (PCT) on morbidity and mortality in patients with chronic…
- Trial name
- BPCTréa (NCT02521636)
- Testing
- Antibiotic therapy randomization, Serum PCT dosage
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Alzheimer's Disease
Cerebral Substrates of Prospective Memory in Young and Its Disruption in Normal Aging and in Alzheimer's Disease: A Study in Anatomical MRI, Diffusion Tensor MRI and Functional MRI
Investigators propose in this study to evaluate prospective memory (MP) in all its complexity as well as the processes, cognitive and brain, the underlying.
- Trial name
- IMPRO (NCT02522091)
- Testing
- functional brain MRI, Neuropsychology tests
- Where
- France
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Osteoporosis
Vitamin D Supplementation in Postmenopausal Women With Osteoporosis: Proposal of a Therapeutic Regimen in Practice
The vitamin D deficiency (25OHD) is very common and affects about 80% of the population of French osteoporotic women over 50 years [5]. It contributes significantly to bone fragility and consequently the risk of fracture.
- Trial name
- VITAD (NCT02518763)
- Testing
- Vitamin D3, 100 000 IU weekly, 4 times, 25 OH vitamin D serum concentration measurements
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Caen
Healthy Volunteers
Dynamics of Stroke Volume and Cardiac Output During Parabolic Flight, and Its Relationship to Intravascular Volume
To understand the cardiovascular reactions of the human body to changing conditions of gravity is an important aim of space science. In this context, cardiac output (CO) is a key value to estimate the human cardiovascular system.
- Trial name
- DYMCO (NCT02518880)
- Testing
- Parabolic flight, plasma volume measurements
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Multiple Sclerosis
Influence of Emotional Disorders and Executive on the Components Retrograde and Anterograde Episodic Memory in MS
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system responsible for physical disability but can also cause cognitive disturbances annoying social and professional life of patients with the disease.
- Trial name
- ITEMS (NCT02518776)
- Testing
- Neuropsychological tests
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy
Hearing and Vestibular Interactions in the Collection of Own Body and Sense of Self
The investigators objective is twofold. Investigators propose to study how the vestibular and auditory information interact in the construction of coherence between the staff and extrapersonal space.
- Trial name
- AUDIOSELF (NCT02518074)
- Testing
- Hearing and Vestibular Interactions
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy
Alterations in Autonomic Cardiovascular Control Induced at Partial G Forces
As a direct consequence of exposure to microgravity, astronauts experience a number of physiological changes which can lead to serious medical implications.
- Trial name
- AUTOCARD (NCT02517177)
- Testing
- Parabolic flight, Cardiovascular parameters measurements
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy
The Effect of Altered Gravity Condition on Postural Control
The scientific goal of this experiment is to evaluate changes in balance control in response to microgravity during reactive balance tasks.
- Trial name
- POSTURGRAV (NCT02517229)
- Testing
- Parabolic flight, balance control measurements, electromagnetic maneuverable postural platform
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy
Coherence Between Brain Cortical Function and Neurocognitive Performance During Changed Gravity Conditions
Alongside a well-known physiological deconditioning, such as a decrease in muscle mass or bone demineralization, extended stays in weightlessness also cause cognitive dysfunction.
- Trial name
- CORTICOG (NCT02516787)
- Testing
- Parabolic flight, EEG measurement, NIRS measurements
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Bloodstream Infection
The Only Blood Culture for Diagnosis of Bacteremia - Comparative Study of Practice
Current recommendations for the diagnosis of bacteremia based on the embodiment February-March blood cultures separated by a minimum interval of 30 minutes.
- Trial name
- HEMU (NCT02516514)
- Testing
- Single-sampling strategy vs multi-sampling strategy for the diagnosis of bacteremia
- Volunteers
- 302 people
- Sponsor
- University Hospital, Caen
Healthy
Parabolic Flight Induced Neuroplasticity Studied With Advanced Magnetic Resonance Imaging Methods
Weightlessness profoundly modifies many physiological systems and especially the nervous system and the vestibular system. The changes in the nervous system are based in part on brain plasticity mechanisms, that is to say on…
- Trial name
- BrainDTI (NCT02517216)
- Testing
- parabolic flight, MRI
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy
Effects of Repeated Short-term Microgravity During Parabolic Flight Conditions on Neuro-endocrine, Immune and Metabolic Changes
From previous parabolic flight campaigns completed by our research group investigators gathered data showing important changes in neuro-endocrine and also immunological changes.
- Trial name
- COSI@PFC (NCT02517190)
- Testing
- Parabolic flight, neuro-endocrine measurements, immunological measurements
- Where
- France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Accidental Falls
Role of Vitamin D Levels (Serum 25-hydroxyvitamin D) and Cognitive Impairment in the Occurrence of Falls
Every year, nearly 30% of people aged over 65 fall at least once and about 15% fall at least twice. These falls can have serious consequences that are a significant threat to the independence and well-being of older people.
- Trial name
- VITADCOG (NCT02517164)
- Testing
- Measurement of serum 25-hydroxyvitamin D, Analysis of global cognitive efficiency score assessed by the "Montreal Cognitive Assessment" (MoCA).
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Healthy
Right-front Direction in Parabolic Flight
The goal of this study is to objectively determine the perceived direction of the right-front by the subjects in weightlessness.
- Trial name
- DROITDEVANT (NCT02517138)
- Testing
- Parabolic flight, Measurements of eye movements and perception
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy
3D Ballistocardiography in Microgravity
3-D Ballistocardiography (BCG) recording was performed in microgravity during the Spacelab D2 missions on a single astronaut. The results from this experiment have been published in the literature: the influence of respiration…
- Trial name
- B3D (NCT02517112)
- Testing
- Parabolic flight, Cardiovascular parameters measurements, 3D-BCG sensor
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Coronary Artery Disease
Assessment of Coronary Flow Reserve by PET-H215O and FFR. Comparison With Dynamic Acquisition Using CZT Camera
The study will assess coronary flow reserve by PET-H215O and FFR in patients suspected of coroanry artery disease. This a comparative study with dynamic acquisition using CZT camera and 99mcTc-mibi.
- Trial name
- WATERDAY (NCT02278497)
- Testing
- ASSESSMENT OF CORONARY FLOW RESERVE BY PET-H215O AND FFR
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Squamous Cell Carcinoma of the Head and Neck
Performance of PET 18 F-FDG Coupled to CT With Contrast Injection Iodized in the Diagnosis of Early Recurrences of Head and Neck Carcinoma Treated With Concurrent Chemoradiation. Comparison With 18F-FDG PET Coupled With CT Not Injected With Filling CT Standard Injection
Early detection of viable residual tumor or early neoplastic recurrence represents a real challenge in monitoring patients treated with concomitant chemoradiotherapy squamous cell carcinoma of the upper aerodigestive tract.
- Trial name
- TEPVAD (NCT02510872)
- Testing
- 18F-FDG PET combined with CT with iodinated contrast injection, 18F-FDG PET combined with CT without injection
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Caen
Myocardial Infarction
Myocardial Deformation in Real-time 3D Ultrasound. Normal Values in Adults and Validation Against the Tagged MRI
Cardiac exploration almost systematically requires the acquisition and / or calculating function indices. The ejection fraction (LVEF) is probably based index most widely used in all cardiac exploration methods.
- Trial name
- DIRECT (NCT02508727)
- Testing
- MRI, 3D cardiac ultrasound
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy Volunteers
Validation of Methods for Evaluating Operation Force, Motion and Visual Perception in Weightlessness
Previous studies have neglected two important aspects for the China National Space Administration. First, while biomechanical models are very sensitive to the characteristics of the subjects, data have been collected on subjects…
- Trial name
- HopMot (NCT02508558)
- Testing
- motion perception and locomotor operation performance measurements, parabolic flight
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy Volunteers
Influence of Gravity on the Perception of Egocentric Distance (Blindpulling)
Parabolic flight is the only ground-based condition in which weightlessness (0G) can be created long enough for safely testing changes in human perception and behavior.
- Trial name
- Blindpulling (NCT02508545)
- Testing
- perceived egocentric distance (PED) measurements, Parabolic flight
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen