Clinical trials: sponsored by University Hospital, Caen
Alcoholism, Alcohol Amnestic Disorder
From Uncomplicated Alcoholism to Korsakoff's Syndrome
This research project aims to identify factors that contribute to the heterogeneity observed in neuroradiological and neuropsychological signs of chronic alcoholism.
- Trial name
- ALCOBRAIN (NCT01455207)
- Testing
- Neuropsychological testing, blood draw, genetic testing
- Where
- France
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Skin Ulcer
Treatment of Hypertensive Leg Ulcer by Adipose Tissue Grafting
The hypertensive leg ulcer is a very painful leg related to acute skin microangiopathy. It occurs in patients older than 60 years followed for hypertension.
- Trial name
- Angiolipo (NCT01932021)
- Testing
- adipose tissue grafting
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Caen
Amyotrophic Lateral Sclerosis
Study of Cognitive and Emotional Disorders in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that involves not only motor structures, as was previously thought, but also brain areas dealing with cognition as well as parts of the limbic system.
- Trial name
- SLAMEM (NCT01530438)
- Testing
- MRI + 18FDG-PET + neuropsychological assessments ; 18FDG performed especially for the research
- Where
- 2 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Heart Disease
Coronary Flow Reserve Evaluation in PET and in MRI Scanner in Heart Transplanted Patients : Comparison With Multi-detectors Scanner
Heart transplantation is the ultimate therapeutic option in patients with end-stage heart failure. Since advances in the treatment of acute rejection has increased early transplant survival, cardiac allograft vasculopathy (CAV)…
- Trial name
- RECOPE (NCT01231815)
- Testing
- 15O-H2O PET -, MRI
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Giant Cell Arteritis
Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis
The factors underlying the large interindividual variability in response to glucocorticoids in Giant Cell Arteritis are poorly understood.
- Trial name
- PREDICORT (NCT01400464)
- Testing
- Prednisone therapy and pharmacokinetic
- Where
- 12 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Blood Coagulation Disorders, Blood Coagulation Disorder With Prolonged Bleeding Time
Accuracy of a Portable International Normalized Ratio Monitor in Elderly Patients
Oral anticoagulants vitamin K antagonists (VKA) have been used for many years in the treatment of thromboembolic disorders, which are among the most costly diseases in terms of public health resources.
- Conditions
- Blood Coagulation Disorders, Blood Coagulation Disorder With Prolonged Bleeding Time, Blood Coagulation Disorder With Prolonged Coagulation Time
- Trial name
- AGINR (NCT01930916)
- Testing
- INR capillary measurement with INRatio 2 device, antiphospholipid antibodies and lupus anticoagulant
- Where
- 4 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Frontotemporal Lobar Degeneration, Aging
Social Cognition in Ageing and in Frontotemporal Lobar Degeneration
The purpose of this study is to examine the age and the neurodegenerative disease effects on social cognition. Secondary goals are to better understand the relationships between different component of social cognition, executive…
- Trial name
- COSIMAGE (NCT01962064)
- Testing
- Cognitive assessment, Brain imaging examination MRI
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Hypovolemia
Comparison of Cardiac Output Measurement Between Transpulmonary Thermodilution and Photoplethysmography
Monitoring could secure management for patient but stay invasive. The purpose of this study was to compare,after cardiac surgery, the cardiac output measurement between transpulmonary thermodilution(reference method) and digital…
- Trial name
- PANEX (NCT01535703)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Alzheimer's Disease
Multi-modal Neuroimaging in Alzheimer's Disease
According to estimations, Alzheimer's disease affects approximately 860,000 people aged of more than 65 years in France. This disease is characterized by disorders of cognitive functions, including memory, associated with…
- Trial name
- IMAP (NCT01554202)
- Testing
- assessment of memory, circulating tPA dosage, ApoE4
- Where
- 5 sites in France
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cirrhosis
Method of Assessment of Driving Ability in Patients Suffering From Wakefulness Pathologies.
The project will improve scientific knowledge regarding a recent law applying potentially to every french driver. It will give for the first time an indication on the impact of alerting treatments on driving risks.
- Trial name
- AutoSop-Foie (NCT01231828)
- Testing
- L-carnitine, Lactulose
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Caen
Upper Gastrointestinal Endoscopy
Safety and Efficacy of Carbohydrate Drink Ingested Two Hours Before Upper Endoscopy Under General Anaesthesia
In several national anaesthesia societies, clear fluids are allowed up to 2 hours before general anaesthesia (GA) and light meals up to 6h. Because of aspiration risk, strict fasting remains routine.
- Trial name
- ENDOGLUcide (NCT01471600)
- Testing
- group drink
- Where
- France
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Heart Failure
Therapeutic Education by Telemedicine in Chronic Heart Failure
The purpose of the SEDIC study is to test a home based heart failure patient clinical follow-up and therapeutic education using telemedicine.
- Trial name
- SEDIC (NCT00878202)
- Testing
- SCAD information system
- Where
- 6 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Anaplastic Glioma
HYPONCO - Hypoxia in Brain Tumors
Background : In malignant gliomas, hypoxia is associated with tumour angiogenesis and tumour progression. This multidisciplinary preclinical and clinical project aims to validate the use of 18F-FMISO as a hypoxic marker for…
- Trial name
- HYPONCO (NCT01200134)
- Testing
- 18F-FMISO PET-scanning
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Caen
Multiple Sclerosis
Study on Cognitive Disorders of Multiple Sclerosis
The purpose of this study is to determine if memantine is effective in the treatment on cognitive disorders of Relapsing - Remitting multiple sclerosis. m
- Trial name
- NCT01074619
- Testing
- Memantine
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Colorectal Cancer
Comparison of Hemoccult, Magstream and OC-Sensor Faecal Occult Blood Tests in Colorectal Cancer Screening
Colorectal cancer screening by faecal occult blood test (FOBT) is a high public health priority. The interest of guaiac tests (G-FOBT) is limited by their poor sensitivity, while the superiority of I-FOBT in comparison with…
- Trial name
- HeMO (NCT01251666)
- Testing
- Colonoscopy
- Where
- 2 sites in France
- Volunteers
- 19,797 people
- Sponsor
- University Hospital, Caen
Post-operative Patients Treated by Tramadol
CYTRAM (Cytochrome P450, Tramadol)
Many methods to detect CYP2D6 poor metabolizers have been validated. Some of them are based on phenotyping (metabolism of dextromethorphan or debrisoquine) and some others on genotyping.
- Trial name
- CYTRAM (NCT00952159)
- Testing
- Monitoring seric concentrations of O-demethyl-tramadol and tramadol
- Where
- 4 sites in France
- Volunteers
- 301 people
- Sponsor
- University Hospital, Caen
Silent Stroke, Pulmonary Embolism
Risk of Stroke in Pulmonary Embolism With a Patent Foramen Ovale (PFO)
Pulmonary embolism is associated with a small but definite risk of paradoxical embolism in patients with a patent foramen ovale (PFO).
- Conditions
- Silent Stroke, Pulmonary Embolism, Patent Foramen Ovale
- Trial name
- ICEP (NCT00831259)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Caen
Postpartum Haemorrhage
Intrarectal Misoprostol in Postpartum Haemorrhage
Postpartum haemorrhage (PPH) remains the major cause of maternal mortality in France. The most efficient treatment of severe PPH is sulprostone which is associated with cardiac complications.
- Trial name
- HEMOSTOP (NCT01116050)
- Testing
- Misoprostol
- Volunteers
- 116 people
- Sponsor
- University Hospital, Caen
HIV Infections
Adherence, Efficacy and Tolerance of Once-a-day Nevirapine-based Regimen in HIV-1 Infected Patients
Taking antiretrovirals once-a-day is considered the simpler way to improve adherence. However, it is not know if this assertion apply to patients taking their medication twice-a-day who change to once-a-day.
- Trial name
- POSOVIR (NCT00466180)
- Testing
- Nevirapine from twice-a-day to once-a-day
- Volunteers
- 62 people
- Sponsor
- University Hospital, Caen
HIV Infections, Hypercholesterolemia
Efavirenz to Nevirapine Switch and Low-Density Lipoprotein (LDL)-Dyslipidemia
Dyslipidemia and coronary heart disease (CHD) are increasingly recognized in persons with human immunodeficiency virus (HIV) infection.
- Conditions
- HIV Infections, Hypercholesterolemia, Antiretroviral Therapy
- Trial name
- NCT00405171
- Testing
- Nevirapine
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen