Clinical trials: sponsored by University Hospital, Caen
Cardiotoxicity, Heart Failure
ML Score Prediction of Cardiotoxicity in Cancer Patients Receiving Anthracycline Chemotherapy or HER2-Targeted Therapies
Cancer treatments have improved substantially over the past decades, but some effective therapies such as anthracyclines and HER2-targeted agents are associated with severe cardiovascular adverse effects, including heart failure.
- Conditions
- Cardiotoxicity, Heart Failure, Neoplasms, Breast Neoplasms
- Trial name
- ML-CardioTox (NCT07191730)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Alzheimer's Disease (AD), Time Perception
Evaluation of a Neuropsychological Tool to Assess Temporal Processing Abilities in Alzheimer's Disease
Perceiving and representing the passage of time allows us to temporally organize perceptions and memories for the coordination of actions, planning, and the mobilization of cognitive processes toward a goal.
- Trial name
- CHRONOS (NCT07341009)
- Testing
- Chronos battery
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Hematopoietic Stem Cell Transplantation, Microbioata
Respiratory Microbioma and Respiratory Complications After Hematopoietic Stem Cell Transplantion
Allogeneic haematopoietic stem cell transplantation (AHSCT) is a therapeutic resource for many haemopathies. The number of HSCTs has risen sharply in recent years due to the use of attenuated conditioning, which has increased the…
- Conditions
- Hematopoietic Stem Cell Transplantation, Microbioata, Respiratory Complications
- Trial name
- VIREMIG (NCT06639750)
- Volunteers
- 120 people
- Sponsor
- University Hospital, Caen
Colorectal Cancer
Trial of Direct Home Delivery of Colorectal Cancer Screening Kit Without Pre-ordering
The effect of mailing FIT with the invitation on participation and colonoscopy rates will be evaluated in a randomized controlled trial conducted in the Centre-Val de Loire (CVL) region, involving 64,000 people from the…
- Trial name
- EXPEDIT (NCT06032338)
- Testing
- CRC screening invitation not including the screening test., Mailing of FIT with invitation, Information letter before invitation
- Where
- France
- Volunteers
- 64,000 people
- Sponsor
- University Hospital, Caen
Healthy Volunteers
VISUALIZATION OF THE MICROCIRCULATION IN WEIGHTLESSNESS
During weightlessness, the cardiovascular system is subject to rapid changes which has been demonstrated in studies of short term (Space Shuttle) and long term missions to Skylab, MIR, and the International Space Station…
- Trial name
- µGµScan (NCT03561545)
- Testing
- weightlessness (parabolic flight)
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Curarization, Postoperative Residual
A Dose-response Study to Determine the Right Dosage of Sugammadex as a Reversal Agent of Rocuronium in Infants Between 1 and 24 Months Old
Sugammadex is a drug used more and more frequently in infants as a rocuronium' s reversal agent. It has multiples benefits over other reversal agents such as a rapid onset of action and a complete reversal no matter how deep is…
- Trial name
- SUGAPEDIA (NCT07477132)
- Testing
- Sugammadex
- Where
- France
- Volunteers
- 99 people
- Sponsor
- University Hospital, Caen
Cardiac Conduction Disturbance
Bachstim Registry: a Feasability Study of Bachmann's Area Pacing
During pacemaker implantation, the atrial lead is commonly positioned in the right atrium. However, this pacing location can be problematic because it may disrupt physiological atrial activation, leading to atrial dyssynchrony.
- Trial name
- NCT07467031
- Testing
- Bachmann's area pacing
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Pregnancy Related
Telemedicine Anesthesia Consultation, Pilot Study in Obstetrics.
Pilot study in Lower Normandy concerning a total of 90 patients scheduled for a pre-anaesthesia consultation in obstetrics. These parturients who plan to give birth at the maternity hospital of the CHU will be invited to carry…
- Trial name
- CATmedO (NCT05975411)
- Testing
- Anesthesia Consultation with telemedicine
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Age 65 and Older, Cardiac Risk Factors
Focused Echocardiography for Primary Care Physicians
Our society is characterized by a steady improvement in the standard of living of its inhabitants, which is reflected, among other things, in improved healthcare and quality of life (longer life expectancy, lower infant…
- Conditions
- Age 65 and Older, Cardiac Risk Factors, Dyspnea; Cardiac, Oedema
- Trial name
- UPCOMING (NCT07427303)
- Testing
- point of care ultrasound
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Tooth Avulsion, Anxiety
Assessment of the Impact of Virtual Reality on Patient Anxiety During Dental Avulsions Under Local Anesthesia
Fear of the dentist is a very common phenomenon which delays consultations and brings negative consequences on oral and general health. Virtual reality (VR) reduces children's pain and anxiety during dental care or oral surgery.
- Trial name
- REVIDEN (NCT05963750)
- Testing
- virtual reality
- Where
- France
- Volunteers
- 119 people
- Sponsor
- University Hospital, Caen
Simulation-based Training on Residents
Efficacy of Simulation-based Neonatal Echocardiography Training (SimuEchoNeo)
Echocardiographic examination plays a critical role in neonatology, but its bedside training faces challenges due to limited patient access.
- Trial name
- SimuEchoNeo (NCT06442683)
- Testing
- TTE simulation-based medical training
- Where
- 3 sites in France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Caen
Relapsing-Remitting Multiple Sclerosis
Assessment of Attentional and Executive Disorders in Multiple Sclerosis Using Techniques of Virtual Reality
Since many years cognitive disorders are a main topic of clinical research in Multiple Sclerosis (MS) as there could be observed early on in the disease and could induce with time in patients significant socio-professional…
- Trial name
- SEPREV (NCT01805336)
- Testing
- Assessment of attentional functions by traditional tests, Assessment of attentional functions by virtual reality tests, Assessment of executive functions by traditional tests
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Contrast Induced Acute Kidney Injury
Bicarbonates Versus Saline for Contrast Induced Acute Kidney Injury Prevention in Intensive Care Unit
The aim of this study is to compare bicarbonates versus saline for prevention of contrast induced acute kidney injury in critically ill patients.
- Trial name
- HYDRAREA (NCT01636089)
- Testing
- bicarbonates, saline
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Healthy Volunteers
Effects of Parabolic Flight on Spatial Cognition and Hippocampal Plasticity
The main objective of this experiment is to assess the impact of parabolic flight on (1) spatial memory and orientation, (2) the changes in brain structure and function, and particularly the hippocampal formation, and (3)…
- Trial name
- HypoCampus (NCT02789007)
- Testing
- Assess the impact of parabolic flight
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Physical Disability, Neurological Diseases or Conditions
Transcultural Validation of the Physical Activity Scale for Individuals With Physical Disabilities (PASIPD) in French: The PASIPD-Fr
The Physical Activity Scale for Individuals With Physical Disabilities (PASIPD) is a scale that has been developped and validated in English to quantify the level of physical activity for people with physical disabilities.
- Trial name
- PASIPD-Fr (NCT04061616)
- Testing
- PASIPD-Fr
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Morbid Obesity, Bariatric Surgery Candidate
Intravenous Lidocaine in Bariatric Surgery.
Although peroperative intravenous lidocaine has been shown to be useful in early recovery after colorectal surgery, its beneficial effect on the specific population of obese patients scheduled for bariatric surgery remained…
- Trial name
- XYLOBAR (NCT03211455)
- Testing
- Lidocaine, isotonic saline
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Caen
Uveal Melanoma
Study Multicentre Evaluating the Effectiveness and Toxicity Sorafenib (Nexavar®) in Adult Patients With Uveal Melanoma and Metastatic Dissemination
The objective of the study is to determine the efficacy and toxicity of sorafenib in metastatic uveal melanoma. The main objective is to determine the non-tumor progression rate 24 weeks after initiation of treatment with…
- Trial name
- O-Mel-Sora (NCT02517736)
- Testing
- Sorafenib at a dose of 800 mg / day
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Caen
Epilepsy
Impact of Educational Actions on the Quality Of Life of Epileptic Patients
The Epilepsy Patient Education (EPE) is very important for the comprehension of the disease and its management. The EPE allows patients and caregivers to acquire together some autonomy and some skills that will help them live…
- Trial name
- EQOLE (NCT02832349)
- Testing
- Educational Actions
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Caen
Leg Ulcer, Compression; Vein
Haemodynamics Variations of Transcutaneous Oxygen in Patient With Areterio-venous Leg Ulcers Under Venous Compression
Arterio-venous leg ulcers are real problems when it comes to public health because it has a major cost and leads to social and professional handicap.
- Trial name
- NCT03725111
- Testing
- venous compression
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Caen
Bronchopulmonary Dysplasia, Preterm Infant Development
PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants
The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks.
- Conditions
- Bronchopulmonary Dysplasia, Preterm Infant Development, Asthma Childhood, Bronchiolitis
- Trial name
- PremaBiom (NCT07411261)
- Testing
- Nasal swab, blood sampling, Mother milk sampling
- Where
- 6 sites in France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Caen