Clinical trials: sponsored by University Hospital, Caen
Cardiac Resynchronization Therapy, Left Bundle Branch Area Pacing
Feasibility and Outcomes Registry of Lumenless dEfibrillation Leads for Conduction System Pacing
The recent development and market introduction of small diameter implantable defibrillation leads able to deliver left bundle branch area pacing (LBBAP) has opened the possibility of achieving cardiac resynchronization therapy…
- Trial name
- FORGE CSP (NCT07406737)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Multiple Sclerosis
Influence of Therapeutic Failure on the Psychosocial Experience in Multiple Sclerosis
Multiple sclerosis (MS), an inflammatory, neurodegenerative disease of the central nervous system, affects around 120,000 patients in France and is the leading cause of non-traumatic disability in young adults.
- Trial name
- INPSYSEP (NCT07372599)
- Testing
- Questionnaires
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Burnout, Anxiety
Mental Health Outcomes and Variations in Exercise in Residents
The goal of this observational study is to learn about the relationship between physical activity levels and mental health outcomes in French medical residents.
- Conditions
- Burnout, Anxiety, Depression Anxiety Disorder, Physical Activity and Wellbeing
- Trial name
- MOVE-Res (NCT07380074)
- Testing
- Physical Activity and Mental Health Outcomes Assessment
- Where
- France
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen
Neurodevelopmental Disorders, Child Behavior Disorders
Impact of General Anesthesia in Childhood on Cognitive Processes
This study aims to evaluate the potential long-term cognitive effects of general anesthesia administered before the age of 4. Specifically, it investigates executive functions-including inhibition, working memory, and cognitive…
- Trial name
- NCT07141797
- Testing
- Executive functions assessment
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Concussion (Diagnosis), Sport-related Concussion
Longitudinal Monitoring of Head Impacts in Elite Junior Ice Hockey
This study aims to better understand how head impacts during ice hockey affect the brain and body, especially in young athletes.
- Conditions
- Concussion (Diagnosis), Sport-related Concussion, Hockey Player
- Trial name
- DRAK-CARE (NCT07341880)
- Testing
- Head impact monitoring, Heart rate variability monitoring, Dual-task cognitive and motor assessment
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Chronic B-cell Malignancies, BTK Inhibitors
Zanubrutinib and Acalabrutinib Use and Risk of Atrial Fibrillation in Patients With Chronic B-cell Malignancies
Background. Zanubrutinib and acalabrutinib are both associated with an increased risk of atrial fibrillation (AF) but AF comparative risk between these 2 BTK inhibitors (BTKis) remains largely unknown. Objectives.
- Conditions
- Chronic B-cell Malignancies, BTK Inhibitors, Cardiovascular Diseases
- Trial name
- NCT07283965
- Testing
- Zanubrutinib, Acalabrutinib
- Volunteers
- 15,000 people
- Sponsor
- University Hospital, Caen
Binge Drinking, Alcohol Drinking
Alcohol Consumption: Norms, Identities, & Motivations
The emergence of new problematic alcohol consumption practices among young people requires new dynamics in prevention strategies.
- Trial name
- ALCONIM (NCT06447350)
- Testing
- Induced hypocrisy, social identity mapping, Motivational modeling
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Postoperative Care, Analgesia Assessment
Posthectomy in Pediatric Elective Surgery : a Comparison of Perioperative Analgesia Using Echo-guided Penile Block and Pudendal Block With neurostimuLation Technique
Context : Posthectomy is a surgical procedure that concerns around 30% of the male population, mainly in pediatrics. As this procedure is mainly performed on an outpatient basis, the implementation of an enhanced rehabilitation…
- Conditions
- Postoperative Care, Analgesia Assessment, Posthectomy, Postoperative Analgesia
- Trial name
- PinEAPPLE (NCT07191938)
- Testing
- Ultrasound guided penile block, Neurostimulation guided pudendal block
- Where
- France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Caen
Alzheimer Dementia (AD), Caregivers
MUSic Listening Impact on QUality of Life, Brain and Burnout of ALzheimer' Patients Informal Caregivers
Although life expectancy is increasing, the risk of dependence and/or loss of autonomy is increasing too with ageing. Alzheimer's disease affects many people and this kind of disease is constantly growing.
- Trial name
- MUSIQUAL+ (NCT07159542)
- Testing
- listening intervention, Neuropsychology assessment, brain imaging examination
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Heart Failure, Fall
Cardiological Drug Classes And Falls in Older Adults
Heat failure is a fast gowing health issue with a rising incidence in older adults. Recommendations have recently been published to treat heart failure, but most clinical trials leading to these recommendations tended to exclude…
- Trial name
- NCT07150754
- Testing
- Heart failure pharmacological treatments
- Where
- France
- Volunteers
- 100,000 people
- Sponsor
- University Hospital, Caen
ACL Surgery, ACL Injuries
Developing and Validating the Risk-taking Intention and Sport Engagement After ACL Reconstruction (RISE-ACL) Scale
Psychological factors play a critical role in recovery following anterior cruciate ligament (ACL) reconstruction. While tools such as the ACL - Return to Sport after Injury (ACL-RSI) focus on psychological readiness, emphasizing…
- Conditions
- ACL Surgery, ACL Injuries, ACL Reconstruction
- Trial name
- RISE-ACL (NCT06748066)
- Testing
- RISE-ACL development, RISE-ACL scale validation
- Where
- France
- Volunteers
- 162 people
- Sponsor
- University Hospital, Caen
Osteoarthritis
Phenotype/Genotype Correlation in a Family With Early Onset Osteoarthritis
This study will investigate the genes responsible for osteoarthritis. Individuals with osteoarthritis known or suspected to be caused by a gene mutation (change) may be eligible for this study.
- Trial name
- Exorhum (NCT01999166)
- Testing
- radiography (X-ray), DNA sampling
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Caen
Borderline Personality Disorder
NEUROIMAGING OF ADOLESCENT BORDERLINE PERSONALITY DISORDER WITH AND WITHOUT POST-TRAUMATIC STRESS DISORDER
Borderline personality disorder (BPD) is a common mental disorder in adolescents with significant individual and societal repercussions, characterized over the long term by emotional hyperresponsiveness, relational instability…
- Trial name
- BorderStress (NCT04852744)
- Testing
- Brain MRI
- Where
- France
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Delivery Complication, Labor Long
Effect of Oral Carbohydrate Intake > 44kCal Per Hour During Labour on the Rate of Instrumental Vaginal Delivery
Carbohydrate intake during physical exercise improves muscle performance and decreases fatigue. We hypothesized that carbohydrate intake during labor which is a period of significant physical activity can decrease the…
- Conditions
- Delivery Complication, Labor Long, Pregnancy Related
- Trial name
- soliso-2 (NCT05080309)
- Testing
- carbohydrate oral intake, free water only
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Patients With Total Laryngectomy and Their Close Relatives
FRENCH THERAPEUTIC EDUCATION PROGRAM AIMING TO IMPROVE LARYNGECTOMIZED PATIENTS' AND THEIR FAMILY CAREGIVER'S QUALITY OF LIFE
The therapeutic education of patients and their close relations is, as yet, poorly developed in France in the field of oncology (Pérol2007), in particular for cancers of the upper aerodigestive tract (Allison2010).
- Trial name
- PETAL2 (NCT04569500)
- Testing
- PETAL program
- Where
- France
- Volunteers
- 264 people
- Sponsor
- University Hospital, Caen
Subarachnoid Hemorrhage
Intraventricular Fibrinolysis for Aneurysmal Subarachnoid Hemorrhage.
Aneurysmal subarachnoid hemorrhage (SAH) is a devastating form of stroke, with delayed cerebral ischemia (DCI) as a major complication.
- Trial name
- FIVHeMA (NCT03187405)
- Testing
- EVD + IVF with Alteplase
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Caen
Fall Patients
Impact of an Automatic Alert Device on the Occurrence of Nocturnal Falls in Nursing Home Residents
Impact of an automatic alert device on the occurrence of nocturnal falls in nursing home residents Measurement of the number of nocturnal falls between 8 p.m. and 8 a.m.
- Trial name
- NOCTUSAFE (NCT05964972)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Caen
Neuropathic Pain, Anxiety Disorder/Anxiety State
Predictive and Impact of Pain After 6 Months of Radiotherapy, in Head and Neck Cancer
Head and neck cancers are a source of complications and after-effects related to the disease and treatment. These cancers and their treatment alter the quality of life of patients and generate pain with physical and psychological…
- Conditions
- Neuropathic Pain, Anxiety Disorder/Anxiety State, Pain, Chronic, Alcohol Use Disorder
- Trial name
- DIP-CAOS (NCT05505188)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Caen
Transient Ischemic Accident
Correlation Between Cognition and Neuroimaging in TIA Patients
Context: Cognitive impairment is common after a stroke. Out of 100 patients who have suffered a stroke, 50 will develop cognitive impairment.
- Trial name
- COG-TIA (NCT04989608)
- Testing
- Neuroimaging
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen