Clinical trials: sponsored by University Hospital, Caen
Hypothermia
Impact of Prolonged Cold-water Swimming on Heart Rate and Cardiac Function
A significant medical risk associated with hypothermia during exercise in a cold environment cardiac arrhythmia due to a possible autonomic conflict.
- Trial name
- CARDIOCOLD (NCT06296290)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Chronic B-cell Malignancies, BTK Inhibitors
Ibrutinib and Acalabrutinib Use and Risk of Atrial Fibrillation in Patients With Chronic B-cell Malignancies
Background. Ibrutinib and acalabrutinib are both associated with an increased risk of atrial fibrillation (AF) but AF comparative risk between these 2 BTK inhibitors (BTKis) remains largely unknown. Objectives.
- Conditions
- Chronic B-cell Malignancies, BTK Inhibitors, Cardiovascular Diseases
- Trial name
- NCT06561243
- Testing
- BTK inhibitor (Ibrutinib or Acalabrutinib)
- Where
- France
- Volunteers
- 15,000 people
- Sponsor
- University Hospital, Caen
Cancer, Drug Toxicity
Atrial Fibrillation in Active Cancer Patients
Atrial fibrillation is a common complication of both cancer and anticancer drugs but the consequences of such events remain poorly known and are not adressed in both phase III oncological trials and cardiological guidelines.
- Conditions
- Cancer, Drug Toxicity, Atrial Fibrillation, Cardiovascular Complication
- Trial name
- AFIB-CANCER (NCT04696081)
- Testing
- occurence of atrial fibrillation
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Caen
Atrial Fibrillation, Peritoneal Dialysis Complication
Safety and Efficacy of Apixaban Versus Warfarin in Peritoneal Dialysis Patients With Non Valvular Atrial Fibrillation: a Prospective, Randomised, Open-label, Blinded End-point Trial (APIDP2)
Introduction: Several randomised controlled trials have demonstrated that novel oral anticoagulants (NOACs) are safer compared to vitamin K antagonists for the management of non valvular atrial fibrillation (NVAF) to prevent…
- Trial name
- APIDP2 (NCT06045858)
- Testing
- Anticoagulation Agents
- Volunteers
- 178 people
- Sponsor
- University Hospital, Caen
ACL Injury
Association Between Neuromuscular Parameters and Functional Assessment After ACL Reconstruction
The anterior cruciate ligament (ACL) injury is common in athletes aged 18 to 35. ACL reconstruction (ACLR) aims to restore knee stability in the process of returning to sports.
- Trial name
- KASTLAB (NCT06524869)
- Testing
- Isokinetic neuromuscular assessment
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Caen
White Coat Hypertension
Short Term Reproducibility of Office White-coat Effect
While a theoretical increase in systolic blood pressure (BP) of 10 mmHg can triple the relative risk of cardiovascular disease (CVD), the potential presence of a white coat effect (WCE) can interfere with the assessment of blood…
- Trial name
- REBBRE (NCT06523062)
- Testing
- blood pressure measurement
- Volunteers
- 922 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Hypertension,Essential, Cardiovascular Diseases
Prescribing Patterns of Antihypertensive Drugs in Uncomplicated Hypertension
Hypertension incurs substantial cardiovascular morbidity and mortality, particularly in primary prevention settings. General practitioners (GPs) play a pivotal role in the management of hypertension in primary care, yet…
- Trial name
- NCT06517134
- Testing
- Antihypertensive Agents
- Where
- France
- Volunteers
- 3,325,032 people
- Sponsor
- University Hospital, Caen
Psychosis
Psychosis Associated With Methylphenidate in Children and Adolescents
perform a study in VigiBase® to assess if methylphenidate was associated with an over-reporting of psychosis including hallucinations in children and adolescents and to characterize those psychosis.
- Trial name
- NCT06518330
- Testing
- Intake of Methylphenidate
- Where
- France
- Volunteers
- 46,233 people
- Sponsor
- University Hospital, Caen
Sarcopenia, Bladder Cancer
SArcopenia, Mobility, PHYsical Activity and Post-operative Risk of Bladder Carcinoma in the Elderly
Sarcopenia is associated with lower prognosis in solid tumors, but this has not been studied in bladder carcinoma requiring cystectomy.
- Trial name
- SAMPHYR (NCT03362801)
- Testing
- sarcopenia and mobility measurement
- Where
- 3 sites in France
- Volunteers
- 69 people
- Sponsor
- University Hospital, Caen
Hepatocellular Carcinoma
Long-term Management of Patients With Ruptured HCC
The main objective of this work is to evaluate the prevalence and results of specific management of HCC after spontaneous rupture, since the arrival of sorafenib in 2008.
- Trial name
- NCT06505291
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cancer, Side Effect of Drug
Radiopharmaceuticals Analysis for Detailed Insights And INternational Tracking of Safety
Little is known about cancer therapy-related radiopharmaceuticals drugs safety. Here the investigators use VigiBase (http://www.vigiaccess.org/), the World Health Organization (WHO) database of individual safety case reports, to…
- Trial name
- RADIANTS (NCT06483685)
- Testing
- Radiopharmaceuticals drugs
- Where
- France
- Volunteers
- 500,000 people
- Sponsor
- University Hospital, Caen
PSVD With or Without SSc
PortoSinusoidal Vascular Diseases and Systemic Sclerosis
Porto-Sinusoidal Vascular Disorders (PSVD) is a heterogeneous clinico-pathological entity characterized by alterations in small liver vessels. "Nodular regenerative hyperplasia (NRH)" is the most common PSVD.
- Trial name
- NCT06032754
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Caen
Neurodevelopmental Changes (Childhood, Ageing)
Understanding New Semantic Memory Learnings Across the Lifespan
The aim of this research is to specify the changes in brain connectivity (i.e. EEG phase synchronisation between brain regions) associated with semantic learning between individuals belonging to different age groups.
- Trial name
- ULIS (NCT06442670)
- Testing
- Electroencephalography
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Malignancies, Cardiovascular Diseases
Cancer Therapy-related Cardiac Dysfunction Occuring in Children Treated by Anticancer Drugs for Malignancies
Little is known about cancer therapy-related cardiac dysfunction occuring in children treated by anticancer drugs for malignancies.
- Conditions
- Malignancies, Cardiovascular Diseases, Children, Only
- Trial name
- NCT05602103
- Testing
- use of anticancer drugs in monotherapy or in combination therapy
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Caen
Healthy
Drone Biological Samples Transport vs Walking (DBT - Drone Biology Transport)
The transport of biological samples is a key step in the pre-analysis process in health facilities and must meet quality requirements (NF:EN:ISO 151989) to ensure that samples are transported in are transported in good…
- Trial name
- DBT (NCT05957497)
- Testing
- Biological samples transport and analysis
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Hematological Malignancy, Atrial Fibrillation
Is Ibrutinib-related Atrial Fibrillation Dose Dependent
Ibrutinib, an oral inhibitor of Bruton tyrosine kinase (BTK), has recently revolutionized the treatment of various chronic B-cell malignancies and particularly chronic lymphocytic leukemia (CLL).
- Trial name
- NCT06224452
- Testing
- ibrutinib exposure
- Where
- France
- Volunteers
- 18,000 people
- Sponsor
- University Hospital, Caen
the Aim of This Study is to Describe Genomic Epidemiology of MSSA in Neonatal ICU
Epidemiology and Genomic Surveillance of Staphylococcus Aureus in ICU Neonatology
Newborns hospitalized in Neonatology are particularly vulnerable to infections, in particular healthcare associated infection (HAI).
- Trial name
- NEOSAUR (NCT06267352)
- Volunteers
- 120 people
- Sponsor
- University Hospital, Caen
Chronic Myeloid Leukemia, Tyrosine Kinase Inhibitor
Tyrosine Kinase Inhibitor Withdrawal Syndrome in CML Patients: Observatory Trial Studying the Biological Factors.
Patients who suffer from chronic myeloid leukemia are treated by tyrosin kinase inhibitors (TKI) saying imatinib, nilotinib, dasatinib, bosutinib and ponatinib.
- Conditions
- Chronic Myeloid Leukemia, Tyrosine Kinase Inhibitor, Withdrawal Syndrome
- Trial name
- KIWIS (NCT03996096)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Anxiety State, Sleep Disturbance
Anxiety/Depression, Sleep and Alcohol in Elderly Anxiety/Depression, Sleep Disturbances and Alcohol Use Disorder in Elderly With Cognitive Complaints
The goal of MEM-ASA is to investigate the prevalence of anxiety/depression, sleep disturbances and alcohol use disorder in elderly with cognitive complaints.
- Conditions
- Anxiety State, Sleep Disturbance, Alcohol Abuse, Aging
- Trial name
- MEM-ASA (NCT04368416)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Caen
Cardiac Remodeling, Ventricular, Right Ventricular Hypertrophy
Longitudinal Analysis of Right Ventricular Remodeling in Response to Prolonged Strength Training Using 3D-echocardiography
Right ventricular (RV) physiological remodeling in response to prolonged strength exercise remains poorly studied. This prospective, non-randomized, single-center study, proposes to follow 24 healthy sedentary volunteers who will…
- Trial name
- FORCE-VD (NCT04187170)
- Testing
- Strength physical training
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen