Clinical trials: sponsored by University Hospital, Clermont-Ferrand
Dental Pain, Dental Anxiety
Compare the Intensity of Pain Felt by Children During the Local Anesthesia Procedure to That Perceived by the Accompanying Parent.
The goal of this observational study is to compare the intensity of pain experienced by children (aged 6 to 15) during local anaesthesia with that perceived by the parent accompanying them.
- Trial name
- ADDenT (NCT07718477)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infective Endocarditis (IE)
From Commensalism to Pathogenicity: Exploring the Pathophysiology of Bacteremia to Better Understand Enterococcus Faecalis Infective Endocarditis
Enterococci are pathobionts of the human intestinal microbiota: they colonize the gastrointestinal tract as well as the skin, urine, wounds, bile, the oral cavity and endodontic canal, and medical devices (urinary catheters…
- Trial name
- BAC-ENDO (NCT07313865)
- Testing
- Microbiological sampling (swab collection)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Stroke
Predictive Factors for Return to Work After a First Stroke Treated at Clermont-Ferrand University Hospital in Puy de Dôme Between January 2020 and December 2024
Stroke is a leading cause of acquired motor disability and the second most common cause of major cognitive impairment worldwide.
- Trial name
- RTWS2 (NCT07264387)
- Where
- 2 sites in France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Clermont-Ferrand
Periodontitis, Adult, Periodontitis
Evaluation of Changes in Oral Health-related Quality of Life During the Treatment of Periodontitis.
Periodontitis is a chronic inflammatory disease affecting the supporting tissues of the teeth and may negatively affect patients' oral health-related quality of life.
- Conditions
- Periodontitis, Adult, Periodontitis, Oral Disease, Quality of Life
- Trial name
- PAROQoL (NCT07868042)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy Women
Endothelial Function in Healthy Volunteers
The aim of this study is to measure FMD (flow-mediated dilation) in healthy volunteers aged over 50 in order to establish reference values for women aged over 50.
- Trial name
- NormFMD (NCT07837076)
- Testing
- Measurement of endothelial function using FMD
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Self-medication for Pain, Limits on Advice From Community Pharmacists and Referral to a Primary Care Practitioner
Impact of Pharmaceutical Intervention in Self-Medication: Focus on Pain Management in Pharmacies
Self-medication is an increasingly common practice that carries risks. When a patient requests self-medication, the community pharmacist intervenes in the identification, prevention and resolution of medication-related problems.
- Trial name
- AUTOMED'IP-DOL (NCT07867301)
- Testing
- Care monitoring by the pharmacist's telephone call
- Volunteers
- 376 people
- Sponsor
- University Hospital, Clermont-Ferrand
Psychosocial Risk Factors
PSYCHosocial Risk Factors of AThletes, Evaluation of a Questionnaire Constructed by CHATGPT
The goal of this observational study was to assess themes generated by ChatGPT to help organize psychosocial risk factors in professional sport.
- Trial name
- PsyChAt (NCT07862855)
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Physical Activity and Sedentary Behavior
Validation of a Short Physical Activity Questionnaire (Work and Leisure)
Validated physical activity questionnaires are often long and time-consuming, particularly when assessing both leisure-time and occupational physical activity and sedentary behavior.
- Trial name
- Actiwork (NCT07844265)
- Testing
- ACTIWORK questionnaire, Recent Physical Activity Questionnaire (RPAQ), REPEAS questionnaire
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility
Artificial Intelligence in Embryo Selection in Assisted Reproduction for Embryos Cultured to the Fifth Day of Development
Embryo selection is one of the major challenges in Assisted Reproductive Technology (ART) in order to continuously improve clinical pregnancy rates.
- Trial name
- IASEAMP (NCT07844083)
- Testing
- EMA
- Where
- France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Clermont-Ferrand
Knee Osteoarthritis
Effectiveness of the ARTH-e Application for Exercise Adherence in People With Knee Osteoarthritis : RCT
The aim of this study is to investigate the effectiveness of a smartphone-based e-health application (intervention group) compared with standard care (control group) in terms of changes in adherence in patients with knee…
- Trial name
- ARTH-e3 (NCT06359171)
- Testing
- Application ARTH-e
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Preventive Practice
Prevention Habits of Medical Doctors
Preventive practices among physicians remain insufficiently studied, particularly in situations for which recommendations are limited or unavailable.
- Trial name
- Prevmed (NCT07829601)
- Testing
- PREVMED questionnaire
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Clermont-Ferrand
Obesity & Overweight
Childhood Obesity Risk Markers (MARIOBE)
Metabolic diseases, including childhood obesity, represent a major public health challenge. Studies in mice have identified transcriptomic markers in adipose tissue capable of predicting a predisposition to obesity prior to any…
- Trial name
- MARIOBE (NCT07831291)
- Testing
- early transcriptomic markers
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Leukemia in Remission, Myelodysplastic Syndromes
Faecal Microbiota Transplantation After Allogeneic Stem Cell Transplantation
The aim of this study is to assess the Fecal Microbiota Transplantation (FMT) efficacy in the prevention of allogeneic hematopoietic stem cell transplantation (allo-HSCT) complications and particularly Graft versus Host Disease…
- Conditions
- Acute Leukemia in Remission, Myelodysplastic Syndromes, Myeloproliferative Syndrome, Hodgkin Lymphoma
- Trial name
- TMF-Allo (NCT04935684)
- Testing
- Fecal Microbiota Transplantation
- Where
- 20 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Diabetic Retinopathy
Screening for Diabetic RETINopathy Using a Non-mydriatic Retinograph Funduscope in Occupational MEDicine
Diabetic retinopathy is a complication of diabetes that can affect vision. Early detection and appropriate management can help prevent or delay vision loss.
- Trial name
- RETINOMED (NCT07828821)
- Testing
- Non-mydriatic retinography, Self-administered questionnaire
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Clermont-Ferrand
Calcium-phosphorus Metabolism
Study of the Impact of Phosphate Supplementation on FGF23 Concentrations in Patients With Hypophosphatemia
Fibroblast growth factor 23 (FGF23) is the principal hormone regulating serum phosphate homeostasis. Secreted by osteocytes, it promotes renal phosphate excretion and suppresses the synthesis of 1,25-dihydroxyvitamin D.
- Trial name
- PHOSPHO-23 (NCT07827989)
- Testing
- Blood sample
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Kidney Injury, Transient Acute Renal Failure
Impact of the Characteristics of Acute Renal Failure in Intensive Care on the Long-term Renal Prognosis: Prospective Multicenter Cohort Study
The purpose of this study is to assess the impact of Acute Kidney Injury (AKI) characteristics on long-term renal prognosis in Intensive Care Unit (ICU) patients.
- Conditions
- Acute Kidney Injury, Transient Acute Renal Failure, Persistent Acute Renal Failure
- Trial name
- MAKI (NCT05247502)
- Testing
- Data observation
- Where
- 2 sites in France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Urinary Bladder Tumour, MRI
Tumor Staging T of Bladder Tumours: Correlation of MRI and Anatomopathologic Analysis
Urinary bladder tumors with a frequency of 13000 new cases a year, have a heterogeneity in terms of survival according to the stage of local flooding. This is an aggressive tumor because of the potential muscular infiltration.
- Conditions
- Urinary Bladder Tumour, MRI, Invasion, Diagnosis
- Trial name
- IRMAA (NCT05464576)
- Testing
- MRI
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pregnant Woman
Physical Activity and Sedentary Behavior During Pregnancy
Our main objective is to evaluate the intervention that best enables women's adherence to physical activity (PA). Our hypothesis is that identifying types of interventions suitable for pregnant women (in-person PA sessions…
- Trial name
- PREGMOUV (NCT06585085)
- Testing
- In person PA sessions, Interactive videoconference PA sessions, In person and by videoconference (mixed format) PA sessions.
- Where
- France
- Volunteers
- 654 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Necrotizing Enterocolitis, Premature Birth
Cohort of Premature Newborns for Charaterization of the Digestive Microbiota in Ulcerative Necrotizing Enterocolitis in Premature Infants
Compare the bacterial digestive microbiota during the stay in neonatal intensive care between a group of premature newborns developing a NEC (necrotizing enterocolitis) and a group of newborns free from NEC.
- Trial name
- CortECS (NCT04972734)
- Testing
- premature newborns developing a NEC, premature newborns without NEC
- Where
- France
- Volunteers
- 297 people
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson Disease (PD)
Idiopathic Parkinson's Disease: Interest of an Early Group-Based Cognitive Rehabilitation Program (LIFECOG-PD)
Current pharmacological treatments have not demonstrated significant improvement in cognitive impairment in Parkinson's disease (PD).
- Trial name
- LIFECOG-PD (NCT07813156)
- Testing
- cognitive rehabilitation program
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand