Clinical trials: sponsored by University Hospital, Geneva
HIV Infection, Rheumatic Disease
Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients
The objective of this study is to assess vaccine responses to novel adjuvanted influenza A(H1N1) vaccines in patients at high risks of influenza A(H1N1) complications.
- Conditions
- HIV Infection, Rheumatic Disease, Cancer, Transplant
- Trial name
- NCT01022905
- Testing
- Adjuvanted influenza A(H1N1) vaccines
- Where
- Switzerland
- Volunteers
- 1,141 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Prematurity, Neonatal Sepsis
Defects in Opsonophagocytosis in Premature Infants
The purpose of the study is to characterize innate immune function of premature infants, and identify defects that may be responsible for the development of bacterial sepsis.
- Trial name
- NCT00866567
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Diabetes Type 2
Gait and Balance of Diabetes Type 2 Patients
Type 2 diabetes is one of the fastest growing public health problems in both developed and developing countries. It is estimated that the number of people with diabetes in the world will double in coming years, from 171 million…
- Trial name
- NCT00637546
- Testing
- Physiotherapy
- Where
- Switzerland
- Volunteers
- 71 people
- Sponsor
- University Hospital, Geneva
Cancer, Mucositis
Effect of Topical Morphine (Mouthwash) on Oral Pain Due to Chemo- and/or Radiotherapy Induced Mucositis
Introduction: Oral pain due to mucosal lesion is quite frequent in oncology, geriatric as well as palliative care settings. The oncology patient is mainly suffering from radio- and/or chemotherapy induced oral mucositis.
- Trial name
- NCT00613743
- Testing
- mouth wash with morphine
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Sleep Disorders, HIV Infections
Patient Preference, Sleep Quality, and Anxiety/Depression: A Comparison of Raltegravir and Efavirenz
Efavirenz causes neuropsychiatric side effects and sleep disturbance, including vivid dreams, dizziness, and abnormal tiredness.
- Trial name
- Switch-ER (NCT00944957)
- Testing
- Raltegravir for the first 2 weeks, Efavirenz for the last 2 weeks, Efavirenz for the first 2 weeks
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Geneva
Postoperative Nausea and Vomiting
Study of Nicotine for the Prevention of PONV
The purpose of this study is to determine whether nicotine is effective in the prevention of nausea and vomiting in non-smokers undergoing surgery
- Trial name
- NicoPONV (NCT00553709)
- Testing
- Nicotine
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Geneva
Enterobacteriaceae Infections
The Burden and Genetic Variability of Extended-Spectrum ß-Lactamase (ESBL) - Producing Pathogens in Swiss Children
Objectives: The aim of the study is to determine the molecular epidemiology and genetic variability of ESBL-producing enterobacteriaceae (E-ESBL) among children in Switzerland and to estimate the associated clinical burden of…
- Trial name
- NCT00894036
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
Gallbladder Disease
Prospective Evaluation of Laparoendoscopic Single Site Versus Laparoscopic Cholecystectomy
Laparoendoscopic single site cholecystectomy is associated with better cosmetic results and recovery compare to laparoscopic cholecystectomy.
- Trial name
- NCT00961506
- Testing
- LESS cholecystectomy, Laparoscopic cholecystectomy
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Geneva
Human Immunodeficiency Virus, HIV Infections
Adjusting Antiretroviral Therapy Dosage Using Therapeutic Drug Monitoring
Background Low concentrations of protease inhibitors (PIs) or nonnucleoside reverse transcriptase inhibitors (NNRTIs) are associated with an increased risk of virological failure.
- Trial name
- TDM (NCT00836212)
- Testing
- Reducing dose of Lopinavir, Reducing dose of efavirenz
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University Hospital, Geneva
Acute Renal Failure
Recombinant Human Erythropoietin Use in Intensive Care Unit (ICU) Patients: Does it Prevent Acute Renal Failure
Pilot study aiming to assess the effect of two doses of rhu EPO on urine NGAL concentration and on serum cystatin C and creatinine levels in critically ill patients at risk of ARF.
- Trial name
- NCT00676234
- Testing
- epoetinum
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University Hospital, Geneva
Symptomatic Gallbladder Stones, Cholecystitis
Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy
Background: Single port access surgery is a rapidly progressing surgical approach which allows performance of standard laparoscopic surgery through a single transparietal port instead of multiple port accesses.
- Conditions
- Symptomatic Gallbladder Stones, Cholecystitis, Biliary Pancreatitis
- Trial name
- NCT00904865
- Testing
- SPA cholecystectomy, Laparoscopic cholecystectomy
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Geneva
Breech Presentation
Moxibustion for Fetus in Breech Presentation
Objective: To evaluate moxibustion of the BL67 acupoint between 34 and 38 weeks of gestation to facilitate cephalic version of breech presentation in a Western setting.
- Trial name
- NCT00890474
- Testing
- Moxibustion of the BL67 acupoint
- Where
- Switzerland
- Volunteers
- 212 people
- Sponsor
- University Hospital, Geneva
Diverticulitis
Laparoscopic Versus Open Sigmoid Colectomy for Diverticular Disease
Aim: This is a prospective, randomized comparison of traditional open (OS) and laparoscopic sigmoidectomy (LS) in patients with complicated diverticular disease.
- Trial name
- NCT00453830
- Testing
- laparoscopic sigmoid resection
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
Bronchoscopy
Bronchoscopy and Bispectral Index (BIS) - Guided Sedation
Bronchoscopy is performed on a daily basis for diagnostic and therapeutic purposes. This procedure may cause anxiety and discomfort requiring the use of sedative drugs.
- Trial name
- NCT00839371
- Testing
- Propofol, Midazolam
- Where
- Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Typical Atrial Flutter, Radiofrequency Ablation
Typical Flutter Ablation:A Comparison of 4 mm Versus 2 mm Irrigated cathéters
The purpose of this study is to compare the efficacy of 4 mm irrigated catheters with 2 mm irrigated catheters for ablation of typical flutter.It's a prospective randomised multicenter study.
- Conditions
- Typical Atrial Flutter, Radiofrequency Ablation, Irrigated Catheters
- Trial name
- NCT00750711
- Testing
- Radiofrequency ablation for atrial flutter by catheters
- Where
- 2 sites in Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Geneva
Myocardial Infarction
Reperfusion Time in ST Segment Elevation Myocardial Infarction (STEMI)
Reperfusion delay in STEMI has been shown to be excessive in our community. In order to improve delay a fast track (direct transfer in catheterization laboratory) has been implemented.
- Trial name
- NCT00497419
- Testing
- fast track
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Geneva
Non-Dialysis Dependent Severe Renal Dysfunction, Cardiovascular Disease
Preop Hemodialysis or Intraop Ultrafiltration for Patients With Severe Renal Dysfunction Undergoing Open Heart Surgery
The purpose of this study is to determine whether preoperative hemodialysis or intraoperative modified ultrafiltration are effective for patients with non-dialysis dependent severe renal dysfunction undergoing open heart surgery.
- Trial name
- SeRenaD-CPB (NCT00720967)
- Testing
- Open Heart Surgery (OHS), Intraoperative Modified Ultrafiltration (MUF), Hemodialysis (HD)
- Where
- 7 sites in France, Germany and 3 more
- Volunteers
- 450 people
- Sponsor
- University Hospital, Geneva
Sepsis
Procalcitonin-Guided Antimicrobial Discontinuation
The current study aims to validate the diagnostic use of PCT assessing its capability to individualize and shorten the duration of antibiotic therapy in critically ill patients with suspected or confirmed sepsis.
- Trial name
- NCT00250666
- Testing
- PCT measurement
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Geneva
Chronic Renal Failure
Detection of Latent Tuberculosis in Hemodialysis Patients
This study aims to compare the performance of the tuberculin skin test, used for more than 50 years as a diagnostic tool for latent tuberculosis infection, with 2 blood tests which have recently become commercially available…
- Trial name
- NCT00695734
- Where
- Switzerland
- Volunteers
- 62 people
- Sponsor
- University Hospital, Geneva
Emergencies
Evaluation of Emergency Triage Using a Computerized Simulator
A four-level triage scale (the Geneva Emergency Triage Scale, GETS) has been used since 1997 in our emergency department (ED). A recent evaluation of this scale showed that our instrument had an excellent intra-rater reliability…
- Trial name
- NCT00321243
- Testing
- Visual clues
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Geneva