Clinical trials: sponsored by University Hospital, Geneva
Clinical Encounter Quality
Booster of the "More Time for Patients" Program
The goal of this clinical trial is to determine if reactivating a hospital program called "Plus de temps au service des patients" (PTP) can improve the quality of pain management for patients and increase job satisfaction among…
- Trial name
- NCT06491797
- Testing
- Immediate reactivation
- Where
- Switzerland
- Volunteers
- 764 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Psychiatric Hospitalization, Coercion
Evaluation of a New Recovery-oriented Model of Psychiatric Inpatient Care
This project will study the effects of a major reorganization of psychiatric inpatient wards. This reorganization will affect many aspects of day-to-day work, with the aim of improving the individualization of care, the…
- Conditions
- Psychiatric Hospitalization, Coercion, Recovery
- Trial name
- NCT06250296
- Testing
- New model of psychiatric inpatient care
- Where
- Switzerland
- Volunteers
- 700 people
- Sponsor
- University Hospital, Geneva
Partially Edentulous Maxilla, Partially Edentulous Mandible
Peri-implant Bone Formation of Grafted Sites Around Hydrophilic and Non-hydrophilic Dental Implants
Although bone grafting at the same time as the placement of dental implants is a common procedure in implantology, there are currently no data on the influence of different types of implant surfaces on bone healing, which is…
- Trial name
- NCT06460103
- Testing
- Placement of a "Straumann® Bone Level Tapered implant SLActive®" (hydrophilic surface), Placement of a "Straumann® Bone Level Tapered implant SLA®" (hydrophobic surface)
- Volunteers
- 70 people
- Sponsor
- University Hospital, Geneva
Lung Cancer, Organoid
Patient-derived Organoids of Lung Cancer to Test Drug Response
This is a single center, single arm, open and exploratory clinical study, with 50 cases planned for a period of 3 years. The purpose of this study is to evaluate the consistency and accuracy of a Patient-Derived Organoid (PDO)…
- Trial name
- NCT03979170
- Testing
- Lung tumor resection
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Geneva
Peritoneal Carcinomatosis
PIPAC With Nab-paclitaxel and Cisplatin in Peritoneal Carcinomatosis
Phase Ib trial including investigating the combination of nab-paclitaxel and cisplatin in patients diagnosed with peritoneal carcinomatosis related to pancreatic, oeso-gastric, ovarian cancer or primitive peritoneal mesothelioma.
- Trial name
- Nab-PIPAC (NCT04000906)
- Testing
- Nab paclitaxel, Cisplatin
- Where
- 2 sites in Switzerland
- Volunteers
- 18 people
- Sponsor
- University Hospital, Geneva
Surgery
Comparison of Dry-lab Laparoscopic Training and Robotic Virtual Simulator
The objective of the present study is to compare the effectiveness of dry-lab laparoscopic training and robotic simulator training among medical students without any prior laparoscopic experience.
- Trial name
- NCT04989881
- Testing
- da Vinci Simulator, Laparascopic training box
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Stroke
BCI-controlled NMES in Subacute Stroke
Stroke patients with severe upper limb movement deficits have limited treatment options and often remain severely handicapped at the chronic stage.
- Trial name
- NCT03379532
- Testing
- BCI-NMES
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 31 people
- Sponsor
- University Hospital, Geneva
Coronary Stenosis
Saline-induced Distal to Aortic Coronary Pressure Ratio vs. Resting and Hyperemic Indices of Coronary Artery Stenosis Severity
The presence of inducible myocardial ischemia is considered as the prerequisite for the clinical benefit of coronary revascularization.
- Trial name
- SALINE (NCT04284345)
- Testing
- Saline Pd/Pa
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University Hospital, Geneva
Drug Resistant Epilepsy, Healthy
Investigating Surprise Signals in the Anterior Insula
The investigators propose a behavioral experiment with SEEG recording and stimulation, to both confirm the role of a brain region known as the anterior insula in identifying surprise, and disambiguate between competing principles…
- Trial name
- NCT05997758
- Testing
- SEEG stimulation, Adaptation task
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Diabetic Foot, Chronic Osteomyelitis
Predictive Value of Nu.Q™ Biomarkers to Help Guiding the Management of Osteoarticular Infections
Diabetic foot ulcers are frequent with average lifetime risk of 15%, and can lead to bone and joint infections. Current protocols for their management include evaluation of ischemia, assessment of underlying bone infection, sharp…
- Conditions
- Diabetic Foot, Chronic Osteomyelitis, Septic Arthritis
- Trial name
- NCT05593874
- Testing
- Histones H3.1 blood levels
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Impaired Oxygen Delivery, Transplant; Failure, Liver
Non-Invasive Measurement of SjvO2 Using Near Infrared Spectroscopy in Patients Undergoing Liver Transplantation Surgery
Mixed venous oxygen saturation (SvO2) is an important parameter in the management of patient during liver transplantation surgery especially during portal vein clamping.
- Trial name
- NCT04778150
- Testing
- VO 100 medical device from Mespere LifeSciences
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Diabetes Mellitus, Type 2, Anesthesia
Investigation of the Evolution of Gastric Emptying by Gastric Ultra Sonography in Patients Treated With GLP-1 Receptor Agonists on a 7 Days Pausing Period.
Glucagon-like-peptide-1 is a hormone released by the gut enteroendocrine cells. Its secretion occurs after each meal to enable production of insulin and inhibits the production of glucagon to lower after meal glycemia.
- Conditions
- Diabetes Mellitus, Type 2, Anesthesia, Pulmonary Aspiration of Gastric Contents
- Trial name
- NCT06388213
- Testing
- Gastric Ultrasonography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Anesthesia, Pain
Pupillometry Guided Remifentanil Administration In Pediatric Anesthesia
The aim of this prospective randomized study is to evaluate the impact of peroperative pupillometry monitoring on per and post-operative opioid consumption in pediatric anesthesia.
- Conditions
- Anesthesia, Pain, Child
- Trial name
- NCT02683837
- Testing
- Remifentanil, Pupillometry, Sevoflurane
- Where
- Switzerland
- Sponsor
- University Hospital, Geneva
Cardiovascular Diseases
Antithrombotics' Therapeutic Optimization in Hospitalized Patients Using Physiologically- and Population-based Pharmacokinetic Modeling
The main goal of the OptimAT study main goal is to validate a PBPK model for 3 direct oral anticoagulants (rivaroxaban, apixaban, dabigatran) and 3 P2Y12 inhibitors (clopidogrel, ticagrelor, prasugrel) in hospitalized patients.
- Trial name
- OptimAT (NCT03477331)
- Where
- Switzerland
- Volunteers
- 444 people
- Sponsor
- University Hospital, Geneva
Heart Failure With Reduced Ejection Fraction, Heart Failure; With Decompensation
Improving Knowledge in Heart Failure Inpatient With Therapeutic Education
The objective is to evaluate the impact of a pharmacist-led therapeutic education intervention on the knowledge of hospitalized heart failure patients.
- Conditions
- Heart Failure With Reduced Ejection Fraction, Heart Failure; With Decompensation, Pharmacist-Patient Relations, Medication Adherence
- Trial name
- EDUC-IC (NCT05751772)
- Testing
- Patient therapeutic education
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University Hospital, Geneva
Substance Use Disorders
Transitional Case Management for Patients Suffering From Substance Use Disorders
According to the World Health Organization the population suffering from addiction problems is increasing. This population is characterized by multiple needs at the medico-psychosocial level.
- Trial name
- NCT03551301
- Testing
- Transitional Case Management
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Geneva
Parkinson Disease
Electroencephalographic Signatures of Neuropsychiatric Fluctuations in Parkinson's Disease
Dopaminergic replacement therapy while efficient at reducing symptoms of Parkinson's disease is however often associated with motor and non-motor fluctuations which have a severe impact on patient quality of life.
- Trial name
- Transition (NCT06301282)
- Testing
- assessment during the transition between OFF-levodopa (i.e. withdrawal of levodopa phase) and ON-levodopa (i.e. effect of Levodopa phase)states
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Parkinson Disease
Effect of Dopamine on Specific Processing of Shame and Embarrassment in Parkinson's Disease
Shame and embarrassment are two self-conscious emotions frequently experienced by Parkinson's disease (PD) patients. Shame and embarrassment scores strongly correlate with patient's quality of life, anxiety and depression…
- Trial name
- BioDopa (NCT06225869)
- Testing
- Assessments in ON and OFF levodopa state
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Prostate Cancer
Feasibility of Virtual Reality Assistance in Prostate Biopsy Under Local Anesthesia.
The goal of this clinical trial is to test the impact of Virtual Reality (VR) assistance for anxiety management of patients undergoing prostate biopsies in local anaesthesia.
- Trial name
- NCT06274684
- Testing
- Use of Virtual Reality Assistance during prostate biopsies
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
Accidental Hypothermia
International Registry of Accidental Hypothermia
Transient mild hypothermia (core body temperature 35-32°C) is common and usually without consequences for the brain or other organs.
- Trial name
- IHR (NCT06200285)
- Testing
- Registry of patients with accidental hypothermia
- Where
- 16 sites in Austria, Denmark and 7 more
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva