Clinical trials: sponsored by University Hospital, Geneva
Glaucoma and Ocular Hypertension
Prospective,Randomized,Controlled Study to Assess Efficacy,Safety, and Tolerability of SLT vs. PLT in Patients With POAG
A prospective, randomized, controlled study to assess efficacy, safety, and tolerability of selective laser trabeculoplasty vs. pattern laser trabeculoplasty in patients with open-angle glaucoma.
- Trial name
- NCT02231515
- Testing
- Selective laser trabeculoplasty (SLT), Pattern laser trabeculoplasty (PLT)
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- University Hospital, Geneva
Chronic Post Surgical Pain
Enhanced vs.Standard Pain Management of Patients at Risk for Chronic Post-surgical Pain
The goal of this pragmatic pilot clinical trial is to test the feasibility of the trial in terms of the number of patients recruited in a given period.
- Trial name
- ALDOpilot (NCT05787691)
- Testing
- Individualised pain management
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Geneva
Urinary Symptoms, Systemic Sclerosis
Lower Urinary Tract Symptoms in Systemic Sclerosis
Urinary symptoms must be frequent in Scleroderma. In one hand, mobility limitation by joint stiffness and skin sclerosis, forced diuresis due to heart involvement (cardiomyopathy or pulmonary hypertension), diuretics use and…
- Trial name
- NCT01971294
- Where
- 4 sites in France, Italy and 1 more
- Volunteers
- 334 people
- Sponsor
- University Hospital, Geneva
Subarachnoid Hemorrhage, Intracranial Aneurysm
Swiss Study on Subarachnoid Hemorrhage
This registry was created to assess management parameters of patients treated for aneurysmal subarachnoid hemorrhage in Switzerland.
- Trial name
- Swiss-SOS (NCT03245866)
- Testing
- Observational/ no intervention
- Where
- 9 sites in Switzerland
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Geneva
Ebolavirus Disease
VSV-ZEBOV Geneva Vaccine Trial
The hemorrhagic fever resulting from Ebola infection is frequently fatal; the current Ebola outbreak, still in its ascendant phase, has a mortality rate over 50%. There is no proven therapy or prevention available at this time.
- Trial name
- VSV-ZEBOV (NCT02287480)
- Testing
- VSV-ZEBOV
- Where
- Switzerland
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Mother-Infant Interaction
Response of Preterm Infants to Multisensory Stimuli
The aim of this study is to measure the variation of oxytocin and cortisol levels in the saliva of premature neonates and their mother after sensorial stimuli.
- Trial name
- OXYVOICE (NCT04665440)
- Testing
- Voice alone, Voice + tactile stimuli
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University Hospital, Geneva
Aggressive B-Cell Non-Hodgkin Lymphoma
A Study on Fractionated Rituximab to Avoid Lysis Syndrome in Aggressive B-Lymphoma
Tumour lysis syndrome (TLS) occurs as a consequence of the rapid destruction of malignant cells, spontaneously and/or in response to cytotoxic agents and immunotherapies.
- Trial name
- FRILLY (NCT05840289)
- Testing
- fractionated first dose rituximab
- Where
- Switzerland
- Volunteers
- 94 people
- Sponsor
- University Hospital, Geneva
Lymphoproliferative Disorders, Lymphoproliferative Disorder Following Transplantation
Liquid Biopsy to Enable Diagnostics and Monitoring for Immune-mediated Lymphoproliferative Disorders
Immune-mediated lymphoproliferative disorders (ILD), as per World Health Organization (WHO HAEM 5) classification, are rare conditions associated with a poor outcome.
- Trial name
- LIMPID (NCT05803616)
- Testing
- Liquid biopsy
- Where
- 6 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Labor, Induced, Labor, Obstetric
Prediction of Spontaneous Onset of Labor at Term
The study intends to develop a predictive model of spontaneous onset of labor between 39 and 41 weeks of pregnancy in women carrying singletons and without indication of delivery before this date.
- Conditions
- Labor, Induced, Labor, Obstetric, Labor Onset, Predictive Model
- Trial name
- PREDICT (NCT05109247)
- Where
- 3 sites in Switzerland
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Abuse, Child, Protein Disorder, Blood
Biomarker-s of Abusive Head Trauma by Proteomics
The aim of our study is to highlight biomarker-s of Abusive Head Trauma by proteomics analyses on the serum of child victims of abuse.
- Trial name
- NCT05626465
- Testing
- Blood test
- Where
- 2 sites in France, Switzerland
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Emergency General Surgery
Incidence and Outcomes of Emergency Department Patients Requiring Emergency General Surgery
The objectives of this study were (1) to estimate the incidence of emergency general surgery in a Swiss University Hospital, (2) to describe the characteristics and outcomes of patients undergoing such interventions, and (3) to…
- Trial name
- NCT05664360
- Testing
- Age (young versus older)
- Volunteers
- 310,914 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Breast Neoplasm
FDG-PET/CT for Simulation and Radiation Treatment Planning of Early Breast Cancer
The purpose of the study is: to assess the potential benefits of 18F-[FDG] PET/CT and PET/MRI for operable breast cancer in order to define the size and location of the primary tumor, as well as axillary, supraclavicular and…
- Trial name
- NCT01432002
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Geneva
Edentulous Alveolar Ridge Atrophy
Immediate Implants With Customized Abutments
Tooth extraction is followed by marked alterations of the tissue volume. The resorption process of at least the surrounding mucosa can be altered by using immediate implant placement and additional features such as immediate…
- Trial name
- NCT05638958
- Testing
- Immediate post-extractive Implant placement
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University Hospital, Geneva
Drug Intolerance, Cytochrome P450 CYP2D6 Enzyme Deficiency
Evaluation of Pupillometry for cyp2d6 Phenotyping in Children Treated With Tramadol
Pupillometry will be performed before administration of tramadol, at T0 and then 1 to twice per hour in children having received tramadol as a pain killer as part of his/her routine care.
- Conditions
- Drug Intolerance, Cytochrome P450 CYP2D6 Enzyme Deficiency, Drug Effect
- Trial name
- PUPICYP (NCT03052218)
- Testing
- Pupillometry
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Geneva
Gynecologic Cancer
The SERENITY Study: Online Mindfulness-Based Cancer Recovery for Patients With Gynecological Cancer
The overall objective of this project is to explore the feasibility, acceptability and potential effects of the online MBCR program in gynecological cancer settings.
- Trial name
- SERENITY (NCT04564768)
- Testing
- Online Mindfulness-Based Cancer Recovery (MBCR)
- Where
- 2 sites in Switzerland
- Volunteers
- 62 people
- Sponsor
- University Hospital, Geneva
Low Back Pain, Mechanical
Physical Deconditioning in COVID-19 Positive Patients and Non-Specific Low Back Pain
The purpose of this study is to take advantage of cohorts of patients followed for Coronavirus Disease 2019 (COVID19) expected to present poor physical fitness as the consequence of COVID19 to explore the relationship between…
- Trial name
- Phydel (NCT04990518)
- Where
- Switzerland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Pain, Procedural
Effect of the Format of a Video Game on Children's Experience During Venipuncture
Anxiolysis and analgesia are of paramount importance when conducting medical procedures, particularly in children. Nonpharmacologic techniques such as distraction and hypnosis improve the patient experience when used in the…
- Trial name
- NCT05065307
- Testing
- Venipuncture
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Healthy
Risk of CYP2C19 Phenoconversion in Healthy Volunteers With Rapid, Normal, and Intermediate Predicted Metabolizers' Status
CYP2C19 is responsible for the metabolism of approximately 10% of drugs currently on the market, including several proton pump inhibitors, clopidogrel, benzodiazepines and some tricyclic antidepressants, including amitriptyline.
- Trial name
- Switch19 (NCT05264142)
- Testing
- Voriconazole 200mg, FluvoxaMINE 50 Mg Oral Tablet, Omeprazole 10 MG Oral Tablet
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Sickle Cell Disease, Hyperbaric Oxygen Therapy
Hyperbaric-oxygen Therapy (HBOT) Versus Placebo for Treating Vaso-Occlusive Crisis (VOC) in Sickle Cell Disease (SCD)
This is a randomised, controlled, double-blind, placebo trial of HBOT (intervention) superiority in the treatment of VOC in SCD, to demonstrate the effectiveness of HBOT for the decrease in pain level in the treatment of SCD-VOC.
- Conditions
- Sickle Cell Disease, Hyperbaric Oxygen Therapy, Vaso-occlusive Crisis
- Trial name
- HBOT-SCD (NCT05289700)
- Testing
- HBOT in Hyperbaric chamber
- Where
- 3 sites in France, Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
Hypofibrinogenemia, Congenital, Afibrinogenemia, Congenital
Pregnancy and Fibrinogen Disorders
The aim of this observational study is to evaluate the prevalence of uncomplicated pregnancies in women suffering from congenital fibrinogen disorders (i.e, hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia) as well as…
- Conditions
- Hypofibrinogenemia, Congenital, Afibrinogenemia, Congenital, Dysfibrinogenemia, Congenital
- Trial name
- FIBRINOGEST (NCT03920332)
- Where
- 3 sites in France, Slovakia and 1 more
- Volunteers
- 149 people
- Sponsor
- University Hospital, Geneva