Clinical trials: sponsored by University Hospital, Geneva
Perioperative Complication
Reliability and Validity of a New Postoperative Track Assessment Tool
This prospective observational study investigated the validity and reliability of a new postoperative track assessment tool. We hypothesized, first, that this tool estimates the indication and benefit of a management in an…
- Trial name
- POTraTool (NCT05092867)
- Testing
- Po Tra tool
- Where
- Switzerland
- Volunteers
- 879 people
- Sponsor
- University Hospital, Geneva
Rectum Cancer, Rectal Cancer
Neo-adjuvant Pembrolizumab and Radiotherapy in Localised MSS Rectal Cancer
This project investigates the clinical and biological impact of combining immunotherapy (pembrolizumab) with short course radiotherapy (5Gy, five times) in the neo-adjuvant treatment of localised microsatellite stable (MSS)…
- Trial name
- PEMREC (NCT04109755)
- Testing
- Pembrolizumab
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University Hospital, Geneva
Anticoagulants and Bleeding Disorders
DAPHNE Study: Direct Anticoagulant PHarmacogeNEtic
New/direct oral anticoagulants (NOAC/DOAC), like apixaban and rivaroxaban, are an interesting alternative to unfractionated or low molecular weight heparin relayed by oral anti-vitamin K anticoagulants (VKA) for the treatment of…
- Trial name
- DAPHNE (NCT03112525)
- Testing
- CYP3A4/5 and P-gp phenotyping, CYP3A4/5 and P-gp genotyping
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University Hospital, Geneva
HIV
Understanding Barriers and Facilitators to the Participation of Women Living With HIV in Clinical Trials : a Mixed-method Study (EVA)
To identify the most important barriers and facilitators to the participation of cisgender women living with HIV in clinical trials (perceived and real) and to establish possible mechanisms leading to refusal of trial…
- Trial name
- EVA (NCT04655560)
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
COVID, Sars-CoV2
Preventing COVID-19 Complications With Low- and High-dose Anticoagulation
The ongoing COVID-19 pandemic affects millions of humans worldwide and has led to thousands of acute medical hospitalizations. There is evidence that hospitalized cases often suffer from an important infection-related…
- Trial name
- COVID-HEP (NCT04345848)
- Testing
- Enoxaparin
- Where
- 4 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- University Hospital, Geneva
Acute Peripheral Vestibulopathy
Glucocorticosteroid Treatment in Acute Unilateral Vestibulopathy (Vestibular Neuronitis)
The vestibular system is a part of the inner ear and functions as a motion sensor. It provides the central nervous system with information about changes of the head position.
- Trial name
- NCT05024448
- Testing
- Prednisone
- Volunteers
- 96 people
- Sponsor
- University Hospital, Geneva
Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation
Precision Dosing of Busulfan in Children Undergoing HSCT
The objective of this clinical trial is to evaluate the personalization the conditioning regimen prior to the hematopoietic stem cell transplant (HSCT) in children and adolescents, to improve HSCT efficacy while reducing…
- Conditions
- Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Autologous Hematopoietic Stem Cell Transplantation
- Trial name
- BuGenes01 (NCT04822532)
- Testing
- GSTA1 genotyping
- Where
- Switzerland
- Volunteers
- 260 people
- Sponsor
- University Hospital, Geneva
Deep Vein Thrombosis
The API-CALF Study: Apixaban to Treat Calf Vein Thrombosis
Isolated distal DVT (iDDVT) is the most frequent clinical presentation of VTE and is associated with a significant morbidity and risks of long-term complications.
- Trial name
- API-CALF (NCT04981327)
- Testing
- Apixaban 2.5 MG Oral Tablet [ELIQUIS]
- Volunteers
- 1,300 people
- Sponsor
- University Hospital, Geneva
Biological Availability
Bioavailability and Pharmacokinetics of Calcium Dobesilate (Doxium®) in the Nasal Mucosal Tissue, Saliva and Blood of Treated Patients
Calcium dobesilate (CaD) has been shown to have potential antiviral effects, mediated via its interaction with the heparansulfate (HS) binding site of the viral SARS-CoV-2 spike protein (direct action), necessary for interation…
- Trial name
- CaDoBio (NCT04922996)
- Testing
- Calcium Dobesilate
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- University Hospital, Geneva
Alzheimer Disease, Amyloid Plaque
CLearing Alzheimer's Disease Molecular Pathology Without Medications
According to the most popular pathophysiological models of Alzheimer's disease, the amyloid hypothesis, amyloid deposition is the causative event triggering a chain of other downstream events which finally lead to Alzheimer's…
- Conditions
- Alzheimer Disease, Amyloid Plaque, Amyloidosis
- Trial name
- CLAMP (NCT04913454)
- Testing
- 40 Hz multi-sensory (auditory + visual) stimulation and cognitive training, Cognitive training
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Immune Response, Vaccination
Immune Durability After VSV-EBOV Vaccination
This prospective observational cohort study will follow the roughly 100 adults who received the VSV-ZEBOV vaccine in the Geneva phase 1 randomized controlled trial in 2014-2015 in order to determine their long-term (5-year)…
- Conditions
- Immune Response, Vaccination, Durability
- Trial name
- NCT02933931
- Volunteers
- 95 people
- Sponsor
- University Hospital, Geneva
Venous Thromboembolism, Contraception
Longitudinal Hemostatic Profile After Stopping Estroprogestative Contraceptives
This prospective cohort evaluates the longitudinal profile of hemostatic biomarkers during the first 3 months after having stopped a combined oral contraceptive.
- Trial name
- PILL-OFF (NCT03949985)
- Testing
- Tests of biological hemostatic profile associated with contraceptives
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- University Hospital, Geneva
Simulation Training
Impact of Simulation Training for Obstetrics-gynecology Residents.
The main objective of the study is to evaluate the benefit of simulator training for learning external cephalic version (ECV) or vacuum assisted vaginal delivery (hereafter vacuum extraction [VE]) for obstetrics-gynecology…
- Trial name
- NCT03848975
- Testing
- Simulation training for ECV, Simulation training for VE
- Where
- Switzerland
- Volunteers
- 68 people
- Sponsor
- University Hospital, Geneva
Pulmonary Embolism
Age-adjusted D-dimer Cut-off to Rule Out Pulmonary Embolism in the Emergency Department : A Real Life Impact Study
A multicentre multinational prospective management outcome study has recently proven the safety of a diagnostic strategy combining clinical probability assessment with an age-adjusted D-dimer cut-off, defined as a value of (age x…
- Trial name
- RELAX-PE (NCT02601846)
- Testing
- No intervention
- Where
- 10 sites in Belgium, France and 1 more
- Volunteers
- 1,507 people
- Sponsor
- University Hospital, Geneva
Anastomotic Leak
Decreasing Leak Rate in Colorectal Surgery Using Near Infra-red (NIR) Imaging
Anastomotic leak is a devastating complication of colorectal surgery. There is no widespread means of assessing the viability of a laparoscopic anastomosis.
- Trial name
- NCT02459405
- Testing
- NIR anastomotic perfusion assessment, Near infrared camera
- Where
- 4 sites in Ireland, Italy and 2 more
- Volunteers
- 504 people
- Sponsor
- University Hospital, Geneva
Surgical Site Infection, Length of Stay
Prevena to Prevent Surgical Site Infection After Emergency Abdominal Laparotomy
Post-operative wound complications in abdominal surgery have a major impact on patient outcomes and the real impact of Closed incision negative pressure therapy (CINVt) is not clear in the literature moreover concerning its…
- Conditions
- Surgical Site Infection, Length of Stay, Seroma, Hematoma
- Trial name
- CiPNT/SSI (NCT04496180)
- Testing
- Closed incision negative pressure therapy versus standard dressing after emergency abdominal laparotomies
- Volunteers
- 334 people
- Sponsor
- University Hospital, Geneva
Children Who Receive a Stem Cell Transplantation With Busulfan IV
Polymorphisms and Busulfan Pharmacokinetic Study
Test the correlations between the pharmacogenetic and pharmacokinetic of Busulfan IV in children receiving hematopoietic stem cell transplantation.
- Trial name
- NCT01257854
- Where
- 4 sites in Canada, France and 1 more
- Volunteers
- 200 people
- Sponsor
- University Hospital, Geneva
Infective Endocarditis
Clinical Metagenomics of Infective Endocarditis
Infective endocarditis (IE) is an infection of cardiac valves. IE mainly involves bacteria, more rarely fungi. IE is an uncommon diseases with an estimated incidence of 1-12 cases per 100,000 inhabitants per year.
- Trial name
- Meta-ENDO (NCT03199287)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Undernutrition
Microbiota and Protein-energy Wasting (MIDIWA)
Oral supplementation with branched chain amino acids (BCAA) increases the levels of circulating BCAA, stimulates BCAA uptake in muscles, and decreases amino acid release from muscle, eventually promoting muscle anabolism.
- Trial name
- MIDIWA (NCT02962089)
- Testing
- Branched chain amino acids (BCAA)
- Where
- 5 sites in Switzerland
- Volunteers
- 37 people
- Sponsor
- University Hospital, Geneva
Gynecologic Disease
Fast-track in Minimally Invasive Gynaecology
Objective: Evaluate the effects of a fast-track (FT) protocol on costs and postoperative recovery. Design: randomized trial Setting: University Hospitals Population: 170 women undergoing total laparoscopic hysterectomy for a…
- Trial name
- NCT04839263
- Testing
- "FAST TRACK" protocol
- Where
- 2 sites in Switzerland
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva