Clinical trials: sponsored by University Hospital, Geneva
Covid19, Immuno-Deficiency
Preemptive Use of Convalescent Plasma for High-risk Patients With COVID-19
Convalescent plasma therapy has been recognized as safe and plasma transfusion is routinely used in clinical practice. A recent study showed that early administration of convalescent plasma can decrease the risk of complications…
- Conditions
- Covid19, Immuno-Deficiency, Old Age; Debility
- Trial name
- NCT04836260
- Testing
- SARS-CoV-2 convalescent plasma
- Where
- 4 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
Diagnoses Disease
Evaluation of an Innovative Speech-enabled Translator in Emergency Settings
Survey-based satisfaction, performance and technical features evaluation of a speech-enabled fixed-phrase translation tool (BabelDR) in an emergency department.
- Trial name
- NCT04788966
- Testing
- the translation tool BabelDr
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Inflammation
Impact of Acute and Chronic Inflammation on Cytochromes P450 Activity Measured With Dried Blood Spot
Cytochromes P450, main enzymes of drug metabolism, play a prominent role in the first-pass metabolism of oral substances. Inter-individual variability in their activity due to genetic and environmental factors has been observed…
- Trial name
- NCT03262051
- Testing
- CYP phenotyping
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- University Hospital, Geneva
Cervical Intra-epithelial Neoplasia Grade 1 or Worse
Human Papillomavirus (HPV) Self-sampling as a Test of Cure After Treatment of Cervical Intra-epithelial Neoplasia
The purpose of this study is to evaluate the performance of HPV self-sampling (self-HPV) in detecting residual/recurrent disease in women treated by loop electro-surgical excision (LEEP) for CIN1+.
- Trial name
- NCT02780960
- Testing
- HPV self-testing
- Where
- Switzerland
- Volunteers
- 127 people
- Sponsor
- University Hospital, Geneva
Rehabilitation, Fear of Falling
Hypnosis for Fear of Falling in Older Adults
Fear of falling is associated with numerous negative health outcomes in older adults and can limit rehabilitation. Few treatments are effective in fear of falling.
- Conditions
- Rehabilitation, Fear of Falling, Older Adults
- Trial name
- NCT04726774
- Testing
- Hypnosis, Rehabilitation program
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University Hospital, Geneva
Ecology of Nontubercuous Mycobacteria, Geneva Area
An Ecological Analysis of Nontuberculous Mycobacteria in the Geneva Area (2015-2020)
Prevalence of NTM diseases has been increasing regularly over the past 30 years in industrialized countries Although NTM are identified worldwide, there are important geographical disparities as to the relative prevalence of NTM…
- Trial name
- NCT04718571
- Where
- Switzerland
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Hematopietic Stem Cell Transplantation, Blood Virome
DNA and RNA Viruses of the Blood Virome of Allogeneic Hematopoietic Stem Cell Transplant Recipients
The Geneva Blood Virome Project is a longitudinal observational study. The main objective is to describe the kinetics of the plasmatic viral load of a selection of at least 21 DNA and RNA viruses of the blood virome in allogeneic…
- Conditions
- Hematopietic Stem Cell Transplantation, Blood Virome, RNA Virus Infections, DNA Virus Infections
- Trial name
- GeBVir (NCT03642977)
- Testing
- Real time PCR and RT-PCR for DNA and RNA viral species
- Where
- Switzerland
- Volunteers
- 112 people
- Sponsor
- University Hospital, Geneva
Childhood Cancer, Genetic Predisposition
Genetic Risks for Childhood Cancer Complications in Switzerland
The objectives of the GECCOS project are to identify genetic variants associated with complications of childhood cancer using genotype-phenotype association studies.
- Conditions
- Childhood Cancer, Genetic Predisposition, Late Effect
- Trial name
- GECCOS (NCT04702321)
- Testing
- Procedure: Biospecimen Collection, Procedure: Medical Chart Review
- Where
- Switzerland
- Volunteers
- 6,000 people
- Sponsor
- University Hospital, Geneva
Anxiety, Pain
Distraction and Nitrous Oxide for Venous Puncture
This study will compare the efficiency of the iPad distraction or the administration of Nitrous Oxide on the anxiety decrease when a peripheral venous catheter is needed in children between 3 and 9 years old.
- Conditions
- Anxiety, Pain, Venous Puncture
- Trial name
- DISPO (NCT04185233)
- Testing
- Games on an iPad, Nitrous Oxide
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Ankle Sprain
Ankle Sprain Rehabilitation With the Wii Balance Board
Physical activity and in particular sport is beneficial to health. Nevertheless, some of these activities may create a risk of injury. Ankle sprain is the most common sport related injury.
- Trial name
- NCT01449760
- Testing
- Physical Therapy, Wii Balance Board
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University Hospital, Geneva
Anesthesia, Delirium, Dementia, Amnestic, Cognitive Disorders
International Substudy Enigma2 on Postoperative Cognitive Disorders
The study is a substudy of the Enigma2 trial (NCT00430989) which aims at investigating the effectiveness and safety of nitrous oxide (N2O) in anaesthesia.The substudy focus is on postoperative cognitive disorders.
- Trial name
- ISEP (NCT02489097)
- Testing
- Nitrous Oxide
- Where
- 2 sites in China, Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Geneva
Cardiac Pacing, Artificial, Cardiac Resynchronization Therapy
Electrical Resynchronization and Acute Hemodynamic Effects of Direct His Bundle Pacing Compared to Biventricular Pacing
The aims are to compare Direct His Bundle Pacing (DHBP) with biventricular pacing (BiV) in terms of electrical resynchronization using electrocardiographic imaging (ECGI) and also in terms of acute hemodynamical effect using…
- Conditions
- Cardiac Pacing, Artificial, Cardiac Resynchronization Therapy, Direct His Bundle Pacing
- Trial name
- NCT03452462
- Testing
- Pacing
- Where
- Switzerland
- Volunteers
- 19 people
- Sponsor
- University Hospital, Geneva
Trephined Syndrome, Sinking Skin Flap Syndrome
Prevalence of Trephined Syndrome After Decompressive Craniectomy
Decompressive craniectomy is frequently used to treat increased intracranial pressure or an intracranial mass effect. Trephined Syndrome describes a neurological deterioration, which is attributed to a large craniectomy.
- Conditions
- Trephined Syndrome, Sinking Skin Flap Syndrome, Traumatic Brain Injury, Stroke
- Trial name
- TS (NCT03186157)
- Testing
- Decompressive craniectomy, Cranioplasty
- Where
- Switzerland
- Volunteers
- 41 people
- Sponsor
- University Hospital, Geneva
COVID-19
COVID-19 and Vaccination Attitudes
The investigators want to study how the exposure to the covid-19 pandemic affects attitudes towards science and vaccination, and how other general attitudes and values are affected.
- Trial name
- VACAT (NCT04352582)
- Testing
- Survey
- Where
- United Kingdom
- Volunteers
- 1,194 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Afibrinogenemia, Congenital
Quality of Life in Patients With Congenital Afibrinogenemia
The aim of this observational study is to evaluate the quality of life in patients with congenital afibrinogenemia using the Haemo-QoL SF for kids and the Haem-A-QoL for adult patients.
- Trial name
- QualyAFIB (NCT03484065)
- Testing
- Questionnaire quality of life
- Where
- 28 sites in United States, Algeria and 19 more
- Volunteers
- 250 people
- Sponsor
- University Hospital, Geneva
Sterility, Female, Reproductive Technology, Assisted
Prothrombotic Biomarkers and Ovarian Stimulation
The aim of this study is to assess the impact of different protocols used for ovarian stimulation during in vitro fertilization procedures (IVF) on prothrombotic biomarkers (blood coagulation markers associated with…
- Trial name
- HEMOSTIM (NCT04188444)
- Testing
- Blood test
- Where
- 2 sites in Switzerland
- Volunteers
- 65 people
- Sponsor
- University Hospital, Geneva
Choledocholithiasis, Gallstone Migration
Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration
Initial cholecystectomy with intraoperative cholangiogram, followed if required by ERCP, has been implemented at the investigators institution as the standard management strategy for patients at intermediate risk of common bile…
- Conditions
- Choledocholithiasis, Gallstone Migration, Cholecystitis, Gallstone Pancreatitis
- Trial name
- NCT02461147
- Testing
- Cholecystectomy with intraoperative cholangiogram
- Where
- Switzerland
- Volunteers
- 161 people
- Sponsor
- University Hospital, Geneva
Keratitis; Infectious Disease (Manifestation)
Swiss PACK-CXL Multicenter Trial for the Treatment of Infectious Keratitis
To assess the safety and efficacy of PACK-CXL (photoactivated chromophore for infectious keratitis cross-linking) as a firstline treatment for infectious corneal infiltrates and early corneal ulcers, and compare it to the current…
- Trial name
- NCT02717871
- Testing
- PACK-CXL, Cefazolin in combination with either tobramycin or gentamicin, Cycloplegic agents (cyclopentolate 1% eye drops)
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- University Hospital, Geneva
Liver Disease, Immunosuppression
Immunity Against Varicella in Pediatric Orthotopic Liver Transplantation Recipients
Varicella is a vaccine-preventable disease, which can be severe in immunosuppressed children. Currently, the (live) vaccine is not recommended in pediatric orthotopic liver transplant recipients.
- Conditions
- Liver Disease, Immunosuppression, Varicella
- Trial name
- VZVinOLTx (NCT00492739)
- Testing
- Vaccination with VZV vaccine
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University Hospital, Geneva
Covid19, Pneumonia
Evaluation of the Safety and Outcomes of Outpatient Management With Mild to Moderate COVID-19 Pneumonia
The purpose of this study is to evaluate the strategy of investigators for outpatients SARS-CoV-2 moderate pneumonia management in terms of efficacy and patient safety.
- Trial name
- PneumoCoV-Ambu (NCT04542044)
- Testing
- management strategy of outpatient with mild to moderate SARS-CoV-2 pneumonia
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva