Clinical trials: sponsored by University Hospital, Lille
Alzheimer's Disease, Frontotemporal Degeneration (Semantic & Behavioral Variants)
Social & Affective Cognition in Alzheimer's Disease & Associated Disorders
Recent studies have shown that individual neuropsychological scores of patients with Alzheimer's disease and Associated Disorders (ADAD) are only poorly correlated to their behavioral difficulties, such as disinhibition, apathy…
- Trial name
- SOCIALIZE (NCT06338397)
- Testing
- SCANN
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Induction of Labour, Prolonged Pregnancy
Outpatient Foley Catheter for Induction of Labor in Nulliparous for Prolonged Pregnancy
15 to 20 % of nulliparous needs an induction at term. None study has evaluated Foley catheter induction at home versus expectative in this population
- Trial name
- FOLOUT (NCT02932319)
- Testing
- Foley catheter, expectative
- Where
- 5 sites in France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Pneumonia, Ventilator-Associated Healthcare-associated Pneumonia Respiration, Artificial
Combined Strategy Using Automated Subglottic Secretion Drainage and Continuous Cuff Pressure Monitoring to Prevent Microaspiration: a Multicenter Randomized Controlled Trial.
This trial will study the impact of a combined strategy to prevent microaspiration of oropharyngeal secretions or gastric content using automated subglottic secretion drainage and/or continuous cuff pressure monitoring.
- Trial name
- cosmic (NCT07555236)
- Testing
- Combined strategy, Automated subglottic secretion drainage, Automated continuous cuff pressure monitoring
- Volunteers
- 800 people
- Sponsor
- University Hospital, Lille
Chronic Rhinosinusitis With Nasal Polyps
BIOlogics in Severe Nasal POlyposis SurvEy
With a prevalence of 2-4% in western countries, Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is of major concern regarding its substantial impact on the social and physical quality of life.
- Trial name
- BIOPOSE (NCT05228041)
- Testing
- Biologic treatments available in CRSwNP (dupilumab, mepolizumab and benralizumab according to their marketing approval)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Gastrointestinal Fistula, Enteral Nutritional Support
Enteral Versus Parenteral Nutrition in the Conservative Treatment of Upper Gastrointestinal Fistula After Surgery
The incidence of clinically significant anastomotic leaks (AL) after upper gastrointestinal (GI) surgery is approximately 4 % - 20 %, and the associated mortality can be as high as 80 % .
- Trial name
- NUTRILEAK (NCT03742752)
- Testing
- Enteral nutrition, Parenteral nutrition
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Pregnancy
Cardiac Output Monitoring by ccNexfin© in Pregnant Women
Variations of cardiac output are frequent in pregnant women during obstetrical procedures, and may participate to poor foetal outcomes through decrease of uteroplacental bloodflow.
- Trial name
- CoNex (NCT03735043)
- Testing
- cardiac output by ccNexfin ©
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Temporal Lobe Epilepsy, Frontal Lobe Epilepsy
Changes in Attentional Control After a Focal Seizure.
Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI.
- Conditions
- Temporal Lobe Epilepsy, Frontal Lobe Epilepsy, Others Subtypes
- Trial name
- ATTENTIONEPIF (NCT06466681)
- Testing
- All included subjects
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Neurodevelopmental Disorders, Congenital Cardiomyopathy
KIDSHEART AND BRAIN : Early EEG Surgery Congenital Heart Disease Predict Onset of Neurodevelopmental Disorders
Congenital cardiopathy are frequent malformations (1/100 birth). The progress of surgery permit a survival rate at the adult age of more than 90%.
- Trial name
- KHB (NCT05658965)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Myocardial Infarction, Vascular Stiffness
Impact of Peripheral Vascular Stiffness Assessment on Risk Prediction in Patients With Myocardial Infarction
Risk assessment after myocardial infarction is critical in daily practice and evolution toward heart failure especially diastolic heart failure remains a key issue.
- Conditions
- Myocardial Infarction, Vascular Stiffness, Heart Failure
- Trial name
- RIGID-MI (NCT04058782)
- Testing
- Imaging evaluation for vascular assessment
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Lille
Asthma, Asthma; Eosinophilic
Mepolizumab and Physical Activity in Severe Asthma
Severe asthma is a debilitating condition associated with frequent symptoms, life-threatening exacerbations and corticosteroid side-effects.
- Trial name
- TEXAS (NCT05404763)
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Lille
Anorexia Nervosa
Efficacy of a Phone-based Relapse Prevention for Anorexia Nervosa After a First Hospitalization
Anorexia Nervosa (AN) is a highly challenging disease which consequences are serious. Relapse rate is estimated between 38 and 41% during the year following hospitalization.
- Trial name
- EATLINE (NCT04102475)
- Testing
- Eatline, Control
- Where
- 6 sites in France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Lille
Mitochondrial Cytopathies Disorders
Effect Of The System In The Enriched Fat Metabolism Of The Child Reached Mitochondrial Cytopathy
The aim of the present study is to compare Resting Energy Expenditure (REE) between normal fat diet (NFD) as a control vs high fat diet (HFD) as a treatment in Mitochondrial cytopathies disorders ( MID's ) patients.
- Trial name
- MITOX (NCT02385565)
- Testing
- high fat diet, normal fat diet
- Where
- 2 sites in France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Lille
Acute Respiratory Distress Syndrome
Prediction of Outcomes With a Miniaturized Transesophageal Echocardiography Probe in Patients With Acute Respiratory Distress Syndrome
The Superior Vena cava Respiratory Collapse Index (cVCS) is a haemodynamic parameter measured exclusively by transoesophageal ultrasound (TEE), which is used to assess cardiac precharge-dependence status.
- Trial name
- PreMiTE-ARDS (NCT03763773)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Sars-CoV2, Critical Illness
COVID-19 and ICU-acquired MDR Bacteria
This multicenter before-after study aimed to determine the impact of infection related to SARS-CoV-2 on the incidence of ICU-acquired multidrug resistant (MDR) bacteria.
- Trial name
- COVID-BMR (NCT04378842)
- Where
- 7 sites in France
- Volunteers
- 368 people
- Sponsor
- University Hospital, Lille
Alcohol Drinking, Pregnancy
Alcohol Self-reporting During Pregnancy. AUTOQUEST Study.
The effects of alcohol consumption during pregnancy have been known for decades. However, alcohol consumption in pregnant women remains today a public health problem and its identification is primordial.
- Trial name
- AUTOQUEST (NCT04786587)
- Testing
- blood test, self-administered questionnaire
- Where
- France
- Volunteers
- 2,425 people
- Sponsor
- University Hospital, Lille
Critically Ill
Continuous Control of Tracheal Cuff Pressure and Microaspiration in Critically Ill Patients
We hypothesized that continuous control of tracheal cuff pressure would reduce microaspiration of gastric content as determined by pepsin level in tracheal aspirate.
- Trial name
- NCT01082666
- Testing
- Continuous control of cuff pressure, Manual control of cuff pressure
- Where
- France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Lille
Atrial Fibrillation
PROSPective Evaluation of Outcome After CatheTer Ablation in Atrial Fibrillation
Atrial fibrillation ablation is the most common intervention performed worldwide. Up to 20 to 45% of patients show recurrence of AF within 12 month after catheter ablation, however its determinant are incompletely understood.
- Trial name
- PROSPECT-AF (NCT05009797)
- Testing
- atrial fibrillation catheter ablation
- Where
- France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Lille
Healthy Subject
Role of the Posterior Parietal Cortex in the Processing of Sensory Information
Although the primary motor cortex is considered has the common final pathway of motor commands, it is influenced by several structures as, for example, the premotor cortex and the posterior parietal cortex which are involved in…
- Trial name
- CORTEX (NCT03386188)
- Testing
- Transcranial Magnetic Stimulation (TMS), Electrical Muscle Activity (EMG)
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Critical Illness
Development of a Modified Pediatric Early Warning Score: a French Prospective Multicentre Regional Study
Children are admitted in intermediate units when the severity requires continuous monitoring. In France, Resources allocated to intermediate units are determined from lists of diagnoses and associated acts to additional budget.
- Trial name
- NCT02304341
- Where
- 7 sites in France
- Volunteers
- 3,016 people
- Sponsor
- University Hospital, Lille
Healthy Volunteers
Detection of Usability Errors of a Medical Device Zeneo®
The research addresses the question of the number of participants needed to identify as many usability-induced errors as possible in the context of summative usability tests.
- Trial name
- NCT03808246
- Testing
- using the demo version of a self-injector pen
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille