Clinical trials: sponsored by University Hospital, Lille
Diaphragmatic Paralysis
Interscalene Block and Dysfunction Diaphragmatic
The study seeks to show that interscalene injection of a small volume (<8ml) of ropivacaine at a low concentration (0.1%) reduces the frequency of hemi-diaphragmatic paresis compared to low volume injection at the standard…
- Trial name
- NUMEROBIS (NCT04173364)
- Testing
- Ropivacaine 0.5% Injectable Solution, Ropivacaine 0.1% Injectable Solution
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Lille
Gestational Diabetes
Early Gestational Diabetes Mellitus
In 2010, the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) panel published consensus-based recommendations on the diagnosis and classification of hyperglycemia in pregnancy.
- Trial name
- LEMA_GDM (NCT04451915)
- Testing
- late management strategy, early management strategy
- Where
- 10 sites in France
- Volunteers
- 2,010 people
- Sponsor
- University Hospital, Lille
Alcoholic Hepatitis
PROlonged Corticosteroid Treatment or N-ACetylcysteine for Severe Alcoholic Hepatitis
Only patients suffering from a severe form of alcoholic hepatitis (Maddrey's discriminant function greater than 32) require medical treatment.
- Trial name
- PROCORNAC (NCT06956482)
- Testing
- N-Acetylcysteine (NAC) Treatment, Prednisolone, Prednisolone 10mg
- Where
- France
- Volunteers
- 477 people
- Sponsor
- University Hospital, Lille
Tethered Spinal Cord, Including Thickened Filum, Lipomas, Myelomeningocele and Meningocele
Inflammatory Response in Children Suffering From Tethered Cord
Embryologic phenomenons that lead to dysraphisms are known, but pathophysiology remains questioned. It is supposed not to be a simple mechanistic dysfunction, and other biological phenomenons are implied in spinal cord damaging.
- Trial name
- TETHERIC (NCT07611058)
- Testing
- CSF sampling during surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Lille
Stroke
DIROXIMEL FUMARATE TO REDUCE PERIHAEMATOMAL OEDEMA IN INTRACEREBRAL HAEMORRHAGE: DOUBLE BLIND RANDOMIZED CLINICAL TRIAL
Spontaneous intracerebral haemorrhage (ICH) is a life-threatening condition, still devoided of specific treatment. Peri-haematomal oedema (PHO) develops in the ensuing days after ICH onset and worsens functional outcome.
- Trial name
- DARLENE (NCT07275515)
- Testing
- DRF
- Where
- France
- Volunteers
- 192 people
- Sponsor
- University Hospital, Lille
Fall
Contribution of Peripheral Vision in the Risk of Falls in the Elderly
This study is a controlled, open-label biomedical research project in cognitive neuroscience designed to examine the results (postural stability, error rates, and spatiotemporal parameters of eye movements and head movements) of…
- Trial name
- NCT07608263
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Schizophrenia
Research Sense of Familiarity in Psychotic Patients
Categorical perception of familiarity in schizophrenic patients
- Trial name
- NCT07608250
- Testing
- cognitive test
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Cancer, Hematologic Malignancy
Identifying Cellular and Molecular Determinants of Efficacy and Resistance in Patients Undergoing CAR-T Therapy
In recent years we have witnessed a breakthrough in the treatment of leukemia and lymphoma using autologous CAR-T cells that can induce durable remission in patients.
- Trial name
- CAR-Lille (NCT07609485)
- Where
- 2 sites in France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Lille
Urinary Incontinence
Development of a Cardiac Signal Analysis Algorithm for Bladder Filling Assessment: Pilot Study
The puropose of this clinical trial is to build a database of signals issued from the device to delvelop signal processing algorithms to calculat the LFVI.
- Trial name
- ENURESIA 1 (NCT07607652)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Cutaneous Squamous Cell Carcinoma (CSCC)
Follow-up of a French National Cohort of Patients With Cutaneous Squamous Cell Carcinoma Requiring Systemic Treatment.
In the context where advanced cutaneous squamous cell carcinoma (cSCC) is currently a public health issue due to its increasing incidence and where its management is rapidly evolving, it is essential to characterize and monitor…
- Trial name
- CAREPI (NCT07606508)
- Testing
- Systemic treatment
- Where
- 29 sites in France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Lille
Malocclusions
Genetic Basis of Musculoskeletal Status Malocclusions
Genetic basis of musculoskeletal status malocclusions
- Trial name
- NCT07605910
- Sponsor
- University Hospital, Lille
Emphysema
Lung Disease and FLNA Mutations
Some sparse scientific data support the hypothesis that otherwise unexplained emphysema may be associated with FLNA variants. This transversal multicentric study aimed to describe the frequency of emphysema in patients carrying…
- Trial name
- FLN-Air (NCT07592637)
- Testing
- Radiation: Chest HRCT
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Lille
Anxiety
Assessment of the Aromatherapy to Alleviate Peri Operative Anxiety in Ambulatory Elective Upper Limb Surgery Under Loco-regional Anesthesia
AROMA study is a randomised controlled parallel-group single-site study. Patients randomized in the experimental group benefit from the aromatherapy at their arrival in the operating theatre in the recovery room.
- Trial name
- AROMA (NCT03583801)
- Testing
- Olfactory aromatherapy, without aromatherapy
- Where
- France
- Volunteers
- 289 people
- Sponsor
- University Hospital, Lille
Cognitive Dysfunction
MOBility Disorders Assessment in Patients With Mild COGnitive Disorders
Mild cognitive impairment (MCI) is defined by lower performance in one or more cognitive domains with preservation of independence in functional abilities.
- Trial name
- COG-MOB (NCT05273125)
- Testing
- Gait disorders and falls risk assessment
- Where
- 2 sites in France
- Volunteers
- 417 people
- Sponsor
- University Hospital, Lille
Congenital Hypothyroidism
Evaluation of an Intensified Systematic Screening for Congenital Hypothyroidism in Premature Newborns
Currently in France, screening for congenital hypothyroidism (CH) in premature infants is done by a single TSH assay on filter paper. However, European recommendations advise repeating the assay within the first month of life.
- Trial name
- PREMATHYRO (NCT07425028)
- Testing
- Blood test
- Where
- France
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Lille
Aortic Valve Stenosis, Aortic Valve Insufficiency
Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes
Paravalvular regurgitation (PVR) is an important complication of Transcatheter Aortic Valve Implantation (TAVI) that is associated with a 2.5-fold increase risk of mortality.
- Trial name
- WITAVI-REAL (NCT03728049)
- Testing
- CT-ADP performed during TAVI procedure, No CT-ADP performed during TAVI procedure
- Where
- 9 sites in France
- Volunteers
- 944 people
- Sponsor
- University Hospital, Lille
Pulmonary Disease, Chronic Obstructive, Bacterial Infections
Study of the Involvement of IL-17 / IL-22 Pathway in Bacterial Exacerbations of COPD
Chronic obstructive pulmonary disease (COPD) is a worldwide chronic inflammatory disease of the airways linked to environmental exposure.
- Trial name
- COPD1722 (NCT02655302)
- Testing
- Sample collecting, Lung function measure
- Where
- 4 sites in France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Lille
Cognitive Decline, Stroke
Identification of Epigenetic Risk Factors for Ischemic Complication During the TAVR Procedure in the Elderly
Over the past ten years, the number of endovascular procedures has increased by 5% per year in Europe with the development of interventional cardiology, such as percutaneous coronary angioplasty, aortic valve replacements (TAVR)…
- Trial name
- METHYSTROKE (NCT02972008)
- Where
- France
- Volunteers
- 542 people
- Sponsor
- University Hospital, Lille
Hemodynamic
Use of the Aortic Time-velocity Integral Via Suprasternal Ultrasound to Search Preload Dependence in Paediatric Surgery : Kid's Fluid Management (FM)
After major surgery, fluid overload is associated with an increase of morbidity and mortality. Fluid administration should therefore be given wisely.
- Trial name
- Kid's FM (NCT07099664)
- Testing
- Measurement of aortic Vmax and VTI with suprasternal doppler.
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Lille
Sars-CoV2, Chronic Inflammatory Rheumatism
Covid-19 in Patients With Chronic Inflammatory Rheumatism, Auto-immune or Auto-inflammatory Rare and Non-rare Diseases
Since December 2019, an international outbreak of respiratory illnesses caused by SARS-CoV-2 called covid-19 has become a global challenge.
- Conditions
- Sars-CoV2, Chronic Inflammatory Rheumatism, Autoimmune Diseases
- Trial name
- covid19 fai2r (NCT04353609)
- Where
- France
- Volunteers
- 13,770 people
- Sponsor
- University Hospital, Lille