Clinical trials: sponsored by University Hospital, Lille
Bone Marrow Failure, Trauma
Identification of Autoantibodies and Autoantigens in the Cerebrospinal Fluid of Patients With Spinal Cord Trauma
The purpose of the study is to detect the presence of autoantibodies and autoantigens in cerebrospinal fluid early (<48 hours) following spinal cord trauma.
- Trial name
- TRAME (NCT03249129)
- Sponsor
- University Hospital, Lille
Geriatrics
Evaluation of a T-shirt "Balance" Containing Ceramic Fibers
Falls are frequent and often serious events in the elderly. The consequences of falls are often severe: traumatic (fractures, hematomas, ..) and psychological.
- Trial name
- Equi-tee-shirt (NCT04146675)
- Testing
- TRICOT JERSEY VANISE DOUBLE FACE, TRICOT JERSEY SIMPLE
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Lille
Adrenal Disease
DAnalysis of the Distribution of Adrenal Steroids in a Control Population
This is a biomedical research study on the determination of adrenal steroids. It has been proposed in recent years as a tool for the diagnostic orientation of an adrenal pathology.
- Trial name
- STEROTEM (NCT04139447)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Anticoagulant
Determinants of Oral Anticoagulants' Activity
The primary objective of the present study is to determine the clinical, biological and genetic determinants of the anticoagulant activity in patients treated with either anti-IIa or anti Xa oral anticoagulants.
- Trial name
- ANTIGOAG (NCT03172546)
- Testing
- PK-PD genetic polymorphisms
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Lille
Earache
Interest of Pregabalin (Lyrica) on the Treatment of Reflex Earache in Head and Neck Cancer.
Referred otalgia is one of the symptoms of oropharynx and hypopharynx cancer. It can be primary (otodynia) or secondary (referred otalgia and projected pain).
- Trial name
- LYRORL (NCT02924675)
- Testing
- Pregabalin
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Lille
Crohn's Disease, Genetic Predisposition
Abnormal Fecal Microbiota in Healthy Subjects at High Risk for Crohn's Disease
Transversal multicentric French study on the microbiota in patients with Crohn's disease and their first degree healthy relatives The primary objective is the comparison of microbiota between patients with CD, healthy controls…
- Trial name
- MAGIC (NCT02826330)
- Testing
- biomarkers
- Where
- 10 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Pregnancy, High Risk
Perception of Risks Into Work During Pregnancy Among Post-partum Women in the Lille Metropolis
In ten years, the labor force has grown by 1.4 million people according to French national institute for statistical and economic studies. This increase is partly due to the increased presence of women in the labor market.
- Trial name
- PERISTRAG (NCT03651843)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Ovarian Hyperstimulation Syndrome, Hypercoagulability
Ovarian Hyperstimulation Syndrome in Patients Triggered by GnRH Agonist for Excessive Follicular Response
In the literature, the risk of moderate to severe OHSS is 3 to 6% and reaches 31% in high risk populations 9 days after oocyte triggering with hCG.
- Trial name
- COAGO (NCT02701452)
- Testing
- COAGO
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Congenital Malformation
The Impact of the Birth of a Child With a Rare Abdomino-thoracic Malformation
Qualitative study in psychology whose main objective is to propose a grounded theory to report the dynamics of parental adjustment for the period from the announcement of the diagnosis to one year of the child affected by a rare…
- Trial name
- INEMAT (NCT03565822)
- Testing
- Interview
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Lung Cancer Metastatic
Early Palliative Care in Metastatic Lung Cancer in Northern France
Single-center, prospective, controlled, open-label, randomized, two parallel arms comparing early Palliative care versus Standard care in patients with non-small-cell metastatic lung cancer
- Trial name
- IMPAQ (NCT02308865)
- Testing
- multi disciplinary palliative care monthly consultations
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Lille
Heart Failure
Prevention of Hemorrhage After Implantation of Mechanical Circulatory Support
Main objective of the study is to demonstrate that a prophylactic treatment with VWF factor concentrate after implantation of continuous-flow left ventricular assist device (CF-LVAD) reduces the frequency of clinically…
- Trial name
- PHAM (NCT02488525)
- Testing
- Prophylactic treatment with Wilfactin
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Lille
Obesity, Heart Failure
Characterization of Obesity-related Cardiomyopathy Through Exploration of Human Atrial Trabeculae Contraction
The investigators aim to explore obese cardiomyopathy by studying contractile twitch force, sarcomere sensitivity to calcium and mitochondrial function in atrial myocardial samples of patients grouped according to their body mass…
- Trial name
- NCT02384252
- Testing
- functional tissu atrial analysis
- Where
- France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Lille
Primary Immunodeficiency
IgG Level in Primary Immunodeficiency Switching From Standard SCIG to Every Other Week HyQvia
Most immunodeficiencies are related to severe immunoglobulin deficiencies which require lifelong replacement therapy with immunoglobulin G (IgG) to reduce the incidence and severity of infections.
- Trial name
- NCT02881437
- Testing
- IgHy10
- Where
- 7 sites in France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Lille
Crohn Disease
Search for New Genetic Mutations Major Effect in Crohn's Disease
This study highlight genetics mutations with major effect in Crohn's Disease (CD) by WES in individuals affected and healthy individuals from EPIMAD Inserm InVS registry families.
- Trial name
- MC-WES (NCT02851134)
- Testing
- genetic analysis, blood and stools samples
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Lille
Inflammatory Bowel Diseases
Evaluation of the Clinical and Immunological Impact of Two Therapeutic Strategies in Chronic Inflammatory Diseases
This study evaluates 2 therapeutic strategies (increase infliximab dose or add an immunosuppressant) in patients with inflammatory bowel disease in loss of response to infliximab.
- Trial name
- STAMP (NCT03370601)
- Testing
- Infliximab, Mercaptopurine, Azathioprine
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Lille
Inflammatory Bowel Diseases
Role of the Chemical Environment in the Pathogenesis of Inflammatory Bowel Disease
Inflammatory Bowel Diseases (IBD) including Crohn's disease and ulcerative colitis are multifactorial diseases leading to chronic inflammation of intestinal mucosa. Their etiology is still unknown.
- Trial name
- CHIMICI (NCT03376230)
- Testing
- Collect of blood, urines, and intestinal biopsies
- Where
- France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Lille
Multiple Sclerosis
Alexithymia Frequency and Interhemispheric Transfer in Patients With a First Demyelinating Event
Prevalence of alexithymia in multiple sclerosis (MS) is closed to 50% but is unknown in clinically isolated syndrome (CIS).The present study sought to characterize alexithymia in CIS patients and his link between psycho…
- Trial name
- ALEXCIS (NCT03796247)
- Where
- France
- Volunteers
- 57 people
- Sponsor
- University Hospital, Lille
Asthma
Regulation of CCL18 by Corticosteroids in Severe Asthma
The majority of asthmatic patients are well controlled by inhaled corticosteroid treatment, however some severe asthma resist this treatment.
- Trial name
- CCL18 (NCT03779152)
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Nociceptive Pain, Surgical Procedure, Unspecified
Monitoring Analgesia by ANI (Analgesia The Nociception Index)
The objective of this research is to study the variations of the ANI(Analgesia The Nociception Index) according to 2 periods: the "NoStim" period before surgical incision under general anesthesia and the period of hemodynamic…
- Trial name
- ANI-MICI (NCT03749304)
- Testing
- ANI monitor
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Lille
Inflammatory Bowel Diseases
Genetic an Functional Studies of Patient With Inflammatory Bowel Disease
The objective of this study is to study the response of macrophages, isolated from patients with ulcerative colitis (Crohn's disease) or Crohn's disease (CD), to 6 candidate enterogenous and their derivatives, depending on the…
- Trial name
- MINOTOR (NCT03751722)
- Where
- France
- Volunteers
- 630 people
- Sponsor
- University Hospital, Lille