Clinical trials: sponsored by University Hospital, Lille
COPD, Pulmonary Fungal Diseases
Clinical Impact of Fungal Domestic Environmental Exposure on COPD Patients
Fungal infections could play a role in chronic obstructive pulmonary disease (COPD) patient's exacerbations and in lung function impairment.
- Conditions
- COPD, Pulmonary Fungal Diseases, Environmental Exposure
- Trial name
- FungiCOPD (NCT02318524)
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Lille
Glioblastoma
Search of Protein Biomarkers in Order to Achieve a Molecular Classification of Gliomas
The aim is to classify high grade glioma by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI). In order to provide more specific informations for the diagnosis and the prognosis of high grade…
- Trial name
- GLIOMIC (NCT02473484)
- Where
- France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Lille
Cystic Fibrosis, Dietary Modification
Nasal Mucin Oral Supplementation Treatment Respiratory Inflammation Using PUFA in Cystic Fibrosis (CF) Patients
Background : Cystic fibrosis (CF) patients are prone to recurrent pulmonary infection have different secreted mucin pattern from healthy subjects.
- Trial name
- NOSTRIL (NCT01329172)
- Testing
- polyunsaturated fatty acids n-3
- Where
- 3 sites in France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Lille
Dystonia, Primary, Dysarthria
Study of Speech Disorders , Voice and Swallowing in Primary Dystonia Oromandibular
To better define the clinical characteristics of oromandibular dystonia, we aimed to study voice, speech and swallowing disorders in idiopathic oromandibular We planned to include consecutive patients followed in Lille Movement…
- Conditions
- Dystonia, Primary, Dysarthria, Dysphonia, Dysphagia
- Trial name
- DOM (NCT03380676)
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Keratosis, Actinic
Evaluation of Non-inferiority and Tolerability of the Device PHOS-ISTOS
This study aims to compare the efficacy and tolerance of a new photodynamic therapy device (PHOS-ISTOS) with the conventional PDT device (Aktilite®) for the treatment of actinic keratosis of the scalp
- Trial name
- PHOS-ISTOS (NCT03076892)
- Testing
- Aktilite® Galderma, PHOS ISTOS PDT
- Where
- 2 sites in France, Germany
- Volunteers
- 47 people
- Sponsor
- University Hospital, Lille
Systemic Sclerosis
Neuropsychiatric Scleroderma Study: Systematic Evaluation of Neuropsychiatric Involvement in Systemic Sclerosis
Systemic sclerosis is a rare disease with vascular involvement and systemic fibrosis. This disease is usually thought to spare central nervous system.
- Trial name
- NeuroScS (NCT01488214)
- Testing
- Magnetic resonance Imaging
- Where
- 4 sites in France
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Evaluations, Rehabilitation
3 Minutes Chair Rise Test (3CRT) in Patients With COPD
Improvement in the functional functioning and dyspnea of COPD patients after a rehabilitation program (RHB) is assessed by exercise tests and questionnaires difficult to replicate outside specialized centers.
- Conditions
- Evaluations, Rehabilitation, COPD
- Trial name
- 3CRT (NCT03286660)
- Testing
- Chair Rise Tests and short questionnaire
- Where
- 2 sites in France
- Volunteers
- 127 people
- Sponsor
- University Hospital, Lille
Pain, Postoperative
The Interest of the Xylocaine® and Ketamine on the Management of Acute and Chronic Ain After Colectomy by Laparoscopy
Recent clinical studies in abdominal surgery have shown that the use of Xylocaine® parenterally intraoperative at plasma concentrations below the toxic threshold of 5 .mu.g / ml, had an analgesic effect and decreased…
- Trial name
- KETALIDO (NCT02969733)
- Testing
- Xylocaine, Ketamine, isotonic saline serum intravenous administration
- Where
- France
- Volunteers
- 135 people
- Sponsor
- University Hospital, Lille
Acute Myeloblastic Leukemia
Transplant T CD4+ CCR7+ In Hematopoietic Stem Cells Allograft
This is a preclinical study prior to the establishment of a cell therapy protocol applicable to humans. The main objective is to evaluate the decrease in alloreactivity of TCD4 + population by partial selective depletion of CD4 +…
- Trial name
- CCR7-CD4-DPL (NCT03280290)
- Testing
- blood
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Lille
Alcohol Use Disorder
Study of Mechanisms of Emotion Regulation in Alcohol-abstinent Patients
Background: Difficulties in assigning and identifying emotional states, or to regulate the emotional costs are recognized as one of the major factors of relapse.
- Trial name
- REAL (NCT02881983)
- Testing
- the presentation of pictures (static stimuli) or videos (dynamic stimuli)
- Where
- 2 sites in France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Epidural Block, Oesophageal Cancer
The Hemodynamic Effect Between Two Types of Anesthesia in Esophageal Surgery
Continuous Paravertebral block (PVB) was reported to provide less episodes of hypotension than continuous thoracic epidural block (TEB).
- Conditions
- Epidural Block, Oesophageal Cancer, Oesophagectomy
- Trial name
- HEMOBLOC (NCT03185403)
- Testing
- paravertebral block, thoracic epidural block, ropivacaine
- Where
- France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Pain, Postoperative
TAP Block Efficacy After Lumbar Spine Surgery Through Anterior Approach: a Randomized, Placebo-controlled Study
Anterior Lumbar Interbody Fusion (ALIF) as well as Direct Lateral Interbody Fusion (DLIF) are established techniques for lumbar interbody fusion.
- Trial name
- TAP-LIF (NCT02778178)
- Testing
- ropivacaine plus clonidine, ultrasound
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Parkinson's Disease
Study of Dysarthria, Swallowing Disorders and Respiratory in Parkinson's Disease
The investigators prospectively enrolled 64 early PD patients (less than 3 years after the first symptom) in order to prospectively assess the natural history of non-dopaminergic symptoms.
- Trial name
- ProdDiGYPark (NCT02627664)
- Testing
- observational study
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Dysmetabolic Syndrome, Hyperferritinemia
Respiratory Variations for Assessing Blood Withdrawal 2
OBJECTIVES: To investigate whether respiratory variations of the inferior vena cava (ΔIVC) and internal jugular vein (ΔIJV) diameters during standardized breathing (ΔIVCST and ΔIJVST) increase after a therapeutic bleeding in…
- Conditions
- Dysmetabolic Syndrome, Hyperferritinemia, Obese
- Trial name
- ReVAs2 (NCT03066401)
- Testing
- echography
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Lille
Systemic Inflammatory Response Syndrome, Circulatory Failure
Accuracy of Pulse Pressure Variations Measured by a Non Invasive Digital Device to Predict Fluid Responsiveness
It has been well established that only 40 to 60% of the patients hospitalized for inflammatory response syndrome (SIRS) positively respond to volume expansion (VE).
- Conditions
- Systemic Inflammatory Response Syndrome, Circulatory Failure, Mechanical Ventilation
- Trial name
- NCT03066388
- Testing
- Pulse pressure variations
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Sepsis, Circulatory Failure
Respiratory Variations For Predicting Fluid Responsiveness 2
Objectives: To investigate whether respiratory variations of inferior vena cava diameters (cIVC) predict fluid responsiveness in spontaneously breathing patients with septic acute circulatory failure and irregular heartbeats.
- Conditions
- Sepsis, Circulatory Failure, Respiratory Physiological Phenomena
- Trial name
- ReVaPreF2 (NCT03066375)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Lille
Genetic Hemochromatosis
Respiratory Variations For Assessing Blood Withdrawal
OBJECTIVES: To investigate whether respiratory variations of the inferior vena cava (ΔIVC) and internal jugular vein (ΔIJV) diameters during standardized breathing (ΔIVCST and ΔIJVST) increase after a therapeutic bleeding in…
- Trial name
- ReVAs (NCT03066414)
- Testing
- echography
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Lille
Allergy to Fish, Allergy
Anisakis Blastocystis Cryptosporidium Fish Serology
Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic diseases agents, and have a high impact on human health.
- Conditions
- Allergy to Fish, Allergy, Anisakis
- Trial name
- ABCFish2 (NCT02666092)
- Testing
- Questionnaire, Detection of anti-Anisakis and anti-fish antibodies
- Where
- France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Thromboangiitis Obliterans, Atheromatous Arteritis
ADDICTAO: Psychological and Addictive Profile of Patients With Buerger's Disease
Background: Buerger's disease (thromboangiitis obliterans or TAO) is a rare disease (1/ 10 000) characterized by the development of segmental thrombotic occlusions of the medium and small arteries of the extremities.
- Trial name
- ADDICTAO (NCT01064206)
- Where
- 16 sites in France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Lille
Coronary Artery Disease
Characterization of Factors Influencing the Cognitive Decline in Patients With Coronary Artery Disease
The real impact of cardiac surgery and coronary angioplasty remains to be clarified and, where appropriate, the influencing factors in a way beneficial or deleterious remain to be identified.
- Trial name
- COGCAR (NCT00946959)
- Testing
- Cardiac surgery
- Where
- France
- Volunteers
- 155 people
- Sponsor
- University Hospital, Lille