Clinical trials: sponsored by University Hospital, Lille
Catatonia
Blood Concentration in Lorazepam and Treatment in Adult Catatonia
Catatonia is a severe form of psychomotor disturbance with a heterogenous presentation. It affects approximately 10% of acute psychiatric inpatients.
- Trial name
- PHARMAPREDICAT (NCT04530734)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Alcohol Abuse
Evaluation of the Threshold for the Interpretation of the Results of a Method for the Blood Determination of Phosphatidyléthanol
For an analytical validation of the method for the determination of blood hosphatidylethathanol, it is necessary to: to compare the results of chronic and excessive ethanol patients with the cut-off proposed in the literature.
- Trial name
- PETHOXICO (NCT04557631)
- Sponsor
- University Hospital, Lille
Neonatal Critical Care
Palliative Care in Maternity and Neonatology
Palliative care is now an accepted principle in most maternity and neonatology wards, however not much is known about its psychological and social consequences on families.
- Trial name
- VESPAN (NCT04619901)
- Testing
- Semi-structured interviews, Questionnaire, following Scales
- Where
- 4 sites in France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Periodontal Health, Gingivitis
Effect of Probiotics on the Periodontal Status of Orthodontic Patients
Gingival inflammation (gingivitis) is commonly reported in teenagers with fixed orthodontic devices (FOD). Indeed, FODs promote the accumulation of plaque and interfere with the efficacy of tooth brushing.
- Trial name
- POP (NCT04634201)
- Testing
- Oral probiotics (L. reuteri)
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Lille
Frontotemporal Dementia
GENetic Fronto Temporal Dementia Initiative in Lille
GENFI Lille is a French cohort that belongs to the international initiative GENFI2, a five year longitudinal biomarker cohort study of genetic FTD and its associated disorders (including MND/ALS) investigating members of families…
- Trial name
- GENFI-LILLE (NCT04639622)
- Testing
- Investigation procedures
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Covid19, Metabolism, Inborn Errors
COVID-19 and Hereditary Metabolic Diseases
No additional risk factors have been identified in patients with Inherited Metabolic Diseases (IMD) for contracting or presenting complications of COVID-19 compared to the general population.
- Trial name
- COVID19-MHM (NCT04645498)
- Where
- France
- Sponsor
- University Hospital, Lille
Myotonic Dystrophy 1, Diabetes
Myotonic Dystrophy - Vascular and Cognition
The cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia).
- Conditions
- Myotonic Dystrophy 1, Diabetes, Carbohydrate Intolerance
- Trial name
- DM-VASCOG (NCT04656210)
- Testing
- MRI, neuropsychological tests
- Where
- France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Lille
Retinal Dystrophy, Cone-Rod, Cone Dystrophy
Study of New Mutations in Cone Disorders
High throughput sequencing gives the opportunity to improve the genetic diagnosis for patients suffering from retinal dystrophies and specially from cone disorders.
- Conditions
- Retinal Dystrophy, Cone-Rod, Cone Dystrophy, Cone Rod Dystrophy, Macular Degeneration
- Trial name
- INTROCONE (NCT04658251)
- Testing
- Blood and/or skin biopsy
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Lille
Dermatitis, Atopic
Efficacy and Tolerance of JAK Inhibitors in ATU for Atopic Dermatitis
The aim is to assess effectiveness (EASI, SCORAD, IGA, DLQI, pruritus, sleep loss) and safety (clinical and biological adverse events) of JAK inhibitors in adults with moderate-to-severe atopic dermatitis in a real-life French…
- Trial name
- JAKIGREAT (NCT04761978)
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Crohn Disease, Ulcerative Colitis
Occupational Insertion and Educational Level of Adult Patients With Pediatric Early Inflammatory Bowel Disease (IBD)
The main objective of this project is to assess the occupational insertion of these adult patients with pediatric-onset IBD and to compare it with the general population. The secondary objectives are: 1.
- Trial name
- PROMICI (NCT04887428)
- Where
- France
- Volunteers
- 343 people
- Sponsor
- University Hospital, Lille
Covid19, SARS-CoV Infection
Collection of the Thrombo-VaxCov Cohort
In the context of anti-Covid19 vaccination, atypical thrombosis have occured and potential link with vaccination is under investigation.
- Conditions
- Covid19, SARS-CoV Infection, Venous Thrombosis, Thrombocytopenia
- Trial name
- THROMBO-VAXCOV (NCT04889326)
- Testing
- Retrospective data and biological samples
- Where
- France
- Sponsor
- University Hospital, Lille
Frailty
Evaluation of Frail Elderly in Ambulatory Primary Care
Evaluate the sensitivity of the GERONTOPOLE scale, used by general practitioners in primary care outpatients for the diagnosis of frailty in non-dependent people more than 65 years old, using as reference the "évaluation…
- Trial name
- EPAFRA (NCT05182879)
- Testing
- Assessement with GERONTOPOLE scale
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Lille
Severe COVID-19
COVID-19 and VA-LRTI: Second Versus First Wave of the Pandemic
Multicenter observational retrospective cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic.
- Trial name
- CoVAPid2 (NCT05256511)
- Where
- France
- Sponsor
- University Hospital, Lille
Cognitive Dysfunction
MOBility Disorders Assessment in Patients With Mild COGnitive Disorders
Mild cognitive impairment (MCI) is defined by lower performance in one or more cognitive domains with preservation of independence in functional abilities.
- Trial name
- COG-MOB (NCT05273125)
- Testing
- Gait disorders and falls risk assessment
- Where
- 2 sites in France
- Volunteers
- 417 people
- Sponsor
- University Hospital, Lille
Mucorales Infection, Mucormycosis
Biomarkers for Invasive Mucormycosis
Mucormycosis (MM) is one of the main invasive fungal infection (IFI), and is determined by filamentous fungi belonging to the order of Mucorales, with a mortality rate ranging from 20 to 60% according to localization.
- Trial name
- BIM (NCT05406037)
- Testing
- Venous sample
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Pediatric Cancer, Chronic Sinusitis
Post-radiotherapy Rhinosinusitis in Children
Chronic rhinosinusitis (CRS) is a frequent complication of facial cancer treatment, mainly related to radiotherapy. However, while radiological involvement is frequent, clinical expression seems less important.
- Trial name
- PRRSC (NCT05454163)
- Testing
- SNOT 22 questionnaire
- Sponsor
- University Hospital, Lille
Severity of Illness Index
Performance for French Pediatric Intensive Care Units
Introduction. The measurement of severity scores in adult and pediatric resuscitation provides a tool for evaluating the clinical performance of resuscitation services.
- Trial name
- QUAL-REAPED (NCT05491018)
- Volunteers
- 13,270 people
- Sponsor
- University Hospital, Lille
Amelia, Femur Fibula Ulna Syndrome
Methylome Study in Sporadic Limb Malformations
Some limb malformations are known to be sporadic (non hereditary). For these malformations, no molecular cause was identified, even after whole genome sequencing.
- Trial name
- METHYLIMB (NCT05555225)
- Testing
- Methylome
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Cancer Colorectal
Blood Screening for Adult Colorectal Cancer
Multicenter, inter-regional, case-control study with the primary objective of evaluating the discriminative power of the blood biomarker TFPI-1 to separate patients with histologically proven CRC from an asymptomatic control…
- Trial name
- BACCHUS (NCT05577143)
- Where
- France
- Volunteers
- 303 people
- Sponsor
- University Hospital, Lille
Stroke, Stroke Sequelae
Neural Bases of Post-stroke Emotion Perception Disorders
This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs. healthy controls using MRI (functional and structural connectivity) and EEG.
- Conditions
- Stroke, Stroke Sequelae, Emotions
- Trial name
- STROKEM (NCT05595005)
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille