Clinical trials: sponsored by University Hospital, Lille
Lymphoma, Follicular
Long-term Ovarian Fertility in Patients Treated for Lymphoma.
This is an observational, single-center, longitudinal cohort study. In order to evaluate the gonadotoxicity of chemotherapy, an AMH monitoring was initiated in 2006 in our fertility observatory in young patients with lymphoma…
- Trial name
- FERTILymph (NCT05616325)
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Lille
Congenital Diaphragmatic Hernia
Engagement in Physical Activities and Sports in Adolescents With Diaphragmatic Hernia
The objective is to understand how a population of adolescents - who have undergone diaphragm surgery within their first month of life (i.e.
- Trial name
- CHASAM (NCT05666986)
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Cardiac Surgery
Optimization Strategy for Oxygen Delivery Under Cardiopulmonary Bypass
Cardiac surgery is a frequent procedure that can lead to serious complications, including acute kidney injury (AKI) or postoperative delirium.
- Trial name
- OPTI-DO2 (NCT05984563)
- Testing
- Cardiopulmonary bypass
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Patient Treated With Lithium, With Bipolar or Schizo-affective Disorder, Hospitalized in a Psychiatric Ward
Validation of the French Version of the Lithium Knowledge Test (LKT)
Lithium is a drug used to treat several psychiatric illnesses. This medication requires particular vigilance because it has a narrow therapeutic margin: the dose necessary to obtain an effective treatment is close to the toxic…
- Trial name
- LKT (NCT06033326)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Lille
Cerebral Microbleeds, Congenital Haemophilia, Congenital Von Willebrand Disease
Severe Congenital Hemostatic Defects, Cerebral MIcrobleeds and COGnition
Cerebral microbleeds (CMBs) are haemosiderin deposits, resulting from the leakage of erythrocytes from small cerebral vessels, which can be detected noninvasively using susceptibility-sensitive magnetic resonance imaging (MRI)…
- Trial name
- HEMICOG (NCT06090201)
- Testing
- 3-Tesla brain MRI and a comprehensive neuropsychological assessment
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Lille
Post-traumatic Stress Disorder
TREATMENT OF POST-TRAUMATIC STRESS DISORDER USING AUGMENTED IMAGINATION EXPOSURE PSYCHOTHERAPY WITH VOCAL FEEDBACK: AN ACCEPTABILITY STUDY
We now have many pharmacological and psychotherapeutic treatments for patients suffering from Post Traumatic Stress Disorder (PTSD), including cognitive and behavioral therapy (CBT) by reactivation of traumatic memories.
- Trial name
- TRAUMAVOICE (NCT06129981)
- Testing
- Imaginary exposure therapy augmented by vocal feedback
- Sponsor
- University Hospital, Lille
Hemodynamic
Use of the Aortic Time-velocity Integral Via Suprasternal Ultrasound to Search Preload Dependence in Paediatric Surgery : Kid's Fluid Management (FM)
After major surgery, fluid overload is associated with an increase of morbidity and mortality. Fluid administration should therefore be given wisely.
- Trial name
- Kid's FM (NCT07099664)
- Testing
- Measurement of aortic Vmax and VTI with suprasternal doppler.
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Lille
Parkinson Disease
Evaluation of Long-term Safety in Parkinsonian Patients With Intracerebroventricular Administration of A-dopamine (Anaerobic Dopamine)
Patients included in DIVE I have been receiving this treatment for several years as part of their participation in the study, which is scheduled to end on September 30, 2025.
- Trial name
- DIVE-FOLLOW UP (NCT07214285)
- Testing
- A-DOPAMINE
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Keratosis, Actinic Keratoses
Efficacy and Safety of Cryotherapy Followed by Tirbanibulin Ointment for Actinic Keratosis on the Scalp and Forehead
The aim of the study is to evaluate the efficacy and safety of a combined approach of cryotherapy and tirbanibulin for the treatment of actinic keratosis of the scalp and forehead, repeated every 4 months.
- Trial name
- TIRBACRYO (NCT07273656)
- Testing
- Cryotherapy + Tirbanibulin
- Volunteers
- 59 people
- Sponsor
- University Hospital, Lille
Obstetrics
Autonomic Nervous System Intrapartum Monitoring to Prevent Neonatal Adverse Outcomes
Perinatal asphyxia affects 3 to 8 newborns per 1,000 births, with moderate or severe anoxic-ischemic encephalopathy occurring in 0.5 to 1 per 1,000 births.
- Trial name
- ANSINAO (NCT07409545)
- Testing
- Recording of fetal and maternal heart rate
- Volunteers
- 760 people
- Sponsor
- University Hospital, Lille
Congenital Hypothyroidism
Evaluation of an Intensified Systematic Screening for Congenital Hypothyroidism in Premature Newborns
Currently in France, screening for congenital hypothyroidism (CH) in premature infants is done by a single TSH assay on filter paper. However, European recommendations advise repeating the assay within the first month of life.
- Trial name
- PREMATHYRO (NCT07425028)
- Testing
- Blood test
- Where
- France
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Lille
Suicide
Self-hangIng Patient and Hyperbaric Oxygen Therapy _ SIPHON Study
During an attempted hanging, patients present severe neurological distress that can lead to major neuropsychiatric sequelae. These sequelae are notably due to significant cerebral edema related to hanging.
- Trial name
- SIPHON (NCT07461272)
- Testing
- OXYGENE MEDICINAL LIQUIDE AIR PRODUCTS MEDICAL
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Von Willebrand Diseases, Glanzmann Thrombasthenia
Videomicroscopy for the Prediction of Bleeding in Constitutional Haemorrhagic Diseases
In Willebrand disease, there is currently no test available to identify non-invasively patients with a high risk of bleeding from angiodysplasias The study propose to use a sublingual capillary bed analysis by video-microscopy, a…
- Trial name
- VIDEO-BLEED (NCT04119908)
- Testing
- Sublingual videomicroscopy, blood sample
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Lille
Rare Diseases, Congenital Diaphragmatic Hernia
Intact Cord Resuscitation in CDH
Isolated CDH is a rare disease (1/3500) and displays a wide range of severity and outcome. Despite attempts to standardize the management of this disease at birth and during the first months of life, the mortality varies from 20…
- Trial name
- CHIC (NCT04429750)
- Testing
- Immediate umbilical cord clamping, intact cord resuscitation
- Where
- 3 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Lille
Hemophilia A
UPLC-MS/MS Monitoring of Emicizumab Therapy
Emicizumab is a monoclonal bispecific antibody with a terminal half-life of 28 days which is now licensed in the treatment of severe haemophilia A with or without inhibitors.
- Trial name
- EMICARE (NCT04472169)
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Newborn, Infant, Disease, Neurodevelopmental Disorders
Perinatal Covid-19 Infection, NO Pathway, and Minipuberty
Some evidence exists that SARS-COV-2 may infect pituitary axis, and therefore may alter hypothalamic function. Whether perinatal COVID-19 is associated with alterations in the maturation of the Hypothalamic-Pituitary-Gonadal…
- Trial name
- miniNO-COVID (NCT04952870)
- Testing
- Inhaled NO, routine care
- Where
- 2 sites in France, Greece
- Volunteers
- 180 people
- Sponsor
- University Hospital, Lille
Gender Dysphoria
Evaluation of the Variation in Quality of Life During Medical Transition for Transgender People.
Transgender people can benefit from psychological, psychiatric, endocrinological support, sexual reassignment surgery, sexology support and dermatological care. The value of transitional care courses is scientifically recognized.
- Trial name
- TRANS'ITION (NCT05273112)
- Where
- 13 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Lille
Polycystic Ovary Syndrome
The Psychological and Social Impact of PCOS
The aim of the study is to assess the association between the quality of life of patients with PCOS and various factors (age, BMI, socio-professional category, delay in diagnostic of PCOS, infertility, hyperandrogenism, parity…
- Trial name
- SPICE (NCT05982236)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Invasive Candidiasis
Early Discontinuation of Empirical Antifungal Therapy and Biomarkers
Empirical antifungal therapy (EAT) is frequently prescribed to septic critically ill patients with risk factors for invasive Candida infections (ICI).
- Trial name
- SEAT (NCT03538912)
- Testing
- Biomarker strategy, Routine strategy
- Where
- 10 sites in France
- Volunteers
- 192 people
- Sponsor
- University Hospital, Lille
Alcoholic Liver Disease, Severe Alcoholic Hepatitis
Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease
Alcoholic hepatitis carries a risk of high mortality at short term, especially in its severe form. Its diagnosis is confirmed by liver biopsy.
- Conditions
- Alcoholic Liver Disease, Severe Alcoholic Hepatitis, Alcoholic Cirrhosis
- Trial name
- COMADHAA (NCT04106518)
- Where
- 9 sites in France
- Volunteers
- 447 people
- Sponsor
- University Hospital, Lille