Clinical trials: sponsored by University Hospital, Lille
Stroke
Clinical Biological and Pharmacological Factors Influencing Stroke Outcome
In a previous suty, we have demonstrated that prior transient ischemic attack, treatment lipid-lowering drug or physical activity are associated to a better outcome of stroke.
- Trial name
- biostroke (NCT00763217)
- Where
- France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Lille
Necrotizing Fascitis, Cellulitis
Validation of the Use of the Arteriovenous Tension Difference in CO2 Under Hyperbaric Conditions
The central venous-arterial carbon dioxide tension difference is used daily in intensive care to establish peripheral tissue hypoperfusion, mainly mediated by a low cardiac index.
- Conditions
- Necrotizing Fascitis, Cellulitis, Septic Shock
- Trial name
- SEPTICO2HBO (NCT07492030)
- Testing
- Echography
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Lille
Gambling Disorder
Virtual Reality Exposure Therapy for Gambling Disorder
Gambling disorder (GD) is recognized as an addictive disorder in the DSM-5. Craving is a core phenomenon in addiction that can lead to relapse in problem gambling for pathological gamblers.
- Trial name
- VIRET-GAD (NCT04467502)
- Testing
- cognitive-behavioral therapy for gambling disorder, imaginal exposure therapy focus on gambling cues, virtual reality exposure therapy focus on gambling cues
- Where
- 10 sites in France
- Volunteers
- 124 people
- Sponsor
- University Hospital, Lille
Suicide, Attempted
Effectiveness of a Case Management Algorithm: ALGOS After a Suicide Attempt
The suicidal behaviors are phenomena eminently multifactorial. It is thus always difficult to define univocal strategies of prevention of suicide repetition, during the emergency stay, i.e. almost in general population.
- Trial name
- ALGOS (NCT01123174)
- Testing
- ALGOS algorithm of case management
- Where
- 23 sites in France
- Volunteers
- 1,040 people
- Sponsor
- University Hospital, Lille
Signet Ring Cell Gastric Adenocarcinoma
Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma
The ADCI 002 trial is a large multicenter phase II-III prospective randomized controlled trial comparing primary surgery versus primary chemotherapy followed by surgery in patients with a resectable signet ring cell gastric…
- Trial name
- ADCI002 (NCT01717924)
- Testing
- peri-operative chemotherapy, Surgery first
- Where
- France
- Volunteers
- 314 people
- Sponsor
- University Hospital, Lille
Parkinson Disease
Dopaminergic restauratIon by intraVEntriculaire Administration
Prospective monocentric randomized controlled open-label proof-of-concept study in cross-over of two 1-month periods and a long-term follow-up period not to exceed September 30, 2023, with 2 groups: Intracerebroventricular…
- Trial name
- DIVE (NCT04332276)
- Testing
- A-dopamine, optimized oral treatment
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Lille
Esophageal Disease
The French EsoGastricTumours Data Base
This retrospective study aims at evaluating the outcomes of gastrointestinal stromal tumor after surgery.
- Trial name
- FREGAT (NCT02526095)
- Where
- 31 sites in France
- Volunteers
- 15,000 people
- Sponsor
- University Hospital, Lille
Parkinson's Disease, Amyotrophic Lateral Sclerosis
Oxidative Stress and Apoptosis of Energy Metabolism by Deferiprone From the Circulating Lymphocytes
Peripheral blood mononuclear cells (PBMC) and platelets could be interesting ex vivo models to study brain diseases. Indeed, there is no access to neurons from patients.
- Conditions
- Parkinson's Disease, Amyotrophic Lateral Sclerosis, Oxidative Stress, Iron Overload
- Trial name
- LymphoEnergy (NCT02880033)
- Testing
- deferiprone
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Stress Disorders, Post-Traumatic, Stress Disorders, Traumatic, Acute
DEPITAC : Short Screening Scale for Psychotraumatic Disorders After Motor Vehicle Accident
Posttraumatic stress disorder (PTSD) is a serious and often chronic response to overwhelmingly stressful events as Road Traffic Accident.
- Trial name
- DEPITAC (NCT01200628)
- Testing
- DEPITAC
- Where
- 6 sites in France
- Volunteers
- 274 people
- Sponsor
- University Hospital, Lille
Suicide, Attempted
Evaluation of a Regional Post-discharge Monitoring System for Suicide Attempters
VigilanS is an innovative healthcare program. Participants of this program are all patients leaving in the Nord-Pas de Calais region who survived a suicide attempt.
- Trial name
- EVAL-VIGILANS (NCT03134885)
- Where
- 28 sites in France
- Volunteers
- 12,989 people
- Sponsor
- University Hospital, Lille
Post-Traumatic Stress Disorder, Violence-Related Symptom
A Case Management Algorithm for Women Victims of Violence
A considerable body of research has demonstrated that women who are victims of interpersonal violence are at substantially elevated risk for the development of post-traumatic stress disorder (PTSD).
- Trial name
- VIGITRAUMA (NCT04953273)
- Testing
- Vigitrauma
- Where
- 8 sites in France
- Volunteers
- 756 people
- Sponsor
- University Hospital, Lille
Parkinson's Disease, Gait Disorders, Neurologic
Study of Memantine for Gait Disorders And Attention Deficit In Parkinson's Disease
Along with cognitive and psychobehavioural disorders, gait disorders represent a major problem in the treatment of advanced Parkinson's disease (PD).
- Trial name
- FOGG-I (NCT01108029)
- Testing
- memantine
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Lille
Valve Heart Disease, Coronary Artery Disease
Post-Operative Myocardial Incident & Atrial Fibrillation
To explore predictors of major cardio-vascular events after cardiac surgery and trans-catheter valve implantation with a specific interest in studying mechanisms linking pre-operative leukocyte, fat and myocardial phenotypes with…
- Trial name
- POMI-AF (NCT03376165)
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Lille
Inflammatory Bowel Disease
Physical Activity and Bone Mineral Density in Children and Adolescents With Chronic Inflammatory Bowel Disease
This study is an observational study. The purpose of this study is to assess the relationship between bone health and daily physical activity in children and adolescents with inflammatory bowel disease (IBD).
- Trial name
- PHYSICOSMICI (NCT02341742)
- Testing
- multiple examinations
- Where
- 7 sites in France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Lille
Congenital Heart Disease
Neurodevelopmental Disorders in Children With Congenital Heart Disease
Children with congenital heart disease are at risk for neurodevelopmental disorders, these disorders impacting their quality of life and their integration into society.
- Trial name
- NeuroDis-CHD (NCT03360370)
- Testing
- Ages & Stages Questionnaires, Third Edition in French (ASQ-3™)
- Where
- France
- Volunteers
- 233 people
- Sponsor
- University Hospital, Lille
SPINAL Fracture, Pain, Postoperative
Effectiveness of Erector Spinae Plane Block for Percutaneous Arthrodesis of Spinal Fractures
Spinal fracture surgery is a common surgery. Post-operative pain has been reduced by the advent of so-called minimally invasive techniques.
- Trial name
- SPINERECTOR (NCT06200298)
- Testing
- Erector spinae plane block with naropeine [3,75 mg/mL], ESPB with saline 0,9%
- Where
- France
- Volunteers
- 86 people
- Sponsor
- University Hospital, Lille
Asthma in Children
Consequences of COVID 19 Pandemic on Childhood Asthma
The SARS-CoV2 pandemic, which emerged in the first quarter of 2020, has led to an unprecedented health crisis in our modern healthcare systems and has resulted in strong national public health measures.
- Trial name
- VIRASTHCOVID (NCT04821908)
- Where
- France
- Volunteers
- 577 people
- Sponsor
- University Hospital, Lille
Geriatric Disorder
Patient Outcomes After Hospitalization in Acute Geriatric Unit
Three events can be considered of major importance for patients after a hospitalization in an AGU: death, hospital readmission, and institutionalization.
- Trial name
- DAMAGE (NCT02949635)
- Where
- 6 sites in France
- Volunteers
- 3,532 people
- Sponsor
- University Hospital, Lille
Anisakis, Allergy
Anisakis Blastocystis Cryptosporidium Fish Prevalence
Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic agents, and have a high impact on human health.
- Conditions
- Anisakis, Allergy, Occupational Exposure
- Trial name
- ABCFish1 (NCT02661074)
- Testing
- Questionnaire
- Where
- 3 sites in France
- Volunteers
- 486 people
- Sponsor
- University Hospital, Lille
Post-Traumatic Stress Disorder
Cognitive and Emotional Factors in Visual Exploration Among Patients With Post-Traumatic Stress Disorder (SAILLANCE2)
Post-traumatic stress disorder (PTSD) is characterized by hypervigilance. In particular, previous works suggest that patients tend to scan constantly the environment for possible threats.
- Trial name
- SAILLANCE2 (NCT03519789)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Lille