Clinical trials: sponsored by University Hospital, Lille
Breast Cancer, Invasive Breast Carcinoma
Individual Factors Associated With Care Pathways Delays in Breast Cancer in Hauts-de-France.
Women in the Hauts-de-France region show higher breast cancer mortality despite no overall higher incidence, suggesting differences in the care pathway.
- Trial name
- E-C-HAU (NCT07475325)
- Where
- 34 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Lille
Chronic Rhinosinusitis With Nasal Polyps, Obstructive Sleep Apnea
Polysomnographic Findings in Nasal Polyposis
Nasal polyposis (NP) is a chronic inflammatory disease of the nasal and sinus mucosa leading to protrusion of edematous polyps in the nasal cavity. Prevalence of NP among the chronic rhinosinusitis patients is 25-30 %.
- Trial name
- POLYSOMNO (NCT03725956)
- Testing
- Endoscopic sinus surgery
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Functional Pituitary Adenomas
Study of 18FET PET in Functional Pituitary Adenomas With Indeterminate MRI Findings
Pituitary adenomas (PAs) are common benign tumors, but their potential for tumor aggression and hormone secretion make them serious tumors.
- Trial name
- FET-PIT (NCT07360548)
- Testing
- fluoroethyl-L tyrosine (18F)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Depression
Clinical and Objective Psychiatric Analyses in Severe Depression.
Participation in the CALYPSO project will be offered to all patients with severe depression hospitalized in the adult psychiatry department of Lille CHU.
- Trial name
- CALYPSO (NCT06095310)
- Testing
- New computer vision methods
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Lille
Bladder Hyperactivity, Sacral Neuromodulation
Evaluation of Autonomic Nervous System Changes in Response to Stimulation by Sacral Neuromodulation
Overactive bladder syndrome (OAB) is defined by urgent and frequent urges to urinate associated with frequent night-time urination and sometimes urinary incontinence.
- Trial name
- ESTIME (NCT06434831)
- Testing
- Medical device for SNM: Interstim X or Interstim micro
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Extubation, Postoperative Complications
Does Positive Pressure Extubation Reduce Postoperative Desaturation?
Single-center, prospective, controlled, parallel, randomized, single-blind study comparing the conventional extubation technique to two positive pressure extubation techniques on postoperative desaturations
- Conditions
- Extubation, Postoperative Complications, Lung Ultrasound Score
- Trial name
- EXTUBPOS (NCT05295095)
- Testing
- positive pressure during extubation procedure
- Where
- France
- Volunteers
- 264 people
- Sponsor
- University Hospital, Lille
Arthralgia
Evaluation of the Frequency of Occurrence of Joint Pain With Bevacizumab in Patients With Ovarian, Colorectal or Bronchopulmonary Cancer
Self-administered questionnaire survey to determine the presence or absence of joint pain during bevacizumab treatment for lung, ovarian, colorectal cancers.
- Trial name
- BEVARTHRALGIA2 (NCT03455907)
- Where
- 2 sites in France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Lille
Esophageal Atresia
National Register of Oesophageal Atresia
The esophageal atresia is a group of birth defects including a break in continuity of the esophagus with or without persistent communication with the trachea (tracheoesophageal fistula), sometimes associated (from 50%) of other…
- Trial name
- REGATE (NCT02883725)
- Testing
- data collection
- Where
- 37 sites in France, Guadeloupe and 1 more
- Volunteers
- 1,460 people
- Sponsor
- University Hospital, Lille
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Study of Predictive Factors of Progression of Motor Neurone Disease
Amyotrophic lateral sclerosis (ALS) is a complex polymorph and devastating neurodegenerative disease. Although the pathophysiological mechanisms underlying the development of ALS remain to be fully elucidated, there have been…
- Trial name
- PULSE (NCT02360891)
- Testing
- biomarkers (composite analysis)
- Where
- 13 sites in France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Systemic Sclerosis
Evaluation of Aesthetic Impact in Patients With Systemic Sclerosis
The primary objective is to assess the burden of aesthetic complication in systemic sclerosis. Systemic sclerosis is associated with changes in skin aspect which can impact the appearance.
- Trial name
- SCLERO-ESTHET (NCT03271320)
- Testing
- appearance scales
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Lille
Chronic Inflammatory Disease, Angioedema
Deployment o the Multidisciplinary Prospective Cohort Imminent
Immune-mediated inflammatory diseases (IMIDs) most often affect young patients and have high impact on morbidity and mortality with a significant alteration in the quality of life of patients with professional, social and…
- Conditions
- Chronic Inflammatory Disease, Angioedema, Severe Asthma, Lupus
- Trial name
- IMMINeNT (NCT04334031)
- Testing
- Biobanking with genetic analysis, SF-12 questionnaire
- Where
- France
- Volunteers
- 2,200 people
- Sponsor
- University Hospital, Lille
Paget Disease of the Vulva, Paget Disease, Extramammary
PAGETEX® Photodynamic Therapy Device for the Treatment of Extra Mammary Paget's Disease of the Vulva (EMPV).
Vulvar Paget's disease is a rare skin tumour which affect Caucasian post-menopausal women. The disease is revealed by erythematous, eczematous, pruritus and vulvar burns.
- Trial name
- PAGETEX (NCT03713203)
- Testing
- pagetex PDT
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Lille
Radiation Burn, Aortic Aneurysm, Abdominal
Evaluation of 3D Rotational Angiography After EVAR
This is a randomized prospective monocentric study to evaluate the benefits of a 3D rotational acquisition (3DRA) to assess technical success after treatment of infra-renal aneurysm with bifurcated endograft.
- Trial name
- EVAR (NCT02894749)
- Testing
- 3D rotational angiography (3DRA)
- Where
- France
- Volunteers
- 427 people
- Sponsor
- University Hospital, Lille
Angio Edema
Research of Biomarkers Associated With the Diagnosis and Severity of Bradykinin Angioedema
The unpredictable nature of the attacks is one of the essential characteristics of bradykinin angioedema. The two main difficulties for physicians managing a patient with bradykinin angioedema are to make the diagnosis and…
- Trial name
- BRADYDIAG (NCT04963634)
- Testing
- Biobanking
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Multiple Sclerosis
Phenotypic and Functional Study of 4BL B Cells in Multiple Sclerosis (MS)
Recent works highlight the B cells involvement in multiple sclerosis (MS) pathology but their role remains poorly understood. It was previously described that activated memory B cells called 4BL due to the increased expression of…
- Trial name
- 4BLMS (NCT03796611)
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Alzheimer Disease, Battery
Prediction of Cognitive Properties of Memantine for Neurodegenerative Diseases
The early assessment of new drugs for Alzheimer's disease remains difficult because of the lack of predictive end-point. The use of a battery including different parameters could improve this early development of new drugs.
- Trial name
- WP3_P002 (NCT02288000)
- Testing
- Memantine
- Where
- 3 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Systemic Sclerosis
Implementation of a Biological Sample Collection in Systemic Sclerosis Patients
Systemic sclerosis (SSc) is the most severe of the systemic autoimmune diseases. It is characterized by skin and organ fibrosis (mainly interstitial lung disease, which affects 40-50% of patients), as well as severe vascular…
- Trial name
- SCLERO-BIOBANK (NCT04986514)
- Testing
- Bio-banking without genetic analysis
- Sponsor
- University Hospital, Lille
Alzheimer's Disease, Frontotemporal Degeneration (Semantic & Behavioral Variants)
Social & Affective Cognition in Alzheimer's Disease & Associated Disorders
Recent studies have shown that individual neuropsychological scores of patients with Alzheimer's disease and Associated Disorders (ADAD) are only poorly correlated to their behavioral difficulties, such as disinhibition, apathy…
- Trial name
- SOCIALIZE (NCT06338397)
- Testing
- SCANN
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Parkinson Disease
Education for Adapted Physical Activity in Parkinson's Disease
Parkinson's disease is a progressive disorders characterized by motor and non-motor symptoms. Actual medical treatments are symptomatic and have little efficacy on late stage axial motor symptoms.
- Trial name
- ACTIF-PARK (NCT04340492)
- Testing
- Education to Adapted Physical Activity, Standard care
- Where
- France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Lille
Neonatal, Pain Measurement
Assessment of the NIPE in Very Premature Infant Ventilated and Sedated in Neonatal Reanimation.
The Newborn Infant Parasympathetic Evaluation (NIPE) was developed as a method of analysis of the heart rate variability. The monitor gives a value between 0 (low value of the parasympathetic component) and 100 (high value of the…
- Conditions
- Neonatal, Pain Measurement, Reanimation
- Trial name
- NIPEpréma (NCT05223790)
- Testing
- Pain measurement during care procedures in neonatal reanimation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille