Clinical trials: sponsored by University Hospital, Montpellier
Retinal Dystrophies
iPS Cells of Patients for Models of Retinal Dystrophies
The investigators are focused on inherited retinal dystrophies with an aim to further understand disease pathophysiology and to elaborate novel treatments, as, to date, there is no effective treatment to prevent blindness.
- Trial name
- RETIPS (NCT03853252)
- Testing
- Skin biopsy
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Hepatocellular Carcinoma, BCLC Stage B Hepatocellular Carcinoma
Liver Cancer and Immunotherapy in the Liquid Biopsy Era
The goal of this prospective clinical trial is to identify a predictive biomarker in patients with advanced HCC (stage B and C) using a combinatorial approach of the liquid biopsy.
- Conditions
- Hepatocellular Carcinoma, BCLC Stage B Hepatocellular Carcinoma, BCLC Stage C Hepatocellular Carcinoma, Immune Checkpoint Inhibitor
- Trial name
- LILIPSY (NCT05810402)
- Testing
- Liquid Biopsy
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Pancreatic Cancer Resectable, Pancreatic Ductal Adenocarcinoma
French Assessment of MRD by Liquid Biopsies in PDAC Patients (FRENCH.MRD.PDAC)
The overall objective of this GUIDE.MRD consortium is to confirm that ctDNA detected after curative intended treatment for PDAC is a marker of residual disease and for risk-of-recurrence, and applicable in clinical practice.
- Conditions
- Pancreatic Cancer Resectable, Pancreatic Ductal Adenocarcinoma, Minimal Residual Disease, Liquid Biopsy
- Trial name
- NCT06287749
- Testing
- Blood sample/Liquid Biopsy
- Where
- France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Montpellier
Non-Small Cell Lung Cancer
Tumor Associated Neutrophils as a Biomarker of Chemo-immunotherapy Response in Locally Advanced Non-small Cell Lung Cancer : a Model Based on Neoadjuvant Strategy
evaluate the predictive value of circulating neutrophil DNA methylation profiles, identified from the ALCINA 2 cohort, on pre-treatment blood samples (T0), for the histological response to neoadjuvant chemo-immunotherapy in…
- Trial name
- NEO-TAN (NCT06974097)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Montpellier
Acute Respiratory Failure (ARF), Non Invasive Ventilation (NIV)
Music Therapy During NIV Implantation in Pediatric Intensive Care Units
Non-invasive ventilation makes it possible to avoid intubation and improve patients' quality of life. However, pain is associated with discomfort and could lead to failure of this technique.
- Trial name
- MusiNIV (NCT06848218)
- Testing
- Music Therapy, Setting Up NIV
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Montpellier
Neuropathology, Cognitive Decline
Sleep Impairment in Subjects at Risk of Developing Alzheimer's Disease
Alzheimer's disease (AD) is characterised by a progressive loss of memory and cognitive function. In the early stages of AD, there is a progressive accumulation of molecules: β-amyloid peptides (Aβ) in the brain.
- Conditions
- Neuropathology, Cognitive Decline, Sleep Disorder
- Trial name
- WAVE-APOE4 (NCT05649514)
- Testing
- Polysomnography, Neuropsychological assessment, Questionnaires on sleep and behavioural problems
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Violence Against Children, Sexual Violence
How do Adults Sexual Offender Against Pre-pubescent Minors Perceive the Notion of Consent Based on the Account of Their Lived Experience ? (SOconsent)
In 2024, the police and gendarmerie recorded 12,260 victims of sexual violence, an increase of 7% compared with 2023. In 2019, 36,000 cases of sexual violence (rape or sexual assault) were handled by the public prosecutor's…
- Conditions
- Violence Against Children, Sexual Violence, Consent
- Trial name
- SOconsent (NCT07035717)
- Testing
- Patient interview
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Non-small Cell Lung Cancer
Complication and Lung Function Impairment Prediction Using Perfusion and CT Air Trapping
The primary objective of the CLIPPCAIR study is to construct and validate a new algorithm for predicting post-operative forced expiratory volume in 1 second (FEV1) values for lung resection candidates; this new model will be…
- Trial name
- CLIPPCAIR (NCT03885765)
- Testing
- Predictive data, Lung resection
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Montpellier
Prostate, Cancer
Synthetic Metabolic and Genetic Networks for Medical Diagnosics
This is a category 3 human study, prospective, comparative, in parallel groups. A comparative qualitative and quantitative analysis of several markers in 250 samples is proposed.
- Trial name
- SynBioDiag (NCT04518072)
- Testing
- Blood sample (1 EDTA tube, 1 SST tube, 1 Streck tube) and urine sample (100 ml)
- Where
- 2 sites in France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Montpellier
Severe Asthma, Allergy to House Dust Mites
Potency of HDM Sublingual AIT Tablets in Assuring the Persistency of Asthma Control in HDM Allergic Patients With Severe Asthma, Treated With Tezepelumab
The aim of this drug trial is to evaluate the annualized asthma exacerbation rate under treatment with Acarizax versus placebo. The trial is intended for adults aged 18 to 65 with severe uncontrolled asthma and a house dust mite…
- Trial name
- TEZEPAIT (NCT07013123)
- Testing
- Tezepelumab, Acarizax
- Volunteers
- 38 people
- Sponsor
- University Hospital, Montpellier
Post Thrombotic Syndrome, Venous Thromboses
Exercise Tolerance After Venous Recanalization for Post-thrombotic Syndrome
Post-thrombotic syndrome (PTS) is the most frequently observed chronic complication of deep vein thrombosis (DVT), with an estimated cumulative incidence of 20-50%.
- Conditions
- Post Thrombotic Syndrome, Venous Thromboses, Claudication, Intermittent
- Trial name
- ETERecaVSPT (NCT05794932)
- Testing
- Stress test
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Montpellier
Ovarian Cyst
Prognosis and Long Term Pubertal Outcome of Girls Previously Diagnosed With a Prenatal Ovarian Cyst
Puberty and long-term ovarian function of patients with a ovarian prenatal cyst has not described to date.
- Trial name
- KYSTOV (NCT02482467)
- Testing
- Hormonal analysis, pelvic US
- Where
- France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Fabry Disease, Nephropathy
Screening for Fabry Disease in Renal Transplantation
Single centre, prospective pilot study examining the relevance to screen for Fabry disease in a cohort of patients who have undergone renal transplantation for nephropathy of indeterminate cause, vascular nephropathy, diabetic…
- Trial name
- DEFYT (NCT03886714)
- Testing
- Screening for Fabry disease, Screen for α-galactosidase mutation
- Where
- France
- Volunteers
- 592 people
- Sponsor
- University Hospital, Montpellier
Diaphragm Dysfunction, Mechanical Ventilation
A Biobank for Diaphragm Muscular Fiber
This non-interventional study focuses on mechanical ventilation used in intensive care unit to supplement ventilatory function in patients.
- Trial name
- BOTAN (NCT02900300)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Montpellier
Fall Prevention, Falls (Accidents) in Old Age
Validation of the Self-Assessment for Falls in the Elderly (SAFE) Questionnaire to Assess the Risk of Falls in People Aged 60 or Over.
This single-centre, cross-sectional diagnostic study will determine whether the new self-completed Self-Assessment for Falls in the Elderly (SAFE) questionnaire can classify fall-risk level (low, moderate, high) in adults ≥ 60…
- Trial name
- SAFE (NCT06961812)
- Testing
- Questionnaire and Physical Exam, Safe Self-Administered Questionnaire
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Cholinergic Urticaria
Identification of Subpopulations of Patients With Cholinergic Urticaria Based on Infrared Exposure Test Results.
This study aims to identify subpopulations of patients with cholinergic urticaria based on their sensitivity to infrared (IR) radiation exposure.
- Trial name
- UCHOL (NCT06948188)
- Testing
- Infrared exposure test
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Cardiogenic Shock
Optimal ECMO Flow in the Critical Phase of Cardiogenic Shock to Optimize Peripheral Organ Perfusion and Myocardial Stress
Veno-arterial ECMO (VA ECMO) is considered the ultimate lifesaving technique in refractory cardiogenic shock (CS). However, VA ECMO is associated with potentially serious adverse effects and complications.
- Trial name
- ECMO-FLOW (NCT06936839)
- Testing
- Obversation
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Staphylococcus Aureus
Impact of 18 FDG PET/CT on the Management of Patients With Staphylococcus Aureus Bloodstream Infection
S. aureus bloodstream infection (SAB) is a severe disease associated with a 30% case-fatality rate at 12 weeks. Severity of this disease is related to the high prevalence of staphylococcal Deep Foci of Infection (SA-DFI), which…
- Trial name
- TEPSTAR (NCT03419221)
- Testing
- PET/CT Positron emission tomography (PET) using small radiotracers, a special camera and a computer to evaluate organ and tissue functions, Patients' routine care with performance of explorations based on anamnesis and clinical symptoms
- Where
- France
- Volunteers
- 291 people
- Sponsor
- University Hospital, Montpellier
Hippocampal Sclerosis, Dysembryoplastic Neuroepithelial Tumor
Exploration and Evaluation of Amygdalo-Hippocampectomy According to Prof. Coubes' Technique: An Anatomical, Clinical, and Educational Approach
The goal of this retrospective study is to evaluate the long-term clinical outcomes and complications associated with amygdalo-hippocampectomy using the surgical technique developed by Pr. Coubes (Montpellier, FRANCE).
- Conditions
- Hippocampal Sclerosis, Dysembryoplastic Neuroepithelial Tumor, Cortical Dysplasia, Ganglioglioma
- Trial name
- NCT06915649
- Testing
- Amygdalo-Hippocampectomy
- Where
- France
- Volunteers
- 3,504 people
- Sponsor
- University Hospital, Montpellier
Diabetes
Efficacy of Automated Insulin Therapy Early Initiated After Diagnosis on Blood Glucose Control in Children and Adolescents With Type 1 Diabetes
The main objective is to assess whether hybrid closed-loop (HCL) insulin delivery initiated early after diagnosis of Type 1 diabetes (T1D) allows a better efficacy on glucose control than conventional standard insulin therapy…
- Trial name
- APATDIAGNOSIS (NCT06283797)
- Testing
- OmniPod 5, Dexcom G6, PAID questionnaires
- Where
- 4 sites in France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Montpellier
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