Clinical trials: sponsored by University Hospital, Montpellier
Infertility
Sexual Intercourse and Vaginal Absorption of Progesterone
The objective of this project is to compare the vaginal absorption of progesterone administered in the vaginal ovum by measuring progesteroneemia in 3 situations (or "sexual event"): abstinence, sex protected by condoms and…
- Trial name
- SexVAP (NCT05232344)
- Testing
- Estradiol / Progesterone, Sexual event
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Myopathy, Phenotypic Abnormality
Improvement of DIAgnostic and Phenotype-genotype Correlation Studies in Patients With MYOpathy Suspected of TITinopathy
Due to the widespread use of NGS, TTN is emerging as a major causative gene in neuromuscular disorders, with high clinical heterogeneity.
- Conditions
- Myopathy, Phenotypic Abnormality, Genetic Disease
- Trial name
- DIAMYOTIT (NCT03998540)
- Testing
- Western blot, Protein interaction studies, Mass Spectometry
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Cystic Fibrosis in Children
Cardiopulmonary Fitness in Children With Cystic Fibrosis Compared to Healthy Children
Cystic fibrosis is the most common severe genetic disease with autosomal recessive transmission in the Caucasian population. Its prognosis has improved considerably since the creation of Cystic Fibrosis centers (CF centers) and…
- Trial name
- VOmuco (NCT06242951)
- Testing
- VO2 max assessment
- Where
- France
- Volunteers
- 345 people
- Sponsor
- University Hospital, Montpellier
Eating Disorders, Eating Disorder Binge
Conceptualisation of a Network Approach to Complete the Classification of Eating Disorders With the Aim of Better Personalising Their Management
Eating disorders (EDBs) are mental disorders with a great impact on the lives of individuals as well as a great cost imposed on society.
- Trial name
- CASCADE (NCT06252688)
- Testing
- Ambulatory cares in a day-hospital (Lapeyronie, Montpellier) specialized in the evaluation of eating disorders.
- Volunteers
- 840 people
- Sponsor
- University Hospital, Montpellier
Dystonia, Parkinson Disease
Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation
The study of the impact of music on emotional, motor and cognitive aspects remains recent. Music therapy has experienced a major boom over the last half century thanks to neuroradiological techniques for investigating the brain…
- Conditions
- Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- Music-QOL (NCT05214313)
- Testing
- Music Therapy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Acute Kidney Injury
Urinary Parameters to Predict Weaning of Renal Replacement Therapy in the Critically Ill
Data on the optimal period for RRT weaning in critically ill patient are scarce. The current practice for RRT weaning is based on urine output, the threshold of which is debatable.
- Trial name
- WeCAN (NCT06214390)
- Testing
- Single strategy, Combined strategy
- Where
- 2 sites in France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Montpellier
Sensorineural Hearing Loss
Immunity After Cochlear Implantation and Perilymph Molecular Profiles in Sensorineural Hearing Loss
Many patients receiving cochlear implant (CI) have some residual hearing prior to implantation surgery. However, approximately one third of them will lose it in next 6 months after cochlear implantation.
- Trial name
- PERILOTO (NCT05670158)
- Testing
- Blood sampling, Perilymph sampling
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
Study of the Functional Status Neutrophils in Rheumatoid Arthritis Patients to Identify New Biomarkers of Response to Anti-TNFalpha Therapy
The goal of this interventional pathophysiological exploratory, cohort, prospective, with a 6-month follow-up study is to characterize phenotypic and functional alterations of PolyMorphonuclear Neutrophils as well as…
- Trial name
- NeutroARTherap (NCT05802719)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Non-ST Elevated Myocardial Infarction
Low Risk Non ST Elevation Myocardial Infarction With or Without Intensive Care Unit Admission
Favourable in-hospital outcome is observed in numerous patients after Non ST myocardial infarction (NSTEMI) with invasive strategy but European guidelines proposed systematic intensive care unit monitoring up to 24 h in lower…
- Trial name
- SELECTNSTEMI (NCT05153889)
- Testing
- Hospitalized in Intensive care unit, Hospitalized in General cardiology ward
- Where
- 3 sites in France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Montpellier
Coronary Syndrome, Hemodynamic Instability
5 Years Follow up of the SAPIEN 3 Valve From the DIRECTAVI Trial
A strategy of Transcatheter Aortic Valve Replacement (TAVR) without balloon predilatation has shown to be feasible in routine in observational studies and in two recent randomized trial including the DIRECTAVI trial.
- Trial name
- DIRECTAVILONG (NCT05140317)
- Testing
- Transcatheter heart valve implantation with or withour predilatatation
- Where
- France
- Volunteers
- 236 people
- Sponsor
- University Hospital, Montpellier
Chronic Heart Failure
Interval Training in Heart Failure
Heart failure (HF) is currently considered a common pathology, with 15 million adults in Europe and 26 million worldwide. The American Heart Association (AHA) estimates that their number will increase by 25% by 2030.
- Trial name
- PROVO2MAX (NCT03955029)
- Testing
- Progressive Interval training, Conventional Interval training
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Somnolence Disorder, Excessive
Constitution of a Clinical, Neurophysiological and Biological Cohort for Chronic Sleep Disorders Responsible of Hypersomnolence
Chronic sleep disorders result from multiple pathophysiological mechanisms and are often associated with severe hypersomnolence, responsible for major disability.
- Trial name
- Somnobank (NCT03998020)
- Testing
- scale of severity, blood sample
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Montpellier
Sexual Assault
Detection of Saliva by Immunoaffinity and Mass Spectrometry
The identification of saliva in genital area during a criminal investigation can be a critical component in the prosecution of a sexual assault in France, as non-consensual oral-genital intercourses have been considered as crimes…
- Trial name
- SIMS (NCT06183385)
- Testing
- Saliva collection, Vaginal secretion collection, IP-LC-MS/MS : immunoprecipitation enrichment with liquid chromatography coupled to tandem mass spectrometry
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Chronic Spotaneous Urticaria, Idiopathic Non Histaminergic Angioderma, Hereditary Angioedema With C1 Inhibitor Deficiency
The Role of the Coagulation Pathways in Recurrent Angioedema
Previous studies reported infraclinical modifications of the homeostasis in chronic urticaria, recurrent idiopathic angioedema and hereditary angioedema.
- Trial name
- Angiocoag (NCT02892682)
- Testing
- BLOOD TEST
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Montpellier
Female, Borderline Personality Disorder
Reactivity of Patients With Borderline Personality Disorder to an Ecological Interpersonal Stress
Use lay language. According to the World Health Organization 1 death by suicide occurs every 40 seconds, leading suicide prevention to one of the public health priority.
- Trial name
- ROI (NCT03602521)
- Testing
- Interpersonal stress
- Where
- France
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Carcinomatous Resections, Violent Trauma
Evaluation of the PICO® Negative Pressure Dressing System on the Fibula Free Flap Donor Site's Skin Graft.
A fibula free flap can be used for the reconstruction of a mandible or a maxillar when the lack of bonne exceeds 3cm. This flap is made of the fibula bone, some muscle around, the fibular vascular pedicle and a skin paddle to…
- Trial name
- PICOFLAP (NCT04628416)
- Testing
- PICO dressing, Conventional dressing
- Where
- France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Montpellier
Suicide, Depression
Inflammation and Blood Brain Barrier Integrity as Biomarkers of Suicidal Behavior
Recent studies have revealed an association between history of suicide attempt and inflammatory markers in both the cerebrospinal fluid and the plasma.
- Trial name
- IBBBiS (NCT06047613)
- Testing
- Blood samples, Hetero-questionnaires and auto-questionnaires, Magnetic Resonance Imaging (MRI)
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Infant, Newborn, Diseases, Congenital Malformations
Fast Exome for Diagnosis of Congenital Conditions in Infants Under 12 Months of Age Hospitalized in Intensive Care Unit
An early diagnosis of congenital malformations and suspected genetic conditions in critically ill infants is essential to perform specific adapted care, prevention, and give proper genetic counseling.
- Conditions
- Infant, Newborn, Diseases, Congenital Malformations, Intensive Care Unit, Neurologic Symptoms
- Trial name
- REUNIR (NCT03831035)
- Testing
- Genetic analyse by whole exome sequencing
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Autism Spectrum Disorder
Intelligent Robotic Interactions for Children With Autism Spectrum Disorders
For several years, studies have been developed on the contribution of social robots as a tool for interventions for children with autism spectrum disorders (ASD).
- Trial name
- I-ROBI (NCT05991791)
- Testing
- Early Start Denver Model (ESDM)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Montpellier
Obesity, Anxiety
Clusters in Obesity: Intuitive Eating and Mental Health Key for Personalisation
Objective: To determine clusters among weight-loss-seeking individuals for personalised obesity management and find questionnaires to help identify those who could benefit from psychological support.
- Conditions
- Obesity, Anxiety, Stress
- Trial name
- NCT06125600
- Testing
- Clustering of people living with obesity using behavioural questionnaires
- Where
- France
- Volunteers
- 989 people
- Sponsor
- University Hospital, Montpellier
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