Clinical trials: sponsored by University Hospital, Montpellier
Depression
Inflammatory Biomarkers and Brain Metabolites, a Study Based on Magnetic Resonance Spectroscopy
Suicidal behaviors (SB) are a major health problem in France : 10 000 suicides and 220 000 suicide attempts every year. SB management is therefore a major public health issue.
- Trial name
- BICS (NCT03052855)
- Testing
- Magnetic Resonance Imaging (MRI) and biological samples
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Pneumonia, Viral, SARS-Cov-2
Biomarkers for Dexamethasone Response in Sars-Cov-2 / COVID-19 Pneumonia
The primary objective of this study is to demonstrate (at the time of admission) biomarkers of interest (Human Plasma BAK125 panel + interferon panel) for dexamethasone responders versus non-responders in SARS-CoV-2 hypoxemic…
- Trial name
- CortiCORONA (NCT04619693)
- Where
- 2 sites in France
- Volunteers
- 79 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes Mellitus in Prepubertal Children
Efficacy of Closed-loop Insulin Therapy in Prepubertal Child in Free-life
The study is a randomized trial preceded by a run-in period and followed by a non-randomized study extension. After 3 weeks of outpatient use of study pump (1 week) and study pump+CGM (2weeks) as run-in period, patient and…
- Trial name
- FREELIFE-KID (NCT03739099)
- Testing
- Closed-loop insulin infusion driven by continuous glucose monitoring through an algorithm, in free-life conditions
- Where
- France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Montpellier
Coronavirus Infection, Pneumonia, Viral
Hydroxychloroquine Plus Azithromycin Versus Hydroxychloroquine for COVID-19 Pneumonia (COVIDOC Trial)
Double blinded randomized clinical trial designed to evaluate the efficacy and safety of hydroxychloroquine combined with azithromycin compared to hydroxychloroquine monotherapy in patients hospitalized with confirmed COVID-19…
- Trial name
- COVIDOC (NCT04345861)
- Testing
- hydroxychloroquine + azithromycin
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes Mellitus With Hypoglycemia
Efficacy of Closed-loop Insulin Therapy in Adults Prone to Hypoglycemia
This study is a RCT of 3 month at home comparing closed-loop control (CLC) system vs sensor and pump therapy (S\&P), with a 3-month extension phase, in Type 1 diabetic patient prone to hypoglycemia.
- Trial name
- DCLP2 (NCT04266379)
- Testing
- Closed-loop insulin infusion driven by continuous glucose monitoring through an algorithm, in free-life conditions, Continuous Subcutaneous Insulin Infusion and Continuous Glucose Monitoring
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Montpellier
Active Tuberculosis
Serological Test for the Diagnosis of TB
TB remains a health problem in France with about 5,000 new cases per year. Development of new screening tests is a priority for TB.
- Trial name
- MycoTB (NCT02898623)
- Testing
- No intervention
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Montpellier
Breast Cancer
Genotype and Phenotype in Early Onset Breast Cancer in Young Women on the Two Shores of the Mediterranean Sea
Breast cancer are common on mediterranean basin. Epidemiological data suggest that breast cancer in young women (< 40years old) is more aggressive in the Maghreb countries comparatively to western countries.
- Trial name
- MediSein (NCT02541188)
- Testing
- Genetic analysis
- Where
- France
- Volunteers
- 460 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes, Basal-bolus Multiple-dily Insulin Injections
Self-management of Type 1 Diabetes Under Functional Insulin Therapy
Therapeutic education of patients is a mandatory component of intensive insulin therapy of type 1 diabetes in order to reach optimal safety and efficacy.
- Conditions
- Type 1 Diabetes, Basal-bolus Multiple-dily Insulin Injections, Insulin Pump (CSII)
- Trial name
- EVAUTODIAB (NCT02272348)
- Testing
- Training course to functional insulin therapy, Usual diabetes management.
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Montpellier
Pressure Ulcer, Bedsore
Correlation Between Pressure Differences and Micro-vascularization Changes in Bedridden Paraplegic Patient
Paraplegic patients have defective wound healing for sore below the level of spinal lesion. Defect of vascularization of the healing zone certainly participate to this effect.
- Conditions
- Pressure Ulcer, Bedsore, Spinal Cord Injury, Paraplegia
- Trial name
- VASCIP (NCT03114345)
- Testing
- Measurement of interface pressure, Measurement of micro-vascularization related parameters
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Montpellier
Type1diabetes
Can Continuous Glucose Measurements Help Diabetic Patients Treated With an Implantated Pump?
During this study, we propose to assess the utility of Continuous Glucose Measurements (CGM) in a group of Type 1 diabetic patients treated with an implanted insulin pump.
- Trial name
- CGMIP (NCT03048227)
- Testing
- Continuous Glucose Measurement (CGM)
- Where
- 10 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes
Study the Feasibility of Permanent Use of inControl for the Treatment of Type 1 Diabetes
A new version of the DiAs artificial pancreas (AP) system has been developed in view of wide scale outpatient trials. Denominated as inControl , it includes improved user interface and communication modules while closed-loop…
- Trial name
- IDCLTraining (NCT02892604)
- Testing
- insulin pump to inControl AP platform
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Montpellier
Obesity
Reduction of Emotional Eating After a Behavior Change Program in Obesity
Recent studies show that overweight people have a greater sensitivity to the rewarding aspect of food due to the disturbance of the dopaminergic system.
- Trial name
- NCT01997697
- Testing
- behavior change program
- Where
- France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Montpellier
Personal History of a Recent Suicidal Crisis, Suicidal Ideation
SmartCriseS - Smartphone Survey of Suicidal Risk
Sleep and appetite disorders as well as social exclusion, have been linked to the emergence of suicidal ideation (SI) and suicide attempts.This study aims to evaluate the relationship between those factors and suicidal ideation…
- Conditions
- Personal History of a Recent Suicidal Crisis, Suicidal Ideation, Suicidal Behaviour
- Trial name
- SmartCriseS (NCT03720730)
- Testing
- EMA
- Where
- 2 sites in France, Spain
- Volunteers
- 1,044 people
- Sponsor
- University Hospital, Montpellier
Aging
Effect of Ageing on Airway Remodeling
The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.
- Trial name
- NCT01230879
- Testing
- EFR and TDM
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Attention Deficit Disorder
Effectiveness of a Therapeutic Education Program in Improving Quality of Life of Children With ADHD and Their Parents
Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by attention deficit, impulsivity and hyperactivity. It's one of the most frequently encoutered disorder in child psychiatry.
- Trial name
- NCT05133284
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Montpellier
Lymphoma, B-Cell
Characterisation of TIM-3/Gal-9 Immune Checkpoints in Primary Central Nervous System Diffuse Large B Cell Lymphomas
Primary central nervous system diffuse large B cell lymphoma is a rare and aggressive entity of diffuse large B cell lymphoma. A previous transcriptomic study showed an overexpression of TIM-3 and Gal-9 in the tumor…
- Trial name
- NCT05133505
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Montpellier
Essential Tremor
Essential Tremor in Children and Adolescent
Essential tremor (TE) is the most common abnormal movement of the adult. His diagnosis is based on a bundle of clinical arguments (Movement Disorders Society, 1998).
- Trial name
- NCT03487705
- Testing
- electromyographic essential tremor
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Montpellier
Robertsonian Translocation
Management of Robertsonian Translocation PGT-SR Attempts
to analyze if a probe strategy choice for PGT-SR studies of Robertsonian translocations (RT) influences the fate of embryos? Few studies discussed the importance of probe choices.
- Trial name
- NCT05109962
- Where
- France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Montpellier
CTLA4 Haploinsufficiency
Neurologic and Immunologic Characteristics of CTLA-4 and LRBA Hereditary Deficiency
CTLA4 and LRBA deficiencies are rare genetic disorders, recently described, and associated with multiple clinical features. It ranges from recurrent infections, auto-immunity, and organ infiltration with lymphocytes.
- Trial name
- NCT05040256
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Colic, Nephropathy
Neonatal Outcome of Children With Antenatal Colic Hyperechogenicity
Fetal colic hyper-echogenicity is a presenting symptoms for cystinuria lysinuria. A few cases of fetuses with dibasic protein intolerance (more complex prognosis) presented with colic hyper-echogenicity antenatal.
- Trial name
- COLONECHOGENE (NCT04983069)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Montpellier
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