Clinical trials: sponsored by University Hospital, Montpellier
Eustachian Tube Disorder
Long Term Evaluation of Tubal Expansion on Obstructive Dysfunctions of Eustachian Tube
The study aim is to evaluate the tubal score on patients who suffer from obstructive dysfunction of eustachian tube before and after the eustachian tube dilatation.
- Trial name
- NCT02123277
- Testing
- Balloon catheter for the Eustachian tube
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Montpellier
Acute Abdominal Pain, Pelvic Pain
MRI as an Alternative to CT for Exploration of Acute Abdominal Pain in Young Women
Objective : To demonstrate diagnostic performances of Magnetic Resonance Imaging (MRI) as compared to Computed Tomography (CT) as a second intention imaging modality in young women with acute non traumatic abdominopelvic pain and…
- Trial name
- IRMADA (NCT03281031)
- Testing
- Additional MRI Examination
- Where
- France
- Volunteers
- 149 people
- Sponsor
- University Hospital, Montpellier
Metabolic Acidosis
Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill
The purpose of the present study is to compare the adjunct treatment of metabolic or mixed severe acidosis in the critically ill using Sodium Bicarbonate as a buffer to increase the plasma pH vs no buffering therapy.
- Trial name
- (BICAR-ICU) (NCT02476253)
- Testing
- Sodium Bicarbonate
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Montpellier
Intubation Complication, Critically Ill
Effect of Endotracheal Tube Plus STYLET Versus Endotracheal Tube Alone
Patients admitted to Intensive Care Units (ICU) often require respiratory support. Orotracheal intubation is one of the most frequent procedures performed in ICU.When performed in emergency settings, intubation is a challenging…
- Trial name
- STYLETO (NCT04079387)
- Testing
- ENDOTRACHEAL TUBE + STYLET, ENDOTRACHEAL TUBE ALONE
- Where
- France
- Volunteers
- 1,040 people
- Sponsor
- University Hospital, Montpellier
Bronchiolitis
Comparison Between 2l vs 3l in HFNC During the Initial Management of Severe Bronchiolitis in Infants
The purpose of the study is to evaluate prospectively the clinical benefits of 2 different flow with High flow nasal canula (HFNC: 2l/kg/min) versus (HFNC: 2l/kg/min) in the initial management of bronchiolitis in infants.
- Trial name
- TRAMONTANE2 (NCT02824744)
- Testing
- treatment by 2l/min/kg in High Flow Nasal cannula (HFNC), treatment by 3l/min/kg in High Flow Nasal cannula (HFNC)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Asthma
CT Air-trapping for the Early Identification of Benralizumab Responders Among Eosinophilic Asthma Patients
BenraliScan aims to obtain thoracic computed tomography imaging data to predict the future level of patient response to a monoclonal antibody.
- Trial name
- BenraliScan (NCT03976310)
- Testing
- 48 weeks of Benralizumab, Computed tomography
- Where
- 2 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Montpellier
Patients With Anorexia Nervosa
Bone Loss in Patients With Anorexia Nervosa
Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term…
- Trial name
- NCT01907464
- Testing
- clinical parameters description, para clinical parameters description, hormonal parameters dosing
- Where
- France
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Heart Failure, Diastolic Heart Failure
ST2 for the Management of Heart Failure - STADE-HF
Heart failure (HF) is a severe disease, burdened with a poor prognosis (30% mortality at 2 years, 30% of rehospitalization within 1 month).
- Conditions
- Heart Failure, Diastolic Heart Failure, Systolic Heart Failure Stage C
- Trial name
- STADE-HF (NCT02963272)
- Testing
- Conventional strategy, ST2-guided strategy
- Where
- France
- Volunteers
- 123 people
- Sponsor
- University Hospital, Montpellier
COPD Exacerbation
Eosinophil-driven Corticotherapy for Patients Hospitalized for COPD Exacerbation
The primary objective of this study is to compare treatment failure rates between a group of eosinophilic (eosinophilia > 2% on day 1 of hospitalization) patients hospitalised for a COPD exacerbation treated via corticotherapy…
- Trial name
- eo-Drive (NCT04234360)
- Testing
- 5 days of systemic corticotherapy (prednisone)
- Where
- 18 sites in France
- Volunteers
- 182 people
- Sponsor
- University Hospital, Montpellier
Chronic Inflammatory Rheumatism
COVID-19 in Rheumatic Inflammatory Diseases Under Immuno-suppressive Drugs
Accurate knowledge of the humoral immune responses induced by SARS-CoV-2 in patients undergoing immunosuppressive therapy is essential to guide recommendations for infected patients and for vaccination policy for uninfected…
- Trial name
- COVIDRIC-2 (NCT04530682)
- Testing
- Biological samples
- Where
- France
- Volunteers
- 163 people
- Sponsor
- University Hospital, Montpellier
Monogenic Diseases
NIPD of CFTC by WGA Coupled to Mini-exome Sequencing
The purprose of this study is to develop a single test based on circulating fetal trophoblastic cells (CFTC) analysis from maternal blood, searching for the familial mutation for a wide range of monogenic diseases.
- Trial name
- DIAFEXOME (NCT03743948)
- Testing
- Non invasive prenatal diagnosis
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
SARS-CoV-2
Evaluation of Quickly Diagnostic Saliva Tests for SARS-CoV-2
Coronavirus disease 2019 or COVID-19 is a highly contagious infectious disease. Symptoms of the disease are non-specific (fever, cough, dyspnea and fatigue), common with many seasonal viruses, which complicates the diagnosis.
- Trial name
- EasyCoV (NCT04337424)
- Testing
- Sampling salivary
- Where
- France
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Acute Coronary Syndrome, Continuous Glucose Measurement
Predictive Value of Glycemic Parameters Measured With the FSL Pro iQ During ACS
Disorders of glycemic regulation are common in patients hospitalized for acute coronary syndrome (ACS). Abnormal glycaemia is observed in 50% of cases, in 30-40% diabetes, and in 25-35% fasting hyperglycaemia or glucose…
- Conditions
- Acute Coronary Syndrome, Continuous Glucose Measurement, Glycemic Variability, Cardiovascular Event
- Trial name
- FREESCA (NCT06014112)
- Testing
- Freestyle Libre Pro iQ
- Where
- 9 sites in France
- Volunteers
- 850 people
- Sponsor
- University Hospital, Montpellier
Undergoing Nonemergent Cardiac Surgery, Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure)
SvO2 Trigger in Transfusion Strategy After Cardiac Surgery
Current international guidelines suggest a restrictive transfusion strategy, setting that Hb level at 7 g/dl is a reasonable threshold.
- Conditions
- Undergoing Nonemergent Cardiac Surgery, Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure), Anemia (<9g/dL) Requiring Blood Transfusion, Hemodynamic and Respiratory Stability
- Trial name
- ReTSEACS (NCT02761564)
- Testing
- Red blood cell tranfusion, ScvO2 measure
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Myocardial Infarction, Acute
COLchicine to Prevent Sympathetic Denervation After an Acute Myocardial Infarction
This study evaluates the benefit of colchicine on induced denervation after myocardial infarction. Patients who have suffered a documented De Novo myocardial infarction and completed a revascularization procedure will receive…
- Trial name
- COLD-MI (NCT04420624)
- Testing
- Colchicine
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Montpellier
Low Back Pain
Pilot Study of Vagal Stimulation in Chronic Low Back Pain
Low back pain is a major public health problem. It is the leading cause of disability in the world. The factors that lead to chronicity of low back pain are multi-factorial and are essentially represented by psychosocial factors…
- Trial name
- VALOM (NCT05639270)
- Testing
- use of an auricular electrode
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Drug Hypersensitivity
Drug Provocation Test (DPT) to Paracetamol
Background : Paracetamol (acetaminophen) drug hypersensitivity reactions (DHR) are oonfirmed in about 10% of alleged cases. The diagnosis is made via an empirical drug provocation test (DPT).
- Trial name
- Paracetamol (NCT03771118)
- Where
- France
- Volunteers
- 498 people
- Sponsor
- University Hospital, Montpellier
Cystic Fibrosis
Small Circulating RNA as Molecular Markers of Lung Disease in Cystic Fibrosis
The aim of our study is to assess miRNAs expression profiles in the circuling blood of patients with cystic fibrosis and highlight "signatures" that could reflect the pulmonary status of patients
- Trial name
- MIRDIAMUCO (NCT02992080)
- Testing
- miRNAs isolation from blood samples of patients and control
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Peripheral Muscle Dysfunction, COPD
Muscle Training Induced Angiogenesis in COPD
COPD patients experiment a peripheral muscle dysfunction which impact their exercise tolerance and health-related quality of life. The capillary to fiber interface is reduced and impact the exercise capacity of the patients.
- Trial name
- COPDµvasc (NCT02040363)
- Testing
- Muscular biopsy, 5-10 weeks sport training
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Resident of Languedoc-roussillon, Carrying a Chronic Wound
Medico-economic Evaluation of a Project of Wounds by a Remote Network
Estimate in 6 months the impact of the telemedicine on the cure rate of the chronic wounds compared with the usual care(with or without CICAT-LR Network).
- Trial name
- DOMOPLAIES (NCT02545374)
- Testing
- Telemedicine, Control
- Where
- France
- Volunteers
- 193 people
- Sponsor
- University Hospital, Montpellier
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