Clinical trials: sponsored by University Hospital, Tours
Healthy Volunteer
Neurophysiological Study of Sensory and Cognitive Processes in Healthy Children and Adults
It is now widely accepted that autism is linked to a developmental disorder and cerebral function. Our research team (UMR U930 INSERM, François-Rabelais University of Tours, whom Pr F Bonnet-Brilhault is responsible for team…
- Trial name
- PROSCEA (NCT03182400)
- Testing
- Neurophysiological assessment, Neuropsychological assessment
- Where
- France
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Alzheimer Disease, Benson's Disease
Tau Brain Imaging in Typical and Atypical Alzheimer's Disease (AD)
Recently revised Alzheimer Disease (AD) diagnostic1described nonamnestic presentations: 1/ language presentation (logopenic progressive aphasia) 2/ visuospatial presentation (posterior cortical atrophy or PCA) and 3/ executive…
- Trial name
- TEPTAU (NCT03022968)
- Testing
- [18F]T807 PET
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Cognitive Disorders, Motor Disorders
Evaluation of Cognitive and Motor Neurological Disorders in the Short and Long Term After Surgery for the Removal of a Diffuse Low-grade Glioma of the Supplementary Motor Area
Background : The supplementary motor area is the most common/preferential brain location of LGG. This area plays an important role in many motor and cognitive functions such as motor initiation, bimanual coordination and…
- Conditions
- Cognitive Disorders, Motor Disorders, Low-grade Glioma
- Trial name
- POG-C (NCT05373394)
- Testing
- Test battery
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Tours
Healthy Volunteers
Brain Changes in EEG and Brain Pulsatility to Novel Stimuli (Electro-PulCe)
The oddball paradigm is one of the most widely used methods of brain exploration for the study of attentional processes. It allows the measurement, by means of an Electro-Enchephalogram (EEG), of evoked potentials reflecting the…
- Trial name
- Electro-Pulce (NCT04702919)
- Testing
- Registration, Auditive oddball task
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Post-Op Complication, Otologic Disease
Interest of Wicking for Ossicular Surgery and Myringoplasty
Myringoplasties and ossicular surgery are very common procedures. Following these otological surgeries, most surgeons install a wicking.
- Trial name
- MECH-ORL (NCT05269368)
- Testing
- Wicking, No wicking
- Where
- 6 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Cystic Fibrosis, Innate Immunity
Implication of UNconventionaL T Lymphocytes in Cystic Fibrosis (UNLOCk)
Cystic fibrosis (CF) is characterized by a decrease in mucociliary clearance, recurrent infections and airway inflammation. This inflammatory process in airway mucosa is persistent, uncontrolled, but, somewhat paradoxically…
- Conditions
- Cystic Fibrosis, Innate Immunity, Inflammatory Response
- Trial name
- UNLOCk (NCT03886350)
- Testing
- blood and sputum samples
- Where
- 2 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Tours
Psoriasis
Utility of Squamous Cell Carcinoma Antigen (SCCA) in Psoriasis
Squamous Cell Carcinoma Antigen (SCCA) contributes to the pathogenesis of psoriasis by inhibiting cell apoptosis, exacerbating epidermal hyperplasia and skin inflammation.
- Trial name
- SCCAPSO (NCT04308616)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Tours
Autism Spectrum Disorder
Intestinal Microbiota, Tryptophan and Autism
Autism Spectrum Disorder refers to complex neuro-developmental disorders that affect social communication and behavioral adaptation.
- Trial name
- MTA (NCT03751930)
- Testing
- Samples
- Where
- 2 sites in France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Cystic Fibrosis
RhDNase and Biodistribution of PMN Serine Proteases in Cystic Fibrosis Sputum
Serine proteases belonging to the elastase family are mainly responsible for lung tissue destruction as observed during cystic fibrosis.
- Trial name
- BioDNase (NCT00843817)
- Testing
- Pulmozyme
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Tours
Mucopolysaccharidoses
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis
Mucopolysaccharidosis (MPS) are a group of inherited, metabolic diseases caused by a deficiency of lysosomal enzymes that degrade glycosaminoglycans (GAGs).
- Trial name
- RespiGAG (NCT04112602)
- Testing
- Sputum, Tracheal aspiration
- Where
- 7 sites in France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Tours
Rheumatoid Arthritis, Gout
Effect of a New BI-specifiC Antibody Towards Dendritic Cells on Inflammation in Rheumatoid Arthritis
First, this study will evaluate, in vitro, the cellular composition of the synovial fluid from patient with rheumatoid arthritis, gout or osteoarthritis.
- Conditions
- Rheumatoid Arthritis, Gout, Osteoarthritis
- Trial name
- BIC_RA (NCT03416543)
- Testing
- Puncture
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Tours
Neuromuscular Diseases in Infants, Neuromuscular Diseases in Children
Study of the Correlation Between Muscle Oxygenation and Motor Function in Children With Neuromuscular Disease.
Preliminary data underline the fact that muscular deoxygenation during training happens earlier in adult patients suffering from neuromuscular disorders in comparison to controls. Up to date, pediatric data are lacking.
- Trial name
- OXMNM (NCT03471676)
- Testing
- Muscular oximetry
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Tours
Idiopathic Pulmonary Fibrosis
Impulse Oscillometry for Prognostication in Idiopathic Pulmonary Fibrosis
A 5-point decline of forced vital capacity expressed as % predicted, over 6 months, is the current definition of disease progression (fast decline in lung function) in idiopathic pulmonary fibrosis.
- Trial name
- OSCILLO (NCT03898284)
- Testing
- Impulse Oscillometry
- Where
- 4 sites in France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Tours
Left Bundle Branch Area Pacing
Cardiac ResynchronizatiOn and arrhythmiaS Sensing Via the LEFT Bundle.
Evaluation of ventricular arrhythmias sensing via a left bundle branch area pacing lead.
- Trial name
- CROSS LEFT (NCT05102227)
- Testing
- Left bundle branch area pacing
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Tours
Cervical Cancer Screening, Cervical Cancer
Evaluation of Three Strategies Based on Vaginal Self-sampling Kit Send to Home of Unscreened Women for Cervical Cancer
Despite the existence of an effective screening test (pap smear), cervical cancer is, every year in France, the cause of more than 3,000 new cases and 1,100 deaths.
- Trial name
- APACHE-4 (NCT03856684)
- Testing
- Self-sampling kit sent at home, Self-sampling kit sent at home + SMS reminder, Letter offering a self-sampling kit "on request"+ SMS reminder
- Where
- France
- Volunteers
- 10,400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Critical Care
Montreal Toulouse Test With Eye Tracking in Intensive Care Unit to Evaluate Comprehension
Assessment of the level of oral comprehension of the intensive care patient is essential to improve their care because they have often troubles like delirium.
- Trial name
- MEXICO (NCT05078632)
- Testing
- Montreal-Toulouse Test adapted in eye tracking
- Where
- France
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Idiopathic Pulmonary Fibrosis
ThOracic Ultrasound in Idiopathic Pulmonary Fibrosis Evolution
Idiopathic pulmonary fibrosis (IPF) is one of the most common chronic idiopathic fibrotic interstitial lung disease (ILD). IPF is an evolving disease that requires regular follow-up through clinical examination, respiratory…
- Trial name
- TOUPIE (NCT03944928)
- Testing
- Lung ultrasound
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Primary Burning Mouth Syndrome
Identification of Pathophysiological Pathways and Therapeutic Targets in Primary Stomatodynia by Salivary Metabolomics
Burning mouth syndrome (BMS) is defined by a chronic oral pain affecting especially postmenopausal women. Its physiopathology is still unknown and several hypotheses have been put forward to explain this syndrome, such as…
- Trial name
- SESAME (NCT04704128)
- Testing
- Salivic sample
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Adhd
Identification of Biomarkers of Attention Deficit Disorder With or Without Hyperactivity (ADHD) by a Metabolomic Approach in Children
Attention-deficit with or without hyperactivity disorder (ADHD) is a real health public concern. No easy-use diagnosis tool are available.
- Trial name
- METHADA (NCT03436017)
- Testing
- Metabolomic approach
- Where
- France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Tours
Respiratory Rehabilitation, Pulmonary Rehabilitation
Association of Psycho-social Traits for the Benefit of a First Respiratory Rehabilitation Course - Exploratory Study.
Respiratory Rehabilitation (RR) is based on a comprehensive multidisciplinary program of personalized and tailored care for patients with chronic respiratory diseases.
- Trial name
- RESPIRSO (NCT04279002)
- Testing
- Brief 15-question questionnaire
- Where
- France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Tours