Clinical trials: sponsored by University Hospital, Tours
Cystic Fibrosis
Biodistribution of Neutrophile Proteases in the Sputum of Patients Affected by Cystic Fibrosis
The purpose of the proposed project is to characterize the neutrophile proteases which participate in the chronic inflammatory phenomenon associated with the cystic fibrosis and which are responsible for the degradation of the…
- Trial name
- Pro-Muco (NCT00750932)
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Autism
Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism
Neurophysiological, Molecular and Developmental Analysis of the glutamate synapse in Autism
- Trial name
- NMDA-Autism (NCT01770548)
- Testing
- analysis of the glutamate synapse in autism, DNA collection, Auditory evoked potentials
- Where
- 4 sites in France
- Volunteers
- 497 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Developmental Dyslexia
Morphofunctional Imaging and Developmental Dyslexia
Developmental dyslexia is a frequent learning disability. The aim of this study is to analyze cortical thickness and phonological treatment in right handed adults with developmental dyslexia.
- Trial name
- PHR04-CH/DYS (NCT00254644)
- Testing
- Morphological and functional MRI
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Acute Lung Injury
Recruitment Maneuvers in ARDS: Effects on Respiratory Function and Inflammatory Markers.
Acute Respiratory Distress Syndrom is associated to lung and systemic inflammation, which could be worsened by mechanical ventilation.This included a proteasis - antiproteasis imbalance which could participate to a fibrosis…
- Trial name
- NCT00263146
- Testing
- recruitment maneuver
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
PKU, Hyperphenylalaninemia
Antioxidant Signature in Adult Patients With Phenylketonuria
To date, oxidative stress in PKU has been evaluated only with fragmented approaches.The aim of the present study is to investigate oxidative stress in PKU with more comprehensive methods.The relationship between oxidative stress…
- Trial name
- StressOX-PCU (NCT02212288)
- Testing
- Blood sample, Urine sample
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Ankylosing Spondylitis
Infliximab and Methotrexate in Ankylosing Spondylitis
There is a great individual variability of pharmacokinetic of infliximab in patients treated for ankylosing spondylitis (AS). Moreover, some patients have a treatment with methotrexate (MTX), others have not.
- Trial name
- SPAXIM (NCT00507403)
- Testing
- infliximab
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Validate the French Version of GMS Package
Validation of the French Version of the Geriatric Mental State (GMS)
A major public health issues of today's aging population is the development of knowledge and expertise in geriatric medicine and psychiatry of the elderly.
- Trial name
- GMS-Package (NCT01061827)
- Where
- 2 sites in France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Tours
Metastatic Colorectal Cancer
Evaluation of Contrast-enhanced Ultrasound Imaging for the Early Estimate of Bevacizumab Effect on Colorectal Cancer Liver Metastases
Bevacizumab, an anti-angiogenic agent, plus fluorouracil based chemotherapy is considered a new standard for the treatment of metastatic colorectal cancer.
- Trial name
- NCT00489697
- Testing
- real-time contrast-enhanced ultrasound imaging (CEUS)
- Where
- 12 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Tours
Severe Chronic Obstructive Pulmonary Disease
Evaluation of Benefit of Nebulized Bronchodilators at Home in Severe Chronic Obstructive Pulmonary Disease and Very Severe Steady State
Design studies of nebulization in COPD does not respond adequately to the clinically relevant question: the intervention of administering nebulized bronchodilators at home it is likely to make a profit, compared to the standard…
- Trial name
- Nebuadom (NCT02103374)
- Testing
- Atrovent + Bricanyl or Atrovent + Ventoline
- Where
- 13 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Tours
Alzheimer's Disease, Mild Cognitive Impairment
FluoroAv45 Imaging Research-in Alzheimer's Disease
Rationale: improving the early detection of AD at prodromal pre-dementia stages has become a major matter of concern. There is now an important body of literature stating that early isolated cognitive deficits (Mild Cognitive…
- Trial name
- FAIR-AD (NCT01325259)
- Testing
- neuropsychologic assessment, [18F]AV-45 PET, 18-FDG PET
- Where
- 4 sites in France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Hepatitis C
Identification of Viral Variants Involved in the Transmission of Hepatitis C and Characterization of Antigenic and Functional Properties of Their Envelope Glycoproteins
The study consists to Identify viral variants involved in the transmission of hepatitis C and characterize the antigenic and functional properties of their envelope glycoproteins at very early stage of infection (before…
- Trial name
- VINTAGE VHC (NCT02574884)
- Testing
- Blood sample (act specific of blood withdrawal for the study)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Tours
Alterations of the Achilles Tendon
Biomechanical and Ultrasonic Assessment of the Achilles Tendon in Vivo (MEDUSAA)
Among Musculoskeletal disorders (MSD) the rupture of the Achilles tendon is the most common. Up today, the mechanical and elastic properties of the Achilles tendon are still unknown, and that both in healthy subjects in…
- Trial name
- MEDUSAA (NCT02567058)
- Testing
- Ultrasound exam, IPAQ questionnaire
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Breast Cancer, Colorectal Cancer
Randomized Trial Evaluating the Effectiveness of the General Practitioner Involvement in Cancer Screening Invitations
Our goal is to evaluate, in France, the effectiveness (in terms of participation) of the general practitioner involvement (signature) and a more personalized communication in invitation letters to organized screening of breast…
- Conditions
- Breast Cancer, Colorectal Cancer, Cervical Cancer
- Trial name
- GPs (NCT02367001)
- Testing
- Normal invitation, revised invitation signed by the coordinating doctor, Revised invitation signed by the attending physician
- Where
- France
- Volunteers
- 53,978 people
- Sponsor
- University Hospital, Tours
Cystic Fibrosis
Induction of Neutrophilic Traps ( NETs ) by the Environment and Infectious Inflammatory Lung Cystic Fibrosis
The study is defined in 3 stages of in vitro assays : Phase 1 : Secretion of NETs in response to lung disease and their secretion of factors.
- Trial name
- MucoNETs (NCT02564393)
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Adolescent Idiopathic Scoliosis
Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA)
Adolescent idiopathic scoliosis (AIS) is a complex deformity with different curves. These different curves may be distinguished by different physiopathologic mechanisms.
- Trial name
- MOR-FO-SIA (NCT02302534)
- Testing
- MRI
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Metastatic Breast Cancer, Progesterone Receptor Positive Tumor
A Randomised Study of Docosahexaenoic Acid (DHA) in Metastatic Breast Cancer
The aim of this study is to increase, by DHA-induced chemosensitization, the activity of anticancer chemotherapy in patients with a metastatic advanced breast cancer, by a nutritional approach with marin-derived PolyUnsaturated…
- Conditions
- Metastatic Breast Cancer, Progesterone Receptor Positive Tumor, Estrogen Receptor Positive Tumor, HER-2 Negative Tumor
- Trial name
- DHALYA (NCT01548534)
- Testing
- Dietary supplementation with fish oil., Dietary supplementation with vegetable oil
- Where
- 11 sites in France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Tours
Rheumatoid Arthritis
Pharmaco Kinetic Variability of Infliximab in Rheumatoid Arthritis
Infliximab is a chimeric monoclonal antibody directed towards Tumor Necrosis Factor -alpha that is largely used in inflammatory diseases such as rheumatoid arthritis (RA).
- Trial name
- FAKIR (NCT00840957)
- Testing
- infliximab
- Where
- 6 sites in France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Tours
Cervical Cancer, Human Papillomavirus Infection
Self-sampling and Human Papillomavirus (HPV)-Testing for Unscreened Women in Cervical Cancer Prevention
Scientific Context: High-risk types of human papillomavirus (HPV) are the causative agents for cervical cancer. Cervical cancer screening strategies rely on periodic Papanicolaou (Pap) testing.
- Trial name
- APACHE-2 (NCT01588301)
- Testing
- Attending for cervical cytology, Kit for Self-collected vaginal sample
- Volunteers
- 5,998 people
- Sponsor
- University Hospital, Tours
De Novo Transplant Disease
Prospective Study to Measure Vascular Parameters (Ancillary Study of ADEQUATE)
The purpose of this study is to compare parallel-group effects between 4 months and 12 months post-transplantation 2 values of target residual concentrations of Advagraf on vascular parameters in de novo renal transplant patients.
- Trial name
- ADEQUATEartère (NCT02154854)
- Testing
- Tacrolimus targeted half-dose, Tacrolimus targeted plain dose
- Where
- 11 sites in France
- Volunteers
- 104 people
- Sponsor
- University Hospital, Tours
Hip Prosthetic Joint Infection
Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection
The purpose of this study is to evaluate the efficacy of oral linezolid-rifampin combination therapy (over 4 or 6 weeks) versus the standard of care in the treatment of Gram-positive prosthetic hip joint infection with a…
- Trial name
- LIZ-BONE (NCT01757236)
- Testing
- VANCOMYCIN, CEFTRIAXONE, CLINDAMYCIN
- Where
- 9 sites in France, Italy and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours