Clinical trials: sponsored by University Hospital, Tours
Unresectable Metastatic Colorectal Cancer
Bevacizumab-based Chemotherapy Adapted to Bevacizumab Pharmacokinetics in 1st-line Treatment
Bevacizumab is a standard drug for metastatic colorectal cancer (mCRC) in combination with cytotoxic chemotherapy. However, inter-individual pharmacokinetic variability was observed for bevacizumab and an exposure-response…
- Trial name
- PHARBEVACOL (NCT06642844)
- Testing
- Avastin, 25 Mg/mL Intravenous Solution
- Where
- 4 sites in France
- Volunteers
- 244 people
- Sponsor
- University Hospital, Tours
Peripheral Arterial Disease
Cost-utility Analysis, Cost-effectiveness Analysis, Budget Impact Analysis
Cardiovascular pathologies (CV), the second leading cause of death just behind tumors, are particularly frequent in France and strongly mobilize the resources of the healthcare system (ambulatory and health facility).
- Trial name
- DAMAGE (NCT04283565)
- Testing
- Systematic screening of AOMI by BPI measurement., Management of CVRF by a motivationnal interviewing.
- Where
- France
- Volunteers
- 614 people
- Sponsor
- University Hospital, Tours
Alzheimer's Disease (AD)
Effects of Auditory Brain Stimulation by "Pink Noise" on Memory Capacities in Alzheimer's Disease: Proof of Concept Study
Alzheimer's disease (AD) is a neurodegenerative disorder affecting almost 6% of the world's population over the age of 65. This disease, in its most typical sporadic form, is characterized by an episodic memory impairment linked…
- Trial name
- PINK-AD (NCT04570761)
- Testing
- Dreem headband
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Autism Spectrum Disorder, Bipolar Disorder
Features Emotional Responses in Adults With Autism: Comparison With Bipolar Disorder (REMBAU)
The objective of this study is to identify the specific characteristics of Autism Spectrum Disorder (ASD) in emotional response profiles and shared with Bipolar Disorder (BD) characteristics.
- Trial name
- REMBAU (NCT02423499)
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
COVID-19
Efficacy and Safety of Corticosteroids in Oxygen-dependent Patients With COVID-19 Pneumonia
To date, there is no efficient therapeutics to prevent or treat COVID-19 related pulmonary failure. Corticosteroids (CS) could be a helpful therapeutic.
- Trial name
- CORTICOVIDHUGO (NCT04359511)
- Testing
- Prednisone, Hydrocortisone
- Sponsor
- University Hospital, Tours
Pulmonary Malformations, Child
Impact of Forced Expiration On Pleural Drainage Duration (KPDP)
Following thoracic surgery, pleural effusion in pleural cavity requires post-operative drainage. Pleural effusion is responsible for pulmonary congestion, atelectasis, hypoventilation, lower efficacy of diaphragmatic curse, lower…
- Trial name
- KPDP (NCT02660203)
- Testing
- Forced expiration
- Where
- 10 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Tours
Liver Steatosis
Fibroscan® Medical Device, Assessment for Non Invasive Diagnosis of Liver Steatosis
Hypothesis of this study is the existence of a relation between parameters measured by FibroScan® FS 502 according to our non invasive method and liver steatosis condition.
- Trial name
- TRANSTEATOSE (NCT02575625)
- Testing
- Fibroscan, Blood test for biological assessment of liver function, MRI
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Merkel Cell Carcinoma
SerUM Markers in MERkel Cell Carcinoma Patients: a Longitudinal moniTorIng Study for optiMization of European Guidelines
Merkel cell carcinoma (MCC) is a rare aggressive skin carcinoma. Approximately 80% of MCC are related to the Merkel Cell Polyomavirus (MCPyV). Although rates of relapse are high, the follow-up strategy lacks consensus.
- Trial name
- SUMMERTIME (NCT04705389)
- Testing
- Samples
- Where
- 10 sites in Austria, Finland and 8 more
- Volunteers
- 35 people
- Sponsor
- University Hospital, Tours
Interstitial Lung Disease With Systemic Sclerosis
Evaluation of Efficacy and Safety of Rituximab and Mycophenolate Mofetil Combination in Patients With Interstitial Lung Disease Related to Systemic Sclerosis
The goal of this clinical trial is to evaluate the efficacy on lung function after 24 weeks of rituximab + MMF combination comparatively to placebo + MMF combination in patients with SSc-ILD severe at the initial assessment or at…
- Trial name
- EVER-ILD 3 (NCT06549231)
- Testing
- Rituximab
- Where
- France
- Volunteers
- 102 people
- Sponsor
- University Hospital, Tours
Acute Respiratory Distress Syndrome, Pressure Ulcers Stage III
Comparaison of Two Prone Position Techniques on Occurence of Pressure Sores in ICU
Acute respiratory distress syndrome (ARDS) is a diffuse inflammation of the lungs that occurs in a variety of diseases. According to the Berlin definition, ARDS is characterized by diffuse lung damage in patients with…
- Trial name
- PROPOSE (NCT05894291)
- Testing
- Swimmer Prone Position, Prone position with arms alongside the body
- Where
- France
- Volunteers
- 334 people
- Sponsor
- University Hospital, Tours
Humoral Rejection in Kidney Transplantation
Impact of Treatment With Rituximab on the Progression of Humoral Acute Rejection After Renal Transplantation
Assessing the impact of J12 curative treatment with rituximab (375 mg / m² on J5) based on a composite "TREATMENT FAILURE"
- Trial name
- RITUX-ERAH (NCT01350882)
- Testing
- MabThera, Physiological serum : sodium chloride, sodium citrate
- Where
- 30 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Tours
Psychiatric Disorders
Effectiveness of the SKILLS Program in the Management of Psychiatric Disorders
Epidemiological studies show that one person in eight suffers from at least one psychiatric disorder. Mental health is therefore a major public health issue, and care for these disorders must continue to be improved.
- Trial name
- P-SKILLS (NCT06622993)
- Testing
- Psychotherapy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Tours
Autism Spectrum Disorder
Use of Immersive Virtual Reality to Train the Multisensory Processing Capacities of Children Aged 8 to 16 Years-old With an Autism Spectrum Disorder: Single-center Randomized Pilot Study in Parallel Groups - SEVIRE. (Sensory Virtual Reality)
Autism Spectrum Disorder (ASD) is defined as a neurodevelopmental disorder that affects the functioning and development of social communication (DSM5 - 2013).
- Trial name
- SEVIRE (NCT05171244)
- Testing
- virtual reality training, usual care
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Tours
Stress Disorders, Post-Traumatic
Potentiation of Trauma Exposure in Post-traumatic Stress Disorder by Repeated Transcranial Magnetic Stimulation
The aim of this study is to assess the efficacy in PTSD treatment of concomitant voluntary reactivation of personal traumatic memories with neuromodulation of the right dorsolateral prefrontal cortex using 10Hz rTMS, compared to…
- Trial name
- TETT-STIM (NCT02584894)
- Testing
- rTMS 1Hz, rTMS 10Hz, psychoneurological assessment
- Volunteers
- 39 people
- Sponsor
- University Hospital, Tours
Epithelial Ovarian Cancer
Health-Economic Evaluation of Early Diagnosis of Epithalial Ovarian Cancer Recurrence Using the ROMA Score: a Prospective Multicenter Randomized Trial
In this study, we hypothesize that calculating the ROMA score (CA125 + HE4 blood marker assay) will enable faster, more targeted diagnosis and management of epithelial ovarian cancer recurrence than the CA125 marker assay alone.
- Trial name
- ROMECO (NCT05991752)
- Testing
- ROMA score evaluation
- Sponsor
- University Hospital, Tours
ADHD - Attention Deficit Disorder With Hyperactivity, Fibromyalgia (FM)
Comorbidity Between Attention Deficit Hyperactivity Disorder and Fibromyalgia
The overall objective of the research project presented here is to assess the prevalence of fibromyalgia in patients being treated for ADHD, the prevalence of ADHD in patients being treated for fibromyalgia, and the…
- Conditions
- ADHD - Attention Deficit Disorder With Hyperactivity, Fibromyalgia (FM), Chronic Pain
- Trial name
- HYPERPAIN (NCT07443800)
- Testing
- Samples, Questionnaires, Sensitivity to mechanical pain
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
PKU, Hyperphenylalaninemia
Study of a National Cohort of Adult Patients With Phenylketonuria
Phenylketonuria (PKU) is a metabolic disease of genetic origin. This is a rare disease (incidence 1 / 16000 births) which is the subject of a systematic neonatal screening in France, because it is treatable by a diet low in…
- Trial name
- ECOPHEN (NCT01619722)
- Where
- 16 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Tours
Elderly, Major Depression
Depression in the Elderly and Cerebral Amyloid Plaques: Characterization by [18F] AV-45 Affectives Symptoms and Amyloïd Plaques (ASAP)
The primary objective of the study is to compare the brain amyloid load in fully, partially and non remitting depressed elderly patients at 8 weeks of antidepressant therapy, by using PET with [F18]AV45.
- Trial name
- ASAP (NCT01962753)
- Testing
- 18FAV45
- Where
- 10 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Tours
Neurocognitive Disorders
Cognitive Disorders and Brain Pulse
Following an initial consultation with a memory, resources and research centre (MRRC) doctor, a day hospital may be prescribed to carry out an assessment of cognitive disorders.
- Trial name
- COG-PULCE (NCT05129150)
- Testing
- Ultrasound examination
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Tours
Intracerebral Hemorrhage (ICH)
Improving the Prognosis for Cerebral Hemorrhage A Study of Clinical, Biological, and Imaging Markers
This study will establish a prospective, multicenter national cohort of patients with spontaneous intracerebral hemorrhage (ICH).
- Trial name
- TIPITCH (NCT07444853)
- Where
- 4 sites in France
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Tours