Clinical trials: sponsored by University Hospital, Tours
Amyotrophic Lateral Sclerosis
New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects central and peripheral motor neurons. None of the clinical trials conducted have been clearly successful and the disease remains incurable, putting…
- Trial name
- METABOCALS (NCT03984708)
- Testing
- Samples, Indirect calorimetry, Electrical bioimpedance
- Where
- 2 sites in France
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Melanoma, Screening
Comparison of Two Strategies for Counseling Skin Examination and Sun Protection in First-degree Relatives of Patients With Melanoma
First-degree relatives of patients with melanoma have a greater risk of developing melanoma. Patients are advised orally to inform their first-degree relatives that they should protect their skin from UV radiation and ask for a…
- Trial name
- FADEMELA (NCT02917473)
- Testing
- In-person counseling, Written advice, Medical skin screening
- Where
- 9 sites in France
- Volunteers
- 420 people
- Sponsor
- University Hospital, Tours
Lung Disease, Interstitial
Evaluation of Efficacy and Safety of Rituximab With Mycophenolate Mofetil in Patients With Interstitial Lung Diseases
The purpose of the study is to evaluate the efficacy on lung function 6 months after one course of rituximab (2 infusions) and mycophénolate mofétil (MMF) treatment compared to one course of placebo and 6 months of MMF treatment…
- Trial name
- EvER-ILD (NCT02990286)
- Testing
- Rituximab, Mycophenolate Mofetil
- Where
- 5 sites in France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Tours
Neurological Diseases
In Vivo and ex Vivo Validation of MR Tractography of Brain White Matter Tracts - FIBRATLAS II-III
White matter tracts connect cortical areas to other parts of the cortex, to basal ganglia and to the brain stem and spinal cord. These tracts form the internal part of the brain and transmit the nervous impulses.
- Trial name
- FIBRATLAS (NCT02455284)
- Testing
- MRI
- Where
- 7 sites in France
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Neonatal Seizures
Levetiracetam Treatment of Neonatal Seizures: Safety and Efficacy Phase II Study
LEVNEONAT is a multicentre French clinical trials with the aim to develop new treatment strategies for the treatment of neonatal seizures using Levetiracetam.
- Trial name
- LEVNEONAT-1 (NCT02229123)
- Testing
- Intravenous Levetiracetam
- Where
- 8 sites in France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Tours
Cardiovascular Diseases, Mental Disorder
A Phone-call With a Student/General Practitioner Team to Impact Morbidity of Chronic Patients During COVID-19 Containment
Following the announcement of the containment of the population due to the COVID-19 epidemic on March 17, 2020 in France, a notable decrease in the number of consultations in general practice was reported.
- Trial name
- COVIQuest (NCT04359875)
- Testing
- Phone-call screening and management by a medical student/general practitioner tandem
- Where
- France
- Volunteers
- 22,000 people
- Sponsor
- University Hospital, Tours
Prosthesis-related Infections
Treatment of the Infections on Osteo-articular Prostheses by 6 Versus 12 Weeks of Antibiotherapy
The study is a prospective, open randomized, non-inferiority trial with two parallel groups, comparing 6 weeks versus 12 weeks of antibiotic treatment following surgery procedure (debridement and retention, 1-stage or 2 stage…
- Trial name
- DATIPO (NCT01816009)
- Testing
- duration of antibiotic treatment
- Where
- 37 sites in France
- Volunteers
- 410 people
- Sponsor
- University Hospital, Tours
Venous Insufficiency, Lymphedema
Transient Elastography DEdicated to Cosmetology And Dermatology (TEDECAD)
Explorative study on a medical device with two steps. The first pilot step will be on 8 patients (4 with lymphedema and 4 with venous insufficiency).
- Trial name
- TEDECAD (NCT02061254)
- Testing
- Cutometer, High resolution ultrasonography (echography), Elastography
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
HIV
Trial to Evaluate the Interest of a Reductive Anti Retroviral Strategy Using Dual Therapy Inspite of Triple Therapy
In the early 2000s, the "TRILEGE©" study was realized to determine if the reductive anti retroviral strategy from an initial triple therapy (based on a protease inhibitor as the third agent) towards a dual therapy of nucleoside…
- Trial name
- TRULIGHT (NCT02302547)
- Testing
- triple therapy, dual therapy
- Where
- 16 sites in France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Tours
Prostatic Hypertrophy, Benign
Assessing the Impact of the PVP With Greenlight Laser Using Prostatic MRI and Contrast-enhanced Ultrasound
The PVP by Greenlight laser 180W is becoming a potential therapeutic alternative in the treatment of benign prostatic hypertrophy (BPH) as recommended.
- Trial name
- PROPIL (NCT01732991)
- Testing
- prostatic photo-vaporization (PVP)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Tours
Interstitial Lung Disease (ILD)
Safety Profile of Ultrasound-guided Transparietal Lung Biopsy in Patients With Diffuse Interstitial Lung Disease
Rationale Interstitial lung diseases (ILDs) require accurate histological diagnosis when imaging is inconclusive, yet current techniques-surgical lung biopsy and transbronchial cryobiopsy-carry significant risks and lack…
- Trial name
- TOUCANS (NCT07305220)
- Testing
- Transthoracic ultrasound-guided lung biopsy
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Tours
Major Depressive Disorder
Comparative Study of Physiological and Cerebrovascular Reactivity in Depression, at the Three Phases of Emotion
The main objective is to compare the physiological reactivity (heart and respiratory rates, galvanic skin response, cerebral perfusion, and startle) in the three phases of emotion between depressive subjects, subjects remitted…
- Trial name
- EMPHILINE (NCT02026622)
- Testing
- psychometric tests, MRI, transcranial doppler and TPI
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Post-traumatic Stress Disorder
Post-traumatic Stress Disorder Treatment Using Transcranial Direct Current Stimulation (tDCS) Enhancement of Trauma-focused Therapy : a Two-arm Randomized Controlled Multicentric Study.
Post-Traumatic Stress Disorder (PTSD) is an anxiety disorder that can develop after exposure to a terrifying event or ordeal in which there was the potential for or actual occurrence of grave physical harm.
- Trial name
- T-TREAt (NCT02900053)
- Testing
- tDCS
- Where
- 5 sites in France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Tours
Placenta Accreta
Placenta Accreta : Contrast-enhanced Ultrasound Analysis in High Risk Population
Abnormally invasive placenta (AIP) is defined as an abnormal placental attachment of a part or the entire chorionic plate with penetration of chorionic villi in the myometrium and absence of the decidua basalis.
- Trial name
- NCT02302573
- Testing
- contast-enhanced ultrasound with sonovue
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Tours
Hypoglycemia
Real-time Continuous Glucose Monitoring in Very Low Birth Weight Neonates
Hypoglycemia is frequent in very low birth weight (VLBW) neonates and compromises their neurological outcome. The aim of this study was to compare real-time continuous glucose monitoring system (RT-CGMS) to standard method by…
- Trial name
- NCT01942239
- Testing
- real time continuous glucose monitoring
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Tours
Treatment Resistant Depression, Nitrous Oxyde
Brain Reactivity to Nitrous Oxyde in Depression : an MRI and Ultrasound Study (PROTOBRAIN Pilote)
Recent evidence suggest that Nitrous Oxyde (N2O) could exhibit antidepressant effect in treatment-resistant depression (TRD). However, the pathophysiology of this effect remains unclear and could include glutamatergic activity…
- Trial name
- NCT04199143
- Testing
- Nitrous Oxide-Oxygen, Tissue Pulsatility Imaging - TPI, Magnetic Resonance Imaging - MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Depression
BDNF Gene Polymorphism and Antidepressants Treatment
The main hypothesis is that the therapeutic response and pharmacological resistance to ADs in depressed patients can be associated with a polymorphism for the BDNF gene.
- Trial name
- NCT00308893
- Testing
- Genetic analysis
- Where
- France
- Volunteers
- 188 people
- Sponsor
- University Hospital, Tours
Renal Transplantation
Metabolomics in Assessing the Quality of Kidney Transplants Retained on a LifePort® Perfusion Machine
When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft.
- Trial name
- RENALIFE (NCT03024229)
- Testing
- LifePort® perfusion machine
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Tours
Depression
Biomarkers of Antidepressant Resistance
According to the WHO, major depressive disorders have become the second worldwide cause of disability. Treatment, long-term medication, leads to frequent resistance (up to 40%).
- Trial name
- BIORESA (NCT03118193)
- Testing
- olfactive tests, blood test, Collection of faeces
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Tours
Focal Liver Lesions, Liver Cancer
Characterization of Focal Liver Lesions by Real-time Contrast-enhanced Ultrasound Imaging (CEUS)
The conventional sonography is frequently used to detect incidental focal liver lesions because of its availability, innocuity and low cost.
- Conditions
- Focal Liver Lesions, Liver Cancer, Liver Cirrhosis
- Trial name
- NCT00243633
- Testing
- Real-time contrast-enhanced ultrasound sonography
- Where
- 15 sites in France
- Volunteers
- 878 people
- Sponsor
- University Hospital, Tours