Clinical trials: sponsored by University Hospital, Tours
Aging, Cerebral Pulsatility
Ultrasonic Explorations of Cerebral Tissue Motions - Influence of Aging
The new technical of ultrasonic exploration of this project purpose to validate the measurement of cerebral pulsatility by a new way called "Fast Cerebral Pulsatility Imaging" (FCPI).This will somehow determine the natural…
- Trial name
- COSTUM (NCT01737606)
- Testing
- Fast Cerebral Pulsatility Imaging
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Pre-eclampsia, Intra-uterine Growth Restriction
Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers
The objective of this study is to test the efficacy of low-dose aspirin (160 mg/day), given bedtime and started early during pregnancy (≤ 15 +6 weeks of gestation) in nulliparous pregnant women selected as "high-risk" by the…
- Trial name
- PERASTUN (NCT01729468)
- Testing
- Aspirin
- Where
- 17 sites in France, Martinique
- Volunteers
- 1,106 people
- Sponsor
- University Hospital, Tours
Rheumatoid Arthritis
Serum Concentration of Adalimumab as a Predictive Factor of Clinical Outcomes in Rheumatoid Arthritis (AFORA)
Adalimumab is a fully human monoclonal antibody to tumor necrosis factor-alpha (TNF-α) approved in rheumatoid arthritis (RA) refractory to disease modifying anti rheumatic drugs (DMARDs) and for the treatment of severe, active…
- Trial name
- AFORA (NCT01382160)
- Testing
- adalimumab
- Where
- 7 sites in France
- Volunteers
- 69 people
- Sponsor
- University Hospital, Tours
Community Acquired Pneumonia
Community-Acquired Pneumonia : Evaluation of Corticosteroids
Mortality of severe Community-Acquired Pneumonia (CAP) has not declined over time and is between 25 and 30% in sub-groups of patients.
- Trial name
- CAPE_COD (NCT02517489)
- Testing
- Hydrocortisone
- Where
- 32 sites in France
- Volunteers
- 952 people
- Sponsor
- University Hospital, Tours
Other Reconstructive Surgery
On the Impact of Bleeding on Two Strategies Osteosynthesis of Trochanteric Fractures
Fractures of the trochanter in the elderly have a terrible prognosis both vital and functional. It is certainly possible to reduce the medical and economic impact of this disease by reducing surgical trauma, by means of minimally…
- Trial name
- MISSvsPHS (NCT01427036)
- Testing
- MISS, PHS
- Where
- 2 sites in France
- Volunteers
- 108 people
- Sponsor
- University Hospital, Tours
Weight Loss, Ovarian Carcinoma
Skeletal Muscle Energy Metabolism in Women With Weight Loss and Ovarian and/or Endometrial Cancer With Weight Loss
the aim is to study skeletal muscle metabolism alterations métaboliques associated with weight loss in women with ovarian and/or endometrial cancer according to BMI.
- Conditions
- Weight Loss, Ovarian Carcinoma, Endometrial Carcinoma
- Trial name
- METERMUS-IMC (NCT03027479)
- Testing
- Samples
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Tours
Prolonged Pregnancy
Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies
A pregnancy is considered ''prolonged'' from 41 weeks of gestation. Prolonged Pregnancies (PP) are associated with increased maternal morbidity: emergency caesarean, 3rd and 4th degree perineal lesions and postpartum haemorrhage.
- Trial name
- NCT02907060
- Testing
- Mechanical cervical ripening, Pharmacological cervical ripening
- Where
- 14 sites in France
- Volunteers
- 1,224 people
- Sponsor
- University Hospital, Tours
Vascular Malformation
suPERficial Slow-flow Vascular malFORMations Treated With sirolimUS
The most recent classification, adopted by International Society for the Study of Vascular Anomalies (ISSVA) in 1996, and updated in Melbourne in 2014, divides these lesions into two broad categories: vascular tumors and vascular…
- Trial name
- PERFORMUS (NCT02509468)
- Testing
- Sirolimus
- Where
- 12 sites in France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Tours
Amyotrophic Lateral Sclerosis
Muscular Biomarkers in Amyotrophic Lateral Sclerosis
The first objective is to find some biomarkers, or a profile of biomarkers of ALS to help to diagnosis. The second objective is to better understand the pathogenesis of this disease by the exploration of muscle, blood and…
- Trial name
- METABOMU (NCT02670226)
- Testing
- Samples
- Where
- 2 sites in France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Chronic Obstructive Pulmonary Disease
Evaluation of the Effectiveness of the Nebulization Bronchodilators Under High Nasal Flow Humidified
The principal objective is to show noninferiority of nebulized salbutamol through the high flow nasal system moistened AIRVO ™ 2 in terms of reversibility of airflow obstruction compared to nebulization by the usual method (spray…
- Trial name
- AirvoNEB (NCT02812979)
- Testing
- Airvo2 with Aerogen Solo, Mask, arm control Airvo2 without nebulization of salbutamol
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Tours
Phenylketonuria
Study of Low-grade Systemic Inflammation in Adult Patients With Phenylketonuria
Patient suffering from phenylketonuria have chronic hyperphenylalaninemia. Hyperphenylalaninemia is known to be toxic to central nervous system and cardiovascular system in particular through oxydative stress.
- Trial name
- INGRAPH (NCT04879277)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Acute Respiratory Distress Syndrome, COVID-19
Prone Position in Patients on High-flow Nasal Oxygen Therapy for COVID-19 (HIGH-PRONE-COVID-19)
Acute Respiratory Distress Syndrome (ARDS) induces high mortality, particularly in the context of COVID-19 disease. Preliminary data from patients with ARDS related to COVID-19 disease appear to show significant effectiveness of…
- Trial name
- NCT04358939
- Testing
- Prone decubitus
- Where
- 24 sites in France
- Volunteers
- 405 people
- Sponsor
- University Hospital, Tours
Cirrhotic Portal Hypertension
PTFE Covered Stents Versus Naked Stents in the TIPS (Transjugular Intra-hepatic Porto-systemic Shunt)
Transjugular intrahepatic portosystemic shunts (TIPS) have been increasingly used for the treatment of complications of portal hypertension in patients with cirrhosis.
- Trial name
- NCT00593528
- Testing
- Naked Stents: Wallstent® (Boston Scientific), Luminexx® (Bard), Zilver® (Cook), Palmaz Genesis® and Smart Control® (Cordis), PTFE Covered Stents: Fluency® (Bard), Advanta V12® (Atrium) and Viatorr® (Gore), Transjugular intrahepatic portosystemic shunt (TIPS)
- Where
- 12 sites in France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Tours
Pneumonia, Ventilator-Associated
Study Comparing Inhaled Amikacin Versus Placebo to Prevent Ventilator Associated Pneumonia
The objective of the study is to prove that after the third day of invasive mechanical ventilation a three-day course of inhaled amikacin reduces the incidence of subsequent VAP.
- Trial name
- AMIKINHAL (NCT03149640)
- Testing
- Inhaled amikacin
- Where
- 18 sites in France
- Volunteers
- 850 people
- Sponsor
- University Hospital, Tours
Acute Circulatory Failure
Measuring the Plasma Clearance of Iohexol to Estimate Glomerular Filtration Rate in Intensive Care Unit Patients: Preliminary Feasibility Study
The objective of this study is to assess the feasibility of estimating the clearance of iohexol as an indirect measure of glomerular filtration rate in patients with unstable renal function in the intensive care unit through…
- Trial name
- IoxRea (NCT02050269)
- Testing
- Iohexol
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Cancer Cervix
Vaginal Self-sampling and Human Papillomavirus Testing in Unscreened Women
Despite the existence of an effective screening test (pap smear), cervical cancer is, every year in France, the cause of more than 3,000 new cases and 1,100 deaths.
- Trial name
- APACHE-3 (NCT02255084)
- Testing
- Group 1 remove self sample kit at gp consulting room or perform pap smear, Group 2 perform self sample at home or pap smear
- Where
- France
- Volunteers
- 3,612 people
- Sponsor
- University Hospital, Tours
Undernutrition, Gastrointestinal Cancer
Skeletal Muscle Energy Metabolism in Undernourished Patients With Gastrointestinal Cancer
Undernutrition associated with cancer, or cancer cachexia results from a deterioration of the energy balance that leads to a gradual mobilization of energy reserves in the body and to increasing deterioration of the nutritional…
- Trial name
- METERMUCADIG (NCT02573974)
- Testing
- Samples
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Tours
Chronic Respiratory Failure
Beta Agonist Nebulization in Non Invasively Ventilated COPD Patients: Safety, and Therapeutic Efficacy Range.
randomized double-blind controlled study in parallel groups Salbutamol is a β2 mimetic short-acting to be administered by nebulization in this study.
- Trial name
- BANNISTER (NCT01958814)
- Testing
- Salbutamol
- Where
- 3 sites in France
- Volunteers
- 43 people
- Sponsor
- University Hospital, Tours
Amyotrophic Lateral Sclerosis
Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is the most common neurodegenerative disease affecting the motor neuron. Currently, there is no diagnostic test and no examination that can predict the evolution of this pathology.
- Trial name
- LARMOMIQUE (NCT04953286)
- Testing
- Measure of visual acuity, Interferometry, Samples of basal tears
- Where
- 3 sites in France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Cataract
Effect of the Color of the Intra-eye Implant in the Cataract Surgery on the Sleep
The cataract surgery (550 000 operations per year in France) is to replace the cloudy lens with a refractive implant. Two colors of implants are available: white implants, filtering out ultraviolet and yellow implants, filtering…
- Trial name
- IOL et sommeil (NCT02304900)
- Testing
- white implant, yellow implant
- Where
- 3 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Tours