Clinical trials: sponsored by University Hospital, Tours
Port Wine Stain, Klippel Trenaunay Syndrome
French National Cohort of Children With Port Wine Stain
Port Wine Stain on a limb can be either isolated or associated with complications (venous or orthopedic impairment, arteriovenous malformations), leading sometimes to complex syndromes (Klippel-Trenaunay syndrome,Parkes-Weber…
- Conditions
- Port Wine Stain, Klippel Trenaunay Syndrome, Parkes Weber Syndrome
- Trial name
- CONAPE (NCT01364857)
- Testing
- search for polymorphisms of RASA1 gene
- Where
- 17 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Acute Circulatory Failure
Early Versus Differed Arterial Catheterization in Critically Ill Patients With Acute Circulatory Failure:
The objective of the present research is a combination of a one-sided test of non-inferiority and a one-sided test of superiority. A stepped approach will be used to evaluate these hypotheses: 1.
- Trial name
- EVERDAC (NCT03680963)
- Testing
- Non-invasive strategy, Control strategy
- Where
- 9 sites in France
- Volunteers
- 1,010 people
- Sponsor
- University Hospital, Tours
Neurogenic Bladder, Urinary Tract Infection
Safety and Efficacy of a Weekly Oral Cyclic Antibiotic Programme in the Prevention of Urinary Tract Infection on Neurological Bladder
Symptomatic urinary tract infections (UTIs) are one of the main causes of morbidity and the main cause of re-hospitalization in subjects with neurogenic bladder.
- Trial name
- PACHIU (NCT01388413)
- Testing
- Weekly Oral Cyclic Antibiotic programme
- Where
- 4 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Tours
Systemic Sclerosis
Clinical Relevance of Thoracic Echography for the Early Diagnosis of Interstitial Lung Disease in Systemic Scleroderma - Pilot Study
Diffuse interstitial lung disease (PID) is the leading cause of death in systemic scleroderma (SSc). Major progress has recently been made in its therapeutic management. Early diagnosis is essential to optimize this management.
- Trial name
- PRECOSS (NCT04725786)
- Testing
- thoracic echography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Urinary Infection
Relevance of the Urine Bacterial Culture Performed Before Double J Ablation for Post-operative Urinary Tract Infection Prevention
The value of cytobacteriological examination of urine (CBEU) before double J catheter removal has not been demonstrated. The aim of this study is to define the interest of this CBEU.
- Trial name
- AblaJ (NCT04913753)
- Testing
- CBEU, No CBEU
- Where
- France
- Volunteers
- 2,200 people
- Sponsor
- University Hospital, Tours
Hemodialysis Catheter Infection, Infection, Bacterial
Pharmacokinetics Study of Cefazolin in Hemodialysis (CEFAZODIAL)
In chronic hemodialysis patients, bacteremia is most commonly caused by dialysis catheter infections. It is estimated that the vast majority (52-84%) of these infections are due to Gram-positive cocci, particularly Staphylococcus…
- Trial name
- CEFAZODIAL (NCT06093269)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Tours
Cystic Fibrosis
Impact of a Coordinated Dietetic-adapted Physical Activity Program on the Percentage of Lean Body Mass in Adults With Cystic Fibrosis Treated With Elexacaftor-Tezacaftor-Ivacaftor: Multicentre Randomised Controlled Trial
Cystic fibrosis is an autosomal recessive inherited disease linked to various mutations in the gene coding for the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, with respiratory and digestive disorders…
- Trial name
- DIAPASOM (NCT06457451)
- Testing
- DIAPASOM program
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Idiopathic Pulmonary Fibrosis
Effect of Intrapulmonary Percussion Ventilation on Deposition of Inhaled Aerosols in Idiopathic Pulmonary Fibrosis
This protocol aims to evaluate the feasibility and benefit of Intrapulmonary Percussive Ventilation (IPV) to improve deposition of inhaled radiolabelled aerosols in fibrotic lung regions of patients with Idiopathic Pulmonary…
- Trial name
- AEROPERC (NCT05366387)
- Testing
- intrapulmonary percussive ventilation, delivery of 99mTc-DTPA aerosol
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Tours
Post Traumatic Stress Disorder
Identification of the Clinical Specificities of Complex Posttraumatic Stress Disorder
Identification of the clinical specificities of complex post-traumatic stress disorder post-traumatic stress disorder
- Trial name
- IDPLEX (NCT05592652)
- Testing
- Survey
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Kidney Stone
Impact of Forced Diuresis on the Residual Fragment Rate After Flexible Ureteroscopy for Destruction of Kidney Stones With Laser
In view of the positive results of the numerous studies conducted on forced diuresis after extra-corporeal lithotripsy, the investigators chose to evaluate forced diuresis by injection of Furosemide associated with intravenous…
- Trial name
- FIREStones (NCT05916963)
- Testing
- Furosemide 40 mg
- Where
- 9 sites in France
- Volunteers
- 374 people
- Sponsor
- University Hospital, Tours
Late-Life Depression, Resistant Depression, Treatment
Nitrous Oxide for Late-Life Depression - PROTO-BRAIN
Resistant Depression is a common condition in older adults and there is an urgent need for novel antidepressant in this population.
- Trial name
- PROTO-BRAIN (NCT05007028)
- Testing
- EMONO, Medical Air
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Tours
Offense, Sex
Impact of a Structured Clinical Assessment MIDSA, Its Feedback and Support for Change on Commitment to Care of Perpetrators of Sexual Offenses
Evaluate the effectiveness of an intervention including the clinical assessment carried out with the (Multidimensional Inventory of Development, Sex, and Aggression) MIDSA and the review of the results with the professional in…
- Trial name
- EV-AICS (NCT05013996)
- Testing
- MIDSA, Usual methods of evaluation
- Where
- 5 sites in France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Tours
Lingual Microcystic Lymphatic Malformations
TOPical Sirolimus in linGUal Microcystic Lymphatic Malformation -TOPGUN
Lingual microcystic lymphatic malformations (LMLMs) are rare congenital vascular malformations, presenting as clusters of cysts filled with lymph fluid or blood.
- Trial name
- TOPGUN (NCT04128722)
- Testing
- Sirolimus Oral Liquid Product 1mg/mL
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Tours
Community-acquired Pneumonia, Acute Respiratory Distress Syndrome
Innate Immune Response During Community Acquired Pneumonia
Community acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide. Despite recent improvement in acute management (specifically for administration of antibiotics) many severe presentations of pneumonia…
- Conditions
- Community-acquired Pneumonia, Acute Respiratory Distress Syndrome, Innate Immunity
- Trial name
- ImPACT (NCT03379207)
- Testing
- Blood samples, Tracheal Aspirates, Surplus of Broncho-alveolar lavage fluid
- Where
- 3 sites in France
- Volunteers
- 258 people
- Sponsor
- University Hospital, Tours
Shoulder Prosthesis
Open-label, Prospective, Multicenter, Post-market Study to Evaluate the Reverse Medacta Shoulder System of Total Shoulder Prosthesis.
The goal of this study is to evaluate the performance of the Medacta Shoulder System total reverse shoulder prosthesis, at 2 years of follow up, in patients who required this prosthesis for primary omarthrosis, cuff tear…
- Trial name
- MSS (NCT04431973)
- Testing
- Medacta Shoulder System
- Where
- 5 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Acute Lymphoid Leukemia, Acute Myeloid Leukemia in Children
Study of the Medullary Microenvironment in Acute Childhood Leukemia
Acute leukemia (AL) is the most common cancer in children. Despite the optimization of chemotherapy treatments and the development of supportive care, a certain number of LAs relapse and/or progress to death of the child.
- Trial name
- MILA (NCT05792007)
- Testing
- Biological sampling in patients, Biological sampling in control patients
- Where
- 3 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Colorectal (Colon or Rectal) Cancer
Colorectal Cancer Screnning Colonoscopy Under Hypnosis
Through this study, the effectiveness of hypnosis in the realization of a colonoscopy for the detection of colorectal cancer will be evaluated
- Trial name
- CODEPICCH (NCT05051046)
- Testing
- Colonoscopy under hypnosis
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Tours
Undernutrition, Elderly Person
Finger Food, Pleasure at Your Fingertips: Randomized Pilot Study, Open-label and Parallel Groups
Food is available in easy-to-grip bites that allow residents in care settings to use their fingers for food. This new way of eating can help limit weight loss, increase food intake, gain independence and improve the enjoyment of…
- Trial name
- PLAID (NCT05389098)
- Testing
- Hand-Eating, Control
- Where
- 2 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Coronary Artery Disease, Inflammatory Response
Effect of Influenza Vaccination on Global Systemic Inflammatory Markers in Patients With Stable Coronary Artery Disease
Observational and randomized studies suggest that influenza vaccine may reduce future cardiovascular events in patients with cardiovascular disease.
- Conditions
- Coronary Artery Disease, Inflammatory Response, Atherosclerosis
- Trial name
- IVAMI (NCT06508437)
- Testing
- Influenza Vaccination
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Tours
Obesity, Food Addiction
Impact of a Phone-based Cognitive and Behavioral Therapy on Food Addiction in Patients With Severe or Morbid Obesity
Morbid or severe obesity is a chronic pathology of multifactorial etiology that affects 4.3% of the French population. In these patients, eating disorders are frequent and must be managed as they are considered risk factors with…
- Trial name
- ADALOB (NCT04626570)
- Testing
- Cognitive and Behavioral Therapy
- Where
- 9 sites in France
- Volunteers
- 154 people
- Sponsor
- University Hospital, Tours