Clinical trials: sponsored by University Hospital, Tours
Alzheimer Disease
Identification of Diagnosis Biomarkers in the Tears of Alzheimer's Disease Patients: The COG-EYE Pilot Study
The diagnosis of Alzheimer's disease (AD) relies on the detection of protein biomarkers, particularly in cerebrospinal fluid (e.g., Aβ and phosphorylated Tau) or through brain imaging.
- Trial name
- COG-EYE (NCT06661564)
- Testing
- Basal tear collection for the analysis of metabo-lipidomic profiles and concentrations of protein biomarkers (Tau, phosphorylated Tau, Aβ 1-40, and Aβ 1-42), Collection of a blood sample (5 mL) for blood biomarkers analysis
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Severe Mental Disorders
Health-economic Evaluation of the IPS (Individual Placement and Support) Model for Helping People With Severe Mental Disorders Access Employment in the Ordinary Labor Market, Compared to Standard Methods of Helping People Return to Work: a Prospective Real-life Study
The Individual Placement and Support (IPS) model was developed in the United States in the 1990s to help people with severe mental health issues get back into regular jobs.
- Trial name
- MEDECO-IPS (NCT07206316)
- Testing
- Individual Placement and Support Model, Standard Method
- Where
- 11 sites in France
- Volunteers
- 234 people
- Sponsor
- University Hospital, Tours
Hypoxemic Acute Respiratory Failure
Apneic Oxygenation With High-flow Nasal Oxygenation After Preoxygenation With Noninvasive Ventilation Before Intubation in Hypoxemic Patients in Intensive Care Unit.
The aim of this clinical study is to assess whether apneic oxygenation with High-Flow Nasal Oxygen (HFNO) would decrease the incidence of severe hypoxemia compared to no apneic oxygenation during the intubation procedure (from…
- Trial name
- APNEIC (NCT07189338)
- Testing
- Apneic oxygenation, Usual Care
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Tours
Attention Deficit Hyperactivity Disorder (ADHD), Obesity (Body Mass Index &Amp;Amp;gt;30 kg/m2)
PHArmaCokinetics of methYLphenidate in Adult Patients With Attention-Deficit /Hyperactivity Disorder
PHACYLOB PHArmaCokinetics of methYLphenidate in adult patients with Attention-Deficit Hyperactivity Disorder (ADHD) : comparison between patients with and without OBesity.
- Conditions
- Attention Deficit Hyperactivity Disorder (ADHD), Obesity (Body Mass Index &Amp;Amp;gt;30 kg/m2), Methylphenidate, Obesity &Amp; Overweight
- Trial name
- PHACYLOB (NCT07121621)
- Testing
- PHArmacoKinetics of methYLphenidate in adult patients with ADHD: comparison between patients with and without OBesity.
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Lung Cancer (NSCLC)
Inflammation, Cachexia and Therapeutic Response in Lung Cancer Treated With Immune Checkpoint Inhibitors: Exploratory Observational Study
Lung cancer is the leading cause of cancer-related death in France and globally, with 2.48 million new cases diagnosed in 2022, accounting for nearly 13% of global cancer incidence.
- Trial name
- LCab (NCT07004868)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Renal Transplant, Conversion
Early Pharmacological and Immune Monitoring After Conversion to Belatacept in Renal Transplant Patients
Single-center, prospective, translational, clinical-biological, multidisciplinary study
- Trial name
- EPIMAC-BELA (NCT05632523)
- Testing
- Blood sample, urinary sample
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Tours
Acute Hypoxemic Respiratory Failure, High-flow Nasal Oxygen Therapy
Weaning Protocol for High-flow Nasal Oxygen Therapy in Intensive Care
High-flow nasal oxygen therapy (HFNO) is an oxygenation technique frequently used in intensive care. The main objective of our study is to show that the use of a protocol for weaning patients off high-flow nasal oxygen therapy…
- Trial name
- HiFloWEAN (NCT06104956)
- Testing
- HFNO weaning protocol, HFNO Standard of care
- Where
- 11 sites in France
- Volunteers
- 370 people
- Sponsor
- University Hospital, Tours
Chronic Kidney Disease Requiring Hemodialysis
Efficacy of Live Online Course Mindfulness Program on Perceived Fatigue in Hemodialysis Patients
The goal of this clinical trial is to assess the efficacy of a 2-month live online mindfulness meditation program in reducing perceived fatigue (measured by the SONG-HD Fatigue Scale) in patients undergoing chronic hemodialysis.
- Trial name
- MEDIA (NCT07054112)
- Testing
- Mindfulness-Based Stress Reduction (MBSR) meditation program, Control group
- Where
- 10 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Tours
ADHD, Behavioral Addiction
Feasibility and Efficacy of Cognitive-Behavioral Therapy for Patients With ADHD/Behavioral Addiction Comorbidity
The main objective of this pilot study is to assess preliminary data on the feasibility of CBT and its evaluation in a randomised trial in patients with co-occurring ADHD and behavioural addiction: Evaluation and comparison of…
- Trial name
- ADHDDICT (NCT06797726)
- Testing
- Cognitive behavioral therapy
- Where
- 3 sites in France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Tours
Asymptomatic Cirrhosis, Clinically Significant Portal Hypertension
Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial
Decompensation of cirrhosis is a turning point in cirrhosis course, as associated with a marked decrease in life expectancy. Thus, prevention of decompensation is crucial.
- Trial name
- CARVECIR (NCT06263816)
- Testing
- Experimental group: Patients will be treated with carvedilol.
- Where
- 24 sites in France
- Volunteers
- 290 people
- Sponsor
- University Hospital, Tours
Viral Pneumonia, Acute Respiratory Distress Syndrome (ARDS)
Mucosal Associated Invariant T Cell During Viral Pneumonia and Acute Respiratory Distress Syndrome
Viral pneumonia, including SARS-CoV-2 and influenza A virus (IAV), can culminate in acute respiratory distress syndrome (ARDS), a severe form of respiratory failure with high mortality.
- Trial name
- MAIT-VECTORS (NCT06720818)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Vasculitis
Search for BIO Diagnostic and Prognostic Markers in Adult VAScularitis
To date, there are no reliable diagnostic blood markers of adult vasculitis. To date, the diagnosis of vasculitis is based on invasive procedure, biopsy of affected tissues potentially at risk of complication .
- Trial name
- BIOVAS (NCT05565885)
- Testing
- Sampling
- Where
- France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Tours
Hemolytic-Uremic Syndrome, Atypical
Personalized Spacing of Eculizumab Infusions Based on Therapeutic Pharmacological Monitoring (EspacECU)
Eculizumab is an anti-C5 monoclonal antibody approved for rare diseases including atypical haemolytic-uraemic syndrome. The maintenance phase dosing regimen is identical for all adult patients but several studies have shown a…
- Trial name
- EspacECU (NCT04859608)
- Testing
- Spacing of Eculizumab infusions
- Where
- 18 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Tours
Anesthesia, Intensive Care Medicine
Optimization of Morphinomimetic Administration Intraoperatively: Evaluation of the Impact of the NOL Index on the Occurrence of Postoperative Adverse Events Related to Morphinomimetics
Reducing the quantity of morphinomimetics during the operative period reduces the prevalence and intensity of adverse effects. However, morphinomimetics are indispensable during surgery, as they limit the autonomic nervous…
- Trial name
- NOL-Impact (NCT06861634)
- Testing
- Nol index
- Where
- 6 sites in France
- Volunteers
- 332 people
- Sponsor
- University Hospital, Tours
Primary Care, Alzheimer Disease
Designing a Tailored Primary Care Intervention to Manage the Burden of Caring for Patients Living with Alzheimer's Disease (or a Related Dementia)
The design of the intervention is an ongoing process which will consist of two phases: a determination of the intervention using the Delphi-modified consensus method and an assessment of its acceptability, as described in the…
- Trial name
- ISAMA-PP (NCT06852326)
- Where
- 3 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Depressive Episode
Characterisation of Fundamental Decision Making in People Suffering From a Characterised Depressive Episode
The investigators will include patients suffering from Major Depressive Disorder (MDD), in episode. The patients will undertake neuropsychological tasks evaluating executive function and clinical assessment related to depressive…
- Trial name
- MINDDE (NCT05654948)
- Testing
- computerised cognitive performance test : MindPulse
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Tours
Addiction Disorders, Primary Care
Problematic Use and Addiction in Primary Care
The morbi-mortality and social cost of addictive disorders led the French authorities to set up a government plan in 2018 to combat drugs and addictive behavior (Interministerial mission to combat drugs and addictive behaviour …
- Trial name
- PAPRICA (NCT06580756)
- Testing
- Short training program
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Tours
Autism Spectrum Disorder
REward SYSTem in Autism Spectrum Disorder and Addictive Disorder
An MRI Study in Subjects with Autism Spectrum Disorder and Subjects with Food Addictive Disorder compared to healthy volunteers.
- Trial name
- RESYSTAA (NCT05391113)
- Testing
- MRI, EEG
- Where
- 3 sites in France
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Psychological Health, Physical Health
Dynamic Predictions of the Links Between Psychological and Physical Health of Older Patients in Nursing Home
Taking the older person as a whole is now essential to age well and prevent loss of functional independence. However, the relationship between physical and mental health remains not well understood.
- Trial name
- BioMIND (NCT05729906)
- Testing
- psychological and physical tests
- Where
- 5 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Female Infertility
Female Fertility, Environmental Agents and Stress Oxidant
Synthetic products used in industrial, pharmaceutical, agro-alimentary or agricultural fields are found in our environment. Thus, humans could be simultaneously exposed to several of these pollutants.
- Trial name
- FERTENOX (NCT04866329)
- Testing
- Blood sample, Urine sample, Follicular fluid and granulosa cells sample
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Tours