Clinical trials: sponsored by University Hospital, Tours
Lung Diseases
Evaluation of Efficacy and Safety of Rituximab in Patients With Progressive Interstitial Lung Disease (ILD) With Inflammatory Component: a Multicentre Double-blind Placebo-controlled Randomized Trial
The main objective of the EvER-ILD2 study is to evaluate the efficacy on lung function at 6 months of one course rituximab (2 infusions) comparatively to one course of placebo (2 infusions) in a broad range of progressive ILD…
- Trial name
- EvER-ILD2 (NCT05596786)
- Testing
- Rituximab
- Where
- France
- Volunteers
- 126 people
- Sponsor
- University Hospital, Tours
Posterior Reversible Encephalopathy Syndrome
Copeptin Kinetics in Critically Ill Patients With Posterior Reversible Encephalopathy Syndrome
XPRESSE is a multicenter observational prospective biomarker study in which critically ill patients with MRI-based PRES diagnosis will have copeptin kinetics from a daily blood sample for 6 days and a 3-month follow-up.
- Trial name
- XPRESSE (NCT04950270)
- Testing
- Blood copeptin monitoring, phone interview
- Where
- 4 sites in France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Tours
Suicidal Ideation, Emergency Psychiatric
Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide
Suicide prevention is a major public health concern, with nearly 9,000 suicides and over 200,000 suicide attempts reported each year in France.
- Conditions
- Suicidal Ideation, Emergency Psychiatric, Nitrous Oxide
- Trial name
- PROTORISC (NCT06430489)
- Testing
- Nitrous oxide, Medical air
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Elastographic Measurement, Intravesical Pressure Measurement
Elastographic Analysis of Urothelial Bladder Tumours
The preoperative evaluation of bladder tumors includes either computed tomography, magnetic resonance imaging in B-mode, or a cystoscopy in the absence of a radiological diagnosis.
- Trial name
- SONURO (NCT06225726)
- Testing
- urethral bladder resection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Tours
Focal Epilepsy
Optimized Volumetry in Radiology: Interest in Pediatric Brain MRI in the Exploration of Focal Epilepsy
Multicentre cross-sectional study with prospective recruitment comparing the detection rate of lesions on brain MRI without and with quantitative volumetry and T1 relaxometry information during the management of children with…
- Trial name
- ORACLE (NCT05100771)
- Testing
- Pediatric brain MRI
- Where
- 5 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Tours
Small Vessel Disease
Small Vessel Diseases: Ultra-realistic Microstructure Computational Model to Refine Individual Treatment
Small vessel disease (SVD) accounts for 25% of strokes and is the second most common cause of dementia after Alzheimer's disease.
- Trial name
- SUMMIT-WP3 (NCT06159140)
- Testing
- MRI
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Pregnant Woman
Modifying Nutrition to Modify Delivery in Nulliparous Women
In France, around 20% of women exceed the term of 41 weeks' amenorrhoea (SA). Maternal and foetal morbidity and mortality are increased when the term is exceeded, which justifies inducing labour.
- Trial name
- MAMAN (NCT06419192)
- Testing
- dietary advice, dietary advice alone, food supplied
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Cardiac Resynchronization Therapy
cArdiac Non Invasive MApping in resynchronizaTION
Non-invasive mapping using the Cardio Insight system is performed in heart failure patients requiring biventricular pacing to optimize therapy, and understand mechanisms underlying pacing-induced cardiomyopathy and ventricular…
- Trial name
- ANIMATION (NCT04347109)
- Testing
- Non invasive epicardial mapping
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Tours
Atrial Fibrillation
REgistry on Real-Life EXperience With Left Atrial Appendage Occlusion
The objective of this observational non-randomized multicenter study is to compile real-world clinical characteristics and outcomes data for patients treated with LAA (left atrial appendage) closure systems in a daily clinical…
- Trial name
- RELEXAO (NCT03279406)
- Testing
- Percutaneous Left Atrial Appendage Occlusion
- Volunteers
- 400 people
- Sponsor
- University Hospital, Tours
Schizophrenia
Evaluation of the Individual Early Psychoeducation Program for Schizophrenic Disorders in Inpatients
Schizophrenia affects about 0.7% of the population. Poor insight, which is common in this disease, linked to poor drug compliance is leads to rehospitalisation with major impact on quality of life.
- Trial name
- PEPITS (NCT05329363)
- Testing
- PEPITS Programme, Usual care
- Where
- 11 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Tours
Kidney Graft
Evaluation of Kidney Graft's Fibrosis With Real Time Shear-wave Elastography
Kidney graft's fibrosis is correlated with prognostic of kidney's graft, wathever the initial etiology. Actually, that evaluation is based on histologic score of Banff FI/AT (0 to III).
- Trial name
- Elastogreffe (NCT03819400)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Tours
Total Hip Arthroplasty
Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO)
NEFARTHRO is a multicentric randomized controlled trial comparing the effects of discontinuous infusions of nefopam (bolus) versus continuous infusion of intravenous nefopam (via an infusion pump) versus placebo on the…
- Trial name
- NEFARTHRO (NCT06349798)
- Testing
- Nefopam, NaCl 0.9%
- Where
- 7 sites in France
- Volunteers
- 546 people
- Sponsor
- University Hospital, Tours
Circulating Tumor DNA, Metastatic Prostate Cancer
Evaluation of the Technical Feasibility of Testing ct DNA for Homologous Recombination Gene Variants in Metastatic Prostate Cancer.
Evaluation of technical feasibility for Homologous Recombination (HR) genes variants research on circulating tumor DNA (ctDNA) from plasma and urine of patients with a metastatic prostate cancer.
- Trial name
- PROMECI (NCT05415787)
- Testing
- Blood sample, Urine sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Tours
Infection, Bacterial, Infection, Fungal
How to Reduce Unnecessary Blood Cultures: Construction and Validation of a Predictive Score for Blood Culture Positivity in Intensive Care
Prospective observational cohort consisting of all adult patients admitted to participating critical care units (ICU and CCU) during the study period, with blood cultures collected as part of their care, and who did not express…
- Conditions
- Infection, Bacterial, Infection, Fungal, Bacteremia
- Trial name
- PROBIty (NCT05686577)
- Testing
- no intervention
- Where
- 10 sites in France
- Volunteers
- 2,411 people
- Sponsor
- University Hospital, Tours
Amyotrophic Lateral Sclerosis
DIAGALS: Relation Between Tar DNA Binding Protein(TDP)-43 et Nrf-2 in ALS: a Track to Improve Diagnosis and Prognosis of the Disease
In response to oxidative stress, cells activate the Nrf-2 pathway, which induces translation of its target genes and corresponding proteins involved in the antioxidant response.
- Trial name
- DIAGALS (NCT06230562)
- Testing
- Blood sample
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Oxidative Stress, Analgesia
Oxidative Stress in the Patient With Peroperative Analgesia by Intravenous Lidocaine
Depending on the anesthesiologist's habits, injection or not of a 1.5 mg/kg bolus of lidocaine at induction of anesthesia followed by a continuous infusion of 1.5 mg/kg/h.
- Trial name
- OSPAIL (NCT05562141)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Tours
Non-squamous Lung Cancer, Metastatic Lung Cancer
Immune Response Under Immunotherapy in Metastatic NSCLC: Sputum, Blood Samples and Microbioata Study
Prospective pathophysiological exploratory monocentric study, focusing on adult patients with non-small cell lung cancer (NSCLC) : non-squamous type without oncogenic addiction, metastatic, treated with immune checkpoint…
- Trial name
- RICEPS (NCT04804137)
- Testing
- Blood, sputum, saliva
- Where
- 2 sites in United States, France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Tours
Chronic Adult Hydrocephalus
Multimodal Investigation in the Diagnosis and Treatment of Chronic Adult Hydrocephalus
Idiopathic chronic adult hydrocephalus (ICAH) is due to expansion of the fluid-filled cavities in the brain. The clinical symptoms are gait disturbance, mental decline and incontinence.
- Trial name
- Multimod'HCA (NCT02278848)
- Testing
- Diagnosis of ICAH using new investigative techniques (computerised gait analysis, ultrasound, MRI flow, urinary incontinence scale)
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Tours
Brain Tumor, Primary
Ultrasound Elastography and Ultrasentive Doppler for Surgery of Brain Tumors
Surgery for brain gliomas is usually guided by different imaging techniques including neuronavigation MRI and intraoperative ultrasound that do not allow visualization of the low-density peri-lesional tumor infiltration present…
- Trial name
- ELASTOGLI (NCT03970499)
- Testing
- brain tumor resection
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Tours
Amyotrophic Lateral Sclerosis
Frequency of SOD1 and C9orf72 Gene Mutations in French ALS
The purpose of the study is to determine the frequency of mutations in the C9orf72 and SOD1 genes in the incident population of ALS patients followed in the FILSLAN centres
- Trial name
- GENIALS (NCT04819555)
- Testing
- Blood
- Where
- 20 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Tours