Clinical trials: sponsored by University Hospital Tuebingen
Next-Generation-Sequencing
CIRculating Cell-free nUcLeic Acids in Cancer Therapy Monitoring -01
In cooperation with the molecular tumor board of the University Hospital Tübingen (UKT), a prospective collection of blood samples during the course of therapy is planned.
- Trial name
- CIRCULATING-01 (NCT05871593)
- Testing
- Molecular genetic diagnostic
- Volunteers
- 200 people
- Sponsor
- University Hospital Tuebingen
Impulsivity
fNIRS Neurofeedback in Highly Impulsive Participants With ROI Regions DLPFC and IFG
The aim of the following study is to investigate which is the best region of interest (ROI) for a functional near-infrared spectroscopy (fNIRS)-based neurofeedback (NF) training for highly-impulsive individuals (and consequently…
- Trial name
- NCT05863169
- Testing
- fNIRS-Neurofeedback
- Where
- Germany
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Small Bowel Perforations
Retrospective Analysis on Small Bowel Perforations
A retrospective, monocentric, code-related data analysis of patients with small bowel perforations was performed for the period 2010 to 2019.
- Trial name
- SBP (NCT05471999)
- Testing
- surgery
- Where
- Germany
- Volunteers
- 270 people
- Sponsor
- University Hospital Tuebingen
Trauma, Brain, Subarachnoid Hemorrhage
Non-invasive ONSD-based Neuromonitoring in a Neurointensive Care Setting
Intensive care patients with established invasive intracranial neuromonitoring due to neurotrauma are subjected to a repeated non-invasive sonographic recording of the optic-nerve-sheath-diameter (ONSD).
- Conditions
- Trauma, Brain, Subarachnoid Hemorrhage, Intracranial Hypertension
- Trial name
- ONSDDynamics (NCT05818371)
- Testing
- Sonographic determination of the optic nerve sheath diameter
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Parkinson Disease
Progression in Cognitive ADLs in Parkinson's Disease
Mild cognitive impairment (PD-MCI) is one of the greatest risk factors for future Parkinson's disease dementia (PDD). A recent meta-analysis found that, on average, 31% of patients with PD-MCI converted to PDD within seven years…
- Trial name
- PRICOG-PD (NCT05806866)
- Testing
- Cognition scores, cognitive instrumental activities of daily living scores
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- University Hospital Tuebingen
Melanoma
Complete Lymph Node Dissection vs Watchful Waiting in Patients With Malignant Melanoma (Thickness of 1,0mm+ and Evidence of Metastases in the Sentinel Node)
Sentinel lymph node biopsy (SLNB) is considered as standard diagnostic procedure in melanoma patients carrying a reasonable risk for metastases.
- Trial name
- DeCOG-SLT (NCT02434107)
- Testing
- Completion Lymphadenectomy, Clinical Monitoring (Palpation and node ultrasound)
- Where
- 41 sites in Germany
- Volunteers
- 483 people
- Sponsor
- University Hospital Tuebingen
Metastatic Melanoma (Carrying BRAF V600 Mutation)
Evaluation of Photosensitivity in Dabrafenib or Vemurafenib Treated Metastatic Melanoma Patients - a Phase IIa/IIb Study
The BRAF inhibitors dabrafenib and vemurafenib belong both two a new class of potent anti-cancer drugs and are highly efficacious in tumors harboring the BRAF V600E mutation.
- Trial name
- NCT02052193
- Testing
- Dabrafenib, Vemurafenib
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- University Hospital Tuebingen
Leukemia, Chronic Lymphatic
iVAC-CLL01: Patient-individualized Peptide Vaccination After First Line Therapy of CLL
The aim of this study is to induce a peptide-specific immune response in CLL patients by multi-peptide vaccination with a patient-individualized peptide cocktail.
- Trial name
- NCT02802943
- Testing
- Peptide Vaccine, Imiquimod
- Where
- 5 sites in Germany
- Volunteers
- 56 people
- Sponsor
- University Hospital Tuebingen
Soft Tissue Sarcoma
Trial for Localised High-risk Rhabdomyosarcoma and Rhabdomyosarcoma-like Soft Tissue Sarcoma
The purpose of this study is to investigate whether the addition of oral maintenance chemotherapy with O-TIE (Etoposide, Idarubicin, Trofosfamide) for 6 months improves the event free survival (EFS) in patients with localised…
- Trial name
- CWS-2007-HR (NCT00876031)
- Testing
- trofosfamide, idarubicin, etoposide
- Where
- 87 sites in Austria, Germany and 3 more
- Volunteers
- 195 people
- Sponsor
- University Hospital Tuebingen
Brain Tumor, Recurrent, Vestibular Schwannoma
Vegetative Monitoring During Brainstem-associated Surgery
Intraoperative Monitoring of Heart rate variability, Blood pressure variability, Baroreceptorsensivity etc.
- Conditions
- Brain Tumor, Recurrent, Vestibular Schwannoma, Brainstem Neoplasm, Brainstem Glioma
- Trial name
- NCT03666507
- Testing
- Intraoperative Monitoring during resection of brain tumor
- Where
- Germany
- Volunteers
- 103 people
- Sponsor
- University Hospital Tuebingen
Rare Diseases, Genetic Predisposition
Whole Genome Trio Sequencing as a Standard Routine Test in Patients With Rare Diseases - "GENOME FIRST APPROACH"
The GENOME FIRST APPROACH project will enroll patients (n = 450) and their healthy parents with unclear molecular cause of the disease, suspected genetic cause of the disease and the healthy parents of those affected for trio…
- Trial name
- NCT03954652
- Testing
- WGS-Diagnostic
- Where
- Germany
- Volunteers
- 1,350 people
- Sponsor
- University Hospital Tuebingen
Parkinson Disease
DESENSITIZE-PD: Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Support Dopaminergic Desensitization in PD
20 patients with idiopathic Parkinson's disease, who are planned to undergo intestinal L-Dopa + entacapone (Lecigon®) treatment will be included into this observational single-armed study.
- Trial name
- NCT05579379
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Vaccination Reaction
Early Antibiotic Therapy and Vaccinations in Preterm Infants
Since the neonatal sepsis is still one of the most common causes of death in preterm infants up to 80% receive an perinatal antibiotic treatment.
- Trial name
- NCT05563753
- Testing
- ABT
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- University Hospital Tuebingen
Vestibular Schwannoma
Remote Ischemic Preconditioning in Vestibular Schwannoma Surgery
Vestibular schwannomas are primarily benign (WHO grade I) tumors originating from the Schwann cells of the vestibular nerve and are among the most common tumors of the skull base.
- Trial name
- RIC-VS (NCT05567341)
- Testing
- Remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Tuebingen
Pain
The Effect of Two Different Non-pharmacologic Methods for Painandfear Relief During Blood Specimen Collection Inchildren
Introduction: Pain is defined as an unpleasant emotional and sensorial feeling that arises from any part of the body progresses with possible tissue damage and covers all past experiences of individuals.
- Trial name
- NCT05560074
- Testing
- Buzzy, DistrACTION® Cards
- Where
- Germany
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Acute Ischemic Stroke
Penumbral Rescue by Normobaric O2 Administration in Patients With Ischemic Stroke and Target Mismatch ProFile
The main objective of the PROOF trial is to investigate efficacy and safety of normobaric hyperoxygenation (NBHO) as a neuroprotective treatment in patients with acute ischemic stroke due to large vessel occlusion likely to…
- Trial name
- PROOF (NCT03500939)
- Testing
- Medical oxygen, Standard of care
- Where
- 22 sites in Belgium, Finland and 3 more
- Volunteers
- 223 people
- Sponsor
- University Hospital Tuebingen
Hereditary Spastic Paraplegia, Hereditary, Spastic Paraplegia, Autosomal Dominant
The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4
Study goals 1. Prospective longitudinal data on progression in the natural course of SPG4 in presymptomatic mutation carriers prior to clinical disease onset and in early stages of disease 2.
- Trial name
- NCT03206190
- Testing
- SPRS Score and clinical signs, Cognition Testing using CANTAB, Lumbar Puncture and blood draw
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Tuebingen
Gestational Diabetes
Gestational Diabetes
Due to a changed lifestyle with less physical activity, unfavorable diets rich in fat and calories and obesity, the prevalence of diabetes mellitus is increasing worldwide.
- Trial name
- PREG (NCT04270578)
- Where
- Germany
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Carcinoma, Non-Small-Cell Lung, Pathology, Molecular
Influence of Biopsy Technique on Moleculargenetic Tumor Characterisation in NSCLC
Study design Prospective multicentre explorative randomized single blinded study to evaluate accuracy of molecular genetic characterisation of NSCLC.
- Trial name
- PROFILER (NCT03971175)
- Testing
- Forceps biopsy, Cryobiopsy
- Where
- Germany
- Volunteers
- 540 people
- Sponsor
- University Hospital Tuebingen
Cardiovascular Diseases
Reveal Transition - A Mechanistic Study in Transition / Stabilized Phase of CAD
Longterm oral anticoagulation with very low dose rivaroxaban (2.5mg bid) in combination with aspirin has been shown superior over standard aspirin monotherapy in patients with stable coronary artery disease (CAD) in the COMPASS…
- Trial name
- RevealTrans (NCT04032665)
- Testing
- Rivaroxaban
- Where
- Germany
- Sponsor
- University Hospital Tuebingen