Clinical trials: sponsored by University Hospital Tuebingen
Psychotherapy Intervention Evaluation
iCBT for Children and Adolescents With Obsessive-compulsive Disorder II
Internet-based psychotherapy for children and adolescents with obsessive-compulsive symptoms and an age of 6 to 18 years. Sessions are verified with teleconferencing with an psychotherapist, children and their parents.
- Trial name
- NCT05037344
- Testing
- Cognitive-behavioral psychotherapy
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Haploidentical Stem Cell Transplantation With CD3/CD19 Depletion and Reduced Intensity Conditioning in Patients With Acute Leukemia
Feasibility and toxicity of haploidentical allogeneic HCT after a reduced intensity conditioning regimen with CD3/CD19 depleted grafts.
- Trial name
- CD3/CD19 Haplo (NCT00961142)
- Testing
- Fludarabine, Thiotepa, Melphalan, Thymoglobuline (ATG)
- Where
- 8 sites in Germany
- Volunteers
- 23 people
- Sponsor
- University Hospital Tuebingen
Neuropathic Pain, Phantom Pain
Neuropathic Pain After Orchidectomy and Sex Reassignment Surgery
Phantom pain is associated with cortical reorganization after amputation. This phenomenon should not play a role in transsexual women, since the cortical representation of the male sex organs is presumably altered.
- Conditions
- Neuropathic Pain, Phantom Pain, Sex Reassignment Surgery
- Trial name
- NPASRS (NCT04538170)
- Testing
- pain after surgery
- Where
- Germany
- Volunteers
- 423 people
- Sponsor
- University Hospital Tuebingen
Depression, Cognitive Impairment
Efficacy of Gamified Cognitive Control Training Using de:)Press on Depression Severity add-on to Treatment as Usual
Depression is one of the most frequent and devastating psychiatric diseases with a substantial bur-den for patients and society.
- Conditions
- Depression, Cognitive Impairment, Cognitive Dysfunction, Depressive Disorder
- Trial name
- de-press-2 (NCT05385614)
- Testing
- de:)press
- Where
- Germany
- Volunteers
- 112 people
- Sponsor
- University Hospital Tuebingen
Rare Diseases, Genetic Predisposition
Diagnostic Research in Patients With Rare Diseases - Solving the Unsolved Rare Diseases
The DiRiP study will enroll patients (n = 3500) with unclear rare diseases and suspected genetic reasons. In group 1 (n = 500) subjects are clinically characterized in the context of outpatient/ inpatient standard care at the UKT…
- Trial name
- DiRiP-RD (NCT03491280)
- Testing
- NGS Diagnostic
- Where
- Germany
- Volunteers
- 5,500 people
- Sponsor
- University Hospital Tuebingen
Renal Insufficiency, Acute
Determination of the "Tissue Transit Time" (TTT)
Determination of Tissue Transit Time (TTT) as a parameter with high prognostic value to predict the functional course of the differential renal function and the development of the differential renal function after pyeloplasty
- Trial name
- NCT03311256
- Testing
- Tissue Transit Time
- Where
- 9 sites in Germany, Switzerland
- Volunteers
- 119 people
- Sponsor
- University Hospital Tuebingen
Obesity, Child
Kids Obesity Prevention Program Part 2
Obesity and its associated comorbidities are becoming a key and rapidly growing public health problem. The cause of obesity is an imbalance between energy intake and energy expenditure in favor of the former.
- Trial name
- KOP-2 (NCT02942823)
- Testing
- The serious game "KOP"
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Obesity
Transport of Satiety Factors Into the CSF
The blood-brain barrier regulates the passage of peripheral built appetite-suppressing hormones from the blood to the brain and informs the brain about the nutritional- and energy status.
- Trial name
- NCT04038086
- Testing
- oral glucose tolerance test, circadian rhythm, effect of insulin on peptide transport
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Tuebingen
Gestational Diabetes
Prevention of Gestational Diabetes
Pregnancy is a vulnerable period for both a mother and her developing child. The investigator hypothesizes that diet-induced glucose excursions in the pregnant mother are a key contributor to unfavourable brain development and…
- Trial name
- NuPreGDM (NCT04028089)
- Testing
- Diet Modification Group, Regular Diet Group
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
COVID-19 Vaccine
Safety and Immunogenicity Trial of Multi-peptide Vaccination to Prevent COVID-19 Infection in Adults
Part I: 12 subjects will receive an open-label 500 µl subcutaneous injection via needle and syringe of the study IMP (CoVac-1). No more than one subject per day will be enrolled.
- Trial name
- pVAC (NCT04546841)
- Testing
- multipeptide cocktail
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Parkinson Disease
Cognitive-driven ADL Impairment as a Predictor for PDD
Mild cognitive impairment in Parkinson's disease (PD-MCI) is the highest risk factor for Parkinson's disease dementia (PDD). The core feature for differentiating PDD from PD-MCI is the loss of the ability to perform activities of…
- Trial name
- NCT03687203
- Testing
- Functional Activities Questionnaire
- Where
- Germany
- Volunteers
- 182 people
- Sponsor
- University Hospital Tuebingen
Secondary Sclerosing Cholangitis, COVID-19
SSC-COVID in Patients After COVID-19
Analysis of occurrence of SSC-COVID in SARS-CoV-2-patients after the first wave of COVID-pandemic
- Trial name
- NCT05233553
- Testing
- control of liver enzymes
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- University Hospital Tuebingen
Head and Neck Cancer
Individualized Response-adaptive Radiation Dose Prescription in HNC Based on MRI
This Phase 1 dose-finding study investigates the maximal tolerated dose for a subsequent phase 2 trial testing MR-guided individualized response-adaptive dose prescription in HNC.
- Trial name
- MRL-02 (NCT05160714)
- Testing
- Real-time ADC-guided response adaptive Boost in HNC
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Tuebingen
ARDS, COVID-19
Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory Distress Syndrome (ARDS)
To evaluate the safety, toxicity and immunological effects of infusion of allogeneic bone marrow-derived human mesenchymal stem (stromal) cells (MSCs) and whether this therapy has an influence on the resolution processes in ARDS…
- Trial name
- NCT04377334
- Testing
- MSC
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Cardiac Disease, Vascular Diseases
Perioperative Three-dimensional Echocardiography in Cardioanesthesia.
The aim of this study is to investigate the significance of intraoperative echocardiography on the surgical course and association with patient outcome.
- Trial name
- NCT05191173
- Testing
- Cardiac Surgery
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Tuebingen
COVID, ARDS
Intensive Care Therapy of Covid-19 Disease in Germany
Multi-center retrospective and prospective observational study of Covid-19 patients with severe or critical illness treated on a German ICU
- Trial name
- NCT04455451
- Where
- 27 sites in Germany
- Volunteers
- 2,054 people
- Sponsor
- University Hospital Tuebingen
Obesity
Effect of Bariatric Surgery on Brain Insulin Sensitivity
Adiposity is associated with prediabetes and type 2 diabetes. In very severe cases of adiposity in combination with type 2 diabetes, bariatric surgery has proven to be a successful therapy option.
- Trial name
- NCT03705923
- Testing
- Bariatric surgery
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- University Hospital Tuebingen
Respiratory Distress Syndrome, Adult
Iloprost in Acute Respiratory Distress Syndrome
The patients will be randomized into one of two groups. Both groups will receive standard care as is state of the art. The intervention group will receive Iloprost nebulized as inhalative therapy.
- Trial name
- ThIlo (NCT03111212)
- Testing
- Iloprost, control
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Tuebingen
Type 2 Diabetes Mellitus (T2DM)
Dapagliflozin Effect on Erythropoiesis and Physical Fitness
Dapagliflozin effect on erythropoiesis and physical fitness in patients with type 2 diabetes - a randomized, partly double-blinded, controlled, three armed, parallel group, exploratory study
- Trial name
- NCT03423355
- Testing
- Dapagliflozin (Forxiga®), Hydrochlorothiazide 25 mg
- Where
- Germany
- Sponsor
- University Hospital Tuebingen
Major Depressive Disorder
tVNS Effects on Motivation in Depression
Attaining goals or rewards commonly entails response costs. In light of cost and benefits, how do participants decide what effort should be put in to give it a shot? Figuratively, you may "go with your gut", but the literal…
- Trial name
- NCT05120336
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Germany
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen