Clinical trials: sponsored by University Hospital Tuebingen
Pre-diabetes
Efficacy of Whole-body Electromyostimulation (WB-EMS) Training in Participants With Pre-diabetes
The goal of this pilot study is to assess the efficacy of the intervention (WB-EMS Training) in a sedentary group of adults with pre-diabetes and to estimate the potential effect sizes.
- Trial name
- NCT06188481
- Testing
- whole-body electromyostimulation training, activity tracker, evidence-based lifestyle education program
- Where
- Germany
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Major Depressive Disorder
Effects of Ghrelin Administration on Motivation
Everyday humans are confronted with a plethora of rewards competing for their attention. Nevertheless, to obtain a goal or reward, humans often need to invest effort.
- Trial name
- NCT06576440
- Testing
- Ghrelin, Saline
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Major Depressive Disorder
Effects of Ghrelin Administration on Dopamine and Effort
Ghrelin is a stomach-derived hormone and the only known circulating peptide that stimulates appetite. Animal studies have conclusively shown that ghrelin increases dopaminergic neurotransmission and, thereby, enhances effort.
- Trial name
- NCT05318924
- Testing
- Ghrelin
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Post-Stroke Delirium
Delirium Incidence and Indwelling Urinary CathEterization After Acute Stroke
The main goal of this study is to identify indwelling urinary catheterization (IUC) as a predictive factor of the development of delirium in male acute stroke patients.
- Trial name
- DICES (NCT07264244)
- Testing
- condom catheter
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Tuebingen
Obesity
Dopamine Action on Metabolism in Relation to Genotype
Obesity is a widespread disease with increasing prevalence and associated with serious secondary complications. So far, the origin of the disease, regardless of an existing positive energy balance, is not fully understood.
- Trial name
- NCT03525002
- Testing
- Bromocriptine
- Where
- 3 sites in Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Tuebingen
AML (Acute Myeloid Leukemia), MDS/AML
Venetoclax- Augmented Treosulfan-Based Reduced Intensity Conditioning Before Allogeneic Stem Cell Transplantation
Safety and Feasibility of a Venetoclax- Augmented Treosulfan-Based Reduced Intensity Conditioning Before Allogeneic Stem Cell Transplantation in AML, MDS/AML and Higher Risk MDS
- Conditions
- AML (Acute Myeloid Leukemia), MDS/AML, MDS (Myelodysplastic Syndrome)
- Trial name
- NCT07214064
- Testing
- RIC regimen
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Anorexia Nervosa, Bulimia Nervosa
Development of Gastrointestinal Symptoms in Patients With Anorexia Nervosa and Bulimia Nervosa During Weight Rehabilitation Over Time, Depending on the Nutritional Strategy
This prospective observational study investigates the development of gastrointestinal (GI) symptoms in patients with anorexia nervosa (AN) and bulimia nervosa (BN) during multi-week inpatient weight rehabilitation.
- Trial name
- GastroRehab (NCT07112014)
- Where
- Germany
- Volunteers
- 185 people
- Sponsor
- University Hospital Tuebingen
Major Depressive Disorder
Treatment of Major Depressive Disorder With Bilateral Theta Burst Stimulation
This is a randomized, double-blind, sham-controlled multicenter clinical trial. The aim is to provide evidence for efficacy of TBS in the treatment of patients with major depression.
- Trial name
- TBS-D (NCT04392947)
- Testing
- Transcranial Magnetic Stimulation
- Where
- 7 sites in Germany
- Volunteers
- 238 people
- Sponsor
- University Hospital Tuebingen
Perioperative Myocardial Injury
Anesthesia Induced Myocardial Injury in Non-cardiac Surgery (AIMY)
Myocardial injury during non-cardiac surgery (PMI) affects up to 16% of high-risk patients and represents a significant burden on healthcare systems.
- Trial name
- AIMY (NCT07179029)
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- University Hospital Tuebingen
Breast Cancer Female
Impact of Recurrence Score on Adjuvant Treatment Decisions in Breast Cancer Patients
IRMA is a Prospective, monocenter, non-interventional investigator initiated (IIT) registry that aims to investigate the use of the CE-marked OncotypeDX and its impact on adjuvant therapy recommendations in the clinical routine.
- Trial name
- NCT03961880
- Where
- Germany
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Stroke, Acute, Brain Edema
Automatic PredICtion of Edema After Stroke
To use machine learning for early detection of malignant brain edema in patients with MCA ischemia
- Trial name
- APICES (NCT04057690)
- Where
- 19 sites in Austria, Germany and 1 more
- Volunteers
- 1,687 people
- Sponsor
- University Hospital Tuebingen
Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms
CD318-targeted CAR-T Cell Therapy in Patients With Pancreatic Cancer (ResCPa)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with limited therapeutic options and a five-year survival rate below 10 % in advanced stages.
- Trial name
- ResCPa (NCT07153289)
- Testing
- CD318-CAR-T cells
- Volunteers
- 38 people
- Sponsor
- University Hospital Tuebingen
Psoriasis (PsO), Psoriasis Arthritis
Molecular Inflammation Board at the Center for Personalized Medicine
Molecular Inflammation Board at the Center for Personalized Medicine
- Conditions
- Psoriasis (PsO), Psoriasis Arthritis, Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Spondylarthropathies
- Trial name
- MEB@ZPM (NCT07132333)
- Testing
- Biologic Agent
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- University Hospital Tuebingen
Lymphoma, CLL
A Phase I Dose Finding Study of MB-CART2219.1
A Phase I dose finding study of MB-CART2219.1 targeting CD19/CD22 in adult and pediatric patients with relapsed/refractory B-cell malignancies
- Conditions
- Lymphoma, CLL, Acute Lymphoblastic Leukemia, Pediatric
- Trial name
- NCT07108868
- Testing
- CAR-T cells targeting CD19 and CD22
- Where
- 2 sites in Germany
- Volunteers
- 36 people
- Sponsor
- University Hospital Tuebingen
Fatigue, Pain
Auricular Acupuncture in Patients With Advanced Cancer: a Randomized Clinical Trial.
In the present study, the effect of ear acupressure treatment according to the NADA protocol on the quality of life of patients with advanced tumour diseases. (all stages) will be investigated.
- Conditions
- Fatigue, Pain, Depression, Advanced Tumour Diseases
- Trial name
- MY_ACU (NCT05762250)
- Testing
- Auricular Acupuncture
- Where
- 2 sites in Germany
- Volunteers
- 125 people
- Sponsor
- University Hospital Tuebingen
Post-COVID-19 Syndrome, Fatigue Post Viral
Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome
Evaluation of the short- and medium-term effect of a yoga intervention in addition to routine care compared to health education in addition to routine care on fatigue in patients with post covid syndrome.
- Trial name
- YoFaPoCo (NCT05890599)
- Testing
- Yoga Therapy, Health Education
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Stargardt Disease
ABCA4-associated Disease in Childhood and Adolescence - a Phenotype Study
Retrospective chart review study to elucidate the phenotype and genotype of children with ABCA4-associated Stargardt disease.
- Trial name
- NCT06377150
- Where
- Germany
- Volunteers
- 39 people
- Sponsor
- University Hospital Tuebingen
Elective Heart Surgery
Ear Acupressure for Reducing Anxiety and Pain During Heart Surgery
Acupuncture and acupressure, rooted in Traditional Chinese Medicine, are used to treat a variety of symptoms. One specific and easy-to-apply method is ear acupuncture/acupressure following the NADA protocol (developed by the…
- Trial name
- NCT07010003
- Testing
- Acupressure
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- University Hospital Tuebingen
Acute Respiratory Distress Syndrome
Early Versus Late Initiation of ECMO (Extracorporal Membrane Oxygenation) Trial (ELIEO-Trial)
This trial is a prospective randomized multicenter trial that assigns patients to either a treatment for Acute Respiratory Distress Syndrome (ARDS) with an Extracorporal Membrane Oxygenation (ECMO) immediately after admission to…
- Trial name
- ELIEO (NCT04208126)
- Testing
- ECMO
- Where
- Germany
- Volunteers
- 508 people
- Sponsor
- University Hospital Tuebingen
Hematologic Malignancy
CD45RA Depleted DLI After TCRα/β Depleted Haploidentical HCT
The purpose of this clinical trial is to examine safety and toxicity of CD45RA depleted donor lymphocyte infusion (DLI) after transplantation of TCRα/β/CD19 depleted peripheral blood stem cells.
- Trial name
- CD45RADLIHaplo (NCT05943067)
- Testing
- CD45RA depleted donor lymphocyte infusion (DLI)
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen