Clinical trials: sponsored by University Hospital Tuebingen
AML, MDS
Combination Salvage Therapy With Venetoclax and Decitabine in Relapsed/Refractory AML
The goal of this prospective, phase II single center, one arm, open label clinical trial is to test the efficacy and feasibility of a combination salvage therapy with Venetoclax and intensified Decitabine in patients with newly…
- Trial name
- VenSwitch (NCT06156579)
- Testing
- Decitabine, Venetoclax
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University Hospital Tuebingen
Depressive Disorder, Major
The Effect of Mediterranean Diet and Mindfulness Eating on Depression Severity in People With Obesity and Major Depressive Disorder
The present study investigates the effect of Mediterranean Diet and Mindful Eating on depression severity in people with obesity and major depressive disorder.
- Trial name
- MEDIMIND (NCT06621394)
- Testing
- nutritional intervention, Mindful Eating, Attention Control
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Leptomeningeal Disease
Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26)
To determine the safety of intrathecal (IT) PD1 antibody for Intrathecal application of PD1 antibody in metastatic solid tumors with leptomeningeal disease of solid tumors.
- Trial name
- IT-PD1 (NCT05112549)
- Testing
- Nivolumab [Opdivo]
- Where
- 9 sites in Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital Tuebingen
Gastric Neoplasms
Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Gastric Cancer
This study investigates the effect of a combined therapy with gastrectomy and HIPEC in localized advanced gastric cancer.
- Trial name
- ProPeC (NCT04180761)
- Testing
- intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC)
- Where
- Germany
- Sponsor
- University Hospital Tuebingen
Rare Diseases, Genetic Predisposition to Disease
Genetic Causes of Discrepant Clinic in Monogenic Twins
In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics technologies and/ or…
- Trial name
- DISCO-TWIN (NCT04046796)
- Testing
- NGS Diagnostic
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Tuebingen
Rare Diseases, Genetic Predisposition
Mitochondrial Diseases - Long-read Genome and Transcriptome Sequencing in Cases Unresolved After Short-read Genomics
The MiDiSeq project will enroll 20 unresolved index patients with suspected mitochondrial disease prioritized for genomic analysis.
- Trial name
- NCT03962452
- Testing
- Next Generation Sequencing (NGS)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Normal Weight, Overweight and Obesity
Effect of GLP1 Receptor Agonist on Brain Insulin Responsiveness
The overarching goal of the current study is to investigate the effect of GLP-1 on brain insulin responsiveness in a randomized, single-blinded, within subject cross-over study design.
- Conditions
- Normal Weight, Overweight and Obesity, Insulin Sensitivity, Insulin Resistance
- Trial name
- NCT06487832
- Testing
- Subcutaneous GLP1-RA
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Insulin Resistance, Obesity
Enhancing Brain Health by TDCS in Persons with Overweight and Obesity
Disturbances in the hypothalamus communication pathways with other regions in the brain and the periphery may represent a potential link between metabolic and cognitive health.
- Conditions
- Insulin Resistance, Obesity, Diabetes Type 2
- Trial name
- STIM (NCT05228067)
- Testing
- anodal transcranial direct current stimulation, cathodal transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Atrial Fibrillation, Atrial Flutter
Risk Factors in Tachycardiomyopathy
Decision between rate control and rhythm control can be a challenge in clinical practice. While there is some guiding evidence, we still lack a comprehensive insight into different subgroups of patients that will benefit from a…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Ventricular Premature Complexes
- Trial name
- EMPATHY (NCT03418467)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Major Depressive Disorder
Pharmacologic Treatment Augmentation in Chronic Depression
To enroll in this clinical trial, prospective participants must meet stringent criteria. The participants need to fall within the age range of 18 to 64 and exhibit chronic depression at therapy resistance stage 2.
- Trial name
- Ket+CBASP (NCT06410599)
- Testing
- Ketamine, CBASP, TAU
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Healthy
OPTImisation and Standardization of CIRCulating Cell-free DNA Ex-traction Protocols in a Diagnostic Setting
comparison of blood collection tubes and cell-free DNA extraction to evaluate the best possible combination to obtain high quantity and quality cell-free DNA sample for NGS analyses
- Trial name
- OPTICIRC (NCT06869070)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Breast Cancer Metastatic
E-Health Portal for Individualized Treatment Monitoring and Patient Engagement in Oncology Research
Evaluation of patient acceptance and characterization of response behaviour for web-based compared with respective paperbacked patient reported outcomes.
- Trial name
- NCT03132506
- Testing
- patient-reported-outcomes
- Where
- Germany
- Volunteers
- 106 people
- Sponsor
- University Hospital Tuebingen
Infertility, Female
Plasma Concentrations of Calcium, Phosphate, FGF23, Klotho, 25 (OH) D3 and 1,25 (OH) 2D3 from Patients Who Wants to Have Children
1,25-dihydroxy-vitamin D3 (1,25 (OH) 2D3) or calcitriol regulates plasma calcium and phosphate concentrations in the blood by stimulating intestinal absorption and renal reabsorption of calcium and phosphate.
- Trial name
- NCT03173235
- Testing
- Plasma level of vitamin D
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Uterine Neoplasms
Analysis and Optimization of Predictive and Therapeutic Models in Uterine Neoplasms
Evaluation of clinical, therapeutic and prognostic relevance of new experimental results as well as optimization of therapeutic models and development of a new algorithm for therapeutic plan and therapy in patients with uterine…
- Trial name
- NCT03624712
- Testing
- uterine neoplasms
- Where
- Germany
- Volunteers
- 580 people
- Sponsor
- University Hospital Tuebingen
Nephrotic Syndrome, Edema
Amiloride in Nephrotic Syndrome
The AMILOR study compares treatment of edema in nephrotic syndrome with Amiloride vs. Furosemide.
- Conditions
- Nephrotic Syndrome, Edema, Sodium Retention
- Trial name
- AMILOR (NCT05079789)
- Testing
- Amiloride, Furosemide
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Glioblastoma Multiforme of Brain
Multi Peptide Vaccination with XS15 in Addition to Standard Postoperative Radiation Therapy and Temozolomide Chemotherapy in Newly Diagnosed Glioblastoma
Newly diagnosed HLA-A2-positive MGMT-methylated glioblastoma patients will be vaccinated with a Multi peptide vaccination with Pam3Cys-GDPKHPKSF (XS15) as an immunomodulator in addition to standard postoperative radiation therapy…
- Trial name
- GLIO-XS15 (NCT04842513)
- Testing
- Multipeptide plus XS15
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University Hospital Tuebingen
Meningeoma, Thrombembolism
Meningioma and Embolism Thrombosis Risk & Investigation of Coagulation
Despite being generally benign tumors, meningiomas are associated with an increased risk for thrombembolic complications after surgical resection. The molecular mechanisms underlying this circumstance are still unknown.
- Conditions
- Meningeoma, Thrombembolism, Surgical Resection
- Trial name
- 001_2024_BO2 (NCT06709833)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Gynecologic Cancer
Clinical Value of Molecular Genetic Analyzes in Gynecological Malignomas
The aim of the planned research project is to find out the clinical significance of molecular genetic analyzes in gynecological malignomas.
- Trial name
- MAGynMA (NCT03194347)
- Testing
- molecular genetic analyses
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Tuebingen
Smoking, Tibia Fracture
Effect of Tobacco Heating System (THS) on Closed Lower Limb Fracture Healing
The goal of this clinical trial is to investigate the role of switching from cigarette smoking (CS) to tobacco heat system (THS) on the clinical outcome of closed lower limb (tibia and femur) fractures from smokers' orthopedic…
- Trial name
- NCT05859451
- Testing
- Tobacco Heating System (THS), Smoking abstinence
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Tuebingen
Chronic Lymphocytic Leukemia
Personalized Multi-peptide Vaccination in CLL Patients
The aim of this study is to evaluate the efficiency along with safety and toxicity of a personalizied multi-peptide vaccine in combination with the TLR1/2 ligand XS15 in CLL patients undergoing ibrutinib-based regimes.
- Trial name
- NCT04688385
- Testing
- Multipeptide Vaccine+ XS15
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen