Clinical trials: sponsored by University Hospital Tuebingen
One or More Uterine Fibroids
Pregnancy Outcome Following Global Fibroid Ablation Using the Acessa™ System
Prospective, interventional, single-center, longitudinal, single-arm pilot study to evaluate pregnancies following the Acessa™ treatment of uterine myomas in women who desire future childbearing
- Trial name
- NCT03028610
- Testing
- radiofrequency generator
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- University Hospital Tuebingen
Fibrolamellar Hepatocellular Carcinoma
FusionVAC22_01: Fusion Transcript-based Peptide Vaccine Combined with Immune Checkpoint Inhibition
The aim of this clinical trial is to evaluate the immunogenicity along with safety and toxicity as well as first efficacy of a DNAJB1-PRKACA fusion transcript-based peptide vaccine (Fusion-VAC-XS15) in combination with…
- Trial name
- FusionVAC22 (NCT05937295)
- Testing
- Fusion-VAC-XS15
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Castration-Resistant Prostatic Cancer
The Bispecific PSMAxCD3 Antibody CC-1 in Patients with Castration Resistant Prostate Carcinoma
This trial is a first in human (FIH) study in patients with castration resistant metastatic prostate cancer (CRPC) after failure of third-line therapy aiming to evaluate safety and efficacy of CC-1, a bispecific antibody (bsAb)…
- Trial name
- PSMAxCD3 (NCT04104607)
- Testing
- CC-1, PSMAxCD3
- Where
- 2 sites in Germany
- Volunteers
- 86 people
- Sponsor
- University Hospital Tuebingen
Chronic Lymphoid Leukemia in Relapse
Belimumab in Patients with Chronic Lymphocytic Leukemia
This study is a phase II trial of belimumab in combination with rituximab/venetoclax in patients with refractory or relapsed chronic lymphocytic leukemia (CLL).
- Trial name
- BeliVeR (NCT05069051)
- Testing
- Belimumab 200 MG/ML [Benlysta], standard of care
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Tuebingen
Eating Behavior, Habits
Goal-directed and Cue-dependent Behavior in Severe Obesity
The current proposal aims to investigate implicit and explicit priming paradigms for changing cue-dependent and goal-directed nutritional behavior in participants with severe obesity before and after bariatric surgery as well as…
- Conditions
- Eating Behavior, Habits, Obesity
- Trial name
- PIT_BS (NCT04187066)
- Testing
- mindset induction
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Staphylococcus Aureus
First-in-man Single-dose and Multiple Dose Study to Evaluate the Safety, Tolerability and Efficacy ofHY-133
In this clinical trial we will test a new approach for decolonization of S. aureus. As innovative product HY-133 a recombinant chimeric bacteriophage endolysin will be sprayed in both nostrils of healthy subjects once or five…
- Trial name
- HY-133 (NCT06290557)
- Testing
- HY_133
- Where
- 2 sites in Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Malaria
Comparing Safety and Protective Efficacy of Vaccine Candidate PfSPZ-CVac and MVA ME-TRAP/ ChAd63 ME-TRAP in Adults
This is a single centre, randomized, placebo-controlled phase 1/2 study comparing two malaria vaccine candidates. The first vaccine candidate PfSPZ-CVac (Plasmodium falciparum sporozoites (PfSPZ) challenge administered with a…
- Trial name
- NCT05441410
- Testing
- Pyronaridine Tetraphosphate, Artesunate Drug Combination, PfSPZ Challenge (NF54), MVA ME-TRAP
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Functional Magnetic Resonance Imaging, Habits
Neuronal Correlates of Priming on Goal-directed and Cue-dependent Behavior
The current proposal aims to investigate neuronal correlates of implicit and explicit priming paradigms for changing cue-dependent and goal-directed nutritional behavior.
- Conditions
- Functional Magnetic Resonance Imaging, Habits, Eating Behavior
- Trial name
- NCT03735732
- Testing
- prime
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Postpartum Depression (PPD), Postpartum Anxiety
Investigation of TVNS Administration on Postpartum Mental Health
The aim of the study is to explore whether transcutaneous vagus nerve stimulation (tVNS) may be effective in preventing mood swings and depressive symptoms in the postpartum phase, as well as serving as a supplementary…
- Conditions
- Postpartum Depression (PPD), Postpartum Anxiety, Postpartum Sadness, Postpartum Blues
- Trial name
- NCT06682689
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Melanoma, Spitzoid Melanoma
Identification of Risk Factors, Exposomics and Genetic Susceptibility of Melanoma in Children, Adolescents and Young Adults
The primary objective of this study is the identification of environmental and genetic factors involved in the risk and progression of melanoma in children, adolescents and young adults (CAYA).
- Conditions
- Melanoma, Spitzoid Melanoma, Congenital Nevi
- Trial name
- ExpoMel (NCT06680323)
- Where
- 6 sites in Germany, Italy and 3 more
- Volunteers
- 200 people
- Sponsor
- University Hospital Tuebingen
Post Stroke Delirium, Cognitive Functioning After Stroke
Cognitive Recovery After Post Stroke Delirium (RECOVER)
RECOVER is a Proof-of-Concept study on cognitive functioning following a longitudinal design with three measurements (during the acute- and post-acute phases of a stroke and a 3-month follow-up) and two equally-sized stroke…
- Trial name
- RECOVER (NCT06680336)
- Testing
- Mulit-componant neuropsychological assessment, Multimodal MRI
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Acrophobia
Hypnosis Induction and Height Experience in VR - Control Group Comparison and Three Sessions
This study attempts to test wether a VR-supported trance induction and a subsequent exposure to altitude in VR with hypnotic suggestions via Audio reduces acrophobia more than a control-group intervention without trance…
- Trial name
- NCT06618456
- Testing
- VR dive (with Hypnosis), VR dive (without Hypnosis), Height exposure
- Where
- Germany
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Rare Diseases
Rare Tumours in Children and Adolescents (STEP)
The aim of the STEP registry is to collect and evaluate experience and data on the diagnosis and treatment of rare childhood tumors in order to use the knowledge gained to improve the treatment prospects for our patients.
- Trial name
- STEP 2 0 (NCT05773651)
- Testing
- Data collection
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- University Hospital Tuebingen
Moyamoya Disease, Moyamoya
Imaging in Moyamoya Disease - Study to Investigate Different Imaging Technologies for a Better Understanding of Various Imaging Techniques to Evaluate Cerebral Hemodynamics, Disease-activity and Possibly the Etiology in Moyamoya Patients
Aim of this study is to improve patient care in Moyamoya Patients by improving Imaging technologies and aiming to identify factors involved in disease progression.
- Trial name
- IMAGINE (NCT06330818)
- Testing
- MRI, H2 15O PET/CT, Biosampling
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Preterm Infant, Delivery Room
Feasibility and Reliability of Synchronized Non-invasive Intermittent Positive Pressure Ventilation in Preterm Infants After Birth
The aim of this prospective observational study (pilot study) is to test if synchronized noninvasive positive pressure ventilation (S-NIPPV) is feasible and works appropriately during transition from intrauterine to extrauterine…
- Conditions
- Preterm Infant, Delivery Room, Respiratory Support, Synchronized Noninvasive Positive Pressure Ventilation (SNIPPV)
- Trial name
- SenSyNoPP (NCT05399914)
- Testing
- S-NIPPV
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Tuebingen
Bed Rest, Space Analogue
Impact of Energy Density on Energy Intake During Bed Rest
Brief summary: This study is conducted in the context of a 60 days strict bed-rest study with 6° head-down-tilt (HDT) body position.
- Trial name
- ED-REST (NCT06571877)
- Testing
- Dietary intervention with manipulation of the energy density
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Major Depressive Disorder
Effects of rTMS Compared to SSRI as Early Treatment of Depression (Early-TMS)
The aim of this randomized multicentre phase 2 clinical trial is to compare the effects of rTMS and SSRI medication as early treatment of depression.
- Trial name
- Early-TMS (NCT06545474)
- Testing
- bilateral theta burst stimulation, SSRI treatment
- Volunteers
- 106 people
- Sponsor
- University Hospital Tuebingen
Scleroderma, Cardiac Involvement
Autologous Stem Cell Transplantation for Progressive Systemic Sclerosis
Autologous stem cell therapy has been shown to be effective in patients with systemic sclerosis. Nevertheless treatment is associated with treatment related mortality and patients die during follow up despite successful…
- Conditions
- Scleroderma, Cardiac Involvement, Autologous Stem Cell Transplantation
- Trial name
- AST-MOMA (NCT01895244)
- Testing
- Autologous stemcell transplantation with CD (cluster of differentiation) 34 selected stem cells
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University Hospital Tuebingen
Cervical Intraepithelial Neoplasia
Physical Cold Atmospheric Plasma for the Treatment of Cervical Intraepithelial Neoplasia
Cervical intraepithelial neoplasia will be treated with physical low temperature plasma in the plasma cohort compared to watchful waiting in the control cohort. Primary endpoint after 3-6 months: Pathological remission.
- Trial name
- CAPCIN (NCT03218436)
- Testing
- CAP treatment
- Where
- Germany
- Volunteers
- 63 people
- Sponsor
- University Hospital Tuebingen
Stress Incontinence, Female
Intravaginal Laser Treatment of Mild and Moderate Stress Incontinence
The aim of the study is to evaluate the effectiveness of laser therapy as a non-surgical treatment option in patients with mild and moderate stress incontinence.
- Trial name
- laser (NCT03267719)
- Testing
- laser therapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Tuebingen