Clinical trials: sponsored by University Hospital Tuebingen
Advanced Inoperable Vulva Carcinoma
Electrochemotherapy for the Inoperable Vulva Carcinoma
Electrochemotherapy (ECT) with Bleomycin in non-operable advanced vulva carcinoma
- Trial name
- NCT03142061
- Testing
- Electrochemotherapy
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Tuebingen
Breast Surgery
Conserving Breast Surgery - Comparison of Conventional With Sonography
Aim of the study is to test whether surgical removal of a tumor under sonographic control as compared to conventional method reduces the rate of resections and local relapse
- Trial name
- MAC-001 (NCT02222675)
- Testing
- Sonography assisted breast surgery, Conventional breast surgery
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital Tuebingen
Breast Fibroadenoma
Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)
This is a monocenter, open-label, uncontrolled study in accordance with §23b MPG to evaluate the efficacy of the HIFU-treatment of fibroadenoma using the TH-One device.
- Trial name
- HIFU (NCT03022695)
- Testing
- High Intensity Focused Ultrasound
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University Hospital Tuebingen
Breast Biopsy
14 g vs. 16 g in Breast Biopsy
Comparison of biopsy needles with a different diameter, i.e. 14 vs 16 gauge, used for breast biopsies
- Trial name
- NCT03212040
- Testing
- needle biopsy
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- University Hospital Tuebingen
Breast Cancer Surgery
Comparison of Conventional With Sonography Assisted Breast Surgery
Aim of the study is to test whether surgical removal of a tumor under sonographic control as compared to conventional method reduces the rate of resections and local relapse
- Trial name
- NCT02840864
- Testing
- Sonography assisted breast surgery
- Where
- Germany
- Volunteers
- 374 people
- Sponsor
- University Hospital Tuebingen
Subjective Cognitive Decline
Effects of Individualized Theta-tACS on a Working Memory Training at SCD
The aim of the study is to investigate the effects and mechanisms of action of an individualized transcranial alternating current stimulation in the theta-range (ITF-tACS) on a three day spatial working memory training in healthy…
- Trial name
- tACOSenior (NCT06501755)
- Testing
- transcranial alternating current stimulation (tACS)
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Cervical Intraepithelial Neoplasia III
Treatment of Cervical Intraepithelial Neoplasia (CIN) Grade III With Non-invasive Physical Plasma
The aim of the prospective, unicenter proof-of-principle study is to investigate the anti-neoplastic effectiveness of NIPP against CIN III lesions.
- Trial name
- ZGynO_CINIII (NCT04753073)
- Testing
- Non-invasive physical plasma
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- University Hospital Tuebingen
Acute Respiratory Distress Syndrome
Inflammation During ECMO Therapy and ECMO Weaning
The goal of this interventional clinical trial is to compare patients who undergo ECMO therapy for treatment of acute respiratory distress syndrome (ARDS) and a randomized into one of two possible weaning strategy groups.
- Trial name
- ECMOWean (NCT05640635)
- Testing
- Ventilator weaning first, ECMO weaning first
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Borderline Personality Disorder, Posttraumatic Stress Disorder
FKBP5 Methylation and Childhood Emotional Abuse in Complex Posttraumatic Stress Disorder: Investigating the Relationship and Its Predictive Role in Therapy Outcome
The aim of this study is to investigate the role FKBP5 DNA methylation levels in patients suffering from complex posttraumatic stress disorder, who participated in a 12-weeks disorder-specific DBT-PTSD inpatient treatment.
- Trial name
- NCT06433843
- Testing
- Dialectical behavioral therapy for the treatment of posttraumatic stress disorder (DBT-PTSD)
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- University Hospital Tuebingen
Prostate Cancer Recurrent
Antibody CC-1 in Men With Biochemical Recurrence of Prostate Cancer
This trial is a phase I open-label, single center study designed to evaluate the safety, tolerability and preliminary efficacy of the bispecific prostate specific membrane antigen (PSMA) and cluster of differentiation protein 3…
- Trial name
- ProSperACC-1 (NCT05646550)
- Testing
- CC-1 Infusion
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- University Hospital Tuebingen
Type2 Diabetes Mellitus
Empagliflozin Effect on Glucose Toxicity
Empagliflozin effect on glucose toxicity in type 2 diabetes patients - a randomized, open-label, controlled, parallel group, exploratory study
- Trial name
- NCT03437330
- Testing
- Empagliflozin (Jardiance®), Insulin Glargine (Lantus®)
- Where
- 2 sites in Germany
- Sponsor
- University Hospital Tuebingen
Uterine Diseases
Comparative Prospective Data Collection in Connection With Two Different Treatment Methods: Robotic Assisted Laparoscopy and Conventional Laparoscopy
This is a prospective, randomized, single-center, observational clinical trial at the Department of Women's Health of the University Clinic Tübingen.
- Trial name
- NCT03861195
- Testing
- laparoscopic surgery
- Where
- Germany
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Pregnancy
Stress and Fetal Brain Development
The current proposal aims to investigate the impact of acute stress on the fetal autonomic nervous system.
- Trial name
- NCT03831126
- Testing
- Betamethason Sodium Phosphate
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Hypercholesterolemia, Insulin Resistance
Effect of Serum LDL Cholesterol Concentration on Pancreatic Insulin Secretion
Dyslipidemia is characterized by low levels of HDLs, hypertriglyceridemia as well as an increases proportion of small dense LDLs.
- Conditions
- Hypercholesterolemia, Insulin Resistance, Insulin Secretion
- Trial name
- NCT04314167
- Testing
- Lowering cholesterol concentrations by PCSK-9 inhibitor
- Where
- Germany
- Volunteers
- 9 people
- Sponsor
- University Hospital Tuebingen
Prolactin, Breast Stimulation
Prolactin Release Through Breast Stimulation in Non-lactating Women - Who Does Respond?
Prolactin is a multifunctional hormone which acts in different cell types rather than just modulating reproduction and lactation. One additional point is its action on glucose metabolism which is described especially in rodents.
- Trial name
- NCT05208684
- Testing
- Breast stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Central Insulin Resistance, Diabetes Mellitus, Type 2
Central Insulin Sensitivity in Individuals With Type 2 Diabetes (T2D) and at Risk for Developing T2D
Beside well described peripheral effects, insulin can also affect the human central nervous system. Centrally acting insulin seems to have an influence e.g. on whole-body metabolism and food intake.
- Conditions
- Central Insulin Resistance, Diabetes Mellitus, Type 2, PreDiabetes
- Trial name
- NCT05856877
- Testing
- Human nasal insulin
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Diabetes Mellitus, Type 2
Raclopride-PET/MRT
Cerebral insulin resistance plays an important role in the development of obesity and diabetes mellitus type 2. The aim of this project is to examine the effect of human nasal insulin on the dopaminergic system.
- Trial name
- NCT03637075
- Testing
- intranasal insulin
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Spinal Cord Stimulation (SCS), Blood Glucose Metabolism
SCS Stimulation Clamp to Assess Impact of Stimulation on Glucose Metabolism
In 1967 spinal cord stimulation (SCS) for the treatment of chronic neuropathic pain was established. Today various pain syndromes like the failed back surgery syndrome (FBSS), the complex regional pain syndrome (CRPS), ischemic…
- Conditions
- Spinal Cord Stimulation (SCS), Blood Glucose Metabolism, Euglycemic Hyperinsulinemic Clamp
- Trial name
- NCT04272411
- Testing
- Tonic SCS stimulation, Burst SCS Stimulation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Tuebingen
Diabetes Mellitus, Type 2, Osteoporosis
MR-based Characterization of Bone Marrow in Its Relevance to Skeletal Disease in Patients With Diabetes
For a long time, no direct connection was seen between the two common diseases diabetes mellitus and osteoporosis. However, as more and more younger people are affected by obesity, develop type 2 diabetes mellitus and suffer…
- Conditions
- Diabetes Mellitus, Type 2, Osteoporosis, Insulin Resistance
- Trial name
- NCT04950283
- Testing
- magnetic resonance examination, anthropometric and metabolic characterization
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Spinal Cord Stimulation, Insulin Secretion
Effect of Spinal Cord Stimulation (SCS) on Insulin Secretion in Humans
This trial investigates the effect of BurstDR and tonic spinal cord stimulation (SCS) on glucose metabolism and heart rate variability in patients with neuropathic pain.
- Trial name
- NCT05794776
- Testing
- BurstDR stimulation, Tonic stimulation, No stimulation
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen