Clinical trials: sponsored by University Hospital Tuebingen
Hormonal Changes, Menstrual Cycle
Dopamine, Reward Learning and Sex Hormones
Hormonal transition periods during the menstrual cycle may predispose women to mental disorders. Hormonal fluctuations provide specific neuroendocrine conditions that modulate brain structure and function and these actions affect…
- Trial name
- NCT06365515
- Testing
- Levodopa administration
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Cancer
Personalized Multi-peptide Vaccination in Combination With the TLR1/2 Ligand XS15 in Cancer Patients
The aim of this project is to provide personalized multi-peptide vaccination in combination with the TLR1/2 ligand XS15 to individual patients with advanced solid and hematological malignancies without any approved treatment…
- Trial name
- InHeVac01 (NCT05014607)
- Testing
- Personalized multi-peptide vaccine
- Sponsor
- University Hospital Tuebingen
Influenza, SARS-CoV-2
Immunity to Infection in Healthy Participants and Participants With Cancer
Many cancer patients are highly susceptible to infection and respond poorly to vaccination. This observational study will determine molecular and cellular features of immunity to viral pathogens in participants with cancer and…
- Conditions
- Influenza, SARS-CoV-2, Hematologic Malignancy, Solid Tumor
- Trial name
- SYS01 (NCT05787964)
- Testing
- Biological sample collection
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Cancer
(Bispecific) Antibodies in Cancer Patients
The aim of this project is to provide (bispecific) antibodies to individual patients with advanced solid and hematological malignancies without any available approved treatment options.
- Trial name
- InHeAb01 (NCT05119257)
- Testing
- Bispecific antibodies (bsAB)
- Where
- Germany
- Sponsor
- University Hospital Tuebingen
Retinitis Pigmentosa
Clinical and Genetic Findings in Patients With PRPF31-associated Retinitis Pigmentosa
Retrospective chart review study to elucidate the genotype and phenotype of patients with PRPF31-associated retinitis pigmentosa and asymptomatic carriers of the respective variant(s)
- Trial name
- NCT06368375
- Where
- Germany
- Volunteers
- 87 people
- Sponsor
- University Hospital Tuebingen
Major Depressive Disorder
Brain Oscillation-synchronized Stimulation of the Frontal Cortex in Major Depressive Disorder
Major depressive disorder (MDD) is a common severe psychiatric disease with enormous socioeconomic costs for the patient and society alike.
- Trial name
- BOSSFRONT2 (NCT06345651)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Tuebingen
Hepatocellular Carcinoma, Sorafenib
Fingerprint Characterization Tyrosine Kinase Inhibitors in Advanced HCC
This study is a prospective evaluation of a multiscale prediction model for the treatment with tyrosine kinase inhibitors (TKI) in HCC. Patients with HCC that qualify for systemic treatment with TKIs will be included.
- Trial name
- e:Med-HCC-2 (NCT03958669)
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- University Hospital Tuebingen
Auditory Hallucinations, Schizophrenia
Treatment of Auditory Hallucinations in Schizophrenia With Bilateral Theta Burst Stimulation
This randomized, sham-controlled, double blind, multicentre clinical trial aims at providing evidence for the efficacy and safety of continuous theta burst stimulation (cTBS) in the treatment of auditory hallucinations in…
- Trial name
- cTBS-AH (NCT02670291)
- Testing
- MagPro Cool-B65A/P, Magventure
- Where
- Germany
- Volunteers
- 138 people
- Sponsor
- University Hospital Tuebingen
Leishmaniasis
Safety and Drug Absorption of Orally Administered Oleylphosphocholine (OlPC) in Healthy Adults
The goal of this interventional study is to assess the safety and tolerability of OlPC and to characterize the pharmacokinetics (PK) of OlPC following single, ascending doses administered orally in healthy-fed subjects.
- Trial name
- NCT06124144
- Testing
- Oleylphosphocholine
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Hormonal Contraception
Stress Reactivity and Hormonal Contraception
For almost 60 years, millions of women globally have relied on oral contraceptive (OC) pills for pregnancy prevention and addressing menstrual irregularities.
- Trial name
- NCT06223126
- Testing
- Combined oral contraception, Discontinuation of a combined oral contraception
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Breast Cancer Surgery
Comparison of Conventional With Sonography Assisted Breast Surgery After Neoadjuvant Chemotherapy
Aim of the study is to investigate whether intra-surgical visualisation of malignoma reduces the resection rate in the case of R1 resection compared to the procedure without sonographic visualisation
- Trial name
- NCT03737266
- Testing
- Sonographically assisted breast surgery, Conventional breast surgery
- Where
- Germany
- Volunteers
- 137 people
- Sponsor
- University Hospital Tuebingen
Acute Myeloid Leukemia, Adult
Multi-peptide Vaccination Adjuvanted With XS15 in Acute Myeloid Leukemia Patients
The aim of this Phase I study is to evaluate the immunogenicity along with safety and toxicity as well as first efficacy of a multi-peptide vaccine adjuvanted with the TLR1/2 ligand XS15 emulsified in Montanide ISA 51 VG…
- Trial name
- AML-VAC-XS15 (NCT06252584)
- Testing
- Vaccines, Peptide
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Posttransplant Diabetes Mellitus
Tacrolimus Formulation and Glucose Metabolism After Kidney Transplantation (TAGLUMET Trial)
Posttransplantation diabetes mellitus after kidney transplantation mediated by tacrolimus is mainly dependent on dose and peak plasma concentration.
- Trial name
- TAGLUMET (NCT05396898)
- Testing
- LCP-tacrolimus, twice-daily tacrolimus
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University Hospital Tuebingen
Insulin Resistance
Effect of Weight Loss on Brain Insulin Sensitivity in Humans
Obesity if known to be associated with brain insulin resistance in humans. This condition has not only implication for the brain but also for whole-body energy homeostasis.
- Trial name
- NCT02991365
- Testing
- nasal insulin
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Disorder of Consciousness
Amantadine for Neuroenhancement in Acute Patients Study
Introduction: Many patients on intermediate care (IMC) and intensive care units (ICU) suffer from reduced consciousness. In this situation, a treatment attempt with Amantadine is often undertaken.
- Trial name
- ANNES (NCT05479032)
- Testing
- Amantadine
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Tuebingen
Infant,Premature
Effects of Closed-loop Automatic Control of FiO2 in Extremely Preterm Infants
Extremely low gestational age neonates (ELGANs), i.e. those born at <28 weeks, frequently experience intermittent hypoxemic/hyperoxemic episodes.
- Trial name
- FiO2-C (NCT03168516)
- Testing
- closed-loop automatic control of the inspiratory fraction of oxygen (FiO2-C)
- Where
- 32 sites in China, Germany and 2 more
- Volunteers
- 1,065 people
- Sponsor
- University Hospital Tuebingen
Complex Congenital Heart Disease
Noninvasive Measurement of the Cerebral Autoregulation in Neonates and Infants With Complex Congenital Heart Disease
Feasibility of non-invasive cerebral autoregulation measurement at the PICU and impact of changes in oxygen supply
- Trial name
- NCT04810013
- Testing
- non-invasive measurement of cerebral autoregulation
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Tuebingen
Migraine
Human Electrophysiological Model to Quantify the CGRP-related Axon Reflex of Trigeminal Afferents
The proposed project aims at establishing Calcitonin gene-related peptide (CGRP)-Related Axon Reflex of Trigeminal Afferents as a neurophysiological biomarker for migraine.
- Trial name
- MiPro-CGRP (NCT04796766)
- Testing
- High frequency stimulation (HFS), Low-frequency sinusoidal transcutaneous stimulation (sLFS)
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Smoking Cessation
Benefits of a Cognitive Behavioral Therapy Intervention for Smoking Cessation Supported by Virtual Reality Smoking Cue Exposure
Cognitive-behavioral therapy (CBT) combined with medication is an established intervention for smoking cessation. However, long-term abstinence rates of maximum 35% are yielded.
- Trial name
- ViReTa (NCT03707106)
- Testing
- CBT smoking cessation, virtual reality based cue exposure, progressive muscle relaxation
- Where
- 2 sites in Germany
- Volunteers
- 246 people
- Sponsor
- University Hospital Tuebingen
Severe Acute Respiratory Syndrome
Prevalence of Antibodies Against SARS-CoV-2 Virus That Causes COVID-19 in Tübingen Children
This is a prospective, longitudinal study to determine the incidence of SARS-COV-2 infection in children and adolescents by measuring specific antibodies in non-invasive saliva sampled in kindergartens and schools in a defined…
- Trial name
- Coro-Buddy (NCT04581889)
- Testing
- Diagnostic test
- Where
- Germany
- Volunteers
- 2,380 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen